Shin Lab

Shin Research Lab

Dr. Shin is a member of the Liver Tumor Program. The Shin lab’s research aims to decipher the molecular and cellular mechanism of childhood liver cancer with a focus on fibrolamellar carcinoma and to investigate the role of facultative postnatal hepatic progenitor cells in liver disease. The Shin lab employs molecular genetic approaches to discover novel strategies for prevention and treatment of liver cancer.

Publications

Selected Publications

Whyte, SS; Karns, R; Min, KW; Cho, JH; Lee, S; Lake, C; Bondoc, A; Yoon, JH; Shin, S. Integrated analysis using ToppMiR uncovers altered miRNA- mRNA regulatory networks in pediatric hepatocellular carcinoma-A pilot study. Cancer reports.. 2022.

Holczbauer, Á; Wangensteen, KJ; Shin, S. Cellular origins of regenerating liver and hepatocellular carcinoma. 2022; 4.

Lee, S; Zhou, P; Whyte, S; Shin, S. Adeno-Associated Virus Serotype 8-Mediated Genetic Labeling of Cholangiocytes in the Neonatal Murine Liver. Pharmaceutics. 2020; 12.

Lee, S; Zhou, P; Gupta, A; Shin, S. Reactive Ductules Are Associated With Angiogenesis and Tumor Cell Proliferation in Pediatric Liver Cancer. Hepatology Communications. 2018; 2:1199-1212.

Shin, S; Wangensteen, KJ; Teta-Bissett, M; Wang, YJ; Mosleh-Shirazi, E; Buza, EL; Greenbaum, LE; Kaestner, KH. Genetic lineage tracing analysis of the cell of origin of hepatotoxin-induced liver tumors in mice. Hepatology. 2016; 64:1163-1177.

Shin, S; Upadhyay, N; Greenbaum, LE; Kaestner, KH. Ablation of Foxl1-Cre-labeled hepatic progenitor cells and their descendants impairs recovery of mice from liver injury. Gastroenterology. 2015; 148:192-202.e3.

Shin, S; Kaestner, KH. The origin, biology, and therapeutic potential of facultative adult hepatic progenitor cells. Current Topics in Developmental Biology. 2014; 107:269-292.

Shin, S; Walton, G; Aoki, R; Brondell, K; Schug, J; Fox, A; Smirnova, O; Dorrell, C; Erker, L; Chu, AS; et al. Foxl1-Cre-marked adult hepatic progenitors have clonogenic and bilineage differentiation potential. Genes and Development. 2011; 25:1185-1192.

Gulati, R; Johnston, M; Rivas, M; Cast, A; Kumbaji, M; Hanlon, MA; Lee, S; Zhou, P; Lake, C; Schepers, E; et al. β-catenin cancer-enhancing genomic regions axis is involved in the development of fibrolamellar hepatocellular carcinoma. Hepatology Communications. 2022.

Whyte, SS; Karns, R; Min, KW; Cho, JH; Lee, S; Lake, C; Bondoc, A; Yoon, JH; Shin, S. Integrated analysis using ToppMiR uncovers altered miRNA- mRNA regulatory networks in pediatric hepatocellular carcinoma-A pilot study. Cancer reports.. 2022.

Holczbauer, Á; Wangensteen, KJ; Shin, S. Cellular origins of regenerating liver and hepatocellular carcinoma. 2022; 4.

Fan, L; Pan, Q; Yang, W; Koo, SC; Tian, C; Li, L; Lu, M; Brown, A; Ju, B; Easton, J; et al. A developmentally prometastatic niche to hepatoblastoma in neonatal liver mediated by the Cxcl1/Cxcr2 axis. Hepatology. 2022.

Rivas, M; Johnston, ME; Gulati, R; Kumbaji, M; Margues Aguiar, TF; Timchenko, L; Krepischi, A; Shin, S; Bondoc, A; Tiao, G; et al. HDAC1-Dependent Repression of Markers of Hepatocytes and P21 Is Involved in Development of Pediatric Liver Cancer. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2021; 12:1669-1682.

Lee, S; Zhou, P; Whyte, S; Shin, S. Adeno-Associated Virus Serotype 8-Mediated Genetic Labeling of Cholangiocytes in the Neonatal Murine Liver. Pharmaceutics. 2020; 12.

Lee, S; Zhou, P; Gupta, A; Shin, S. Reactive Ductules Are Associated With Angiogenesis and Tumor Cell Proliferation in Pediatric Liver Cancer. Hepatology Communications. 2018; 2:1199-1212.

Abu-Gazala, S; Horwitz, E; Ben-Haroush Schyr, R; Bardugo, A; Israeli, H; Hija, A; Schug, J; Shin, S; Dor, Y; Kaestner, KH; et al. Sleeve Gastrectomy Improves Glycemia Independent of Weight Loss by Restoring Hepatic Insulin Sensitivity. Diabetes. 2018; 67:1079-1085.

D'Souza, AM; Jiang, Y; Cast, A; Valanejad, L; Wright, M; Lewis, K; Kumbaji, M; Shah, S; Smithrud, D; Karns, R; et al. Gankyrin Promotes Tumor-Suppressor Protein Degradation to Drive Hepatocyte Proliferation. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2018; 6:239-255.

Cast, A; Valanejad, L; Wright, M; Nguyen, P; Gupta, A; Zhu, L; Shin, S; Timchenko, N. C/EBPα-dependent preneoplastic tumor foci are the origin of hepatocellular carcinoma and aggressive pediatric liver cancer. Hepatology. 2018; 67:1857-1871.

Shin, S; Wangensteen, KJ; Teta-Bissett, M; Wang, YJ; Mosleh-Shirazi, E; Buza, EL; Greenbaum, LE; Kaestner, KH. Genetic lineage tracing analysis of the cell of origin of hepatotoxin-induced liver tumors in mice. Hepatology. 2016; 64:1163-1177.

Contact Us

Soona Shin, PhD

Associate Professor
UC Department of Surgery

Member, Division of General & Thoracic Surgery
Cincinnati Children’s Hospital Medical Center

Phone: 513-803-8970
Email: soona.shin@cchmc.org