Troutman Lab

Publications

Bennett, H; Troutman, TD; Zhou, E; Spann, NJ; Link, VM; Seidman, JS; Nickl, CK; Abe, Y; Sakai, M; Pasillas, MP; Marlman, JM; Guzman, C; Hosseini, M; Schnabl, B; Glass, CK. Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes. Nature Immunology. 2023; 24:1825-1838.

Troutman, TD; Kofman, E; Glass, CK. Exploiting dynamic enhancer landscapes to decode macrophage and microglia phenotypes in health and disease. Molecular Cell. 2021; 81:3888-3903.

Seidman, JS; Troutman, TD; Sakai, M; Gola, A; Spann, NJ; Bennett, H; Bruni, CM; Ouyang, Z; Li, RZ; Sun, X; Hosseini, M; Witztum, JL; Germain, RN; Glass, CK. Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis. Immunity. 2020; 52:1057-1074.e7.

Sakai, M; Troutman, TD; Seidman, JS; Ouyang, Z; Spann, NJ; Abe, Y; Ego, KM; Bruni, CM; Deng, Z; Schlachetzki, JC M; Thompson, BM; McDonald, JG; Geissmann, F; Glass, CK. Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity. Immunity. 2019; 51:655-670.e8.

Troutman, TD; Hu, W; Fulenchek, S; Yamazaki, T; Kurosaki, T; Bazan, JF; Pasare, C. Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt. Proceedings of the National Academy of Sciences of USA. 2012; 109:273-278.

Weinhaus, B; Homan, S; Kincaid, M; Tadwalkar, A; Gu, X; Kumar, S; Slaughter, A; Zhang, J; Wu, Q; Kofron, JM; Troutman, TD; DeFalco, T; Lucas, D. Differential regulation of fetal bone marrow and liver hematopoiesis by yolk-sac-derived myeloid cells. Nature Communications. 2025; 16:4427.

Dunn, JL M; Szep, A; Gonzalez Galan, E; Zhang, S; Marlman, J; Caldwell, JM; Troutman, TD; Rothenberg, ME. Eosinophil specialization is regulated by exposure to the esophageal epithelial microenvironment. Journal of Leukocyte Biology. 2024; 116:1007-1020.

Ganguly, S; Rosenthal, SB; Ishizuka, K; Troutman, TD; Rohm, TV; Khader, N; Aleman-Muench, G; Sano, Y; Archilei, S; Soroosh, P; Loomba, R; Glass, CK; Brenner, DA; Dhar, D. Lipid-associated macrophages' promotion of fibrosis resolution during MASH regression requires TREM2. Proceedings of the National Academy of Sciences of USA. 2024; 121:e2405746121.

Proper, SP; Dwyer, AT; Appiagyei, A; Felton, JM; Ben-Baruch Morgenstern, N; Marlman, JM; Kotliar, M; Barski, A; Troutman, TD; Rothenberg, ME; Mersha, TB; Azouz, NP. Aryl hydrocarbon receptor and IL-13 signaling crosstalk in human keratinocytes and atopic dermatitis. Frontiers in Allergy. 2024; 5:1323405.

Abe, Y; Kofman, ER; Ouyang, Z; Cruz-Becerr, G; Spann, NJ; Seidman, JS; Troutman, TD; Stender, JD; Taylor, H; Fan, W; Evans, RM; Kadonaga, JT; Rosenfeld, MG; Glass, CK. A TLR4/TRAF6-dependent signaling pathway mediates NCoR coactivator complex formation for inflammatory gene activation. Proceedings of the National Academy of Sciences of USA. 2024; 121:e2316104121.

Arimoto, KI; Miyauchi, S; Troutman, TD; Zhang, Y; Liu, M; Stoner, SA; Davis, AG; Fan, JB; Huang, YJ; Yan, M; Glass, CK; Zhang, DE. Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis. Nature Communications. 2023; 14:251.

Shao, TY; Jiang, TT; Stevens, J; Russi, AE; Troutman, TD; Bernieh, A; Pham, G; Erickson, JJ; Eshleman, EM; Alenghat, T; Weaver, CT; Haslam, DB; Deshmukh, H; Way, SS. Kruppel-like factor 2+ CD4 T cells avert microbiota-induced intestinal inflammation. Cell Reports. 2023; 42:113323.

Bennett, H; Troutman, TD; Zhou, E; Spann, NJ; Link, VM; Seidman, JS; Nickl, CK; Abe, Y; Sakai, M; Pasillas, MP; Marlman, JM; Guzman, C; Hosseini, M; Schnabl, B; Glass, CK. Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes. Nature Immunology. 2023; 24:1825-1838.

Troutman, TD; Glass, CK. Gene-by-environment regulation of Kupffer cell transcriptomes and epigenomes. Nature Immunology. 2023; 24:1797-1798.

Underwood, B; Troutman, TD; Schwartz, JT. Breaking down the complex pathophysiology of eosinophilic esophagitis. Annals of Allergy, Asthma, and Immunology. 2023; 130:28-39.

Bennett, H; Troutman, T; Zhou, E; Spann, N; Link, V; Seidman, J; Nickl, C; Abe, Y; Sakai, M; Pasillas, M; Marlman, J; Guzman, C; Hosseini, M; Schnabl, B; Glass, C. Systematic analysis of transcriptional and epigenetic effects of genetic variation in Kupffer cells enables discrimination of cell intrinsic and environment-dependent mechanisms. 2022; 2022.09.22.509046.

Troutman, TD; Kofman, E; Glass, CK. Exploiting dynamic enhancer landscapes to decode macrophage and microglia phenotypes in health and disease. Molecular Cell. 2021; 81:3888-3903.

Rosenthal, SB; Liu, X; Ganguly, S; Dhar, D; Pasillas, MP; Ricciardelli, E; Li, RZ; Troutman, TD; Kisseleva, T; Glass, CK; Brenner, DA. Heterogeneity of HSCs in a Mouse Model of NASH. Hepatology. 2021; 74:667-685.

Troutman, TD; Bennett, H; Sakai, M; Seidman, JS; Heinz, S; Glass, CK. Purification of mouse hepatic non-parenchymal cells or nuclei for use in ChIP-seq and other next-generation sequencing approaches. Star Protocols. 2021; 2:100363.

Texari, L; Spann, NJ; Troutman, TD; Sakai, M; Seidman, JS; Heinz, S. An optimized protocol for rapid, sensitive and robust on-bead ChIP-seq from primary cells. Star Protocols. 2021; 2:100358.

Bennett, H; Troutman, TD; Sakai, M; Glass, CK. Epigenetic Regulation of Kupffer Cell Function in Health and Disease. Frontiers in Immunology. 2021; 11:609618.