Moore Lab

Publications

Jamil, Z; Hanson, GF; Iqbal, J; Moreau, GB; Iqbal, NT; Ahmed, S; Hotwani, A; Kabir, F; Umrani, F; Sadiq, K; Ma, JZ; Aziz, F; Ali, SA; Moore, SR. Host-microbiome determinants of ready-to-use supplemental food efficacy in acute childhood malnutrition. JCI insight. 2025; 10:e188993.

VanBuskirk, K; Mweetwa, M; Kolterman, T; Raghavan, S; Ahmed, T; Ali, SA; Nahar Begum, SK; Besa, E; Denno, DM; Jamil, Z; Tarr, PI; Sullivan, PB; Moskaluk, CA; EEDBI Consortium, . Multiplexed immunohistochemical evaluation of small bowel inflammatory and epithelial parameters in environmental enteric dysfunction. American Journal of Clinical Nutrition. 2024; 120 Suppl 1:S31-S40.

Jamil, Z; VanBuskirk, K; Mweetwa, M; Mouksassi, S; Smith, G; Ahmed, T; Chandwe, K; Denno, DM; Fahim, SM; Kelly, P; Tarr, PI; Tearney, GJ; Umrani, F; Yilmaz, OH. Anthropometry relationship with duodenal histologic features of children with environmental enteric dysfunction: a multicenter cross-sectional study. American Journal of Clinical Nutrition. 2024; 120 Suppl 1:S65-S72.

Ehsan, L; Coomes, D; Kelly, P; Greene, AR; Ali, SA; Mulenga, C; Denno, DM; VanBuskirk, K; Raghib, MF; Mahfuz, M; Sullivan, PB; Moskaluk, CA; Syed, S; EEDBI Consortium, . Duodenal quantitative mucosal morphometry in children with environmental enteric dysfunction: a cross-sectional multicountry analysis. American Journal of Clinical Nutrition. 2024; 120 Suppl 1:S41-S50.

Denno, DM; Ahmed, S; Ahmed, T; Ali, SA; Amadi, B; Kelly, P; Lawrence, S; Mahfuz, M; Marie, C; Moore, SR; Ramakrishnan, G; Sadiq, K; Sarker, SA; Umrani, F. The Environmental Enteric Dysfunction Biopsy Initiative (EEDBI) Consortium: mucosal investigations of environmental enteric dysfunction. American Journal of Clinical Nutrition. 2024; 120 Suppl 1:S4-S14.

Kelly, P; VanBuskirk, K; Coomes, D; Mouksassi, S; Smith, G; Jamil, Z; Hossain, MS; Syed, S; Marie, C; Tarr, PI; Sadiq, K; Sarker, SA; Umrani, F; Zyambo, K. Histopathology underlying environmental enteric dysfunction in a cohort study of undernourished children in Bangladesh, Pakistan, and Zambia compared with United States children. American Journal of Clinical Nutrition. 2024; 120 Suppl 1:S15-S30.

Marie, C; Das, S; Coomes, D; Ahmed, T; Ali, SA; Iqbal, J; Kelly, P; Mahfuz, M; Moore, SR; Petri, WA; Tarr, PI; Denson, LA. Duodenal transcriptomics demonstrates signatures of tissue inflammation and immune cell infiltration in children with environmental enteric dysfunction across global centers. American Journal of Clinical Nutrition. 2024; 120 Suppl 1:S51-S64.

Mandal, A; Moneme, C; Tewari, BP; Goldstein, AM; Sontheimer, H; Cheng, L; Moore, SR; Levin, D. A novel method for culturing enteric neurons generates neurospheres containing functional myenteric neuronal subtypes. Journal of Neuroscience Methods. 2024; 407:110144.

Iqbal, NT; Chen, RY; Griffin, NW; Hibberd, MC; Khalid, A; Sadiq, K; Jamil, Z; Ahmed, K; Iqbal, J; Hotwani, A; Moore, SR; Ali, A; Barratt, MJ; Gordon, JI. A shared group of bacterial taxa in the duodenal microbiota of undernourished Pakistani children with environmental enteric dysfunction. Editor, Young VB. mSphere. 2024; 9:e0019624.

Zulqarnain, F; Zhao, X; Setchell, KD R; Sharma, Y; Fernandes, P; Srivastava, S; Shrivastava, A; Ehsan, L; Jain, V; Raghavan, S; Brown, DE; Moore, SR; Ali, SA; Syed, S. Machine-learning-based integrative -'omics analyses reveal immunologic and metabolic dysregulation in environmental enteric dysfunction. iScience. 2024; 27:110013.

Moneme, C; Moore, SR. Microbial cues stimulate linear growth in undernourished mice. Nature Reviews: Gastroenterology and Hepatology. 2023; 20:485-486.

Sarfraz, A; Jamil, Z; Ahmed, S; Umrani, F; Qureshi, AK; Jakhro, S; Sajid, M; Rahman, N; Rizvi, A; Ma, JZ; Iqbal, J; Sadiq, K; Moore, SR; Ali, SA. Impact of diarrhoea and acute respiratory infection on environmental enteric dysfunction and growth of malnourished children in Pakistan: a longitudinal cohort study. The Lancet Regional Health - Southeast Asia. 2023; 15:100212.

Braun, T; Sosnovski, KE; Amir, A; BenShoshan, M; VanDussen, KL; Karns, R; Levhar, N; Abbas-Egbariya, H; Hadar, R; Efroni, G; Ferrer, J; Hyams, JS; Denson, LA; Haberman, Y. Mucosal transcriptomics highlight lncRNAs implicated in ulcerative colitis, Crohn's disease, and celiac disease. JCI insight. 2023; 8:e170181.

Sarfraz, A; Ahmed, S; Muhammad, S; Rehman, N; Soomro, SI; Qureshi, K; Jakhro, S; Umrani, F; Greene, A; Syed, S; Moore, SR; Ali, SA. Standard RUTF vs. locally-made RUSF for acutely malnourished children: A quasi-experimental comparison of the impact on growth and compliance in a rural community of Pakistan. Editor, Vousden G. PloS one. 2023; 18:e0287962.

Sosnovski, KE; Braun, T; Amir, A; Moshel, D; Benshoshan, M; Vandussen, KL; Levhar, N; Abbas-Egbariya, H; Beider, K; Ben-Yishay, R; Ulitsky, I; Hyams, JS; Denson, LA; Haberman, Y. GATA6-AS1 Regulates Intestinal Epithelial Mitochondrial Functions, and its Reduced Expression is Linked to Intestinal Inflammation and Less Favourable Disease Course in Ulcerative Colitis. Journal of Crohn's and Colitis. 2023; 17:960-971.

Khan, M; Jamil, Z; Ehsan, L; Zulqarnain, F; Srivastava, S; Siddiqui, S; Fernandes, P; Raghib, M; Sengupta, S; Mujahid, Z; Moore, S; Ali, SA; Iqbal, J; Syed, S. Quantitative Morphometry and Machine Learning Model to Explore Duodenal and Rectal Mucosal Tissue of Children with Environmental Enteric Dysfunction. American Journal of Tropical Medicine and Hygiene. 2023; 108:672-683.

Narvaez-Rivas, M; Setchell, KD R; Galandi, SL; Zhao, X; Iqbal, NT; Ahmed, S; Iqbal, J; Syed, S; Ali, SA; Moore, SR. Essential Fatty Acid Deficiency Associates with Growth Faltering and Environmental Enteric Dysfunction in Children. Metabolites. 2023; 13:489.

Cowardin, CA; Syed, S; Iqbal, N; Jamil, Z; Sadiq, K; Iqbal, J; Ali, SA; Moore, SR. Environmental enteric dysfunction: gut and microbiota adaptation in pregnancy and infancy. Nature Reviews: Gastroenterology and Hepatology. 2023; 20:223-237.

Kabir, F; Iqbal, J; Jamil, Z; Iqbal, NT; Mallawaarachchi, I; Aziz, F; Kalam, A; Muneer, S; Hotwani, A; Ahmed, S; Sadiq, K; Ma, JZ; Moore, SR; Ali, A. Impact of enteropathogens on faltering growth in a resource-limited setting. Frontiers in Nutrition. 2023; 9:1081833.

Rosselot, AE; Park, M; Kim, M; Matsu-Ura, T; Wu, G; Flores, DE; Subramanian, KR; Lee, S; Sundaram, N; Broda, TR; Wells, JM; Hogenesch, JB; Moore, SR; Hong, CI. Ontogeny and function of the circadian clock in intestinal organoids. The EMBO Journal. 2022; 41:e106973.

Moutinho, TJ; Powers, DA; Hanson, GF; Levy, S; Baveja, R; Hefner, I; Mohamed, M; Abdelghani, A; Baker, RL; Papin, JA; Moore, SR; Hourigan, SK. Fecal sphingolipids predict parenteral nutrition-associated cholestasis in the neonatal intensive care unit. Journal of Parenteral and Enteral Nutrition. 2022; 46:1903-1913.

Bein, A; Fadel, CW; Swenor, B; Cao, W; Powers, RK; Camacho, DM; Naziripour, A; Parsons, A; LoGrande, N; Sharma, S; Moore, SR; Prantil-Baun, R; Goyal, G; Ingber, DE. Nutritional deficiency in an intestine-on-a-chip recapitulates injury hallmarks associated with environmental enteric dysfunction. Nature Biomedical Engineering. 2022; 6:1236-1247.

Fawad, JA; Luzader, DH; Hanson, GF; Moutinho, TJ; McKinney, CA; Mitchell, PG; Brown-Steinke, K; Kumar, A; Park, M; Lee, S; Alenghat, T; Hong, CI; Papin, JA; Moore, SR. Histone Deacetylase Inhibition by Gut Microbe-Generated Short-Chain Fatty Acids Entrains Intestinal Epithelial Circadian Rhythms. Gastroenterology. 2022; 163:1377-1390.e11.

Ahmed, S; Iqbal, J; Sadiq, K; Umrani, F; Rizvi, A; Kabir, F; Jamil, Z; Syed, S; Ehsan, L; Zulqarnain, F; Ann Costa Clemens, S; Talat Iqbal, N; Moore, SR; Ali, A. Association of Anti-Rotavirus IgA Seroconversion with Growth, Environmental Enteric Dysfunction and Enteropathogens in Rural Pakistani Infants. Vaccine. 2022; 40:3444-3451.

Zhao, X; Setchell, KD R; Huang, R; Mallawaarachchi, I; Ehsan, L; Dobrzykowski, E; Zhao, J; Syed, S; Ma, JZ; Iqbal, NT; Haberman, Y; Denson, LA; Ali, SA; Moore, SR. Bile Acid Profiling Reveals Distinct Signatures in Undernourished Children with Environmental Enteric Dysfunction. The Journal of nutrition. 2021; 151:3689-3700.

Ramamoorthy, S; Levy, S; Mohamed, M; Abdelghani, A; Evans, AM; Miller, LA D; Mehta, L; Moore, S; Freinkman, E; Hourigan, SK. An ambient-temperature storage and stabilization device performs comparably to flash-frozen collection for stool metabolomics in infants. BMC Microbiology. 2021; 21:59.

Ahmed, S; Iqbal, N; Sadiq, K; Umrani, F; Rizvi, A; Jamil, Z; Syed, S; Khan, M; Iqbal, J; Qureshi, S; Hotwani, A; Rahman, N; Moore, S; Ali, A. Implementation challenges from a prospective, interventional biopsy-based study of Environmental Enteropathy in rural Pakistan. F1000Prime Reports. 2021; 10:549.

Corden, E; Siddiqui, SH; Sharma, Y; Raghib, MF; Adorno, W; Zulqarnain, F; Ehsan, L; Shrivastava, A; Ahmed, S; Umrani, F; Iqbal, NT; Moore, SR; Ali, SA; Syed, S. Distance from Healthcare Facilities Is Associated with Increased Morbidity of Acute Infection in Pediatric Patients in Matiari, Pakistan. International Journal of Environmental Research and Public Health. 2021; 18:11691.

Syed, S; Moore, SR. Dialing in Prevention of Childhood Stunting and Diarrhea in Low-Income Countries. Clinical Infectious Diseases. 2021; 73:e2569-e2570.

Filho, JQ; Junior, FS; Lima, TB R; Viana, VA F; Burgoa, JS V; Soares, AM; Leite, ÁM; Herron, SA; Newland, HL; Sarnaik, KS; Hanson, GF; Papin, JA; Moore, SR; Lima, AA M. Perinatal Outcomes of Asynchronous Influenza Vaccination, Ceará, Brazil, 2013-2018. Emerging Infectious Diseases. 2021; 27:2409-2420.

Jamil, Z; Iqbal, NT; Idress, R; Ahmed, Z; Sadiq, K; Mallawaarachchi, I; Iqbal, J; Syed, S; Hotwani, A; Kabir, F; Aziz, F; Kalam, A; Moore, SR; Ali, SA. Gut integrity and duodenal enteropathogen burden in undernourished children with environmental enteric dysfunction. Editor, Al-Salem WS. PLoS Neglected Tropical Diseases. 2021; 15:e0009584.

Ahmed, S; Iqbal, N; Sadiq, K; Umrani, F; Rizvi, A; Jamil, Z; Syed, S; Khan, M; Iqbal, J; Qureshi, S; Hotwani, A; Rahman, N; Moore, S; Ali, A. Implementation challenges from a prospective, interventional biopsy-based study of Environmental Enteropathy in rural Pakistan. F1000Prime Reports. 2021; 10:549.

Syed, S; Ehsan, L; Shrivastava, A; Sengupta, S; Khan, M; Kowsari, K; Guleria, S; Sali, R; Kant, K; Kang, SJ; Amadi, BC; Asad Ali, S; Moore, SR; Brown, DE. Artificial Intelligence-based Analytics for Diagnosis of Small Bowel Enteropathies and Black Box Feature Detection. Journal of Pediatric Gastroenterology and Nutrition. 2021; 72:833-841.

Haberman, Y; Iqbal, NT; Ghandikota, S; Mallawaarachchi, I; Tzipi Braun, ; Dexheimer, PJ; Rahman, N; Hadar, R; Sadiq, K; Ahmad, Z; Jegga, AG; Moore, SR; Ali, SA; Denson, LA. Mucosal Genomics Implicate Lymphocyte Activation and Lipid Metabolism in Refractory Environmental Enteric Dysfunction. Gastroenterology. 2021; 160:2055-2071.e0.

Haberman, Y; Iqbal, NT; Ghandikota, S; Mallawaarachchi, I; Braun, T; Dexheimer, PJ; Rehman, NU; Hadar, R; Sadiq, K; Ahmad, Z; Jegga, A; Moore, S; Ali, A; Denson, LA. Su094 IMMUNE AND METABOLIC PATHOGENESIS OF ENVIRONMENTAL ENTERIC DYSFUNCTION IN CHILDHOOD UNDERNUTRITION: A BIRTH INCEPTION COHORT. Gastroenterology. 2021; 160:s-615.

Levin, DE; Mandal, A; Fleming, MA; Bae, KH; Gerry, B; Moore, SR. Intestinal crypt-derived enteroid coculture in presence of peristaltic longitudinal muscle myenteric plexus. Biology Methods and Protocols. 2021; 6:bpaa027.

Shrivastava, A; Adorno, W; Sharma, Y; Ehsan, L; Ali, SA; Moore, SR; Amadi, B; Kelly, P; Syed, S; Brown, DE. Self-Attentive Adversarial Stain Normalization. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). 2021; 12661:120-140.