A photo of Patrick Ryan.

Professor, UC Department of PediatricsUC Department of Environmental Health

513-803-4704

Biography & Affiliation

Biography

My research involves assessing environmental exposures, particularly air pollutants, and studying how they affect pediatric respiratory health and neurodevelopment. My research primarily involves:

  • Air pollution
  • The built environment including greenspace
  • The use of personal monitors and sensors to measure environmental exposures
  • Environmental asbestos exposure

The goals of my research are to answer the following questions: 1) How do we accurately characterize exposure to environmental pollutants, especially air pollutants; and 2) What is the impact or health effects of environmental exposures, especially air pollutants?

Early in my career, I developed the first land-use regression model of elemental carbon, a traffic-related pollutant. This model has been widely applied and used in the Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS) to assess childhood exposure to traffic-related air pollution with childhood wheezing, asthma onset and other respiratory diseases. More recently, we have linked traffic-related air pollution to childhood mental health, including anxiety and depression.

My focus on air pollution has also led to community-based research to study air quality and local schools, to demonstrate the effectiveness of anti-idling campaigns on improving air quality near schools. In addition, I have collaborated with engineers to develop personal monitors for air pollution, including ultrafine particles. My research group is currently utilizing these personal monitors to measure adolescents’ personal exposure to air pollution and understand how they impact respiratory health.

Other research interests include the identification of environmental, demographic, home and other factors associated with personal exposure to specific elemental constituents of particulate matter and the impact of naturally occurring elongated mineral fibers (e.g. asbestos) on respiratory and autoimmune disease in the western United States.

My research has been supported by local and national organizations, including the National Institutes of Health (NIH), the Centers for Disease Control and Prevention (CDC), the Environmental Protection Agency (EPA) and the Health Effects Institute (HEI). The results of these research efforts have been published in more than 100 peer-reviewed papers.

Locally, I serve on multiple mentoring committees including clinical fellows, K recipients and junior faculty. I also currently serve as the co-director of the MS in Clinical and Translational Research program and the director of Translational Workforce Development for the Center for Clinical and Translational Science and Training at Cincinnati Children’s.

Research Interests

Environmental epidemiology; air pollution; personal monitors; greenspace; neurodevelopment; respiratory health

Academic Affiliation

Professor, UC Department of PediatricsUC Department of Environmental Health

Divisions

Biostatistics

Education

PhD: University of Cincinnati, Cincinnati, OH, 2007.

MS: University of Cincinnati, Cincinnati, OH, 2004.

BS: Xavier University, Cincinnati, OH, 2001.

Publications

Effect of greenness on asthma in children: A systematic review. Hartley, K; Ryan, P; Brokamp, C; Gillespie, GL. Public Health Nursing. 2020; 37:453-460.

Atopic dermatitis independently increases sensitization above parental atopy: The MPAACH study. Kroner, JW; Kyzy, AB; Burkle, JW; Martin, LJ; LeMasters, GK; Bernstein, DI; Lockey, JE; Ryan, P; Hershey, GK K; Myers, JM B. Journal of Allergy and Clinical Immunology. 2020; 145:1464-1466.

Expression quantitative trait locus fine mapping of the 17q12–21 asthma locus in African American children: a genetic association and gene expression study. Ober, C; McKennan, CG; Magnaye, KM; Altman, MC; Washington, C; Stanhope, C; Naughton, KA; Rosasco, MG; Bacharier, LB; Billheimer, D; et al. The Lancet Respiratory Medicine. 2020; 8:482-492.

HEPA filtration improves asthma control in children exposed to traffic-related airborne particles. James, C; Bernstein, DI; Cox, J; Ryan, P; Wolfe, C; Jandarov, R; Newman, N; Indugula, R; Reponen, T. Indoor Air: international journal of indoor air quality and climate. 2020; 30:235-243.

Reduced gray matter volume and cortical thickness associated with traffic-related air pollution in a longitudinally studied pediatric cohort. Beckwith, T; Cecil, K; Altaye, M; Severs, R; Wolfe, C; Percy, Z; Maloney, T; Yolton, K; LeMasters, G; Brunst, K; et al. PLoS ONE. 2020; 15:e0228092-e0228092.

A comparison of blood and toenails as biomarkers of children's exposure to lead and their correlation with cognitive function. Dantzer, J; Ryan, P; Yolton, K; Parsons, PJ; Palmer, CD; Cecil, K; Unrine, JM. Science of the Total Environment. 2020; 700:134519-134519.

The Children's Respiratory and Environmental Workgroup (CREW) birth cohort consortium: Design, methods, and study population. Gern, JE; Jackson, DJ; Lemanske, RF; Seroogy, CM; Tachinardi, U; Craven, M; Hwang, SY; Hamilton, CM; Huggins, W; O'Connor, GT; et al. Respiratory Research. 2019; 20.

Pediatric psychiatric emergency department utilization and fine particulate matter: A case-crossover study. Brokamp, C; Strawn, JR; Beck, AF; Ryan, P. Environmental Health Perspectives. 2019; 127:97006-097006.

Myo-inositol mediates the effects of traffic-related air pollution on generalized anxiety symptoms at age 12 years. Brunst, KJ; Ryan, PH; Altaye, M; Yolton, K; Maloney, T; Beckwith, T; LeMasters, G; Cecil, KM. Environmental Research. 2019; 175:71-78.

Combining sensor-based measurement and modeling of PM2.5 and black carbon in assessing exposure to indoor aerosols. Cox, J; Cho, SH; Ryan, P; Isiugo, K; Ross, J; Chillrud, S; Zhu, Z; Jandarov, R; Grinshpun, SA; Reponen, T. Aerosol Science and Technology. 2019; 53:817-829.