Asai Lab

Publications

Sawada, K; Khandelwal, P; Davies, SM; Crooker, A; Mizuno, T; Asai, A. Pharmacokinetic Monitoring of JAK Inhibitor and Tacrolimus for Safe and Effective Management of Graft-Versus-Host Disease After Pediatric Liver Transplantation. Pediatric Transplantation. 2025; 29(7):e70187.

Tominaga, K; Kechele, DO; Sanchez, JG; Vales, S; Jurickova, I; Roman, L; Asai, A; Enriquez, JR; Mccauley, HA; Kishimoto, K; Zorn, AM; Helmrath, MA; Denson, LA; Wells, JM. Deriving Human Intestinal Organoids with Functional Tissue-Resident Macrophages All From Pluripotent Stem Cells. Cellular and Molecular Gastroenterology and Hepatology (CMGH). 2025; 19(4):101444.

Takimoto, A; Wolfe, N; Jiahui, L; Kato, D; Yasui, A; Uchida, H; Asai, A. Portal vein hypoplasia is present in patients with biliary atresia at the time of diagnosis. Journal of Pediatric Gastroenterology and Nutrition. 2024; 79(4):818-825.

Naito, C; Kosar, K; Kishimoto, E; Pena, L; Huang, Y; Hao, K; Bernieh, A; Kasten, J; Villa, C; Kishnani, P; Deeksha, B; Gu, M; Asai, A. Induced pluripotent stem cell (iPSC) modeling validates reduced GBE1 enzyme activity due to a novel variant, p.Ile694Asn, found in a patient with suspected glycogen storage disease IV. Molecular Genetics and Metabolism Reports. 2024; 39:101069.

Wakasa, K; Tamura, R; Osaka, S; Takei, H; Asai, A; Nittono, H; Kusuhara, H; Hayashi, H. Rapid in vivo evaluation system for cholestasis-related genes in mice with humanized bile acid profiles. Hepatology Communications. 2024; 8(4).

Teckman, J; Rosenthal, P; Ignacio, RV; Spino, C; Bass, LM; Horslen, S; Wang, K; Magee, JC; Karpen, S; Asai, A; Guthery, SL; Loomes, KM; Shneider, BL; Sokol, RJ. Neonatal cholestasis in children with Alpha-1-AT deficiency is a risk for earlier severe liver disease with male predominance. Hepatology Communications. 2023; 7(12).

Pandurangi, S; Kim, S; Asai, A; Bondoc, A; Balistreri, W; Campbell, K; Miethke, A; Peters, A; Rogers, M; Taylor, A; Mullapudi, B; Sheridan, R; Tiao, G; Bezerra, JA. Customized Postoperative Therapy Improves Bile Drainage in Biliary Atresia: A Single Center Preliminary Report. Journal of Pediatric Surgery. 2023; 58(8):1483-1488.

Peters, AL; Kim, S; Mourya, R; Asai, A; Taylor, A; Rogers, M; Campbell, K; Fei, L; Miethke, A; Balistreri, WF; Bezerra, JA. Recent Increase in Incidence of Severe Acute Hepatitis of Unknown Etiology in Children is Associated with Infection with Adenovirus and Other Nonhepatotropic Viruses. Journal of Pediatrics. 2023; 259:113439.

Koch, RL; Soler-Alfonso, C; Kiely, BT; Asai, A; Smith, AL; Bali, DS; Kang, PB; Landstrom, AP; Akman, HO; Burrow, TA; Case, LE; Schiffmann, R; Hirano, M; Kishnani, PS. Diagnosis and management of glycogen storage disease type IV, including adult polyglucosan body disease: A clinical practice resource. Molecular Genetics and Metabolism. 2023; 138(3):107525.

Koch, R; Soler-Alfonso, C; Kiely, B; Asai, A; Smith, A; Bali, D; Kang, P; Landstrom, A; Akman, HO; Burrow, TA; Case, L; Schiffmann, R; Hirano, M; Kishnani, P. O18: A path forward for patients with glycogen branching enzyme deficiency: Consensus on diagnosing and managing glycogen storage disease type IV* Genetics in Medicine Open. 2023; 1(1):100114.

Uchida, H; Tiao, GM; Shivakumar, P; Wong, KKY; Asai, A; Amano, H. Editorial: Infants with cholestasis. Frontiers in Pediatrics. 2023; 11:1175231.

Tominaga, K; Haslam, D; Asai, A. Gas Leak in the Port: Portal Venous Gas Associated With Congenital Cytomegalovirus Colitis. JPGN Rep. 2022; 3(4):e267.

Asai, A; Wu, J-F; Wang, KS; Yamataka, A; Nio, M; Su, D-J; Short, C; Tsuboi, K; Ochi, T; Sasaki, H; Okubo, R; Yodoshi, T; Konishi, K; Rogers, ME; Tiao, GM. The Outcome of Patients With Cystic Biliary Atresia With Intact Proximal Hepatic Ducts Following Hepatic-Cyst-Jejunostomy. Journal of Pediatric Gastroenterology and Nutrition. 2022; 75(2):131-137.

Hishida, T; Yamamoto, M; Hishida-Nozaki, Y; Shao, C; Huang, L; Wang, C; Shojima, K; Xue, Y; Hang, Y; Shokhirev, M; Asai, A; Reddy, P; Liu, G-H; Izpisua Belmonte, JC. In vivo partial cellular reprogramming enhances liver plasticity and regeneration. Cell reports. 2022; 39(4):110730.

Li, CZ; Ogawa, H; Ng, SS; Chen, X; Kishimoto, E; Sakabe, K; Fukami, A; Hu, Y-C; Mayhew, CN; Hellmann, J; Hayashi, H; Thompson, RJ; Rashid, ST; Asai, A. Human iPSC-derived hepatocyte system models cholestasis with tight junction protein 2 deficiency. JHEP Reports. 2022; 4(4):100446.

Bezerra, JA; Asai, A; Tiao, G; Mullapudi, B; Balistreri, WF. Biliary Atresia and Other Disorders of the Extrahepatic Bile Ducts. In: Liver Disease in Children. Cambridge University Press (CUP); 2021:162-181.

Clarkston, K; Lee, J; Donoghue, S; Peters, H; Eiroa, H; Shah, AA; Loomes, K; Wen, J; Oliver, M; Hardikar, W; Prada, CE; Asai, A. Acute liver dysfunction with delayed peak of serum aminotransferase levels as a presentation of ornithine transcarbamylase deficiency in females. American Journal of Medical Genetics, Part A. 2021; 185(3):909-915.

Hayashi, H; Osaka, S; Sakabe, K; Fukami, A; Kishimoto, E; Aihara, E; Sabu, Y; Mizutani, A; Kusuhara, H; Naritaka, N; Mayhew, C; Setchell, K; Takebe, T; Asai, A. Modeling Human Bile Acid Transport and Synthesis in Stem Cell-Derived Hepatocytes with a Patient-Specific Mutation. Stem Cell Reports. 2021; 16(2):309-323.

Shinozawa, T; Kimura, M; Cai, Y; Saiki, N; Yoneyama, Y; Ouchi, R; Koike, H; Maezawa, M; Zhang, R-R; Dunn, A; Lewis, K; Thompson, WL; Asai, A; Takebe, T. High-Fidelity Drug-Induced Liver Injury Screen Using Human Pluripotent Stem Cell-Derived Organoids. Gastroenterology. 2021; 160(3):831-846.e10.