A photo of Peter Tang.

Director, Special Chemistry

Clinical Chemist

Associate Professor, UC Department of Pediatrics

513-636-3357

513-636-8850

Biography & Affiliation

Biography

My career began in 1990 when I studied analytical chemistry, biochemistry and clinical pharmacology in graduate school. Seeing the essential role of analytical chemistry in a clinical laboratory setting, together with the role of the clinical scientist in influencing patient health, inspired me to pursue my career in clinical chemistry.

As a technical director of the special chemistry laboratory, my research spans diverse areas, which all relate to improving the capacity of the lab to deliver analytical services to researchers and clinicians. The overall goal of my lab is to develop analytical techniques for measuring and monitoring levels of drugs, drug metabolites, small molecules, bioactive molecules and biomarkers in lab specimens. I then help translate these findings to improve treatment initiatives.

I hold two US patents: #5,240,571 “Quantitative method of detection of analytes in aqueous fluids by detection of NADH and NADPH” and #6,984,308 “Electrochemical analysis of coenzyme Q10 and reduced coenzyme Q10.” Also, in 2013, Pharmaceutical Product Development, LLC (PPD) signed a contract to use our high-performance liquid chromatography (HPLC) laboratory as their core lab for clinical trials involving coenzyme Q10.

As a clinical scientist, I enjoy developing novel methods to measure and monitor new drugs and biomarkers. I also enjoy teaching medical technologists to use analytical methods in routine practice. We must remember that, in modern medicine, biomarkers always have a use as diagnostic tools. They allow a more personalized approach to the diagnosis and treatment of patients.

Clinical Interests

In vitro diagnostics; disease monitoring procedures

Research Interests

Mitochondrial dysfunction; metabolic disorders; neurodegenerative diseases; hemoglobin disorders; neurogenesis; and therapeutic drug monitoring

Academic Affiliation

Associate Professor, UC Department of Pediatrics

Research Divisions

Pathology

Education

PhD: Analytical Chemistry, University of Cincinnati, Cincinnati, OH, 1990.

MS: Biochemistry, Northeast Louisiana University, Monroe, LA, 1985.

BS: Pharmacy, Taipei Medical College, Taipei, Taiwan, 1978.

Publications

Demonstrating Feasibility of an Opportunistic Sampling Approach for Pharmacokinetic Studies of β-Lactam Antibiotics in Critically Ill Children. Tang Girdwood, SC; Tang, PH; Murphy, ME; Chamberlain, AR; Benken, LA; Jones, RL; Stoneman, EM; Kaplan, JM; Vinks, AA. Journal of Clinical Pharmacology. 2021; 61:565-573.

Molecular Adsorbent Recirculating System Therapy with Continuous Renal Replacement Therapy Enhanced Clearance of Piperacillin in a Pediatric Patient and Led to Failure to Attain Pharmacodynamic Targets. Girdwood, ST; Arbough, T; Dong, M; Mizuno, T; Tang, P; Vinks, AA; Kaplan, J. Pharmacotherapy. 2020; 40:1061-1068.

Paediatric ganciclovir dosing in extracorporeal membrane oxygenation: Is standard dosing good enough?. Murphy, M; Chamberlain, A; Tang, P; Turpin, B; Danziger-Isakov, L. Journal of Clinical Pharmacy and Therapeutics. 2020; 45:218-220.

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Bersuker, K; Hendricks, JM; Li, Z; Magtanong, L; Ford, B; Tang, PH; Roberts, MA; Tong, B; Maimone, TJ; Zoncu, R; et al. Nature: New biology. 2019; 575:688-692.

1543. Ceftaroline Model-based Dose Individualization in an Infant with Kidney Disease and Mediastinitis. Murphy, M; Tang-Girdwood, S; Tang, P; Rebecca, BC; Mizuno, T; Vinks, A. Open Forum Infectious Diseases. 2019; 6:s563-s563.

Targeted mitochondrial therapy using MitoQ shows equivalent renoprotection to angiotensin converting enzyme inhibition but no combined synergy in diabetes. Ward, MS; Flemming, NB; Gallo, LA; Fotheringham, AK; McCarthy, DA; Zhuang, A; Tang, PH; Borg, DJ; Shaw, H; Harvie, B; et al. Scientific Reports. 2017; 7.

Determination of Posaconazole in Plasma/Serum by High-Performance Liquid Chromatography with Fluorescence Detection. Tang, PH. Separations. 2017; 4.