Jianqiang Wu, MD, MS

Member, Division of Experimental Hematology & Cancer Biology

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-0955

Fax 513-803-0783

Email jianqiang.wu@cchmc.org

Preclinical therapeutic trial on neurofibroma; cancer stem cell(s) in neurofibroma

MD: Soochow University College of Medicine, SooChow, PR China, 1991.

MS: Soochow University College of Medicine, SooChow, PR China, 1996.

View PubMed Publications

Wu J, Keng WV, Patmore DM, Kendall JK, Patel AV, Jousma E, Jessen WJ, Choi K, Tschida BR, Fan D, et al. Insertional mutagenesis identifies a STAT3/Arid1b/β-catenin pathway driving neurofibroma initiation. Cell Reports. 2016;14(8):1979-90.

Li H, Zhao X, Yan X, Jessen WJ, Kim M-O, Dombi E, Liu PP, Huang G, Wu J. Runx1 contributes to neurofibromatosis type1 neurofibroma formation. Oncogene. 2016;35(11):1468-74.

Wu J*, Huang G, Ratner N. Runx1: a new driver in neurofibromagenesis. Oncoscience. 2015;2(11):904-5. (*Corresponding author)

Jousma E, Rizvi TA, Wu J, Janhofer D, Dombi E, Dunn RS, Kim M, Masters AR, Jones DA, Cripe TP, Ratner N, Jousma E. Preclinical assessments of the MEK inhibitor PD-0325901 in a mouse model of neurofibromatosis type 1. Pediatr Blood Cancer. 2015;62(10):1709-16.

Wu J, Patmore DM, Jousma E, Eaves DW, Schwartz EB, Fuchs JR, Cripe TP, Stemmer- Rachamimov A, Ratner N. EGFR-STAT3 signaling promotes formation of malignant peripheral nerve sheath tumors. Oncogene. 2014;33(2):173-80. 

Jessen W, Miller S,  Jousma  E, Wu  J,  Rizvi  T, Eaves D,  Widemann B,  Dombi E,  Dudley A,  Niwa-Kawakita M, et al.  MEK Inhibition Exhibits Efficacy in Human and Mouse Neurofibromatosis Tumors. J Clin Invest. 2013;123(1):340-7.

Prada CE, Jousma E, Rizvi TA, Wu J, Dunn RS, Mayes DA, Cancelas JA, Dombi E, Kim MO, West BL, Bollag G, and Ratner N. Neurofibroma-associated macrophages play roles in tumor growth and response to pharmacological inhibition. Acta Neuropathol. 2013;125(1):159-68.

Patmore DM, Welch S, Fulkerson PC, Wu J, Choi K, Eaves D, Kordich JJ, Collins MH, Cripe TP, Ratner N. In vivo regulation of TGFβ by R-Ras2 revealed through loss of the RasGAP protein Nf1. Cancer Res. 2012;72(20):5317-27.

Wu J, Williams JP, Rizvi TA, Kordich JJ, Witte D, Meijer D, Stemmer-Rachamimov AO,  Cancelas JA, Ratner N. Plexiform and dermal neurofibromas and pigmentation are caused by Nf1 loss in desert hedgehog expressing cells. Cancer Cell. 2008;13(2):105-116.

*Williams JP, *Wu J, Johansson G, Rizvi TA, Miller SC, Geiger H, Malik P, Li W, Mukouyama YS, Cancelas JA, Ratner N.  Nf1 mutation expands an EGFR-dependent peripheral nerve  progenitor population that confers tumorigenic potential. Cell Stem Cell. 2008; 3(6):658-69 (*contributed equally to the work).