Our scientists perform hypothesis-driven, discovery-based research in cellular, molecular and functional neuroscience to uncover fundamental mechanisms in nervous system development, repair and function. Read more about our research discoveries.
Research suggests that a drug similar to one under evaluation as a possible cancer treatment might eventually help people born with fragile X syndrome (FXS). The study was published in Neuropsychopharmacology.
Researchers, led by Q. Richard Lu, PhD, report in Developmental Cell that mutation or loss of a gene called CHD8 hinders formation of the sheath in developing oligodendrocytes, causing neurological defects in the animals.
Scientists, led by Biplab Dasgupta, PhD, and Rishi Raj Chhipa, PhD, report in Nature Cell Biology finding a potentially promising treatment target for aggressive and deadly high-grade brain cancers like glioblastoma.
Researchers, led by Yutaka Yoshida, PhD, report in Cell Reports the mapping of critical nerve connections to the spine that drive voluntary movement in forelimbs.
Genomic profiling of mostly untreatable and deadly nerve sheath tumors led scientists to test a possible therapy that inhibited tumor growth in lab tests on human tumor cells and mouse models. The study, led by Q. Richard Lu, PhD, was published in Cancer Cell.
Scientists from Cincinnati Children’s test experimental molecular therapy in the mice that restores nerve insulation and improves limb function following nerve injury. The study, led by Q. Richard Lu, PhD, was published in Nature Medicine.
Researchers led by Yutaka Yoshida, PhD, report in Science blocking molecular pruning of sophisticated brain-to-limb nerve connections in maturing mice.
Scientists led by Yutaka Yoshida, PhD, report in Neuron the lost function of two genes prevents infant laboratory mice from developing motor skills as they mature into adults.
Scientists led by Q. Richard Lu, PhD, write in Nature Communications it may be possible to therapeutically fine tune a constantly shifting balance of molecular signals to ensure the body’s peripheral nerves are properly insulated and functioning normally.
Researchers led by Q. Richard Lu, PhD, report in Developmental Cell microRNA treatment partially repaired damaged nerves and restored limb function in mice with MS.
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