A photo of Matthew Skelton.

Neurobiologist, Division of Neurology

Assistant Professor, UC Department of Pediatrics

Biography & Affiliation

Academic Affiliation

Assistant Professor, UC Department of Pediatrics




BA: Biology, Bellarmine University, Louisville, KY, 2000.

PhD: Molecular and Developmental Biology, University of Cincinnati, Cincinnati, OH, 2006.


Male mice placed on a ketogenic diet from postnatal day (P) 21 through adulthood have reduced growth, are hypoactive, show increased freezing in a conditioned fear paradigm, and have spatial learning deficits. Miles, KN; Skelton, MR. Brain Research. 2020; 1734:146697-146697.

Creatine transporter knockout mice (Slc6a8) show increases in serotonin-related proteins and are resilient to learned helplessness. Abdulla, ZI; Pennington, JL; Gutierrez, A; Skelton, MR. Behavioural Brain Research. 2020; 377:112254-112254.

Deletion of the Creatine Transporter (Slc6a8) in Dopaminergic Neurons Leads to Hyperactivity in Mice. Abdulla, ZI; Pahlevani, B; Lundgren, KH; Pennington, JL; Udobi, KC; Seroogy, KB; Skelton, MR. Journal of Molecular Neuroscience. 2020; 70:102-111.

Deletion of the creatine transporter gene in neonatal, but not adult, mice leads to cognitive deficits. Udobi, KC; Delcimmuto, N; Kokenge, AN; Abdulla, ZI; Perna, MK; Skelton, MR. Journal of Inherited Metabolic Disease. 2019; 42:966-974.

Dodecyl creatine ester-loaded nanoemulsion as a promising therapy for creatine transporter deficiency. Ullio-Gamboa, G; Udobi, KC; Dezard, S; Perna, MK; Miles, KN; Costa, N; Taran, F; Pruvost, A; Benoit, J; Skelton, MR; et al. Nanomedicine (London, England). 2019; 14:1579-1593.

Intranasal carnosine attenuates transcriptomic alterations and improves mitochondrial function in the Thy1-aSyn mouse model of Parkinson's disease. Bermudez, M; Skelton, MR; Genter, MB. Molecular Genetics and Metabolism. 2018; 125:305-313.

Cognitive deficits and increases in creatine precursors in a brain-specific knockout of the creatine transporter gene Slc6a8. Udobi, KC; Kokenge, AN; Hautman, ER; Ullio, G; Coene, J; Williams, MT; Vorhees, CV; Mabondzo, A; Skelton, MR. Genes, Brain and Behavior. 2018; 17:e12461-e12461.

Phosphodiesterase-1b (Pde1b) knockout mice are resistant to forced swim and tail suspension induced immobility and show upregulation of Pde10a. Hufgard, JR; Williams, MT; Skelton, MR; Grubisha, O; Ferreira, FM; Sanger, H; Wright, ME; Reed-Kessler, TM; Rasmussen, K; Duman, RS; et al. Psychopharmacology. 2017; 234:1803-1813.

A heterozygous mutation in tubulin, beta 2B (Tubb2b) causes cognitive deficits and hippocampal disorganization. Stottmann, RW; Driver, A; Gutierrez, A; Skelton, MR; Muntifering, M; Stepien, C; Knudson, L; Kofron, M; Vorhees, CV; Williams, MT. Genes, Brain and Behavior. 2017; 16:250-259.

Developmental manganese neurotoxicity in rats: Cognitive deficits in allocentric and egocentric learning and memory. Amos-Kroohs, RM; Davenport, LL; Atanasova, N; Abdulla, ZI; Skelton, MR; Vorhees, CV; Williams, MT. Neurotoxicology and Teratology. 2017; 59:16-26.