Clinical Pharmacology


Chandra, S; Mizuno, K; Zhao, J; Davies, SM; Marsh, RA; Fukuda, T; Setchell, KD R; Vinks, AA; Mehta, PA. Test-dose pharmacokinetics guided melphalan dose adjustment in reduced intensity conditioning allogeneic transplant for non-malignant disorders. British Journal of Clinical Pharmacology. 2022; 88:115-127.

Colman, RJ; Xiong, Y; Mizuno, T; Hyams, JS; Noe, JD; Boyle, B; D’Haens, GR; van Limbergen, J; Chun, K; Yang, J; et al. Antibodies-to-infliximab accelerate clearance while dose intensification reverses immunogenicity and recaptures clinical response in paediatric Crohn's disease. Alimentary Pharmacology and Therapeutics. 2022; 55:593-603.

Contreras, FC; Mizuno, T; Dong, M; Tang, P; Arbough, T; Vinks, A; Kaplan, J; Girdwood, ST. 1001: CEFTRIAXONE CLEARANCE ESTIMATES IN PEDIATRIC PATIENTS ON EXTRACORPOREAL MEMBRANE OXYGENATION THERAPY. Critical Care Medicine. 2022; 50:497-497.

Dong, M; Emoto, C; Fukuda, T; Arnold, DE; Mehta, PA; Marsh, RA; Vinks, AA. Model-informed precision dosing for alemtuzumab in paediatric and young adult patients undergoing allogeneic haematopoietic cell transplantation. British Journal of Clinical Pharmacology. 2022; 88:248-259.

Girdwood, ST; Dong, M; Tang, P; Stoneman, E; Jones, R; Yunger, T; Ostermeier, A; Curry, C; Forton, M; Hail, T; et al. Population Pharmacokinetic Modeling of Total and Free Ceftriaxone in Critically Ill Children and Young Adults and Monte Carlo Simulations Support Twice Daily Dosing for Target Attainment. Antimicrobial Agents and Chemotherapy. 2022; 66.

Mizuno, K; Dandoy, CE; Teusink-Cross, A; Davies, SM; Vinks, AA; Jodele, S. Eculizumab precision-dosing algorithm for thrombotic microangiopathy in children and young adults undergoing HSCT. Blood Advances. 2022; 6:1454-1463.

Mizuno, T; Dong, M; Taylor, ZL; Ramsey, LB; Vinks, AA. Clinical implementation of pharmacogenetics and model-informed precision dosing to improve patient care. British Journal of Clinical Pharmacology. 2022; 88:1418-1426.

Paice, K; Girdwood, ST; Mizuno, T; Tang, P; Curry, C; Jones, R; Stoneman, E; Yunger, T; Dong, M; Vinks, A; et al. 1004: INADEQUATE MEROPENEM TARGET ATTAINMENT EARLY IN PEDIATRIC CRITICAL ILLNESS. Critical Care Medicine. 2022; 50:499-499.

van Hoogdalem, MW; Johnson, TN; McPhail, BT; Kamatkar, S; Wexelblatt, SL; Ward, LP; Christians, U; Akinbi, HT; Vinks, AA; Mizuno, T. Physiologically-Based Pharmacokinetic Modeling to Investigate the Effect of Maturation on Buprenorphine Pharmacokinetics in Newborns with Neonatal Opioid Withdrawal Syndrome. Clinical Pharmacology and Therapeutics. 2022; 111:496-508.

van Hoogdalem, MW; Wexelblatt, SL; Akinbi, HT; Vinks, AA; Mizuno, T. A review of pregnancy-induced changes in opioid pharmacokinetics, placental transfer, and fetal exposure: Towards fetomaternal physiologically-based pharmacokinetic modeling to improve the treatment of neonatal opioid withdrawal syndrome. Pharmacology and Therapeutics. 2022; 234.