A photo of Charles Vorhees.

Co-Director, Animal Behavior Core

Professor, UC Department of PediatricsUC Department of Environmental Health



Biography & Affiliation


Dr. Vorhees came to Cincinnati Children’s in 1976 as a postdoctoral research scholar and was recruited to the faculty in 1978 as assistant professor within the University of Cincinnati College of Medicine. He was promoted to associate professor in 1982, tenured in 1984, and promoted to professor in 1988 with primary appointment in pediatrics and joint appointment in environmental health. He is co-director of the Animal Behavior Core and program director of the Teratology Training Program. He is on the graduate faculty of the Graduate Programs in Neuroscience (NS) and Molecular and Developmental Biology (MDB). He is section editor of the journal Neurotoxicology and Teratology and served as editor-in-chief for nine years. He was director of the MDB Graduate Program for six years and served in other leadership positions for 15 years. Dr. Vorhees has also served in leadership positions in the NS Program and is currently a member of the Admissions Committee. Dr. Vorhees has been extramurally funded for 35 years, receiving grants from NIH, NSF, FDA and other agencies. He holds an NIH T32 training grant funded for years 36-40 through 2017. He is a founding member of the Neurobehavioral Teratology Society in 1977 and was elected president in 1984-85 and 2012-13. He is an elected member of Sigma Xi, an Eli Lilly Distinguished Lecturer in 1990, and a Society for Neuroscience Grass Foundation Lecturer in 2002. Dr. Vorhees has served on multiple FDA, NRC, and EPA advisory panels. He has been an NIH grant reviewer on varies committees for more than 26 years. He has also reviewed grants for NSF, VA, EPA; March of Dimes, and other agencies and foundations in the U.S.; and for funding agencies in Israel, Ireland, Great Britain, and New Zealand. His research focuses on brain development and behavior. As of 2013 he has published than more 276 journal articles and book chapters.

Visit the Vorhees Lab.

Visit the Animal Behavioral Core.

Research Interests

Behavioral neuroscience; neurotoxicology; neuropsychopharmacology

Academic Affiliation

Professor, UC Department of PediatricsUC Department of Environmental Health




BA: University of Cincinnati, Cincinnati, OH, 1971.

MA: Neurobiology Program, Vanderbilt University, Nashville, TN, 1973.

PhD: Neurobiology Program, Vanderbilt University, Nashville, TN, 1976.

Postdoctoral Research Fellow: Cincinnati Children's Research Foundation, Cincinnati, OH, 1978.


Litter effects: Comments on Golub and Sobin's “Statistical modeling of litter as a random effect in mixed models to manage “intralitter likeness””. Vorhees, CV; Williams, MT. Neurotoxicology and Teratology. 2020; 77:106852-106852.

Impairment of cognitive flexibility in type 2 diabetic db/db mice. Yermakov, LM; Griggs, RB; Drouet, DE; Sugimoto, C; Williams, MT; Vorhees, CV; Susuki, K. Behavioural Brain Research. 2019; 371:111978-111978.

Knockout of latrophilin-3 in Sprague-Dawley rats causes hyperactivity, hyper-reactivity, under-response to amphetamine, and disrupted dopamine markers. Regan, SL; Hufgard, JR; Pitzer, EM; Sugimoto, C; Hu, Y; Williams, MT; Vorhees, CV. Neurobiology of Disease. 2019; 130:104494-104494.

Infection-induced endothelial amyloids impair memory. Balczon, R; Pittet, J; Wagener, BM; Moser, SA; Voth, S; Vorhees, CV; Williams, MT; Bridges, JP; Alvarez, DF; Koloteva, A; et al. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019; 33:10300-10314.

Learning and Memory Effects of Neonatal Methamphetamine Exposure in Sprague-Dawley Rats: Test of the Role of Dopamine Receptors D1 in Mediating the Long-Term Effects. Jablonski, SA; Williams, MT; Vorhees, CV. Developmental Neuroscience. 2019; 41:44-55.

Effects of intrastriatal dopamine D1 or D2 antagonists on methamphetamine-induced egocentric and allocentric learning and memory deficits in Sprague-Dawley rats. Gutierrez, A; Regan, SL; Hoover, CS; Williams, MT; Vorhees, CV. Psychopharmacology. 2019; 236:2243-2258.

Deltamethrin Exposure Daily From Postnatal Day 3-20 in Sprague-Dawley Rats Causes Long-term Cognitive and Behavioral Deficits. Pitzer, EM; Sugimoto, C; Gudelsky, GA; Adams, CL H; Williams, MT; Vorhees, CV. Toxicological Sciences (Elsevier). 2019; 169:511-523.

Mouse knockout of guanylyl cyclase C: Recognition memory deficits in the absence of activity changes. Mann, EA; Sugimoto, C; Williams, MT; Vorhees, CV. Genes, Brain and Behavior. 2019; 18:e12573-e12573.

Effects of Preweaning Manganese in Combination with Adult Striatal Dopamine Lesions on Monoamines, BDNF, TrkB, and Cognitive Function in Sprague-Dawley Rats. Bailey, RA; Gutierrez, A; Kyser, TL; Hemmerle, AM; Hufgard, JR; Seroogy, KB; Vorhees, CV; Williams, MT. Neurotoxicity Research. 2019; 35:606-620.

Prenatal exposure to PCBs in Cyp1a2 knock-out mice interferes with F-1 fertility, impairs long-term potentiation, reduces acoustic startle and impairs conditioned freezing contextual memory with minimal transgenerational effects. Hufgard, JR; Sprowles, JL N; Pitzer, EM; Koch, SE; Jiang, M; Wang, Q; Zhang, X; Biesiada, J; Rubinstein, J; Puga, A; et al. Journal of Applied Toxicology. 2019; 39:603-621.