Publications

Seidman, JS; Troutman, TD; Sakai, M; Gola, A; Spann, NJ; Bennett, H; Bruni, CM; Ouyang, Z; Li, RZ; Sun, X; et al. Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis. Immunity. 2020; 52:1057-1074.e7.

Sakai, M; Troutman, TD; Seidman, JS; Ouyang, Z; Spann, NJ; Abe, Y; Ego, KM; Bruni, CM; Deng, Z; Schlachetzki, JC M; et al. Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity. Immunity. 2019; 51:655-670.e8.

Deason, K; Troutman, TD; Jain, A; Challa, DK; Mandraju, R; Brewer, T; Ward, ES; Pasare, C. BCAP links IL-1R to the PI3K-mTOR pathway and regulates pathogenic Th17 cell differentiation. Journal of Experimental Medicine. 2018; 215:2413-2428.

Eichenfield, DZ; Troutman, TD; Link, VM; Lam, MT; Cho, H; Gosselin, D; Spann, NJ; Lesch, HP; Tao, J; Muto, J; et al. Tissue damage drives co-localization of NF-κB, Smad3, and Nrf2 to direct Rev-erb sensitive wound repair in mouse macrophages. eLife. 2016; 5.

Troutman, TD; Hu, W; Fulenchek, S; Yamazaki, T; Kurosaki, T; Bazan, JF; Pasare, C. Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt. Proceedings of the National Academy of Sciences of the United States of America. 2012; 109:273-278.

Bennett, H; Troutman, T; Zhou, E; Spann, N; Link, V; Seidman, J; Nickl, C; Abe, Y; Sakai, M; Pasillas, M; et al. Systematic analysis of transcriptional and epigenetic effects of genetic variation in Kupffer cells enables discrimination of cell intrinsic and environment-dependent mechanisms. 2022.

Troutman, TD; Kofman, E; Glass, CK. Exploiting dynamic enhancer landscapes to decode macrophage and microglia phenotypes in health and disease. Molecular Cell. 2021; 81:3888-3903.

Rosenthal, SB; Liu, X; Ganguly, S; Dhar, D; Pasillas, MP; Ricciardelli, E; Li, RZ; Troutman, TD; Kisseleva, T; Glass, CK; et al. Heterogeneity of HSCs in a Mouse Model of NASH. Hepatology. 2021; 74:667-685.

Texari, L; Spann, NJ; Troutman, TD; Sakai, M; Seidman, JS; Heinz, S. An optimized protocol for rapid, sensitive and robust on-bead ChIP-seq from primary cells. STAR Protocols. 2021; 2.

Troutman, TD; Bennett, H; Sakai, M; Seidman, JS; Heinz, S; Glass, CK. Purification of mouse hepatic non-parenchymal cells or nuclei for use in ChIP-seq and other next-generation sequencing approaches. STAR Protocols. 2021; 2.

Bennett, H; Troutman, TD; Sakai, M; Glass, CK. Epigenetic Regulation of Kupffer Cell Function in Health and Disease. Frontiers in Immunology. 2021; 11.

Irizarry-Caro, RA; McDaniel, MM; Overcast, GR; Jain, VG; Troutman, TD; Pasare, C. TLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylation. Proceedings of the National Academy of Sciences of the United States of America. 2020; 117:30628-30638.

Seidman, JS; Troutman, TD; Sakai, M; Gola, A; Spann, NJ; Bennett, H; Bruni, CM; Ouyang, Z; Li, RZ; Sun, X; et al. Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis. Immunity. 2020; 52:1057-1074.e7.

Sun, X; Seidman, JS; Zhao, P; Troutman, TD; Spann, NJ; Que, X; Zhou, F; Liao, Z; Pasillas, M; Yang, X; et al. Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis. Cell Metabolism. 2020; 31:189-206.e8.

Sakai, M; Troutman, TD; Seidman, JS; Ouyang, Z; Spann, NJ; Abe, Y; Ego, KM; Bruni, CM; Deng, Z; Schlachetzki, JC M; et al. Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity. Immunity. 2019; 51:655-670.e8.

Allan, CM; Heizer, PJ; Tu, Y; Sandoval, NP; Jung, RS; Morales, JE; Sajti, E; Troutman, TD; Saunders, TL; Cusanovich, DA; et al. An upstream enhancer regulates Gpihbp1 expression in a tissue-specific manner. Journal of Lipid Research. 2019; 60:869-879.

Moore, SM; Seidman, JS; Ellegood, J; Gao, R; Savchenko, A; Troutman, TD; Abe, Y; Stender, J; Lee, D; Wang, S; et al. Setd5 haploinsufficiency alters neuronal network connectivity and leads to autistic-like behaviors in mice. Translational Psychiatry. 2019; 9.

Deason, K; Troutman, TD; Jain, A; Challa, DK; Mandraju, R; Brewer, T; Ward, ES; Pasare, C. BCAP links IL-1R to the PI3K-mTOR pathway and regulates pathogenic Th17 cell differentiation. Journal of Experimental Medicine. 2018; 215:2413-2428.

Link, VM; Duttke, SH; Chun, HB; Holtman, IR; Westin, E; Hoeksema, MA; Abe, Y; Skola, D; Romanoski, CE; Tao, J; et al. Analysis of Genetically Diverse Macrophages Reveals Local and Domain-wide Mechanisms that Control Transcription Factor Binding and Function. Cell. 2018; 173:1796-1809.e17.

Muse, ED; Yu, S; Edillor, CR; Tao, J; Spann, NJ; Troutman, TD; Seidman, JS; Henke, A; Roland, JT; Ozeki, KA; et al. Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages. Proceedings of the National Academy of Sciences of the United States of America. 2018; 115:E4680-E4689.

Muse, E; Yu, S; Edillor, C; Tao, J; Spann, N; Troutman, T; Seidman, J; Henke, A; Roland, J; Ozeki, K; et al. Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP pathways in macrophages. 2018.