A photo of Charles Vorhees.

Co-Director, Animal Behavior Core

Professor, UC Department of PediatricsUC Department of Environmental Health

513-636-8622

513-636-3912

Biography & Affiliation

Biography

Dr. Vorhees came to Cincinnati Children’s in 1976 as a postdoctoral research scholar and was recruited to the faculty in 1978 as assistant professor within the University of Cincinnati College of Medicine. He was promoted to associate professor in 1982, tenured in 1984, and promoted to professor in 1988 with primary appointment in pediatrics and joint appointment in environmental health. He is co-director of the Animal Behavior Core and program director of the Teratology Training Program. He is on the graduate faculty of the Graduate Programs in Neuroscience (NS) and Molecular and Developmental Biology (MDB). He is section editor of the journal Neurotoxicology and Teratology and served as editor-in-chief for nine years. He was director of the MDB Graduate Program for six years and served in other leadership positions for 15 years. Dr. Vorhees has also served in leadership positions in the NS Program and is currently a member of the Admissions Committee. Dr. Vorhees has been extramurally funded for 35 years, receiving grants from NIH, NSF, FDA and other agencies. He holds an NIH T32 training grant funded for years 36-40 through 2017. He is a founding member of the Neurobehavioral Teratology Society in 1977 and was elected president in 1984-85 and 2012-13. He is an elected member of Sigma Xi, an Eli Lilly Distinguished Lecturer in 1990, and a Society for Neuroscience Grass Foundation Lecturer in 2002. Dr. Vorhees has served on multiple FDA, NRC, and EPA advisory panels. He has been an NIH grant reviewer on varies committees for more than 26 years. He has also reviewed grants for NSF, VA, EPA; March of Dimes, and other agencies and foundations in the U.S.; and for funding agencies in Israel, Ireland, Great Britain, and New Zealand. His research focuses on brain development and behavior. As of 2013 he has published than more 276 journal articles and book chapters.

Visit the Vorhees Lab.

Visit the Animal Behavioral Core.

Research Interests

Behavioral neuroscience; neurotoxicology; neuropsychopharmacology

Academic Affiliation

Professor, UC Department of PediatricsUC Department of Environmental Health

Department

Neurology

Education

BA: University of Cincinnati, Cincinnati, OH, 1971.

MA: Neurobiology Program, Vanderbilt University, Nashville, TN, 1973.

PhD: Neurobiology Program, Vanderbilt University, Nashville, TN, 1976.

Postdoctoral Research Fellow: Cincinnati Children's Research Foundation, Cincinnati, OH, 1978.

Publications

Amos-Kroohs RM, Usach V, Piñero G, Vorhees CV, Vivot RM, Soto PA, Williams MT, Setton-Avruj P. Metal bashing: Iron deficiency and manganese overexposure impact on peripheral nerves. J Toxicol Environ Hlth, Part A: Current Issues. 2019;82(2):99-112.

Bailey RA, Gutierrez A, Kyser TL, Hemmerle AM, Hufgard JR, Seroogy KB, Vorhees CV, Williams MT. Effects of early manganese exposure with or without 6-hydroxydopamine treatment on monoamines, BDNF, TrkB, and cognitive function in rats. Neurotox Res. 2019;35(3):606-620.

Jablonski SA, Williams MT, Vorhees CV. Learning and memory effects of neonatal methamphetamine exposure in Sprague-Dawley rats: Test of the role of dopamine D1 receptors in mediating the long-term effects. Dev Neurosci. 2019 June 18;1-12.

Williams MT, Gutierrez A, Vorhees CV. Effects of acute exposure of deltamethrin in adult and developing Sprague-Dawley rats on acoustic startle response in relation to and deltamethrin brain and plasma concentrations. Toxicol Sci. 2019;168(1):61-69.

Pitzer EM, Sugimoto C, Gudelsky GA, Huff Adams CL, Williams MT, Vorhees CV. Deltamethrin exposure from postnatal day 3-20 in Sprague-Dawley rats causes long-term cognitive and behavioral deficits. Toxicol Sci. 2019;169(2):511-523.

Gutierrez A, Regan SL, Hoover CS, Williams MT, Vorhees CV. Intrastriatal dopamine receptor D1 or D2 antagonists attenuate methamphetamine-induced egocentric and allocentric learning and memory deficits in Sprague-Dawley rats. Psychopharmacology. 2019;236(7):2243-2258.

Balczon R, Pittet J-F, Wagener BM, Moser SA, Voth S, Vorhees CV, Williams MT, Bridges JP, Alvarez DF, Koloteva A, Xu Y, Zha X-M, Stevens T, Audia JP, Lin MT. Infection-induced endothelial amyloids impair learning. FASEB J. 2019.

Regan SL, Hufgard JR, Pitzer EM, Sugimoto C, Williams MT, Vorhees CV. Knockout of brain-specific Latrophilin-3 (Lphn3) in rats disrupts striatal dopamine resulting in hyperactivity, hyper-reactivity, and under-response to dopamine activation by amphetamine. Neurobiol Dis. 2019;130:104494.

Mann EA, Sugimoto C, Williams MT, Vorhees CV. Mouse knockout model of Guanylyl Cyclase-C: recognition memory deficits in the absence of hyperactivity. Genes Brain Behav. 2019;18(5):e12573.

Yermakov LM, Griggs RB, Drouet D, Sugimotor C, Williams MT, Vorhees CV, Susuki K. Impairment of cognitive flexibility in type 2 diabetic db/db mice. Behav Brain Res. 2019.