Boscolo Lab

Publications

Le Cras, TD; Goines, J; Lakes, N; Pastura, P; Hammill, AM; Adams, DM; Boscolo, E. Constitutively active PIK3CA mutations are expressed by lymphatic and vascular endothelial cells in capillary lymphatic venous malformation. Angiogenesis. 2020; 23:425-442.

Cai, Y; Schrenk, S; Goines, J; Davis, GE; Boscolo, E. Constitutive Active Mutant TIE2 Induces Enlarged Vascular Lumen Formation with Loss of Apico-basal Polarity and Pericyte Recruitment. Scientific Reports. 2019; 9:12352.

Li, X; Cai, Y; Goines, J; Pastura, P; Brichta, L; Lane, A; Le Cras, TD; Boscolo, E. Ponatinib Combined With Rapamycin Causes Regression of Murine Venous Malformation. Arteriosclerosis, Thrombosis, and Vascular Biology. 2019; 39:496-512.

Goines, J; Li, X; Cai, Y; Mobberley-Schuman, P; Metcalf, M; Fishman, SJ; Adams, DM; Hammill, AM; Boscolo, E. A xenograft model for venous malformation. Angiogenesis. 2018; 21:725-735.

Boscolo, E; Limaye, N; Huang, L; Kang, K; Soblet, J; Uebelhoer, M; Mendola, A; Natynki, M; Seront, E; Dupont, S; et al. Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects. The Journal of Clinical Investigation. 2015; 125:3491-3504.

Boscolo, E; Coma, S; Luks, VL; Greene, AK; Klagsbrun, M; Warman, ML; Bischoff, J. AKT hyper-phosphorylation associated with PI3K mutations in lymphatic endothelial cells from a patient with lymphatic malformation. Angiogenesis. 2015; 18:151-162.

Boscolo, E; Mulliken, JB; Bischoff, J. Pericytes from infantile hemangioma display proangiogenic properties and dysregulated angiopoietin-1. Arteriosclerosis, Thrombosis, and Vascular Biology. 2013; 33:501-509.

Boscolo, E; Mulliken, JB; Bischoff, J. VEGFR-1 mediates endothelial differentiation and formation of blood vessels in a murine model of infantile hemangioma. The American journal of pathology. 2011; 179:2266-2277.

Boscolo, E; Stewart, CL; Greenberger, S; Wu, JK; Durham, JT; Herman, IM; Mulliken, JB; Kitajewski, J; Bischoff, J. JAGGED1 signaling regulates hemangioma stem cell-to-pericyte/vascular smooth muscle cell differentiation. Arteriosclerosis, Thrombosis, and Vascular Biology. 2011; 31:2181-2192.

Greenberger, S; Boscolo, E; Adini, I; Mulliken, JB; Bischoff, J. Corticosteroid suppression of VEGF-A in infantile hemangioma-derived stem cells. The New England journal of medicine. 2010; 362:1005-1013.

Khan, ZA; Boscolo, E; Picard, A; Psutka, S; Melero-Martin, JM; Bartch, TC; Mulliken, JB; Bischoff, J. Multipotential stem cells recapitulate human infantile hemangioma in immunodeficient mice. The Journal of Clinical Investigation. 2008; 118:2592-2599.

Schrenk, S; Bischoff, LJ; Goines, J; Cai, Y; Vemaraju, S; Odaka, Y; Good, SR; Palumbo, JS; Szabo, S; Reynaud, D; et al. MEK inhibition reduced vascular tumor growth and coagulopathy in a mouse model with hyperactive GNAQ. Nature Communications. 2023; 14:1929.

Cullion, K; Ostertag-Hill, CA; Pan, M; Timko, B; Boscolo, E; Kohane, DS. Ablation of Venous Malformations by Photothermal Therapy with Intravenous Gold Nanoshells. Nano Letters: a journal dedicated to nanoscience and nanotechnology. 2023; 23:7092-7099.

Boscolo, E; Pastura, P; Schrenk, S; Goines, J; Kang, R; Pillis, D; Malik, P; Le Cras, TD. NRASQ61R mutation in human endothelial cells causes vascular malformations. Angiogenesis. 2022; 25:331-342.

Schrenk, S; Boscolo, E. A transcription factor is the target of propranolol treatment in infantile hemangioma. The Journal of Clinical Investigation. 2022; 132:e156863.

Goines, J; Boscolo, E. A Xenograft Model for Venous Malformation. Vascular Morphogenesis. : Springer US; Springer US; 2021.

Crane, J; Manfredo, J; Boscolo, E; Coyan, M; Takemoto, C; Itkin, M; Adams, DM; Le Cras, TD. Kaposiform lymphangiomatosis treated with multimodal therapy improves coagulopathy and reduces blood angiopoietin-2 levels. Pediatric Blood and Cancer. 2020; 67:e28529.

Le Cras, TD; Goines, J; Lakes, N; Pastura, P; Hammill, AM; Adams, DM; Boscolo, E. Constitutively active PIK3CA mutations are expressed by lymphatic and vascular endothelial cells in capillary lymphatic venous malformation. Angiogenesis. 2020; 23:425-442.

Schrenk, S; Goines, J; Boscolo, E. A Patient-Derived Xenograft Model for Venous Malformation. Jove-Journal of Visualized Experiments. 2020; 2020:1-14.

Cai, Y; Schrenk, S; Goines, J; Davis, GE; Boscolo, E. Constitutive Active Mutant TIE2 Induces Enlarged Vascular Lumen Formation with Loss of Apico-basal Polarity and Pericyte Recruitment. Scientific Reports. 2019; 9:12352.

Boscolo, E; Pastura, P; Glaser, K; Goines, J; Hammill, AM; Adams, DM; Dickie, P; Dickie, BH; Le Cras, TD. Signaling pathways and inhibitors of cells from patients with kaposiform lymphangiomatosis. Pediatric Blood and Cancer. 2019; 66:e27790.

Le Cras, TD; Boscolo, E. Cellular and molecular mechanisms of PIK3CA-related vascular anomalies. Vascular Biology. 2019; 1:H33-H40.

Hall, A; Choi, K; Liu, W; Rose, J; Zhao, C; Yu, Y; Na, Y; Cai, Y; Coover, RA; Lin, Y; et al. RUNX represses Pmp22 to drive neurofibromagenesis. Science Advances. 2019; 5:eaau8389.

Lakes, N; Goines, J; Pastura, P; Le Cras, T; Boscolo, E. Capillary Lymphatic Venous Malformations are caused by Endothelial‐Specific Gain‐of‐Function Mutations in the PIK3CA Gene. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019; 33:527.3.

Li, X; Cai, Y; Goines, J; Pastura, P; Brichta, L; Lane, A; Le Cras, TD; Boscolo, E. Ponatinib Combined With Rapamycin Causes Regression of Murine Venous Malformation. Arteriosclerosis, Thrombosis, and Vascular Biology. 2019; 39:496-512.