I have been a researcher for more than 25 years, and I started working at Cincinnati Children’s in 2003. My research areas of interest include transcriptional factors and microRNA in neurofibromatosis type 1 (NF1) related plexiform neurofibroma (PNF) formation, the influence of microenvironment on PNF formation and pre-clinical testing of PNF.
There is no effective therapy for PNF. Surgery remains the mainstay of treatment, but sometimes surgery is impossible due to the invasive nature of PNFs, their large size and their association with critical anatomic structures.
The Food and Drug Administration (FDA) approved Selumetinib (Koselugo™), a cytostatic MEK inhibitor that shrinks about 70 percent of tumors in Nf1fl/fl; DhhCre neurofibroma-bearing mice and in inoperable PNF patients. Unfortunately, tumors regrow after stopping drug treatment. Therefore, new therapeutic strategies and MEK-independent targets for the treatment of PNFs are urgently needed. My goal is to find a cure for PNF.
One of my lab’s groundbreaking discoveries is developing a PNF mouse model and a method to monitor the drug efficacy for pre-clinical testing on this mouse’s PNFs by measuring tumor volumes on MRI images.
My research has been published in respected journals, such as Cancer Cell, Cell Stem Cell, Science Advances, New England Journal of Medicine, Acta Neuropathologica, Journal of Clinical Investigation, Cancer Research and Oncogene.
Preclinical therapeutic trial on neurofibroma; cancer stem cell(s) in neurofibroma
Associate Professor, UC Department of Pediatrics
Experimental Hematology and Cancer Biology, Cancer and Blood Diseases