A photo of Alexander Opotowsky.

Alexander Opotowsky, MD, MMSc

  • Director, Adult Congenital Heart Disease Program
  • Co-Director, Exercise Laboratory
  • Co-Director, The Heart Institute Research Core
  • Professor, UC Department of Pediatrics



Alexander (Sasha) Opotowsky is director of the Cincinnati Adult Congenital Heart Disease (CINCH) Program. After medical school at Columbia University’s College of Physicians and Surgeons, he completed Internal Medicine residency at Brigham and Women’s Hospital and Cardiology fellowship at the University of Pennsylvania. After a year of specialized adult congenital cardiology and pulmonary hypertension training at Penn, Dr. Opotowsky completed a two-year senior fellowship and joined the staff of the Boston Adult Congenital Heart Service. Dr. Opotowsky founded the Boston ACHD Biobank in 2012, enrolling and collecting bio-specimens from over 1,600 patients. This resource has facilitated high impact research using circulating and urinary biomarkers to better understand and treat adults born with congenital heart disease.

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Prevalence and Prognostic Association of a Clinical Diagnosis of Depression in Adult Congenital Heart Disease: Results of the Boston Adult Congenital Heart Disease Biobank. Carazo, MR; Kolodziej, MS; DeWitt, ES; Kasparian, NA; Newburger, JW; Duarte, VE; Singh, MN; Opotowsky, AR. Journal of the American Heart Association. 2020; 9.


Creatinine versus cystatin C to estimate glomerular filtration rate in adults with congenital heart disease: Results of the Boston Adult Congenital Heart Disease Biobank. Opotowsky, AR; Carazo, M; Singh, MN; Dimopoulos, K; Cardona-Estrada, DA; Elantably, A; Waikar, SS; Mc Causland, FR; Veldtman, G; Grewal, J; et al. American Heart Journal. 2019; 214:142-155.


Relationship of Red Cell Distribution Width to Adverse Outcomes in Adults With Congenital Heart Disease (from the Boston Adult Congenital Heart Biobank). Alshawabkeh, L; Rajpal, S; Landzberg, MJ; Emani, S; Ephrem, G; Gray, C; Singh, MN; Wu, F; Opotowsky, AR. American Journal of Cardiology. 2018; 122:1557-1564.


Prospective cohort study of C-reactive protein as a predictor of clinical events in adults with congenital heart disease: results of the Boston adult congenital heart disease biobank. Opotowsky, AR; Valente, AM; Alshawabkeh, L; Cheng, S; Bradley, A; Rimm, EB; Landzberg, MJ. European Heart Journal. 2018; 39:3253-3261.


Association of Albuminuria With Major Adverse Outcomes in Adults With Congenital Heart Disease: Results From the Boston Adult Congenital Heart Biobank. Rajpal, S; Alshawabkeh, L; Almaddah, N; Joyce, CM; Shafer, K; Gurvitz, M; Waikar, SS; McCausland, FR; Landzberg, MJ; Opotowsky, AR. JAMA Cardiology. 2018; 3:308-316.


EPAS1 Mutations and Paragangliomas in Cyanotic Congenital Heart Disease. Vaidya, A; Flores, SK; Cheng, Z; Nicolas, M; Deng, Y; Opotowsky, AR; Jr, LD M; Barletta, JA; Rana, HQ; Adelaide Pereira, M; et al. New England Journal of Medicine. 2018; 378:1259-1261.


A Randomized Trial Comparing Cardiac Rehabilitation to Standard of Care for Adults With Congenital Heart Disease. Opotowsky, AR; Rhodes, J; Landzberg, MJ; Bhatt, AB; Shafer, KM; Yeh, DD; Crouter, SE; Tikkanen, AU. World journal for pediatric & congenital heart surgery. 2018; 9:185-193.

Long-Term Outcomes After Atrial Switch Operation for Transposition of the Great Arteries. Broberg, CS; van Dissel, A; Minnier, J; Aboulhosn, J; Kauling, RM; Ginde, S; Krieger, EV; Rodriguez, F; Gupta, T; Shah, S; et al. Journal of the American College of Cardiology. 2022; 80:951-963.

Comparison Of 6 Minute Walk Test To Cardiopulmonary Exercise Test In Congenital Heart Disease Patients. Rice, MC; Mays, WA; Knecht, SK; Shertzer, JD; Harmon, MJ; Flairty, JE; Powell, AW; Wittekind, SG; Opotowsky, AR; Chin, C. Medicine and Science in Sports and Exercise. 2022; 54:250-250.

Time in Therapeutic Range With Vitamin K Antagonists in Congenital Heart Disease: A Multicentre Study. Basmaji, S; Samuel, M; Shohoudi, A; Hamilton, RM; Aboulhosn, J; Broberg, CS; Chaix, MA; Cohen, S; Cook, S; Dore, A; et al. Canadian Journal of Cardiology. 2022.

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