Jianqiang Wu, MD, MS

Member, Division of Experimental Hematology & Cancer Biology

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-636-0955

Fax 513-803-0783

Email jianqiang.wu@cchmc.org

Preclinical therapeutic trial on neurofibroma; cancer stem cell(s) in neurofibroma

MD: Soochow University College of Medicine, SooChow, PR China, 1991.

MS: Soochow University College of Medicine, SooChow, PR China, 1996.

View PubMed Publications

Choi K, Komurov K, Fletcher J, Jousma E, Cancelas JA, Wu J*, Ratner N*. An inflammatory gene signature distinguishes neurofibroma Schwann cells and macrophages from cells in the normal peripheral nervous system. Sci Rep. 2017;7:43315. *Co-corresponding author.

Dombi E, Baldwin A, Marcus LJ, Fisher MJ, Weiss B, Kim A, Whitcomb P, Martin S, Aschbacher-Smith LE, Rizvi TA, Wu J, Ershler R, Wolters P, Therrien J, Glod J, Belasco JB, Schorry E, Brofferio A, Starosta AJ, Gillespie A, Doyle AL, Ratner N, Widemann BC. Activity of Selumetinib in Neurofibromatosis Type 1-related Plexiform Neurofibromas. N Engl J Med. 2016;375(26):2550-2560.

Wu J, Liu W, Williams JP, Ratner N. EGFR-Stat3 signaling in nerve glial cells modifies neurofibroma initiation. Oncogene. 2017 Mar 23;36(12):1669-1677.

Wu J, Keng WV, Patmore DM, Kendall JK, Patel AV, Jousma E, Jessen WJ, Choi K, Tschida BR, Fan D, et al. Insertional mutagenesis identifies a STAT3/Arid1b/β-catenin pathway driving neurofibroma initiation. Cell Reports. 2016;14(8):1979-90.

Li H, Zhao X, Yan X, Jessen WJ, Kim MO, Dombi E, Liu PP, Huang G, Wu J. Runx1 contributes to neurofibromatosis type1 neurofibroma formation. Oncogene. 2016:35(11):1468-74.

Wu J*, Huang G, Ratner N. Runx1: a new driver in neurofibromagenesis. Oncoscience. 2015;2(11):904-5. *Corresponding author.

Wu J, Patmore DM, Jousma E, Eaves DW, Schwartz EB, Fuchs JR, Cripe TP, Stemmer-Rachamimov A, Ratner N. EGFR-STAT3 signaling promotes formation of malignant peripheral nerve sheath tumors. Oncogene. 2014;33(2):173-80.

Wu J, Williams JP, Rizvi TA, Kordich JJ, Witte D, Meijer D, Stemmer-Rachamimov AO, Cancelas JA, Ratner N. Plexiform and dermal neurofibromas and pigmentation are caused by Nf1 loss in desert hedgehog expressing cells. Cancer Cell. 2008;13(2):105-116.

*Williams JP, *Wu J, Johansson G, Rizvi TA, Miller SC, Geiger H, Malik P, Li W, Mukouyama YS, Cancelas JA, Ratner N. Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor population that confers tumorigenic potential. Cell Stem Cell. 2008;3(6):658-69. (*contributed equally to the work).

*Ling BC, *Wu J, Miller SJ, Monk KR, Shamekh R, Rizvi TA, Decourten-Myers G, Vogel KS, DeClue JE, Ratner N. Role for the epidermal growth factor receptor in neurofibromatosis- related peripheral nerve tumorigenesis. Cancer Cell. 2005;7(1):65-75. *Contributed equally to the work.

MiR-155 and RUNX function in neurofibroma tumorigenesis and therapy. Principal Investigator. National Institutes of Health. Jul 2016-Jun 2021. R01 NS097233.

Mitogenic Activities in Neurofibromatosis. Co-Investigator. National Institutes of Health. Aug 2017-Aug 2022. R01 NS 28840.