CuSTOM scientists generate the acid secreting part of the human stomach. Reported in Nature, McCracken et al 2017. Description of the generation of the functional fundic stomach organoids from hPSCs paving the way to study and improve treatment of stomach disease and gastric cancer. Read Press Release. Watch Video.
Researchers engineer human intestinal tissue with functioning nerves. A consortium of CuSTOM investigators from the Brugmann, Wells and Helmrath labs has reconstituted a functioning enteric nervous system into human intestinal organoids. Reported in Nature Medicine, this transformative work by Workman et al 2016 will enable the study of intestinal physiology and allow clinical investigators to develop new therapies for intestinal disease. Read Press Release. Watch Video.
Genetic pathways governing embryonic lung development. Reported in Cell Reports, Rankin et al 2016. A team led by the Zorn lab use animal models and human pluripotent stem cells to elucidate the complex genetic pathways controlling the very first step in respiratory system development. Read Publication.
Biomechanics promote vascularized Complex human organ tissue. Reported in Cell Stem Cell, Takebe et al 2015. Mixing epithelial cells with endothelial and mesenchymals cells can promote the formation of multiple different types of organoids including liver, kidney, pancreas, heart, lung and brain, by modulating the stiffness of the tissue. These findings provide a general platform for harnessing mechanical properties to generate vascularized complex organ buds for regenerative medicine. Read Publication.
Intestinal organoids transplanted into mice form mature human tissue. Reported in Nature Medicine, Watson et al 2014. Researchers in the Helmrath lab have successfully transplanted “organoids” grown from pluripotent stem cells in a lab dish into mice. show that the transplanted tissue undergoes extensive maturation. The new findings eventually lead to tissue replacement for people born with genetic defects in their digestive systems or people who have lost intestinal function from cancer, as well as Crohn’s disease and other related inflammatory bowel diseases. Read Press Release.
Scientists generate the first human stomach tissue in lab with stem cells. Reported in Nature, McCracken et al 2014. Scientists generate functional, three-dimensional miniature human stomachs from human pluripotent stem cells. Gastric organoids provide an unprecedented tool for researching development and disease of the stomach including infection by H. pylori bacteria, a major cause of peptic ulcer disease and stomach cancer. Read Press Release and Related Article.
First multicellular liver organoids from iPSC. Reported in Nature, Takebe et al 2013. The first vascularized, functional human liver organoid from human pluripotent stem cells. Liver organoids transplanted into mice improve survival after lethal liver injury providing proof of principle for eventual tissue replacement therapy for patients. Read Publication.
First human intestinal tissue from pluripotent stem cells. Reported in Nature, Spence et al 2011. Scientists from Cincinnati Children’s Hospital Medical Center generate first 3-D complex human intestinal tissue in the lab from pluripotent stem cells. These findings will open the door to unprecedented studies of human intestinal development, function and disease and represent a significant step toward generating intestinal tissue for transplantation. Read Press Release.