Asai Research Lab
The Asai Lab at Cincinnati Children’s is working to discover new treatments for liver diseases caused by genetic mutations.
Each year, nearly 1,000 babies are born in the United States with some form of genetic liver disease. Most genetic liver diseases are not curable, and a significant number of patients require a liver transplant for long-term survival.
Led by Akihiro Asai, MD, PhD, a researcher and a pediatric hepatologist, the Asai Lab targets the following disorders that cause liver injury during fetal development and result in severe fibrosis soon after birth:
- Progressive familial intrahepatic cholestasis (PFIC)
- Glycogen storage disease
- Biliary atresia
- Urea cycle defects (OTC deficiency)
As part of our work, we have established a hepatic differentiation system of human iPSCs (induced pluripotent stem cells) in advanced cell culture systems.