A photo of William Zacharias.

Assistant Professor, UC Department of PediatricsUC Department of Internal Medicine


My Biography & Research

Academic Affiliation

Assistant Professor, UC Department of PediatricsUC Department of Internal Medicine


Neonatology, Neonatology, Pulmonary Biology

My Education

MD: University of Michigan, Ann Arbor, MI, 2011.

PhD: University of Michigan, Ann Arbor, MI, 2011.

Residency: Hospital of the University of Pennsylvania, Philadelphia, PA.

Fellowship: Hospital of the University of Pennsylvania, Philadelphia, PA.

Certifications: Internal Medicine; Pulmonary Medicine; Critical Care Medicine.

My Publications

Selected Publication

Insulin-like Growth Factor 1 Supports a Pulmonary Niche that Promotes Type 3 Innate Lymphoid Cell Development in Newborn Lungs. Oherle, K; Acker, E; Bonfield, M; Wang, T; Gray, J; Lang, I; Bridges, J; Lewkowich, I; Xu, Y; Ahlfeld, S; et al. Immunity. 2020; 52:275-294.e9.

Improving the Quality and Reproducibility of Flow Cytometry in the Lung An Official American Thoracic Society Workshop Report. Tighe, RM; Redente, EF; Yu, Y; Herold, S; Sperling, AI; Curtis, JL; Duggan, R; Swaminathan, S; Nakano, H; Zacharias, WJ; et al. American Journal of Respiratory Cell and Molecular Biology. 2019; 61:150-161.

In utero gene editing for monogenic lung disease. Alapati, D; Zacharias, WJ; Hartman, HA; Rossidis, AC; Stratigis, JD; Ahn, NJ; Coons, B; Zhou, S; Li, H; Singh, K; et al. Science Translational Medicine. 2019; 11:eaav8375-eaav8375.

Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor. Zacharias, WJ; Frank, DB; Zepp, JA; Morley, MP; Alkhaleel, FA; Kong, J; Zhou, S; Cantu, E; Morrisey, EE. Nature. 2018; 555:251-255.

Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells. Jacob, A; Morley, M; Hawkins, F; McCauley, KB; Jean, JC; Heins, H; Na, C; Weaver, TE; Vedaie, M; Hurley, K; et al. Cell Stem Cell. 2017; 21:472-488.e10.

Distinct Mesenchymal Lineages and Niches Promote Epithelial Self-Renewal and Myofibrogenesis in the Lung. Zepp, JA; Zacharias, WJ; Frank, DB; Cavanaugh, CA; Zhou, S; Morley, MP; Morrisey, EE. Cell. 2017; 170:1134-1148.e10.

Hedgehog Is an Anti-Inflammatory Epithelial Signal for the Intestinal Lamina Propria. Zacharias, WJ; Li, X; Madison, BB; Kretovich, K; Kao, JY; Merchant, JL; Gumucio, DL. Gastroenterology. 2010; 138:2368-U226.

Analysis of Germline GLI1 Variation Implicates Hedgehog Signalling in the Regulation of Intestinal Inflammatory Pathways. Lees, CW; Zacharias, WJ; Tremelling, M; Noble, CL; Nimmo, ER; Tenesa, A; Cornelius, J; Torkvist, L; Kao, J; Farrington, S; et al. PLoS Medicine. 2008; 5:e239-e239.

Early lineage specification defines alveolar epithelial ontogeny in the murine lung. Frank, DB; Penkala, IJ; Zepp, JA; Sivakumar, A; Linares-Saldana, R; Zacharias, WJ; Stolz, KG; Pankina, J; Lu, M; Wang, Q; et al. Proceedings of the National Academy of Sciences of USA. 2019; 116:4362-4371.

Neutrophils promote alveolar epithelial regeneration by enhancing type II pneumocyte proliferation in a model of acid-induced acute lung injury. Paris, AJ; Liu, Y; Mei, J; Dai, N; Guo, L; Spruce, LA; Hudock, KM; Brenner, JS; Zacharias, WJ; Mei, HD; et al. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2016; 311:L1062-L1075.