Type 1: The most common type of VWD. There is not enough VWF in the bloodstream.
Type 2: The next most common type of VWD. There may be enough VWF, but it does not work correctly. VWF is made of long strands called multimers. In type 2 VWD, there may be a problem with the multimers working correctly.
Type 2A: VWF does not form the correct multimers and does not stick to the platelets.
Type 2B: VWF multimers stick too tightly to the platelets, which causes the body to get rid of the platelets with the VWF. This results in a low level of platelets and VWF that doesn’t work correctly.
Type 2M: VWF multimers are normal, but VWF is not able to stick to the platelets.
Type 2N: VWF cannot carry factor VIII normally and this causes low factor VIII levels.
Type 3: The rarest form of VWD. There is little or no VWF in the blood. This type is the most severe form of the disease with little to no VWF and low factor VIII levels.