Ronald R. Waclaw, MS, PhD

A photo of Ronald Waclaw.

Member, Division of Experimental Hematology & Cancer Biology

Assistant Professor, UC Department of Pediatrics

513-803-3336

Biography & Affiliation

Research Interests

Forebrain progenitor cell differentiation; “RASopathy” genes

Academic Affiliation

Assistant Professor, UC Department of Pediatrics

Divisions

Experimental Hematology and Cancer Biology, Cancer and Blood Diseases

Education

BA: Biology, North Central College, Naperville, IL, 1997.

MS: Department of Biology, Ball State University, Muncie, IN, 1997-1999.

PhD: Molecular and Developmental Biology, University of Cincinnati, Cincinnati, OH, 1999-2005.

Fellowship: Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2005-2010.

Publications

Selected Publication

Foxo1 is a downstream effector of Isl1 in direct pathway striatal projection neuron development within the embryonic mouse telencephalon. Waclaw, RR; Ehrman, LA; Merchan-Sala, P; Kohli, V; Nardini, D; Campbell, K. Molecular and Cellular Neurosciences. 2017; 80:44-51.

The Protein Tyrosine Phosphatase Shp2 Is Required for the Generation of Oligodendrocyte Progenitor Cells and Myelination in the Mouse Telencephalon. Ehrman, LA; Nardini, D; Ehrman, S; Rizvi, TA; Gulick, J; Krenz, M; Dasgupta, B; Robbins, J; Ratner, N; Nakafuku, M; et al. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014; 34:3767-3778.

Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis. Weng, Q; Wang, J; Wang, J; He, D; Cheng, Z; Zhang, F; Verma, R; Xu, L; Dong, X; Liao, Y; et al. Cell Stem Cell. 2019; 24:707-723.e8.

Gsx transcription factors control neuronal versus glial specification in ventricular zone progenitors of the mouse lateral ganglionic eminence. Chapman, H; Riesenberg, A; Ehrman, LA; Kohli, V; Nardini, D; Nakafuku, M; Campbell, K; Waclaw, RR. Developmental Biology. 2018; 442:115-126.

AMP kinase promotes glioblastoma bioenergetics and tumour growth. Chhipa, RR; Fan, Q; Anderson, J; Muraleedharan, R; Huang, Y; Ciraolo, G; Chen, X; Waclaw, R; Chow, LM; Khuchua, Z; et al. Nature Cell Biology. 2018; 20:823-835.

Gain-of-function mutations in the gene encoding the tyrosine phosphatase SHP2 induce hydrocephalus in a catalytically dependent manner. Zheng, H; Yu, W; Waclaw, RR; Kontaridis, MI; Neel, BG; Qu, C. Science Signaling. 2018; 11:eaao1591-eaao1591.

Dek overexpression in murine epithelia increases overt esophageal squamous cell carcinoma incidence. Matrka, MC; Cimperman, KA; Haas, SR; Guasch, G; Ehrman, LA; Waclaw, RR; Komurov, K; Lane, A; Wikenheiser-Brokamp, KA; Wells, SI. PLoS Genetics. 2018; 14:e1007227-e1007227.

A histone deacetylase 3-dependent pathway delimits peripheral myelin growth and functional regeneration. He, X; Zhang, L; Queme, LF; Liu, X; Lu, A; Waclaw, RR; Dong, X; Zhou, W; Kidd, G; Yoon, S; et al. Nature Medicine. 2018; 24:338-351.

Loss of Intercalated Cells (ITCs) in the Mouse Amygdala of Tshz1 Mutants Correlates with Fear, Depression, and Social Interaction Phenotypes. Kuerbitz, J; Arnett, M; Ehrman, S; Williams, MT; Vorhees, CV; Fisher, SE; Garratt, AN; Muglia, LJ; Waclaw, RR; Campbell, K. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2018; 38:1160-1177.

Characterization of Glcci1 expression in a subpopulation of lateral ganglionic eminence progenitors in the mouse telencephalon. Kohli, V; Nardini, D; Ehrman, LA; Waclaw, RR. Developmental Dynamics. 2018; 247:222-228.