A photo of Jianqiang Wu.

Member, Division of Experimental Hematology & Cancer Biology

Cancer Biology and Neural Tumors Program

Associate Professor, UC Department of Pediatrics

513-636-0955

513-803-0783

Biography & Affiliation

Biography

I have been a researcher for more than 25 years, and I started working at Cincinnati Children’s in 2003. My research areas of interest include transcriptional factors and microRNA in neurofibromatosis type 1 (NF1) related plexiform neurofibroma (PNF) formation, the influence of microenvironment on PNF formation and pre-clinical testing of PNF.

There is no effective therapy for PNF. Surgery remains the mainstay of treatment, but sometimes surgery is impossible due to the invasive nature of PNFs, their large size and their association with critical anatomic structures.

The Food and Drug Administration (FDA) approved Selumetinib (Koselugo™), a cytostatic MEK inhibitor that shrinks about 70 percent of tumors in Nf1fl/fl; DhhCre neurofibroma-bearing mice and in inoperable PNF patients. Unfortunately, tumors regrow after stopping drug treatment. Therefore, new therapeutic strategies and MEK-independent targets for the treatment of PNFs are urgently needed. My goal is to find a cure for PNF.

One of my lab’s groundbreaking discoveries is developing a PNF mouse model and a method to monitor the drug efficacy for pre-clinical testing on this mouse’s PNFs by measuring tumor volumes on MRI images.

My research has been published in respected journals, such as Cancer Cell, Cell Stem Cell, Science Advances, New England Journal of Medicine, Acta Neuropathologica, Journal of Clinical Investigation, Cancer Research and Oncogene.

Research Interests

Preclinical therapeutic trial on neurofibroma; cancer stem cell(s) in neurofibroma

Academic Affiliation

Associate Professor, UC Department of Pediatrics

Divisions

Experimental Hematology and Cancer Biology, Cancer and Blood Diseases

Education

MD: Soochow University College of Medicine, SooChow, PR China, 1991.

MS: Soochow University College of Medicine, SooChow, PR China, 1996.

Publications

The Role of RUNX1 in NF1-Related Tumors and Blood Disorders. Na, Y; Huang, G; Wu, J. Molecules and Cells. 2020; 43:153-159.

The Clinical, Molecular, and Mechanistic Basis of RUNX1 Mutations Identified in Hematological Malignancies. Yokota, A; Huo, L; Lan, F; Wu, J; Huang, G. Molecules and Cells. 2020; 43:145-152.

NF1 patient missense variants predict a role for ATM in modifying neurofibroma initiation. Yu, Y; Choi, K; Wu, J; Andreassen, PR; Dexheimer, PJ; Keddache, M; Brems, H; Spinner, RJ; Cancelas, JA; Martin, LJ; et al. Acta Neuropathologica. 2020; 139:157-174.

The evolution and multi-molecular properties of NF1 cutaneous neurofibromas originating from C-fiber sensory endings and terminal Schwann cells at normal sites of sensory terminations in the skin. Rice, FL; Houk, G; Wymer, JP; Gosline, SJ C; Guinney, J; Wu, J; Ratner, N; Jankowski, MP; La Rosa, S; Dockum, M; et al. PLoS ONE. 2019; 14:e0216527-e0216527.

RUNX represses Pmp22 to drive neurofibromagenesis. Hall, A; Choi, K; Liu, W; Rose, J; Zhao, C; Yu, Y; Na, Y; Cai, Y; Coover, RA; Lin, Y; et al. Science Advances. 2019; 5:eaau8389-eaau8389.

STAT3 inhibition reduces macrophage number and tumor growth in neurofibroma. Fletcher, JS; Springer, MG; Choi, K; Jousma, E; Rizvi, TA; Dombi, E; Kim, M; Wu, J; Ratner, N. Oncogene: Including Oncogene Reviews. 2019; 38:2876-2884.

Cxcr3-expressing leukocytes are necessary for neurofibroma formation in mice. Fletcher, JS; Wu, J; Jessen, WJ; Pundavela, J; Miller, JA; Dombi, E; Kim, M; Rizvi, TA; Chetal, K; Salomonis, N; et al. JCI insight. 2019; 4.

Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis. Wu, LM N; Deng, Y; Wang, J; Zhao, C; Wang, J; Rao, R; Xu, L; Zhou, W; Choi, K; Rizvi, TA; et al. Cancer Cell. 2018; 33:292-308.e7.

A Collaborative Model for Accelerating the Discovery and Translation of Cancer Therapies. Maertens, O; McCurrach, ME; Braun, BS; De Raedt, T; Epstein, I; Huang, TQ; Lauchle, JO; Lee, H; Wu, J; Cripe, TP; et al. Cancer Research. 2017; 77:5706-5711.

The transcription factor Olig2 is important for the biology of diffuse intrinsic pontine gliomas. Anderson, JL; Muraleedharan, R; Oatman, N; Klotter, A; Sengupta, S; Waclaw, RR; Wu, J; Drissi, R; Miles, L; Raabe, EH; et al. Neuro-Oncology. 2017; 19:1068-1078.