Lubov Timchenko, PhD, is a professor in the UC Department of Pediatrics and a member of the Division of Neurology at Cincinnati Children’s Hospital Medical Center.
Dr. Lubov Timchenko received her PhD degree from St. Petersburg Institute of Experimental Medicine in St. Petersburg, Russia. She received post-doctoral training in molecular and human genetics at Baylor College of Medicine in Houston. Since 1995 until 2014, she was a faculty member at Baylor College of Medicine, working on the molecular mechanisms of neuro-muscular disorders, including myotonic dystrophy type 1 (DM1) and myotonic dystrophy type 2 (DM2).
In 2014, Dr. Timchenko joined the Department of Pediatrics at the University of Cincinnati and the Division of Neurology at Cincinnati Children's. Dr. Timchenko is internationally known for her contribution to several fundamental discoveries associated with the identification of a new family of RNA-binding proteins, CUGBP (also known as CUGBP and elav-like proteins, CELF), which play a significant role in the development and function of many tissues, including skeletal muscle, heart, brain and liver. Her studies showed that the proteins of this family regulate proliferation and differentiation in myogenesis and in liver cancer. The functional studies of the member of CUGBP protein family, CUGBP1, in myotonic dystrophy led to the discovery of a novel pathogenic mechanism by which non-coding RNAs cause neuro-muscular diseases. Recent work from Dr. Timchenko’s lab has suggested a new direction for therapy for adult and congenital myotonic dystrophy type 1.
Dr. Timchenko is a recipient of the prestigious Dr. Michael DeBakey’s Excellence in Research award for the outstanding contribution to biomedical research from Baylor College of Medicine. She has served on multiple national and international review boards at the National Institute of Arthritis, Skeletal Muscle and Skin Disorders, National Institute of Neurological Disorders and Stroke, Muscular Dystrophy Association, French Muscular Association, Italian Telethon and others.
Congenital myotonic dystrophy; adult myotonic dystrophy type 1; myotonic dystrophy type 2; FXTAS
Molecular pathobiology and development of therapies for adult and congenital forms of neuro-muscular disease myotonic dystrophy type 1 and myotonic dystrophy type 2; the role of toxic RNAs containing long repeats in regulation of gene expression; skeletal muscle
Professor, UC Department of Pediatrics