A photo of Ronald Waclaw.

Ronald R. Waclaw, PhD


  • Member, Division of Experimental Hematology & Cancer Biology
  • Member, Division of Developmental Biology
  • RASopathy Program
  • Cancer Biology and Neural Tumors Program
  • Associate Professor, UC Department of Pediatrics

About

Biography

I study brain development and neurodevelopmental disorders. In children, these neurodevelopmental disorders can cause problems with speech and language, behavior, motor skills, learning, memory and other neurological functions. Though symptoms and behaviors may change as the child grows older, some disorders may cause permanent disabilities.

My lab studies the development of the anterior forebrain called the telencephalon.

We have two major projects:

  • A study on the molecular genetics of basal ganglia development from the ventral telencephalon.
  • Developing mouse models to study the impact of RASopathy mutations during brain development. RASopathies are rare genetic syndromes that result in several phenotypes including developmental delay and learning disorders.

One of our accomplishments was identifying that a Noonan Syndrome PTPN11 mouse model had altered oligodendrocyte (myelin-forming cells) development. At Cincinnati Children’s, my lab has multiple collaborations including projects with Dr. Kenneth Campbell's lab in the Division of Developmental Biology to study basal ganglia differentiation. We are also part of the RASopathy research program established by Dr. Nancy Ratner in Experimental Hematology and Cancer Biology and are collaborating with the RASopathy program clinical director, Dr. Carlos Prada in the Division of Human Genetics to identify and model new gene mutations that cause neurodevelopment disorders.

I received a PhD in the Molecular and Developmental Biology graduate program at the University of Cincinnati. I was enrolled in the post-doctoral fellowship program at Cincinnati Children's from 2005 to 2010. I continued my career at Cincinnati Children's to start my independent research lab in 2010 and have more than nine years of experience.

My work has been published in various publications, including The Journal of the Society for Neuroscience, Developmental Biology, Cerebral Cortex, Neural Development, The Journal of Comparative Neurology and Molecular and Cellular Neurosciences.

Publications

Selected

Foxo1 is a downstream effector of Isl1 in direct pathway striatal projection neuron development within the embryonic mouse telencephalon. Waclaw, RR; Ehrman, LA; Merchan-Sala, P; Kohli, V; Nardini, D; Campbell, K. Molecular and Cellular Neurosciences. 2017; 80:44-51.

Selected

The protein tyrosine phosphatase Shp2 is required for the generation of oligodendrocyte progenitor cells and myelination in the mouse telencephalon. Ehrman, LA; Nardini, D; Ehrman, S; Rizvi, TA; Gulick, J; Krenz, M; Dasgupta, B; Robbins, J; Ratner, N; Nakafuku, M; et al. Journal of Neuroscience. 2014; 34:3767-3778.

Formation of the Mouse Internal Capsule and Cerebral Peduncle: A Pioneering Role for Striatonigral Axons as Revealed in Isl1 Conditional Mutants. Ehrman, JM; Merchan-Sala, P; Ehrman, LA; Chen, B; Lim, HW; Waclaw, RR; Campbell, K. Journal of Neuroscience. 2022; 42:3344-3364.

Olig2 defines a subset of neural stem cells that produce specific olfactory bulb interneuron subtypes in the subventricular zone of adult mice. Del Águila, Á; Adam, M; Ullom, K; Shaw, N; Qin, S; Ehrman, J; Nardini, D; Salomone, J; Gebelein, B; Lu, QR; et al. Development (Cambridge). 2022; 149.

A Novel Mutation in Cse1l Disrupts Brain and Eye Development with Specific Effects on Pax6 Expression. Blizzard, LE; Menke, C; Patel, SD; Waclaw, RR; Lachke, SA; Stottmann, RW. Journal of Developmental Biology. 2021; 9.

A role for sustained MAPK activity in the mouse ventral telencephalon. Talley, MJ; Nardini, D; Qin, S; Prada, CE; Ehrman, LA; Waclaw, RR. Developmental Biology. 2021; 476:137-147.

Generation of a Mouse Model to Study the Noonan Syndrome Gene Lztr1 in the Telencephalon. Talley, MJ; Nardini, D; Shabbir, N; Ehrman, LA; Prada, CE; Waclaw, RR. Frontiers in Cell and Developmental Biology. 2021; 9.

Analysis of reactive astrogliosis in mouse brain using in situ hybridization combined with immunohistochemistry. Muraleedharan, R; Nardini, D; Waclaw, RR; Dasgupta, B. STAR Protocols. 2021; 2.

Temporally Distinct Roles for the Zinc Finger Transcription Factor Sp8 in the Generation and Migration of Dorsal Lateral Ganglionic Eminence (dLGE)-Derived Neuronal Subtypes in the Mouse. Kuerbitz, J; Madhavan, M; Ehrman, LA; Kohli, V; Waclaw, RR; Campbell, K. Cerebral Cortex. 2021; 31:1744-1762.

Enhanced MAPK1 Function Causes a Neurodevelopmental Disorder within the RASopathy Clinical Spectrum. Motta, M; Pannone, L; Pantaleoni, F; Bocchinfuso, G; Radio, FC; Cecchetti, S; Ciolfi, A; Di Rocco, M; Elting, MW; Brilstra, EH; et al. American Journal of Human Genetics. 2020; 107:499-513.