A photo of Soona Shin.

Assistant Professor, UC Department of Surgery

513-803-8970

Biography & Affiliation

Research Interests

Liver cancer; liver stem cells.

Academic Affiliation

Assistant Professor, UC Department of Surgery

Research Divisions

General and Thoracic Surgery

Education

BS: Pharmacy, Seoul National University, Seoul, South Korea, 2002.

MS: Pharmacy, Seoul National University, Seoul, South Korea, 2004.

PhD: Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD, 2009.

Postdoctoral training: Genetics, University of Pennsylvania, Philadelphia, PA, 2012.

Publications

Selected Publication

Reactive Ductules Are Associated With Angiogenesis and Tumor Cell Proliferation in Pediatric Liver Cancer. Lee, S; Zhou, P; Gupta, A; Shin, S. Hepatology Communications. 2018; 2:1199-1212.

Gankyrin Promotes Tumor-Suppressor Protein Degradation to Drive Hepatocyte Proliferation. D'Souza, AM; Jiang, Y; Cast, A; Valanejad, L; Wright, M; Lewis, K; Kumbaji, M; Shah, S; Smithrud, D; Karns, R; et al. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2018; 6:239-255.

C/EBPα-dependent preneoplastic tumor foci are the origin of hepatocellular carcinoma and aggressive pediatric liver cancer. Cast, A; Valanejad, L; Wright, M; Nguyen, P; Gupta, A; Zhu, L; Shin, S; Timchenko, N. Hepatology. 2018; 67:1857-1871.

Genetic lineage tracing analysis of the cell of origin of hepatotoxin-induced liver tumors in mice. Shin, S; Wangensteen, KJ; Teta-Bissett, M; Wang, YJ; Mosleh-Shirazi, E; Buza, EL; Greenbaum, LE; Kaestner, KH. Hepatology. 2016; 64:1163-1177.

Foxl1-expressing mesenchymal cells constitute the intestinal stem cell niche. Aoki, R; Shoshkes-Carmel, M; Gao, N; Shin, S; May, CL; Golson, ML; Zahm, AM; Ray, M; Wiser, CL; Wright, CV E; et al. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2016; 2:175-188.

Ablation of Foxl1-Cre-labeled hepatic progenitor cells and their descendants impairs recovery of mice from liver injury. Shin, S; Upadhyay, N; Greenbaum, LE; Kaestner, KH. Gastroenterology. 2015; 148:192-202.e3.

CREB mediates the insulinotropic and anti-apoptotic effects of GLP-1 signaling in adult mouse β-cells. Shin, S; Le Lay, J; Everett, LJ; Gupta, R; Rafiq, K; Kaestner, KH. Molecular Metabolism. 2014; 3:803-812.

Bile acid-induced inflammatory signaling in mice lacking Foxa2 in the liver leads to activation of mTOR and age-onset obesity. Bochkis, IM; Shin, S; Kaestner, KH. Molecular Metabolism. 2013; 2:447-456.

Foxl1-Cre-marked adult hepatic progenitors have clonogenic and bilineage differentiation potential. Shin, S; Walton, G; Aoki, R; Brondell, K; Schug, J; Fox, A; Smirnova, O; Dorrell, C; Erker, L; Chu, AS; et al. Genes and Development. 2011; 25:1185-1192.

Foxl1 promotes liver repair following cholestatic injury in mice. Sackett, SD; Gao, Y; Shin, S; Esterson, YB; Tsingalia, A; Hurtt, RS; Brondell, K; Kaestner, KH; Greenbaum, LE. Laboratory Investigation. 2009; 89:1387-1396.