When there is damage to the hypothalamus, the communication between the gut and the brain goes haywire, causing a constant feeling of hunger.
Since the hypothalamus cannot “hear” the signal that comes from the fat that is supposed to tell the hypothalamus to turn off hunger, the person continues to feel hungry. He or she will continue to eat excessively, the extra calories eaten are stored as fat, and the person never feels full. This can cause 1-2 pounds of weight gain a week.
As more and more weight is gained, the body begins to store fat in places that are harmful to health such as in the muscles, liver and in and around other important organs in the belly. This can make it difficult for these important organs to function.
Interventions for weight loss are essential in such patients.