Jeremy Rubinstein, MD, PhD
- Member, Division of Oncology
- Associate Professor, UC Department of Pediatrics
- jeremy.rubinstein@cchmc.org
- Board Certified
About
Biography
As a pediatric oncologist, I specialize in treating pediatric leukemia and lymphoma, emphasizing the use of cellular therapy. Cellular therapy involves modifying a patient’s own cells or cells from a donor to fight disease.
I have long been inspired by the strength and bravery of children going through cancer diagnosis and treatment. It is an incredibly difficult process. I'm passionate about providing longitudinal care while guiding patients and their families through this challenging time. I strive to treat every patient I meet with the utmost respect, care, patience, honesty and dedication.
My research focuses on using new and emerging cellular therapy techniques to better treat difficult-to-manage leukemias and lymphomas and the management of important side effects such as viral infections. I am the recipient of a St. Baldrick's Fellow research grant from July 2020 to July 2022, looking at the use of T-cell therapy to prevent viral infections.
I love to spend my free time with my wife, son and daughter. I also like to run, read books and play basketball.
Undergraduate: University of Virginia, Charlottesville, VA
MD/PhD: University of Virginia, Charlottesville, VA
Residency: Pediatrics, Cincinnati Children’s, Cincinnati, OH
Interests
Pediatric oncology; leukemia; lymphoma; cellular therapy; post-transplant lymphoproliferative disorder (PTLD)
Services and Specialties
Interests
Viral infections are a significant source of morbidity and mortality in patients following hematopoietic stem cell transplant and antiviral medications carry high toxicity profiles often with suboptimal response. Dr. Rubinstein's research focuses on the use of virus-specific T cell (VST) therapy to combat a number of viruses seen after both stem cell transplantation and solid organ transplantation. He is involved in numerous clinical trials seeking to optimize the use of this approach and works closely with laboratory-based collaborators to improve knowledge and understanding of their mechanism of action.
Research Areas
Locations (2)
Insurance Information
Cincinnati Children's strives to accept a wide variety of health plans. Please contact your health insurance carrier to verify coverage for your specific benefit plan.
Publications
Scheduled administration of virus-specific T cells for viral prophylaxis after pediatric allogeneic stem cell transplant. Blood advances. 2022; 6(9):2897-2907.
Virus-specific T cells for adenovirus infection after stem cell transplantation are highly effective and class II HLA restricted. Blood advances. 2021; 5(17):3309-3321.
Virus-specific T-cell therapy to treat BK polyomavirus infection in bone marrow and solid organ transplant recipients. Blood advances. 2020; 4(22):5745-5754.
Chimeric Antigen Receptor T Cell Therapy in Patients with Multiply Relapsed or Refractory Extramedullary Leukemia. Transplantation and Cellular Therapy. 2020; 26(11):e280-e285.
Emapalumab for Immune Effector Cell-Associated Hemophagocytic Lymphohistiocytosis-Like Syndrome Following CD19-Directed CAR-T in Two Patients With B-ALL: Clinical and Biomarker Correlates. Pediatric Blood and Cancer. 2026; e70406.
Third-Party Viral Specific T Cells for Immunocompromised Hosts and Access Barriers: A Review and Commentary by an Expert Panel from ASTCT. Transplantation and Cellular Therapy. 2026.
LONG-TERM CRYOPRESERVATION PRESERVES THE BIOLOGICAL AND MECHANOBIOLOGICAL ACTIVITY OF THIRD-PARTY VIRUS-SPECIFIC T CELLS. Cytotherapy. 2026; 28(5):102608.
Duration of Cryopreservation of Third-Party Viral Specific T-Cells (TP-VSTs) Does Not Influence Clinical Efficacy. Transplantation and Cellular Therapy. 2026; 32(2):s131.
Biomarker Elevations Associated with Immune Effector Cell-Associated Hemophagocytic Lymphohistiocytosis-like Syndrome after CD19-Directed CAR-T Therapy in Children and Young Adults with Acute B-Lymphoblastic Leukemia. Transplantation and Cellular Therapy. 2026; 32(2):s177.
Outcomes with third-party virus-specific T cells after the use of single-antigen cell lines to predict HLA restriction. Blood advances. 2025; 9(24):6305-6313.
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