A photo of Daniel Swarr, MD.

Assistant Professor, UC Department of Pediatrics

513-803-8396

Board Certified

My Biography & Research

Biography

From my first rotations as a medical student, I found caring for children to be the most rewarding area of medicine. Today, as a neonatologist and perinatal medicine specialist, I spend most of my clinical time in the Neonatal Intensive Care Unit (NICU).

The NICU is a truly special place to work. We care for critically ill infants with medical conditions ranging from prematurity to genetic syndromes. It’s gratifying to see some of the most fragile patients in the hospital flourish under our care and go on to lead happy, healthy and productive lives.

Although we are lucky to see so many of our patients thrive after leaving the NICU, as a researcher, I’ve always wanted to improve our understanding of the complex medical conditions that affect these infants — and ultimately provide better treatment options. Fortunately, we are currently in the midst of a revolution in genetics and genomics diagnostics in neonatology, as well as rapid advances in regenerative medicine. It is an exciting and satisfying time to be part of this field.

In my laboratory, we aim to better understand the etiology and pathogenesis of congenital malformations and perinatal lung disorders. Using a wide variety of tools from developmental biology, genetics and epigenetics, we’re investigating the molecular mechanisms underlying lung development, injury, repair and regeneration. Our primary focus is understanding the epigenetic mechanisms by which gene expression modules are established and maintained throughout the lung’s lifespan, and how changes in this “epigenetic code” contribute to pulmonary disease.

The research questions that we ask in the laboratory focus on core biological questions that may seem far removed from clinical care. However, by better understanding basic biology, we will be able to gain insight into the underlying causes of diseases affecting infants and children. This will help us pave the way for novel strategies that encourage the body to repair itself following an injury or disease process.

When I’m not busy in my research lab or the NICU, I also see families as a geneticist for prenatal consultations in the Cincinnati Children’s Fetal Care Center.

Clinical Interests

Isolated and syndromic birth defects; bronchopulmonary dysplasia; pediatric lung diseases; general neonatology

Research Interests

Early endoderm and lung development; epigenetic regulation of gene expression; long non-coding RNAs; Congenital lung malformations; TEF/EA; VACTERL

Academic Affiliation

Assistant Professor, UC Department of Pediatrics

Clinical Divisions

Neonatology, Perinatal

Research Divisions

Neonatology, Perinatal Biology, Pulmonary Biology

My Locations

My Education

MD: Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 2007.

Residency: General Pediatrics, Baylor College of Medicine & Texas Children’s Hospital, Houston, TX, 2007-2010.

Fellowship: Combined Fellowship in Neonatal-Perinatal Medicine and Medical Genetics, The Children’s Hospital of Philadelphia, Philadelphia, PA, 2010-2015.

Board Certifications: General Pediatrics, 2010; Medical Genetics & Genomics, 2015; Neonatal-Perinatal Medicine, 2016.

My Publications

Beyond diagnostic yield: prenatal exome sequencing results in maternal, neonatal, and familial clinical management changes. Tolusso, LK; Hazelton, P; Wong, B; Swarr, DT. Genetics in Medicine. 2021; 23:909-917.

"PIK "ing Out New Epigenetic Markers in Lung Disease. Swarr, D; Putcha, N; Zacharias, W. American Journal of Respiratory and Critical Care Medicine. 2020; 201:1029-1030.

Chapter 67 Cell- and tissue-based therapies for lung disease. Whitsett, JA; Zacharias, W; Swarr, D; Kalinichenko, VV. Principles of Tissue Engineering. 2020.

Making a Genetic Diagnosis in a Level IV Neonatal Intensive Care Unit Population: Who, When, How, and at What Cost?. Swaggart, KA; Swarr, DT; Tolusso, LK; He, H; Dawson, DB; Suhrie, KR. Journal of Pediatrics. 2019; 213:211-217.e4.

The long noncoding RNA Falcor regulates Foxa2 expression to maintain lung epithelial homeostasis and promote regeneration. Swarr, DT; Herriges, M; Li, S; Morley, M; Fernandes, S; Sridharan, A; Zhou, S; Garcia, BA; Stewart, K; Morrisey, EE. Genes and Development. 2019; 33:656-668.

Molecular Determinants of Lung Morphogenesis. Swarr, DT; Wert, SE; Whitsett, JA. Kendig's Disorders of the Respiratory Tract in Children. 2019.

Congenital Cystic Lung Lesions: Redefining the Natural Distribution of Subtypes and Assessing the Risk of Malignancy. Pogoriler, J; Swarr, D; Kreiger, P; Adzick, NS; Peranteau, W. American Journal of Surgical Pathology. 2019; 43:47-55.

2 Molecular Determinants of Lung Morphogenesis. Swarr, DT; Wert, SE; Whitsett, JA. Kendig's Disorders of the Respiratory Tract in Children. 2019.

Novel Molecular and Phenotypic Insights into Congenital Lung Malformations. Swarr, DT; Peranteau, WH; Pogoriler, J; Frank, DB; Adzick, NS; Hedrick, HL; Morley, M; Zhou, S; Morrisey, EE. American Journal of Respiratory and Critical Care Medicine. 2018; 197:1328-1339.

Systematic Review and Meta-analysis: Gene Association Studies in Neonatal Sepsis. Srinivasan, L; Swarr, DT; Sharma, M; Cotten, CM; Kirpalani, H. American Journal of Perinatology. 2017; 34:684-692.