Complications vary with the particular vessels involved in the malformation. In general, the complications are additive for the individual components. For example, a capillary-lymphatic-venous malformation is associated with minor to major overgrowth of the soft tissues and underlying bones, which can cause limb length inequality. Lymphatic vesicles may leak lymphatic fluid or even bleed when associated with an overlying capillary malformation. A lymphatic component also increases the risk of developing a soft tissue or skin infection in the area of the malformation. The venous components can cause pain, swelling, heaviness of the extremity and clotting abnormalities.
In combined lesions with an arteriovenous component, the major complications are due to the abnormal flow of blood from arteries directly into veins. This may cause pain, skin breakdown and/or extremity overgrowth. Combined lesions with arteriovenous components can also lead to congestive heart failure.