Processing text with domain-specific spreading activation methods

Patent number: 8930178

Abstract: A method for performing natural language processing of free text using domain-specific spreading activation. Embodiments of the present invention ontologize free text using an algorithm based on neurocognitive theory by simulating human recognition, semantic, and episodic memory approaches. Embodiments of the invention may be used to process clinical text for assignment of billing codes, analyze suicide notes or legal discovery materials, and for processing other collections of text. Further, embodiments of the invention may be used to more effectively search large databases, such as a database containing a large number of medical publications.

Type: Grant

Filed: January 4, 2008

Date of Patent: January 6, 2015

Assignee: Children's Hospital Medical Center

Inventors: John Pestian, Pawel Matykiewicz, Wlodzislaw Duch, Tracy A. Glauser, Robert A. Kowatch, Jacqueline Grupp-Phelan

Optimization and Individualization of Medication Selection and Dosing

Patent number: 8589175

Abstract: The invention provides population models, methods, and algorithms for targeting a dosing regimen or compound selection to an individual patient. The methods and algorithms of the invention utilize population models that incorporate genotype information for genes encoding drug metabolizing enzymes for one or more compounds of interest. The methods allow integration of genotype information for one or more genes encoding a drug metabolizing enzyme, particularly a cytochrome P450 gene with patient data. The methods allow integration of genotype information and the effect of one or more compounds on one or more drug metabolizing enzymes. The methods allow iterative feedback of drug metabolizing data obtained from a patient into the process of generating a dosage regimen recommendation for a compound of interest for an individual patient.

Type: Grant

Filed: November 28, 2006

Date of Patent: November 19, 2013

Assignee: Children's Hospital Medical Center

Inventors: Tracy A. Glauser, Richard J. Wenstrup, Alexander A. Vinks, John Pestian

Patents - Inventor or Co-Inventor

  1. United States, 8,589,175, 11/19/2014, Optimization and Individualization of Medication Selection and Dosing
  2. Japan, 5567107, 06/27/2014, Optimization and Individualization of Medication Selection and Dosing
  3. Belgium, 2508621BE, 11/15/2014, Optimization and Individualization of Medication Selection and Dosing
  4. European Patent Office, 2508621, 11/15/2015, Optimization and Individualization of Medication Selection and Dosing
  5. France, 2508621FR, 11/15/2015, Optimization and Individualization of Medication Selection and Dosing
  6. Germany, 2508621DE, 11/15/2015, Optimization and Individualization of Medication Selection and Dosing
  7. Italy, 2508621IT, 11/15/2015, Optimization and Individualization of Medication Selection and Dosing
  8. Spain, 2508621ES, 11/15/2015, Optimization and Individualization of Medication Selection and Dosing
  9. Sweden, 2508621SW, 11/15/2015, Optimization and Individualization of Medication Selection and Dosing
  10. Switzerland, 2508621CH, 11/15/2015, Optimization and Individualization of Medication Selection and Dosing
  11. The Netherlands, 2508621NL, 11/15/2015, Optimization and Individualization of Medication Selection and Dosing
  12. United Kingdom, 2508621, 11/15/2015, Optimization and Individualization of Medication Selection and Dosing
  13. United States, 8,930,178, 01/06/2015, Processing Text with Domain-Specific Spreading Activation Methods
  14. Hong Kong, HK1176093, 09/04/2015, Optimization and Individualization of Medication Selection and Dosing
  15. Australia, 2912293861, 11/26/2015, Optimization and Individualization of Medication Selection and Dosing
  16. Canada, 2,630,604, 1/19/2016, Optimization and Individualization of Medication Selection and Dosing
  17. Japan, 5894213, 3/4/2016, Optimization and Individualization of Medication Selection and Dosing
  18. United States, 9.477,655, 10/25/2016, Processing Text with Domain-Specific Spreading Activation Methods
  19. Canada, 2,630,604, 1/19/2016, Optimization and Individualization of Medication Selection and Dosing
  20. Japan, 5894213, 3/4/2016 , Optimization and Individualization of Medication Selection and Dosing
  21. United States, 9.477,655, 10/25/2016, Processing Text with Domain-Specific Spreading Activation Methods
  22. United States, 9,691,411 - System and Method for Assessing Suicide Risk of a Patient Based Upon Non-Verbal Characteristics of Voice Data

Pending Patents - Inventor or Co-Inventor

  1. System and Method for Assessing Suicide Risk of a Patient Based Upon Non-Verbal Characteristics of Voice Data, US Patent Application 14/893,253
  2. Precision dosing pattern, Provisional patent filed April 2017
  3. Identification of Surgery Candidates Using Natural Language Processing Document. United States Patent Application 20160180041 Lead Inventor