A photo of Soona Shin.

Soona Shin, PhD

  • Member, Division of Pediatric General and Thoracic Surgery
  • Associate Professor, UC Department of Surgery


BS: Pharmacy, Seoul National University, Seoul, South Korea, 2002.

MS: Pharmacy, Seoul National University, Seoul, South Korea, 2004.

PhD: Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD, 2009.

Postdoctoral training: Genetics, University of Pennsylvania, Philadelphia, PA, 2012.


Liver cancer; tumor initiation; cell-cell communication; hepatic progenitor cells

Research Areas

General and Thoracic Surgery



Cellular origins of regenerating liver and hepatocellular carcinoma. Holczbauer, Á; Wangensteen, KJ; Shin, S. 2022; 4.


Reactive Ductules Are Associated With Angiogenesis and Tumor Cell Proliferation in Pediatric Liver Cancer. Lee, S; Zhou, P; Gupta, A; Shin, S. Hepatology Communications. 2018; 2:1199-1212.


Genetic lineage tracing analysis of the cell of origin of hepatotoxin-induced liver tumors in mice. Shin, S; Wangensteen, KJ; Teta-Bissett, M; Wang, YJ; Mosleh-Shirazi, E; Buza, EL; Greenbaum, LE; Kaestner, KH. Hepatology. 2016; 64:1163-1177.


Ablation of Foxl1-Cre-labeled hepatic progenitor cells and their descendants impairs recovery of mice from liver injury. Shin, S; Upadhyay, N; Greenbaum, LE; Kaestner, KH. Gastroenterology. 2015; 148:192-202.e3.


The origin, biology, and therapeutic potential of facultative adult hepatic progenitor cells. Shin, S; Kaestner, KH. Current Topics in Developmental Biology. 2014; 107:269-292.


Foxl1-Cre-marked adult hepatic progenitors have clonogenic and bilineage differentiation potential. Shin, S; Walton, G; Aoki, R; Brondell, K; Schug, J; Fox, A; Smirnova, O; Dorrell, C; Erker, L; Chu, AS; et al. Genes and Development. 2011; 25:1185-1192.

Mechanism of paracrine communications between hepatic progenitor cells and endothelial cells. Lee, S; Karns, R; Shin, S. Cellular Signalling. 2022; 100.

A developmentally prometastatic niche to hepatoblastoma in neonatal liver mediated by the Cxcl1/Cxcr2 axis. Fan, L; Pan, Q; Yang, W; Koo, SC; Tian, C; Li, L; Lu, M; Brown, A; Ju, B; Easton, J; et al. Hepatology. 2022; 76:1275-1290.

β-catenin cancer-enhancing genomic regions axis is involved in the development of fibrolamellar hepatocellular carcinoma. Gulati, R; Johnston, M; Rivas, M; Cast, A; Kumbaji, M; Hanlon, MA; Lee, S; Zhou, P; Lake, C; Schepers, E; et al. Hepatology Communications. 2022; 6:2950-2963.