A photo of Soona Shin.

Soona Shin, PhD

  • Member, Division of Pediatric General and Thoracic Surgery
  • Associate Professor, UC Department of Surgery

About

BS: Pharmacy, Seoul National University, Seoul, South Korea, 2002.

MS: Pharmacy, Seoul National University, Seoul, South Korea, 2004.

PhD: Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD, 2009.

Postdoctoral training: Genetics, University of Pennsylvania, Philadelphia, PA, 2012.

Interests

Liver cancer; tumor initiation; cell-cell communication; hepatic progenitor cells

Research Areas

General and Thoracic Surgery

Publications

Selected

HDAC1-Dependent Repression of Markers of Hepatocytes and P21 Is Involved in Development of Pediatric Liver Cancer. Rivas, M; Johnston, ME; Gulati, R; Kumbaji, M; Margues Aguiar, TF; Timchenko, L; Krepischi, A; Shin, S; Bondoc, A; Tiao, G; et al. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2021; 12:1669-1682.

Selected

Adeno-Associated Virus Serotype 8-Mediated Genetic Labeling of Cholangiocytes in the Neonatal Murine Liver. Lee, S; Zhou, P; Whyte, S; Shin, S. Pharmaceutics. 2020; 12.

Selected

Reactive Ductules Are Associated With Angiogenesis and Tumor Cell Proliferation in Pediatric Liver Cancer. Lee, S; Zhou, P; Gupta, A; Shin, S. Hepatology Communications. 2018; 2:1199-1212.

Selected

Gankyrin Promotes Tumor-Suppressor Protein Degradation to Drive Hepatocyte Proliferation. D'Souza, AM; Jiang, Y; Cast, A; Valanejad, L; Wright, M; Lewis, K; Kumbaji, M; Shah, S; Smithrud, D; Karns, R; et al. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2018; 6:239-255.

Selected

C/EBPα-dependent preneoplastic tumor foci are the origin of hepatocellular carcinoma and aggressive pediatric liver cancer. Cast, A; Valanejad, L; Wright, M; Nguyen, P; Gupta, A; Zhu, L; Shin, S; Timchenko, N. Hepatology. 2018; 67:1857-1871.

Selected

Genetic lineage tracing analysis of the cell of origin of hepatotoxin-induced liver tumors in mice. Shin, S; Wangensteen, KJ; Teta-Bissett, M; Wang, YJ; Mosleh-Shirazi, E; Buza, EL; Greenbaum, LE; Kaestner, KH. Hepatology. 2016; 64:1163-1177.

Selected

Ablation of Foxl1-Cre-labeled hepatic progenitor cells and their descendants impairs recovery of mice from liver injury. Shin, S; Upadhyay, N; Greenbaum, LE; Kaestner, KH. Gastroenterology. 2015; 148:192-202.e3.

Selected

CREB mediates the insulinotropic and anti-apoptotic effects of GLP-1 signaling in adult mouse β-cells. Shin, S; Le Lay, J; Everett, LJ; Gupta, R; Rafiq, K; Kaestner, KH. Molecular Metabolism. 2014; 3:803-812.

Selected

Foxl1-Cre-marked adult hepatic progenitors have clonogenic and bilineage differentiation potential. Shin, S; Walton, G; Aoki, R; Brondell, K; Schug, J; Fox, A; Smirnova, O; Dorrell, C; Erker, L; Chu, AS; et al. Genes and Development. 2011; 25:1185-1192.

Cellular Origins of Regenerating Liver and Hepatocellular Carcinoma. Holczbauer, A; Wangensteen, KJ; Shin, S. 2021.