Soona Shin, PhD
- Member, Division of Pediatric General and Thoracic Surgery
- Associate Professor, UC Department of Surgery
About
Biography
My academic journey began with a PhD in pharmacology and molecular sciences at Johns Hopkins University School of Medicine, where I studied transcriptional regulation of the Nrf2-AhR pathway and the role of Nrf2 in adipocyte differentiation and metabolism.
From 2009 to 2012, I conducted postdoctoral research at the University of Pennsylvania's Perelman School of Medicine, focusing on facultative hepatic progenitor cells. I continued there as an instructor until 2015, investigating the role of hepatic progenitor cells in liver regeneration and cancer.
In 2015, I joined the Division of Pediatric General and Thoracic Surgery at Cincinnati Children's and the Department of Surgery at the University of Cincinnati College of Medicine. I currently serve as an associate professor. My research focuses on deciphering the molecular and cellular mechanisms of liver cancer in children and adults, with particular emphasis on cell-to-cell communication, tumor initiation, and cell differentiation.
BS: Pharmacy, Seoul National University, Seoul, South Korea, 2002.
MS: Pharmacy, Seoul National University, Seoul, South Korea, 2004.
PhD: Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD, 2009.
Postdoctoral training: Genetics, University of Pennsylvania, Philadelphia, PA, 2012.
Services and Specialties
Interests
Liver cancer; tumor initiation; cell-cell communication; hepatic progenitor cells
Research Areas
Publications
Mechanism of paracrine communications between hepatic progenitor cells and endothelial cells. Cellular Signalling. 2022; 100:110458.
β-catenin cancer-enhancing genomic regions axis is involved in the development of fibrolamellar hepatocellular carcinoma. Hepatology Communications. 2022; 6:2950-2963.
Cellular origins of regenerating liver and hepatocellular carcinoma. JHEP Reports. 2022; 4:100416.
Adeno-Associated Virus Serotype 8-Mediated Genetic Labeling of Cholangiocytes in the Neonatal Murine Liver. Pharmaceutics. 2020; 12:E351.
Reactive Ductules Are Associated With Angiogenesis and Tumor Cell Proliferation in Pediatric Liver Cancer. Hepatology Communications. 2018; 2:1199-1212.
Genetic lineage tracing analysis of the cell of origin of hepatotoxin-induced liver tumors in mice. Hepatology. 2016; 64:1163-1177.
Ablation of Foxl1-Cre-labeled hepatic progenitor cells and their descendants impairs recovery of mice from liver injury. Gastroenterology. 2015; 148:192-202.e3.
The origin, biology, and therapeutic potential of facultative adult hepatic progenitor cells. Current Topics in Developmental Biology. 2014; 107:269-292.
Foxl1-Cre-marked adult hepatic progenitors have clonogenic and bilineage differentiation potential. Genes and Development. 2011; 25:1185-1192.
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