The Shin lab’s research aims to decipher the molecular basis underlying liver cancer, with a focus on adult hepatic progenitor cells and fetal hepatoblasts. Facultative adult hepatic progenitor cells and fetal hepatoblasts are tissue-specific stem cells that can differentiate into hepatocytes and cholangiocytes, the two major epithelial cell populations in the liver. Our goal is to investigate the role of adult hepatic progenitor cells and fetal hepatoblasts in the development of hepatoblastoma and hepatocellular carcinoma.