A photo of Charles Vorhees.

Co-Director, Animal Behavior Core

Professor, UC Department of PediatricsUC Department of Environmental Health



My Biography & Research


Dr. Vorhees came to Cincinnati Children’s in 1976 as a postdoctoral research scholar and was recruited to the faculty in 1978 as assistant professor within the University of Cincinnati College of Medicine. He was promoted to associate professor in 1982, tenured in 1984, and promoted to professor in 1988 with primary appointment in pediatrics and joint appointment in environmental health. He is co-director of the Animal Behavior Core and program director of the Teratology Training Program. He is on the graduate faculty of the Graduate Programs in Neuroscience (NS) and Molecular and Developmental Biology (MDB). He is section editor of the journal Neurotoxicology and Teratology and served as editor-in-chief for nine years. He was director of the MDB Graduate Program for six years and served in other leadership positions for 15 years. Dr. Vorhees has also served in leadership positions in the NS Program and is currently a member of the Admissions Committee. Dr. Vorhees has been extramurally funded for 35 years, receiving grants from NIH, NSF, FDA and other agencies. He holds an NIH T32 training grant funded for years 36-40 through 2017. He is a founding member of the Neurobehavioral Teratology Society in 1977 and was elected president in 1984-85 and 2012-13. He is an elected member of Sigma Xi, an Eli Lilly Distinguished Lecturer in 1990, and a Society for Neuroscience Grass Foundation Lecturer in 2002. Dr. Vorhees has served on multiple FDA, NRC, and EPA advisory panels. He has been an NIH grant reviewer on varies committees for more than 26 years. He has also reviewed grants for NSF, VA, EPA; March of Dimes, and other agencies and foundations in the U.S.; and for funding agencies in Israel, Ireland, Great Britain, and New Zealand. His research focuses on brain development and behavior. As of 2013 he has published than more 276 journal articles and book chapters.

Visit the Vorhees Lab.

Visit the Animal Behavioral Core.

Research Interests

Developmental neuroscience; developmental neurotoxicology

Academic Affiliation

Professor, UC Department of PediatricsUC Department of Environmental Health


Neurology, Neurology

My Education

BA: University of Cincinnati, Cincinnati, OH, 1971.

MA: Neurobiology Program, Vanderbilt University, Nashville, TN, 1973.

PhD: Neurobiology Program, Vanderbilt University, Nashville, TN, 1976.

Postdoctoral Research Fellow: Cincinnati Children's Research Foundation, Cincinnati, OH, 1978.

My Publications

Amos-Kroohs RM, Davenport LL, Atanasova N, Abdulla ZI, Skelton MR, Vorhees CV, Williams MT. Developmental manganese neurotoxicity in rats: Cognitive deficits in allocentric and egocentric learning and memory. Neurotoxicol Teratol. 2017;59:16-26.

Stottmann RW, Gutierrez A, Driver A, Skelton MR, Stepien C, Knudson L, Vorhees CV, Williams MT. A heterozygous mutation in tubulin, beta 2B (tubb2b) causes cognitive deficits and hippocampal disorganization. Genes Brain Behav. 2017;16:250-259.

Jablonski SA, Graham DL, Vorhees CV, Williams MT. Effects of neonatal methamphetamine and stress on brain monoamines and corticosterone in preweanling rats. Neurotox Res. 2017;31:269-282.

López-Juárez A, Titus-Mitchell HE, Silbak SH, Pressler JW, Rizvi TA, Bogard M, Bennett MR, Ciraolo G, Williams MT, Vorhees CV, Ratner N. Oligodendrocyte Nf1 Controls Aberrant Notch Activation and Regulates Myelin Structure and Behavior. Cell Reports. 2017;19:545-557.

Hufgard JR, Williams MT, Skelton MR, Grubisha O, Ferreira FM, Sanger H, Wright ME, Reed TM, Rasmussen K, Duman RS, Vorhees CV. Stress upregulates phosphodiesterase-1b (Pde1b) whereas knocking out Pde1b causes stress-resistance and upregulation of Pde10 without changes in other Pde isoforms. Psychopharmacology. 2017;234:1803-1813.

Amaraneni M, Pang J, Mortuza TB, Muralidhara S, Cummings BS, White CA, Vorhees CV, Zastre JA, Bruckner JM. Brain uptake of deltamethrin in rats as a function of plasma protein binding and blood-brain barrier maturation. Neurotoxicology. 2017;62:24-29.

Sprowles JLN, Hufgard JR, Gutierrez A, Bailey RA, Jablonski SA, Williams MT, Vorhees CV. Perinatal exposure to antidepressants: Effects on spatial navigation, acoustic startle, and open-field activity in Sprague-Dawley rats. Int J Dev Neurosci. 2017;61:92-111.

Gutierrez A, Jablonski SA, Amos-Kroohs RM, Barnes AC, Williams MT, Vorhees CV. Effects of housing on methamphetamine-induced neurotoxicity and spatial learning and memory. ACS Chem Neurosci. 2017;8:1479-1489.

Jablonski SA, Williams MT, Vorhees CV. Learning and memory effects of neonatal methamphetamine exposure in rats: Role of reactive oxygen species and age at assessment. Synapse. 2017;71(11).

Hufgard JR, Williams MT, Vorhees CV. Phosphodiesterase-1b deletion confers depression-like behavioral resistance separate from stress-related effects in mice. Genes Brain Behav. 2017.