Nikolai Timchenko, PhD

Head of Liver Tumor Biology, Liver Tumor Program

Academic Affiliations

Professor, UC Department of Surgery

Phone 513-636-0129

Email nikolai.timchenko@cchmc.org

Nikolai A. Timchenko, PhD, came to Cincinnati Children’s Hospital Medical Center in June of 2014 from Baylor College of Medicine (BCM), where he was a professor of pathology and was working in the Huffington Center on aging.

Dr. Timchenko obtained his PhD in the Institute of Experimental Medicine in St. Petersburg, Russia in the field of liver biology and molecular genetics. After moving to the US, Dr. Timchenko worked at BCM as an assistant professor, associate professor, and full professor until 2014.

He is currently a professor in the Division of General and Thoracic Surgery at Cincinnati Children's within the UC Department of Surgery. Dr. Timchenko is also the director of the Liver Tumor Program. He investigates mechanisms of liver cancer in children and adults, mechanisms of NAFLD, and mechanisms of age-associated diseases.

Dr. Timchenko is a member of the Digestive Health Center (Cincinnati Children's) and a professor in the Department of Surgery at the University of Cincinnati.

PhD: Institute of Experimental Medicine, St. Petersburg, Russia.

Training: Post-Doc Fellow, Department of Pathology, Baylor College of Medicine, Houston, TX.

View PubMed Publications

Jin J, Hong IH, Lewis K, Iakova P, Breaux M, Jiang Y, Sullivan E, Jawanmardi N, Timchenko L, Timchenko NA. Cooperation of C/EBP family proteins and chromatin remodeling proteins is essential for termination of liver regeneration in mice. Hepatology. 2014.

Hong I, Lewis K, Iakova P, Jin J, Sullivan E, Jawanmardi N, Timchenko L, Timchenko NA. The age-associated change of C/EBP family proteins causes severe liver injury and acceleration of liver proliferation after CCl4-treatments. JBC. 2014;298:1106-1118.

Jin J, Iakova P, Breaux M, Sullivan E, Jawanmardi N, Chen D, Jiang Y, Medrano EE and Timchenko NA. Increased expression of enzymes of triglyceride synthesis plays is essential for the development of hepatic steatosis. Cell Reports. 2013;3:831-843.

Jiang Y, Iakova P, Jin J, Sullivan S, Sharin, V, Hong I-W, Anakk S, Major A, Darlington G, Finegold M, Moore D, Timchenko, NA. FXR inhibits gankyrin in mouse livers and prevents development of liver cancer. Hepatology. 2013;57:1098-1106.

Jones K, Wei C, Iakova P, Bugiardini E, Schneider-Gold Ch, Meola G, Woodgett G, Killian J, Timchenko NA, Timchenko LT. GSK3beta is a key determinant of muscle pathology in DM1. J Clin Invest. 2012;122:4461-4472.

Jones K, Timchenko L, Timchenko NA. The role of CUGBP1 in age-dependent changes of liver functions. Aging Research Reviews 11. 2012;442-449.

Jin J, Iakova P, Jiang J, Medrano EE, Timchenko NA. The reduction of SIRT1 in livers of old mice leads to impaired body homeostasis and to inhibition of liver proliferation. Hepatology. 2011;54:898-998.

Iakova P, Timchenko LT, Timchenko NA. Intracellular signaling and hepatocellular carcinoma. Seminars in Cancer Biology. 2011;21:28-34.

Jin J, Iakova P, Wang G-l, Shi X, Haefliger S, Finegold M, Timchenko NA. Epigenetic changes play critical role in age-associated dysfunction of the liver. Aging Cell. 2010;9:895-910.

Wang G-L, Shi X, Haefliger S, Jin J, Major A, Iakova P, Finegold M, Timchenko NA. Elimination of C/EBP through the ubiquitin-proteasome system promotes the development of liver cancer in mice. J. Clin. Invest. 2010;120:2549-2562.