Translational and Clinical Pharmacology

Publications

Alghamdi, A; Seay, S; Hooper, DK; Varnell, CD; Darland, L; Mizuno, T; Lazear, D; Ramsey, LB. Tacrolimus pharmacokinetics are influenced by CYP3A5, age, and concomitant fluconazole in pediatric kidney transplant patients. Clinical and Translational Science. 2023; 16:1768-1778.

Cervantes, FC; Mizuno, T; Dong, M; Tang, P; Arbough, T; Vinks, AA; Kaplan, JM; Girdwood, SC T. Ceftriaxone Pharmacokinetics and Pharmacodynamics in 2 Pediatric Patients on Extracorporeal Membrane Oxygenation Therapy. Therapeutic Drug Monitoring. 2023; 45:832-836.

Colman, RJ; Mizuno, T; Fukushima, K; Haslam, DB; Hyams, JS; Boyle, B; Noe, JD; D'Haens, GR; Van Limbergen, J; Chun, K; et al. Real world population pharmacokinetic study in children and young adults with inflammatory bowel disease discovers novel blood and stool microbial predictors of vedolizumab clearance. Alimentary Pharmacology and Therapeutics. 2023; 57:524-539.

Colman, RJ; Samuels, A; Mizuno, T; Punt, N; Vinks, AA; Minar, P. Model-informed Precision Dosing for Biologics Is Now Available at the Bedside for Patients With Inflammatory Bowel Disease. Inflammatory Bowel Diseases. 2023; 29:1342-1346.

Dong, M; Ware, RE; Dallmann, A; Vinks, AA. Hydroxyurea treatment for sickle cell anemia during pregnancy and lactation: Current evidence and knowledge gaps. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 2023; 43:419-429.

Galletta, TJ; Dong, M; Vinks, AA; Chiang, SC C; Teusink-Cross, A; Marsh, RA; Davies, SM; Mehta, PA; Khandelwal, P. 356 Children Under 2 Years Old Treated with Ruxolitinib for Acute and Chronic Graft-Versus-Host-Disease Demonstrate Variable Pharmacokinetics. Transplantation and cellular therapy. 2023; 29:s271-s272.

Girdwood, ST; Hasson, D; Caldwell, JT; Slagle, C; Dong, S; Fei, L; Tang, P; Vinks, AA; Kaplan, J; Goldstein, SL. Relationship between piperacillin concentrations, clinical factors and piperacillin/tazobactam-associated acute kidney injury. Journal of Antimicrobial Chemotherapy. 2023; 78:478-487.

Jodele, S; Mizuno, K; Sabulski, A; Vinks, AA. Adopting Model-Informed Precision-Dosing for Eculizumab in Transplant Associated-Thrombotic Microangiopathy to Gene Therapies. Clinical Pharmacology and Therapeutics. 2023; 114:511-514.

Miyagawa, B; Lazear, D; Hooper, DK; Vinks, AA; Mizuno, T. Model-Informed Estimation of Acutely Decreased Tacrolimus Clearance and Subsequent Dose Individualization in a Pediatric Renal Transplant Patient With Posterior Reversible Encephalopathy Syndrome. Therapeutic Drug Monitoring. 2023; 45:376-382.

Mizuno, K; Capparelli, EV; Fukuda, T; Dong, M; Adamson, PC; Blumer, JL; Cnaan, A; Clark, PO; Reed, MD; Shinnar, S; et al. Model-Informed Precision Dosing Guidance of Ethosuximide Developed from a Randomized Controlled Clinical Trial of Childhood Absence Epilepsy. Clinical Pharmacology and Therapeutics. 2023; 114:459-469.

Paice, K; Girdwood, ST; Pavia, K; Mizuno, T; Tang, P; Curry, C; Gibson, A; Jones, R; Stoneman, E; Yunger, T; et al. 38: CRITICALLY ILL CHILDREN WITH SEVERE SEPSIS OFTEN HAVE SUB-TARGET MEROPENEM LEVELS EARLY IN THERAPY. Critical Care Medicine. 2023; 51:19.

Pavia, K; Girdwood, ST; Paice, K; Jones, R; Curry, C; Stoneman, E; Yunger, T; Gamel, N; Gibson, A; Dong, M; et al. 610: RENAL IMPAIRMENT IS ASSOCIATED WITH HIGH CEFEPIME CONCENTRATIONS IN CRITICALLY ILL CHILDREN. Critical Care Medicine. 2023; 51:294.

Pavia, K; Hambrick, HR; Paice, K; Tang, P; Punt, N; Kaplan, J; Goldstein, SL; Vinks, AA; Mizuno, T; Tang Girdwood, S. Cefepime pharmacokinetics in critically ill children and young adults undergoing continuous kidney replacement therapy. Journal of Antimicrobial Chemotherapy. 2023; 78:2140-2147.

Poweleit, EA; Taylor, ZL; Mizuno, T; Vaughn, SE; Desta, Z; Strawn, JR; Ramsey, LB. Escitalopram and Sertraline Population Pharmacokinetic Analysis in Pediatric Patients. Clinical Pharmacokinetics. 2023; 62:1621-1637.

Poweleit, EA; Vinks, AA; Mizuno, T. Artificial Intelligence and Machine Learning Approaches to Facilitate Therapeutic Drug Management and Model-Informed Precision Dosing. Therapeutic Drug Monitoring. 2023; 45:143-150.

Rosen, MJ; Rabizadeh, S; Panetta, JC; Mizuno, T; Vinks, AA; Whaley, KG; Hyams, JS; Kugathasan, S; Boyle, BM; Walters, TD; et al. 714 INFLIXIMAB CLEARANCE IN RELATION TO DISEASE ACTIVITY DURING INDUCTION AND MAINTENANCE THERAPY OF ACUTE SEVERE AND AMBULATORY PEDIATRIC ULCERATIVE COLITIS. Gastroenterology. 2023; 164:s-150.

Sadaf, A; Dong, M; Korpik, J; Pfeiffer, A; Kalfa, TA; Latham, TS; Vinks, AA; Ware, RE; Quinn, CT. Effects of L-Glutamine on Biomarkers of Response in Sickle Cell Disease: A Pharmacokinetics-Pharmacodynamics Analysis. Blood. 2023; 142:1145.

Samuels, A; Punt, N; Mizuno, T; Vinks, AA; Minar, PP. 347 DISEASE PROGRESSION PHARMACOKINETIC MODELING IMPROVES THE ACCURACY OF EARLY INFLIXIMAB CONCENTRATION TARGETS. Gastroenterology. 2023; 164:s-59.

Smart, LR; Charles, M; McElhinney, KE; Dong, M; Power-Hays, A; Howard, T; Vinks, AA; Ambrose, EE; Ware, RE. Hydroxyurea pharmacokinetics and precision dosing in low-resource settings. Frontiers in Molecular Biosciences. 2023; 10:1130206.

Tang Girdwood, S; Tang, P; Fenchel, M; Dong, M; Stoneman, E; Jones, R; Ostermeier, A; Curry, C; Forton, M; Hail, T; et al. Pharmacokinetic parameters over time during sepsis and the association of target attainment and outcomes in critically ill children and young adults receiving ceftriaxone. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 2023; 43:609-621.

Taylor, ZL; Poweleit, EA; Paice, K; Somers, KM; Pavia, K; Vinks, AA; Punt, N; Mizuno, T; Girdwood, ST. Tutorial on model selection and validation of model input into precision dosing software for model-informed precision dosing. CPT: Pharmacometrics and Systems Pharmacology. 2023; 12:1827-1845.

Whaley, KG; Xiong, Y; Karns, R; Hyams, JS; Kugathasan, S; Boyle, BM; Walters, TD; Kelsen, J; LeLeiko, N; Shapiro, J; et al. Multicenter Cohort Study of Infliximab Pharmacokinetics and Therapy Response in Pediatric Acute Severe Ulcerative Colitis. Clinical Gastroenterology and Hepatology. 2023; 21:1338-1347.