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A photo of Jianqiang Wu.

Member, Division of Experimental Hematology & Cancer Biology

Associate Professor, UC Department of Pediatrics

513-636-0955

513-803-0783

Biography & Affiliation

Research Interests

Preclinical therapeutic trial on neurofibroma; cancer stem cell(s) in neurofibroma

Academic Affiliation

Associate Professor, UC Department of Pediatrics

Divisions

Experimental Hematology and Cancer Biology, Cancer and Blood Diseases

Education

MD: Soochow University College of Medicine, SooChow, PR China, 1991.

MS: Soochow University College of Medicine, SooChow, PR China, 1996.

Publications

The Role of RUNX1 in NF1-Related Tumors and Blood Disorders. Na, Y; Huang, G; Wu, J. Molecules and Cells. 2020; 43:153-159.

The Clinical, Molecular, and Mechanistic Basis of RUNX1 Mutations Identified in Hematological Malignancies. Yokota, A; Huo, L; Lan, F; Wu, J; Huang, G. Molecules and Cells. 2020; 43:145-152.

NF1 patient missense variants predict a role for ATM in modifying neurofibroma initiation. Yu, Y; Choi, K; Wu, J; Andreassen, PR; Dexheimer, PJ; Keddache, M; Brems, H; Spinner, RJ; Cancelas, JA; Martin, LJ; et al. Acta Neuropathologica. 2020; 139:157-174.

The evolution and multi-molecular properties of NF1 cutaneous neurofibromas originating from C-fiber sensory endings and terminal Schwann cells at normal sites of sensory terminations in the skin. Rice, FL; Houk, G; Wymer, JP; Gosline, SJ C; Guinney, J; Wu, J; Ratner, N; Jankowski, MP; La Rosa, S; Dockum, M; et al. PLoS ONE. 2019; 14:e0216527-e0216527.

RUNX represses Pmp22 to drive neurofibromagenesis. Hall, A; Choi, K; Liu, W; Rose, J; Zhao, C; Yu, Y; Na, Y; Cai, Y; Coover, RA; Lin, Y; et al. Science Advances. 2019; 5:eaau8389-eaau8389.

STAT3 inhibition reduces macrophage number and tumor growth in neurofibroma. Fletcher, JS; Springer, MG; Choi, K; Jousma, E; Rizvi, TA; Dombi, E; Kim, M; Wu, J; Ratner, N. Oncogene: Including Oncogene Reviews. 2019; 38:2876-2884.

Cxcr3-expressing leukocytes are necessary for neurofibroma formation in mice. Fletcher, JS; Wu, J; Jessen, WJ; Pundavela, J; Miller, JA; Dombi, E; Kim, M; Rizvi, TA; Chetal, K; Salomonis, N; et al. JCI insight. 2019; 4.

Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis. Wu, LM N; Deng, Y; Wang, J; Zhao, C; Wang, J; Rao, R; Xu, L; Zhou, W; Choi, K; Rizvi, TA; et al. Cancer Cell. 2018; 33:292-308.e7.

A Collaborative Model for Accelerating the Discovery and Translation of Cancer Therapies. Maertens, O; McCurrach, ME; Braun, BS; De Raedt, T; Epstein, I; Huang, TQ; Lauchle, JO; Lee, H; Wu, J; Cripe, TP; et al. Cancer Research. 2017; 77:5706-5711.

The transcription factor Olig2 is important for the biology of diffuse intrinsic pontine gliomas. Anderson, JL; Muraleedharan, R; Oatman, N; Klotter, A; Sengupta, S; Waclaw, RR; Wu, J; Drissi, R; Miles, L; Raabe, EH; et al. Neuro-Oncology. 2017; 19:1068-1078.