Boscolo Lab

Publications

Schrenk, S; Sherpa, C; Bischoff, LJ; Cai, Y; Boscolo, E. Semaphorin 3A and 3F Promote Lumen Expansion in TIE2-Mutated Venous Malformation. Arteriosclerosis, Thrombosis, and Vascular Biology. 2025; 45(12):2243-2260.

Bischoff, LJ; Schrenk, S; Soroko, K; Sherpa, C; Arasu, A; Reynaud, D; Boscolo, E. Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodeling. Developmental Dynamics. 2025.

Hammill, AM; Boscolo, E. Capillary malformations. Journal of Clinical Investigation. 2024; 134(8).

Schrenk, S; Bischoff, LJ; Goines, J; Cai, Y; Vemaraju, S; Odaka, Y; Good, SR; Palumbo, JS; Szabo, S; Reynaud, D; Van Raamsdonk, CD; Lang, RA; Boscolo, E. MEK inhibition reduced vascular tumor growth and coagulopathy in a mouse model with hyperactive GNAQ. Nature Communications. 2023; 14(1):1929.

Le Cras, TD; Goines, J; Lakes, N; Pastura, P; Hammill, AM; Adams, DM; Boscolo, E. Constitutively active PIK3CA mutations are expressed by lymphatic and vascular endothelial cells in capillary lymphatic venous malformation. Angiogenesis. 2020; 23(3):425-442.

Cai, Y; Schrenk, S; Goines, J; Davis, GE; Boscolo, E. Constitutive Active Mutant TIE2 Induces Enlarged Vascular Lumen Formation with Loss of Apico-basal Polarity and Pericyte Recruitment. Scientific Reports. 2019; 9(1):12352.

Li, X; Cai, Y; Goines, J; Pastura, P; Brichta, L; Lane, A; Le Cras, TD; Boscolo, E. Ponatinib Combined With Rapamycin Causes Regression of Murine Venous Malformation. Arteriosclerosis, Thrombosis, and Vascular Biology. 2019; 39(3):496-512.

Goines, J; Li, X; Cai, Y; Mobberley-Schuman, P; Metcalf, M; Fishman, SJ; Adams, DM; Hammill, AM; Boscolo, E. A xenograft model for venous malformation. Angiogenesis. 2018; 21(4):725-735.

Boscolo, E; Limaye, N; Huang, L; Kang, K-T; Soblet, J; Uebelhoer, M; Mendola, A; Natynki, M; Seront, E; Dupont, S; Eklund, L; Vikkula, M; Bischoff, J; Boon, LM. Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects. Journal of Clinical Investigation. 2015; 125(9):3491-3504.

Boscolo, E; Coma, S; Luks, VL; Greene, AK; Klagsbrun, M; Warman, ML; Bischoff, J. AKT hyper-phosphorylation associated with PI3K mutations in lymphatic endothelial cells from a patient with lymphatic malformation. Angiogenesis. 2015; 18(2):151-162.

Boscolo, E; Mulliken, JB; Bischoff, J. Pericytes from infantile hemangioma display proangiogenic properties and dysregulated angiopoietin-1. Arteriosclerosis, Thrombosis, and Vascular Biology. 2013; 33(3):501-509.

Boscolo, E; Mulliken, JB; Bischoff, J. VEGFR-1 mediates endothelial differentiation and formation of blood vessels in a murine model of infantile hemangioma. American Journal of Pathology. 2011; 179(5):2266-2277.

Boscolo, E; Stewart, CL; Greenberger, S; Wu, JK; Durham, JT; Herman, IM; Mulliken, JB; Kitajewski, J; Bischoff, J. JAGGED1 signaling regulates hemangioma stem cell-to-pericyte/vascular smooth muscle cell differentiation. Arteriosclerosis, Thrombosis, and Vascular Biology. 2011; 31(10):2181-2192.

Greenberger, S; Boscolo, E; Adini, I; Mulliken, JB; Bischoff, J. Corticosteroid suppression of VEGF-A in infantile hemangioma-derived stem cells. New England Journal of Medicine. 2010; 362(11):1005-1013.

Khan, ZA; Boscolo, E; Picard, A; Psutka, S; Melero-Martin, JM; Bartch, TC; Mulliken, JB; Bischoff, J. Multipotential stem cells recapitulate human infantile hemangioma in immunodeficient mice. Journal of Clinical Investigation. 2008; 118(7):2592-2599.