Translational and Clinical Pharmacology

Publications

Alsoud, D; Moes, DJ A R; Wang, Z; Soenen, R; Layegh, Z; Barclay, M; Mizuno, T; Minichmayr, IK; Keizer, RJ; Wicha, SG; De Vries, A; Papamichael, K; Padullés-Zamora, N; Dreesen, E. Best Practice for Therapeutic Drug Monitoring of Infliximab: Position Statement from the International Association of Therapeutic Drug Monitoring and Clinical Toxicology. Therapeutic Drug Monitoring. 2024; 46:291-308.

Capal, JK; Ritter, DM; Franz, DN; Griffith, M; Currans, K; Kent, B; Bebin, EM; Northrup, H; Koenig, MK; Mizuno, T; Greiner, HM; Holland-Bouley, K; Horn, PS; Krueger, DA. Preventative treatment of tuberous sclerosis complex with sirolimus: Phase I safety and efficacy results. 2024; 2:106-119.

Hambrick, HR; Cervantes, F; Dong, M; Tang, P; Arbough, T; Vinks, AA; Mizuno, T; Goldstein, SL; Kaplan, J; Girdwood, ST. Ceftriaxone Pharmacokinetics and Pharmacodynamic Target Attainment for Three Pediatric Patients Receiving Continuous Kidney Replacement Therapy. Journal of Pediatric Pharmacology and Therapeutics. 2024; 29:180-187.

Hambrick, HR; Fei, L; Pavia, K; Kaplan, J; Mizuno, T; Tang, P; Schuler, E; Benoit, S; Girdwood, ST. Cystatin C Outperforms Creatinine in Predicting Cefepime Clearance in Pediatric Stem Cell Transplant Recipients. Transplantation and Cellular Therapy. 2024; 30:614.e1-614.e11.

Hambrick, HR; Punt, N; Pavia, K; Mizuno, T; Goldstein, SL; Tang Girdwood, S. Monte Carlo simulations of cefepime in children receiving continuous kidney replacement therapy support continuous infusions for target attainment. Journal of Intensive Care. 2024; 12:38.

Jodele, S; Dandoy, CE; Aguayo-Hiraldo, P; Lane, A; Teusink-Cross, A; Sabulski, A; Mizuno, K; Laskin, BL; Freedman, J; Davies, SM. A prospective multi-institutional study of eculizumab to treat high-risk stem cell transplantation-associated TMA. Blood. 2024; 143:1112-1123.

Junior, RM; Mizuno, T; Paice, KM; Pavia, KE; Rhodes Hambrick, H; Tang, P; Jones, R; Gibson, A; Stoneman, E; Curry, C; Kaplan, J; Girdwood, ST. Identifying optimal dosing strategies for meropenem in the paediatric intensive care unit through modelling and simulation. Journal of Antimicrobial Chemotherapy. 2024; 79:2668-2677.

Leino, AD; Kaiser, TE; Khalil, K; Mansell, H; Taber, DJ. Electronic health record-enabled routine assessment of medication adherence after solid organ transplantation: the time is now. American Journal of Transplantation. 2024; 24:711-715.

Leino, AD; Magee, JC; Kershaw, DB; Pai, MP; Park, JM. A Comprehensive Mixed-Method Approach to Characterize the Source of Diurnal Tacrolimus Exposure Variability in Children: Systematic Review, Meta-analysis, and Application to an Existing Data Set. The Journal of Clinical Pharmacology. 2024; 64:334-344.

Leino, AD; Takyi-Williams, J; Park, JM; Norman, SP; Sun, D; Farris, KB; Pai, MP. Clinical validation of two volumetric absorptive microsampling devices to support home-based therapeutic drug monitoring of immunosuppression. British Journal of Clinical Pharmacology. 2024; 90:2897-2909.

Minar, PP; Colman, RJ; Zhang, N; Mizuno, T; Vinks, AA. Precise infliximab exposure and pharmacodynamic control to achieve deep remission in paediatric Crohn's disease (REMODEL-CD): study protocol for a multicentre, open-label, pragmatic clinical trial in the USA. BMJ Open. 2024; 14:e077193.

Minichmayr, IK; Mizuno, T; Goswami, S; Peck, RW; Polasek, TM. Recent Advances Addressing the Challenges of Precision Dosing. Clinical Pharmacology and Therapeutics. 2024; 116:527-530.

Morales, R; Mizuno, T; Paice, KM; Hambrick, HR; Punt, N; Tang Girdwood, S. Impact of fluid balance on beta-lactam antibiotics target attainment: Insights from a simulation-based meropenem study. International Journal of Antimicrobial Agents. 2024; 64:107267.

Nasr, A; Mizuno, T; Irie, K; Dillman, J; Jackson, K; Lynch, K; Horrell, A; Chun, KY; Yang, JM; Hyams, JS; Boyle, BM; Noe, JD; Denson, LA; Minar, PP. 958 ATTAINING EARLY ANTI-TNF EXPOSURE TARGETS IS ASSOCIATED WITH IMPROVED RATES OF ENDOSCOPIC HEALING AND TRANSMURAL HEALING IN CHILDREN WITH CROHN'S DISEASE. Gastroenterology. 2024; 166:s-226-s-227.

Paice, K; Tang Girdwood, S; Mizuno, T; Pavia, K; Punt, N; Tang, P; Dong, M; Curry, C; Jones, R; Gibson, A; Vinks, AA; Kaplan, J. Pharmacokinetic Factors Associated With Early Meropenem Target Attainment in Pediatric Severe Sepsis. Pediatric Critical Care Medicine. 2024; 25:1103-1116.

Paice, K; Tang Girdwood, S; Pavia, K; Mizuno, T; Kaplan, J. 868: EARLY MEROPENEM CLEARANCE OF CRITICALLY ILL PATIENTS IN A PEDIATRIC INTENSIVE CARE UNIT. Critical Care Medicine. 2024; 52:s407.

Power-Hays, A; Dong, M; Punt, N; Mizuno, T; Smart, LR; Vinks, AA; Ware, RE. Rationale, Development, and Validation of HdxSim, a Clinical Decision Support Tool for Model-Informed Precision Dosing of Hydroxyurea for Children with Sickle Cell Anemia. Clinical Pharmacology and Therapeutics. 2024; 116:670-677.

Sagcal-Gironella, AC P; Merritt, A; Mizuno, T; Dharnidharka, VR; McDonald, J; DeGuzman, M; Wahezi, D; Goilav, B; Onel, K; Kim, S; Hersh, A; Huang, B; Devarajan, P; Brunner, H. Efficacy and Safety of Pharmacokinetically-Driven Dosing of Mycophenolate Mofetil for the Treatment of Pediatric Proliferative Lupus Nephritis-A Double-Blind Placebo Controlled Clinical Trial (The Pediatric Lupus Nephritis Mycophenolate Mofetil Study). Journal of Clinical Trials. 2024; 14:563.

Shimamoto, Y; Fukushima, K; Mizuno, T; Ichikawa, H; Kurosaki, K; Maeda, S; Okuda, M. Model-Informed Vancomycin Dosing Optimization to Address Delayed Renal Maturation in Infants and Young Children with Critical Congenital Heart Disease. Clinical Pharmacology and Therapeutics. 2024; 115:239-247.

Strawn, JR; Poweleit, EA; Taylor, ZL; Mizuno, T; Vaughn, S; Desta, Z; Stancil, S; Ramsey, LB. 84 Using Opportunistic Sampling and Remnant Blood Samples to Develop Pediatric Pharmacokinetic Models to Inform Antidepressant Dosing. Journal of Clinical and Translational Science. 2024; 8:22-23.

Takyi-Williams, J; Leino, AD; Li, R; Downes, KJ; Zuppa, AF; Bwint, A; Wen, B; Sun, D; Scheetz, MH; Pai, MP. Bioanalysis of six antibiotics from volumetric microsamples: a new tool for precision dosing in critically ill children. Bioanalysis. 2024; 16:19-31.

van Hoogdalem, MW; Tanaka, R; Abduljalil, K; Johnson, TN; Wexelblatt, SL; Akinbi, HT; Vinks, AA; Mizuno, T. Forecasting Fetal Buprenorphine Exposure through Maternal-Fetal Physiologically Based Pharmacokinetic Modeling. Pharmaceutics. 2024; 16:375.

van Hoogdalem, MW; Tanaka, R; Johnson, TN; Vinks, AA; Mizuno, T. Development and Verification of a Full Physiologically Based Pharmacokinetic Model for Sublingual Buprenorphine in Healthy Adult Volunteers that Accounts for Nonlinear Bioavailability. Drug metabolism and disposition: the biological fate of chemicals. 2024; 52:785-796.

Wilson, NK; Tremblay, S; Shields, AR; Woodle, ES; Alloway, RR; Vinks, AA; Miyagawa, B; Mizuno, T. Belatacept Removal by Plasmapheresis: Dose Adjustments and Clinical Recommendations. Transplantation Direct. 2024; 10:e1677.

Yamashita, Y; Hira, D; Morita, M; Katsube, Y; Takakura, M; Tomotaki, H; Tomotaki, S; Xiong, W; Shiomi, H; Horie, T; Ueshima, S; Mizuno, T; Terada, T; Ono, K. Potential treatment option of rivaroxaban for breastfeeding women: A case series. Thrombosis Research. 2024; 237:141-144.