A photo of Nikolai Timchenko.

Nikolai Timchenko, PhD

  • Head of Liver Tumor Biology, Liver Tumor Program
  • Professor, UC Department of Surgery
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About

Biography

I came to Cincinnati Children’s Hospital Medical Center in June of 2014 from Baylor College of Medicine (BCM), where I was a professor of pathology and working in the Huffington Center on aging.

I obtained my PhD in the Institute of Experimental Medicine in St. Petersburg, Russia in the field of liver biology and molecular genetics. After moving to the US, I worked at BCM as an assistant professor, associate professor, and full professor until 2014.

I am currently a professor in the Division of General and Thoracic Surgery at Cincinnati Children's within the UC Department of Surgery. I am also the director of the Liver Tumor Program. I investigate mechanisms of liver cancer in children and adults, mechanisms of NAFLD, and mechanisms of age-associated diseases.

I am a member of the Digestive Health Center (Cincinnati Children's) and a professor in the Department of Surgery at the University of Cincinnati.

PhD: Institute of Experimental Medicine, St. Petersburg, Russia.

Training: Post-Doc Fellow, Department of Pathology, Baylor College of Medicine, Houston, TX.

Research Areas

General and Thoracic Surgery, Fibrosis

Publications

METTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation. Xue, M; Dong, L; Zhang, H; Li, Y; Qiu, K; Zhao, Z; Gao, M; Han, L; Chan, AK N; Li, W; Chen, J; Shen, B; Chen, H; Su, R. Journal of Hematology and Oncology. 2024; 17:7.

Transcriptional control of a stem cell factor nucleostemin in liver regeneration and aging. Liu, X; Wang, J; Li, F; Timchenko, N; Tsai, RY L. PloS one. 2024; 19:e0310219.

Inhibition of Histone Deacetylase Activity Increases Cisplatin Efficacy to Eliminate Metastatic Cells in Pediatric Liver Cancers. Gulati, R; Fleifil, Y; Jennings, K; Bondoc, A; Tiao, G; Geller, J; Timchenko, L; Timchenko, N. Cancers. 2024; 16:2300.

C/EBPα-mediated epigenetic control of liver disorders in young children. Gulati, R; Timchenko, N. 2024; 5:23-27.

EZH2 is a key component of hepatoblastoma tumor cell growth. Glaser, K; Schepers, EJ; Zwolshen, HM; Lake, CM; Timchenko, NA; Karns, RA; Cairo, S; Geller, JI; Tiao, GM; Bondoc, AJ. Pediatric Blood and Cancer. 2024; 71:e30774.

Cellular origin and molecular mechanisms of lung metastases in patients with aggressive hepatoblastoma. Gulati, R; Lutz, M; Hanlon, M; Cast, A; Karns, R; Geller, J; Bondoc, A; Tiao, G; Timchenko, L; Timchenko, NA. Hepatology Communications. 2024; 8:e0369.

Genetic Ablation of C/EBPα-p300 Pathway Blocks Development of Obese Pregnancy Associated Liver Disorders in Offspring. Hanlon, MA; Gulati, R; Johnston, M; Fleifil, Y; Rivas, M; Timchenko, NA. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2024; 17:347-360.

Ribonucleotide reductase subunit switching in hepatoblastoma drug response and relapse. Brown, A; Pan, Q; Fan, L; Indersie, E; Tian, C; Timchenko, N; Li, L; Hansen, BS; Tan, H; Lu, M; Peng, J; Pruett-Miller, SM; Yu, J; Cairo, S; Zhu, L. Communications Biology. 2023; 6:249.

Therapeutic Targeting of the GSK3β-CUGBP1 Pathway in Myotonic Dystrophy. Lutz, M; Levanti, M; Karns, R; Gourdon, G; Lindquist, D; Timchenko, NA; Timchenko, L. International Journal of Molecular Sciences. 2023; 24:10650.

Phosphorylation-Mediated Activation of β-Catenin-TCF4-CEGRs/ALCDs Pathway Is an Essential Event in Development of Aggressive Hepatoblastoma. Gulati, R; Hanlon, MA; Lutz, M; Quitmeyer, T; Geller, J; Tiao, G; Timchenko, L; Timchenko, N. Cancers. 2022; 14:6062.

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