William J. Zacharias, MD, PhD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

UC Department of Internal Medicine

Phone 513-636-2938

Email william.zacharias@cchmc.org

MD: University of Michigan, Ann Arbor, MI, 2011.

PhD: University of Michigan, Ann Arbor, MI, 2011.

Residency: Hospital of the University of Pennsylvania, Philadelphia, PA.

Fellowship: Hospital of the University of Pennsylvania, Philadelphia, PA.

Certifications: Internal Medicine; Pulmonary Medicine; Critical Care Medicine.

View PubMed Publications

Zacharias WJ, Frank DB, Zepp JA, Morley MP, Alkahleel FA, Kong J, Zhou S, Cantu E, Morrisey EE. Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor. Nature. 2018 Mar 8;555(7695):251-255.

Jacob A, Morley M, Hawkins F, McCauley KB, Jean JC, Heins H, Na C-L, Weaver TE, Vedaie M, Hurley K, Hinds A, Russo SJ, Kook S, Zacharias W, Och M, Traber K, Quinton LJ, Crane A, Davis BR, White FV, Wambach J, Whitsett JA, Cole FS, Morrisey EE, Guttentag SH, Beers MF, Kotton DN. Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells. Cell Stem Cell. 2017 Oct 5;21(4):472-488.e10.

Zepp JA, Zacharias WJ, Frank DB, Cavanaugh CA, Morley MP, Morrisey EE. Distinct mesenchymal lineages and niches promote epithelial self-renewal and myofibrogenesis in the lung. Cell. 2017 Sep 7;170(6):1134-1148.e10.

Paris AJ, Liu Y, Mei J, Dai N, Guo L, Spruce LA, Hudock KM, Brenner JS, Zacharias WJ, Mei HD, Slamowitz AR, Bhamidipati K, Beers MF, Seeholzer SH, Morrisey EE, Worthen GS. Neutrophils promote alveolar epithelial regeneration by enhancing type II pneumocyte proliferation in a model of acid-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2016 Dec 1;311(6):L1062-L1075.

Zacharias WJ, Madison BB, Kretovich KE, Walton KD, Richards N, Udager AM, Li X, Gumucio DL. Hedgehog signaling controls homeostasis of adult intestinal smooth muscle. Dev Biol. 2011 Jul 1;355(1):152-62.

Zacharias WJ, Madison BB, Walton KD, Li X, Kretovich K, Gumucio DL. Epithelial Hedgehog is an anti-inflammatory signal to the intestinal lamina propria. Gastroenterology. 2010 Jun;138(7):2368-77, 2377.e1-4.

Kolterud A, Grosse AS, Zacharias WJ, Walton KD, Kretovich KE, Madison B, Waghray M, Ferris JE, Hu C, Merchant JL, Dlugosz A, Kottmann AH, Gumucio DL. Paracrine Hedgehog Signaling in Stomach and Intestine: New Roles for Hedgehog in Gastrointestinal Patterning. Gastroenterology. 2009 Aug;137(2):618-28.

Lees CW, Zacharias WJ, Tremelling M, Noble CL, Nimmo ER, Tenesa A, Cornelius J, Torkvist L, Kao J, Farrington S, Drummond HE, Ho GT, Arnott ID, Appelman HD, Diehl L, Campbell H, Dunlop MG, Parkes M, Howie SE, Gumucio DL, Satsangi J. Analysis of germline GLI1 variation implicates Hedgehog signaling in the regulation of intestinal inflammatory pathways. PLoS Med. 2008 Dec 9;5(12):e239.

Li X, Madison BB, Zacharias W, Kolterud A, States D, Gumucio DL. Deconvoluting the intestine: molecular evidence for a major role of the mesenchyme in the modulation of signaling cross talk. Physiol Genomics. 2007 May 11;29(3):290-301.

Krause A, Zacharias W, Camarata T, Linkhart B, Law E, Lischke A, Miljan E, Simon HG. Tbx5 and Tbx4 transcription factors interact with a new chicken PDZ-LIM protein in limb and heart development. Dev Biol. 2004 Sep 1;273(1):106-20.