Adherence is Variable Within Treatments and Across Diseases
Epilepsy
60% of patients do not take antiepileptic medications as prescribed.
Modi AC, Rausch JR, Glauser TA. Patterns of Nonadherence to Antiepileptic Drug Therapy in Children With Newly Diagnosed Epilepsy. JAMA. 2011;305(16):1669-1676. doi:10.1001/jama.2011.506.
Asthma
31.5% of prescribed corticosteroid treatments are used by young patients.
Seid M, D'Amico EJ, Varni JW, Munafo JK, Britto MT, Kercsmar CM, Drotar D, King EC, Darbie L. The in vivo adherence intervention for at risk adolescents with asthma : Report of a randomized pilot trial. Journal of Pediatric Psychology 2012;37:390-403.
Leukemia
Among children and adolescents with acute lymphoblastic leukemia prescribed oral mercaptopurine during maintenance treatment:
• 44% are non-adherent (<95% of prescribed doses taken)
• Mean adherence is 93% among children and 86% among adolescents
Bhatia et al. (2012) Treatment adherence in adolescents with inflammatory bowel disease: the collective impact of barriers to adherence and anxiety/depressive symptoms. J Clinical Oncology. 2012;2012;37(3):282-291.
Inflammatory Bowel Disease
Documented IBD adherence rates range from 16% to 62%.
Gray W.N., Denson L.A., Baldassano R.N., Hommel K.A. Treatment adherence in adolescents with inflammatory bowel disease: the collective impact of barriers to adherence and anxiety/depressive symptoms. Journal of Pediatric Psychology 2012;37(3):282-291.
Sickle Cell Disease
Adherence rates ranged from 12% to 100% across all medications.
Kristin Loiselle, PHD, Jennifer L. Lee, MS, Lauren Szulczewski, PSYD, Sarah Drake, BS, Lori E. Crosby, PSYD, and Ahna L. H. Pai. PHD Systematic and Meta-Analytic Review: Medication Adherence Among Pediatric Patients With Sickle Cell Disease. Journal of Pediatric Psychology, 2015, 1–13. doi: 10.1093/jpepsy/jsv084
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