Male mice placed on a ketogenic diet from postnatal day (P) 21 through adulthood have reduced growth, are hypoactive, show increased freezing in a conditioned fear paradigm, and have spatial learning deficits.
Miles, KN; Skelton, MR.
Brain Research.
2020;
1734:146697-146697.
Creatine transporter knockout mice (Slc6a8) show increases in serotonin-related proteins and are resilient to learned helplessness.
Abdulla, ZI; Pennington, JL; Gutierrez, A; Skelton, MR.
Behavioural Brain Research.
2020;
377:112254-112254.
Deletion of the Creatine Transporter (Slc6a8) in Dopaminergic Neurons Leads to Hyperactivity in Mice.
Abdulla, ZI; Pahlevani, B; Lundgren, KH; Pennington, JL; Udobi, KC; Seroogy, KB; Skelton, MR.
Journal of Molecular Neuroscience.
2020;
70:102-111.
Deletion of the creatine transporter gene in neonatal, but not adult, mice leads to cognitive deficits.
Udobi, KC; Delcimmuto, N; Kokenge, AN; Abdulla, ZI; Perna, MK; Skelton, MR.
Journal of Inherited Metabolic Disease.
2019;
42:966-974.
Dodecyl creatine ester-loaded nanoemulsion as a promising therapy for creatine transporter deficiency.
Ullio-Gamboa, G; Udobi, KC; Dezard, S; Perna, MK; Miles, KN; Costa, N; Taran, F; Pruvost, A; Benoit, J; Skelton, MR; et al.
Nanomedicine (London, England).
2019;
14:1579-1593.
Intranasal carnosine attenuates transcriptomic alterations and improves mitochondrial function in the Thy1-aSyn mouse model of Parkinson's disease.
Bermudez, M; Skelton, MR; Genter, MB.
Molecular Genetics and Metabolism.
2018;
125:305-313.
Cognitive deficits and increases in creatine precursors in a brain-specific knockout of the creatine transporter gene Slc6a8.
Udobi, KC; Kokenge, AN; Hautman, ER; Ullio, G; Coene, J; Williams, MT; Vorhees, CV; Mabondzo, A; Skelton, MR.
Genes, Brain and Behavior.
2018;
17:e12461-e12461.
Phosphodiesterase-1b (Pde1b) knockout mice are resistant to forced swim and tail suspension induced immobility and show upregulation of Pde10a.
Hufgard, JR; Williams, MT; Skelton, MR; Grubisha, O; Ferreira, FM; Sanger, H; Wright, ME; Reed-Kessler, TM; Rasmussen, K; Duman, RS; et al.
Psychopharmacology.
2017;
234:1803-1813.
A heterozygous mutation in tubulin, beta 2B (Tubb2b) causes cognitive deficits and hippocampal disorganization.
Stottmann, RW; Driver, A; Gutierrez, A; Skelton, MR; Muntifering, M; Stepien, C; Knudson, L; Kofron, M; Vorhees, CV; Williams, MT.
Genes, Brain and Behavior.
2017;
16:250-259.
Developmental manganese neurotoxicity in rats: Cognitive deficits in allocentric and egocentric learning and memory.
Amos-Kroohs, RM; Davenport, LL; Atanasova, N; Abdulla, ZI; Skelton, MR; Vorhees, CV; Williams, MT.
Neurotoxicology and Teratology.
2017;
59:16-26.