General and Thoracic Surgery

Biliary atresia

Biography

As a pediatric surgeon and a transplant surgeon, Dr. Tiao is involved in the care of children afflicted with biliary atresia from the time of presentation and diagnosis to the initial Kasai portoenterostomy to the liver transplant, when necessary. He sees the many challenges children and their families experience when diagnosed with this life threatening disease process. From that perspective, defining the basis of this disease process such that therapeutic strategies can be developed eliminating these complex interventions is his career goal. His short term goal is to develop an independent research laboratory investigating the pathogenesis of virus induced biliary atresia specifically seeking to determine the mechanistic basis of this disease so that new treatment strategies can be developed to salvage the native liver.

Dr. Tiao's overarching hypothesis is that biliary atresia results from the infection of cholangiocytes by a virus triggering immune-mediated biliary obstruction. His focus is to determine the mechanisms used by RRV to infect cholangiocytes, how RRV undergoes replication within the cholangiocyte, and how infected cholangiocytes modify the microenvironment, activating the immune system resulting in biliary obstruction. Determination of the mechanistic basis of these inter-related events is essential to understanding the pathogenesis of virus induced BA. By focusing on the basis for the viral insult in the initiation of biliary atresia, he has defined an area of independence from Dr. Jorge Bezerra, his primary research mentor.

BS: Northwestern University, Evanston, IL, 1986.

MD: University of Illinois, Chicago, IL, 1990.

Residency: Loyola University, Maywood, IL, 1991-1992; Senior Resident, Department of Surgery, University of Cincinnati, Cincinnati, OH, 1995-1997; Chief Resident, Department of Surgery, University of Cincinnati, Cincinnati, OH, 1997-1998.

Fellowships: Research Fellow, University of Cincinnati, Cincinnati, OH, 1992-1995; Transplant Surgery Fellow, University of Cincinnati, Cincinnati, OH, 2000-2002; Pediatric Surgery Fellow, Los Angeles Children's Hospital, Los Angeles, CA, 1998-2000.

Certification: Pediatric Surgeon, 2000; Transplant Surgeon, 2002.

Coots A, Donnelly B, Mohanty S, Tiao G. Rotavirus Infection of Human Cholangiocytes Parallels the Murine Model of Biliary Atresia. J Surg Res. 2012 Oct;177(2):275-81. 2012.

Meyers RL, Tiao GM, Dunn SP, Langham Jr, MR. Liver transplantation in the management of unresectable hepatoblastoma in children. Front Biosci (Elite Ed). 2012 Jan;E4:1293-302.

Shin CR, Nathan J, Alonso M, Yazigi N, Kocoshis S, Tiao G, Davies SM. Incidence of acute and chronic graft-versus-host disease and donor T-cell chimerism after small bowel or combined organ transplantation. J Pediatr Surg. 2011;46:1732-8.

Fernandez KS, Baum R, Fung B, Yeager N, Leonis MA, Wagner LM, Tiao G, Ross ME. Chemoresistant Hepatoblastoma in a Patient with Mosaic Trisomy 18 Treated with Orthotopic Liver Transplantation. Peditr Blood Cancer. 2011;56:498-500.

Superina R, Magee J, Brandt M, Healey P, Tiao G, Ryckman F, Karrer F, Iyer K, Fecteau A, West K, Burns R, Flake A, Hammin L, Lowell J, Dillon P, Columbani P, Ricketts R, Yun L, Moore J, Kasper W. Childhood Liver Research and Education Network. AnnSurg. 2011.

Bondoc A, Taylor J, Alonso M, Nathan, J, Wang Y, Balistreri W, Bezerra J, Ryckman F, Tiao G. The Beneficial Impact of Revision of Kasai Portoenterostomy for Biliary Atresia: An Institutional Study. AnnSurg. 2012;255(3):570-6.

Wang W, Donnelly B, Bondoc A, Mohanty SK, McNeal M, Ward R, Sestak K, Zheng S, Tiao G. The rhesus rotavirus gene encoding VP4 is a major determinant in the pathogenesis of biliary atresia in newborn mice. J Virol. 2011 Sep;85(17):9069-77.

Jafri M, Donnelly B, Bondoc A, Allen S, Tiao G. Cholangiocyte secretion of chemokines in experimental biliary atresia. J Pediatr Surg. 2009;44(3):500-7.

Bondoc AJ, Jafri MA, Donnelly B, Mohanty SK, McNeal MM, Ward, RL, Tiao GM. Prevention of the murine model of biliary atresia after live rotavirus vaccination of dams. J Pediatr Surg. 2009;44(8):1479-90.

Grants

The Molecular Determinants of Virus Induced Biliary Induced Biliary Asteria. Principal Investigator. Apr 2011-Mar 2016.

Nycomed Liver Trial. Principal Investigator. 2012-present.TC-2402-040-SP.

Faculty

Maria H. Alonso, MD Co-Surgical Director, Intestinal Transplant Surgery

513-636-4371 maria.alonso@cchmc.org

Rebeccah L. Brown, MD, FACS, FAAP Associate Director, Trauma Services

513-636-4371 rebeccah.brown@cchmc.org

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Rebeccah L. Brown, MD, FACS, FAAP

Associate Director, Trauma Services

Academic Affiliations

Professor, UC Department of Surgery

Phone 513-636-4371

Fax 513-636-7657

Email rebeccah.brown@cchmc.org

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Clinical

General pediatric surgery; trauma; injury prevention; minimally invasive surgery; necrotizing enterocolitis; neonatal surgery; minimally invasive surgery; splenectomy for congenital hemolytic anemias; chest wall deformities - pectus excavatum, pectus carinatum, and slipping rib syndrome

Research

Pediatric trauma; injury prevention; chest wall deformities

Biography

Rebeccah L. Brown, MD, FACS, FAAP, received a Bachelor of Science in biology and Bachelor of Arts in chemistry at New Mexico State University in Las Cruces, NM, in 1986. She graduated from University of New Mexico School of Medicine in Albuquerque, NM, with an MD in 1990. She completed her general surgery residency at University of Cincinnati Medical Center, in Cincinnati, Ohio, in 1997.

During her general surgical training, she also performed two years of basic science and clinical research in burn injuries and wound healing at the Shriners Hospitals for Children -- Cincinnati, OH. She also served as an extracorporeal membrane oxygenation (ECMO) fellow at Cincinnati Children's Hospital Medical Center.

After completion of general surgery training, Dr. Brown completed a two-year fellowship in pediatric surgery at Children's Hospital of Buffalo in Buffalo, NY. She then returned to Cincinnati Children's and is currently a professor of clinical surgery and pediatrics within the University of Cincinnati College of Medicine. Her main research interests are trauma and injury prevention, necrotizing enterocolitis, splenectomy for congenital hemolytic anemias, and chest wall deformities. She is currently the associate director of Trauma Services, the fellowship director for the Pediatric Trauma Fellowship, co-director of the Pectus Program, and the director and co-founder of the Buckle Up for Life or Abrochate a la Vida program funded by Toyota.

Dr. Brown's clinical interests besides trauma and injury prevention include general pediatric surgery, minimally invasive surgery, neonatal surgery, necrotizing enterocolitis, splenectomy for congenital hemolytic anemias, and chest wall deformities - pectus excavatum, pectus carinatum, and slipping rib syndrome.

Dr. Brown is a member of multiple professional organizations including the American College of Surgeons, American Medical Association, American Medical Women's Association, American College of Surgeons -- Ohio Chapter, Cincinnati Pediatric Society, Mont Reid Surgical Society, American Pediatric Surgical Association, American Academy of Pediatrics -- Surgical Section and Injury Prevention Section, Eastern Association for the Surgery and Trauma, and Pediatric Trauma Society.

MD: University of New Mexico School of Medicine, Albuquerque, NM, 1990.

Residency: General Surgery, University of Cincinnati Hospital, Cincinnati, OH, 1997.

Fellowship: Shriners Burns Institute, Cincinnati, Ohio, 1992-1994; ECMO, Children's Hospital Medical Center, Cincinnati, Ohio, 1993-1994; Pediatric Surgery Fellow, Children's Hospital of Buffalo, Buffalo, NY, 1997-1999.

Certification: Board-certified General Surgery, 1998, 2007; board-certified, Pediatric Surgery, 2000, 2009.

A. Roshni Dasgupta, MD, MPH Pediatric Surgeon, Division of Pediatric General and Thoracic Surgery

513-636-4371 roshni.dasgupta@cchmc.org

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A. Roshni Dasgupta, MD, MPH

Pediatric Surgeon, Division of Pediatric General and Thoracic Surgery

Academic Affiliations

Associate Professor, UC Department of Surgery

Phone 513-636-4371

Fax 513-636-7657

Email roshni.dasgupta@cchmc.org

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Clinical

Surgical oncology and vascular malformations; minimally invasive surgery; general pediatric surgery

Research

Oncology and vascular malformations

Biography

Roshni Dasgupta, MD, MPH, is a surgeon with the Hemangioma and Vascular Malformations Center and an associate professor with the University of Cincinnati College of Medicine. She has been involved with the HVMC team for the past eight years. Dr. Dasgupta obtained her medical degree at the University of Toronto. She finished her residency at Massachusetts General Hospital at Harvard Medical School. She completed a Rhodes Scholarship at the University of Oxford in Oxford England, followed by a Pediatric Surgery Fellowship at the Hospital for Sick Children in Toronto, Canada. She has also completed her Master of Public Health at the Harvard School of Public Health.

Dr. Dasgupta has authored multiple articles and book chapters on vascular anomalies and will be the next editor of the vascular anomalies edition of Seminars in Pediatric Surgery. She is interested in post-surgical long term outcomes of patients with vascular anomalies, as well as treatment and outcomes of hemangioma patients.

MD: University of Toronto, Toronto Canada, 1996.

Residency: Massachusetts General Hospital, Harvard Medical School 1996-2003.

Research Fellowship: University of Oxford, Oxford, England.

Fellowship: Hospital for Sick Children, Toronto, Canada.

MPH: Harvard School of Public Health, Boston, MA, 2009.

Hamilton TE, Barnhart D, Gow K, Ferrer F, Kandel J, Glick R, Dasgupta R, Naranjo A, He Y, Gratias E, Geller J, Ehrlich P. Inter-rater reliability of surgical reviews for AREN03B2: A COG renal tumor committee study. J Pediatr Surg. 2014 Jan;49(1):154-8.

Drolet BA, Trenor CC 3, Brandão LR, Chiu YE, Chun RH, Dasgupta R, Garzon MC, Hammill AM, Johnson CM, Tlougan B, Blei F, David M, Elluru R, Frieden IJ, Friedlander SF, Iacobas I, Jensen JN, King DM, Lee MT, Nelson S, Patel M, Pope E, Powell J, Seefeldt M, Siegel DH, Kelly M, Adams DM. Consensus-derived practice standards plan for complicated Kaposiform hemangioendothelioma. J Pediatr. 2013 Jul;163(1):285-91.

Burke ME, Lyden ER, Meza, JL, Ladas EJ, Dasgupta R, Wiegner EA, Arndt CA. Does body mass index at diagnosis or weight change during therapy predict toxicity or survival in intermediate risk rhabdomyosarcoma? A report from the Children’s Oncology Group Soft Tissue Sarcoma Committee. Pediatr Blood Cancer. 2013 May;60(5):748-53.

Murrell Z, Dasgupta R. What predicts the risk of recurrent lung metastases? J Pediatr Surg. 2013 May;48(5):1020-4.

Chen W, Gupta A, Adams D, Patel M, Dasgupta R. Generalized lymphatic malformation with chylothorax: long-term management of a highly morbid condition in a pediatric patient. J Pediatr Surg. 2013 Mar;48(3):e9-e12.

Dasgupta R, Rodeberg DA. Update on rhabdomyosarcoma. Semin Pediatr Surg. 2012 Feb; 21(1):68-78.

Rymeski B, Burns K, Nagarajan R, Correll J, Kent D, O'Brien M, Perentesis JP, Dasgupta R. Long-term complications after staging laparotomy for Hodgkin lymphoma. J Clin Oncol 30, 2012.

Richard A. Falcone Jr., MD, MPH Director, Trauma Services

513-636-4371 richard.falcone@cchmc.org

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Richard A. Falcone Jr., MD, MPH

Director, Trauma Services

Associate Chief of Staff, Surgical Services

Academic Affiliations

Associate Professor, UC Department of Surgery

Phone 513-636-4371

Fax 513-636-7657

Email richard.falcone@cchmc.org

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Clinical

Pediatric injury prevention and outcomes; trauma education; management of colorectal disorders; inflammatory bowel disease; minimally invasive surgery; surgical oncology; extracorporeal life support (ECLS)

Research

Injury prevention; health disparities; pediatric colorectal disorders; use of simulation to improve teamwork and safety

MPH: Harvard School of Public Health, Boston, MA, 2007.

MD: New York University School of Medicine, 1995.

General Surgery Residency: University of Cincinnati, 1995-2002.

Pediatric Surgery Fellowship: Cincinnati Children's Hospital Medical Center, 2002-2004.

Certification: Surgery, 2004; Pediatric Surgery, 2006.

Nance ML, Krummel TM, Oldham KT, Falcone R JR, Trauma Committee of the American Pediatric Surgical Association. Firearm injuries and Children: A Policy Statement of the American Pediatric Surgical Association. J Am Coll Surg. 2013 Nov; 217(5): 940-6.

Patterson M, Geis G, Falcone R, LeMaster T, Wears R. In situ simulation: detection of safety threats and teamwork training in a high risk emergency department. BMJ Qual Saf. 2013 Jun;22(6):468-77.

Jurickova I, Collins MH, Chalk C, Seese A, Bezold R, Lake K, von Allmen D, Frischer JS, Falcone RA, Trapnell BC, Denson LA. Paediatric Crohn disease patients with stricturing behaviour exhibit ileal granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibody production and reduced neutrophil bacterial killing and GM-CSF bioactivity. Clin Exp Immunol. 2013 Jun;172(3)455-65.

Beaudin M, Maugans T, St-Vil D, Falcone RA Jr. Inappropriate use of infant seating devices increases risks of injury. J Pediatr Surg. 2013 May;48(5):1071-6.

Cook R, Gillespie GL, Kronk, R, Daugherty M, Moody SM, Allen LJ, Shebesta KB, Falcone RA. Effect of an Educational Intervention on Nursing Staff Knowledge, Confidence, and Practice in the Care of Children with Mild Traumatic Brain Injury. J Neurosci Nurs. 2013 Apr;45(2):108-18.

Kelleher DC, Renaud EJ, Ehrlich PF, Burd RS; Pediatric Trauma Society Guidelines Committee. Guidelines for alcohol screening in adolescent trauma patients: a report from the Pediatric Trauma Society Guidelines Committee. J Trauma Acute Care Surg. 2013 Feb;74(2):671-82.

Daugherty MC, Mehlman CT, Moody S, LeMaster T, Falcone RA Jr . Significant rate of misuse of the Hare traction splint for children with femoral shaft fractures. J Emerg Nurs. 2013 Jan;39(1):97-103.

Chatoorgoon K, Brown RL, Garcia VF, Falcone RA. Role of computed tomography and clinical findings in pediatric blunt intestinal injury: a multi-center study. Pediatr Emerg Care. 2012 Dec;28(12):1338-42.

Beaudin M, Daugherty M, Geis G, Moody S, Brown RL, Garcia VF, Falcone RA Jr. Assessment of factors associated with the delayed transfer of pediatric trauma patients: an emergency physician survey. Pediatr Emerg Care. 2012 Aug;28(8):758-63.

Falcone RA Jr, Haas L, King E, Moody S, Crow J, Moss A, Gaines B, McKenna C, Gourlay DM, Werner C, Meagher DP Jr, Schwing L, Garcia N, Brown D, Groner JI, Haley K, Deross A, Cizmar L, Armola R. A multicenter prospective analysis of pediatric trauma activation criteria routinely used in addition to the six criteria of the American College of Surgeons. J Trauma Acute Care Surg. 2012 Aug;73(2):377-84.

Jason S. Frischer, MD Director, Colorectal Center

is a pediatric surgeon who has matched his clinical interest in inflammatory bowel disease (IBD) with his basic and translational research programs. He is investigating angiogenesis, or the development of blood vessels in IBD (Crohn’s disease and ulcerative colitis), and how it relates to inflammation and healing. He also has interests in ECMO, CDH and anticoagulation outcomes research.

513-636-3240 jason.frischer@cchmc.org

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Jason S. Frischer, MD

Director, Colorectal Center

Director, Extracorporeal Membrane Oxygenation (ECMO) Program

Division of Pediatric General and Thoracic Surgery

Academic Affiliations

Assistant Professor, UC Department of Surgery

Phone 513-636-3240

Fax 513-636-3248

Email jason.frischer@cchmc.org

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Colorectal surgery including inflammatory bowel disease (IBD, Crohn's disease and ulcerative colitis); Hirschsprung disease; anorectal malformations; fecal incontinence and constipation; minimally invasive surgery; ECMO; congenital diaphragmatic hernia (CDH); epidermolysis bullosa (EB)

Biography

Jason S. Frischer, MD, has been named the director of the Colorectal Center at Cincinnati Children's Hospital Medical Center. He earned his medical degree at SUNY Downstate Medical Center. He obtained his medical degree at SUNY Downstate and went on to complete his general surgery and chief residency at the Mount Sinai School of Medicine in New York where he focused his training on inflammatory bowel disease. Additionally, he spent two years as the ECMO fellow and postdoctoral research fellow in angiogenesis at the Children's Hospital of New York, Columbia University. Dr. Frischer completed his pediatric surgery fellowship at the Children's Hospital of New York, Columbia University.

Dr. Frischer has a special interest in pediatric colorectal surgery including inflammatory bowel disease (IBD, Crohn's disease and ulcerative colitis), Hirschsprung’s disease anorectal malformations (ARM), fecal incontinence and constipation. He serves as the director of the ECMO program and is a member of the congenital diaphragmatic hernia (CDH) team. He is also a member of the Epidermolysis Bullosa (EB) Center. He has an interest in neonatal surgery and minimally invasive surgery.

Dr. Frischer is a member of Alpha Omega Alpha (national medical honor society) and was selected by Cincy Magazine Best Doctors from 2010 to 2013. He also was selected by Castle Connolly Medical Ltd. and U.S. News & World Report “Top Doctors” in 2012 and 2013.

BS: Cornell University, Ithaca, NY, 1995.

MD: SUNY Downstate Medical Center, Brooklyn, NY, 1999.

Residency: Mount Sinai School of Medicine, The Mount Sinai Hospital, New York, NY, 2000-2001 and 2003-2006.

ECMO/Research Fellowship: Children's Hospital of New York - Presbyterian, Columbia University, New York, NY, 2001-2003.

Pediatric Surgery Residency: Children's Hospital of New York – Presbyterian, Columbia University, New York, NY, 2006-2008.

Certification: General Surgery, 2007; Pediatric Surgery, 2010.

Chernoguz A, Crawford, K, Vandersall A, Willson T, Denson LA, Frischer JS. Pre-treatment with Anti-VEGF therapy may exacerbate inflammation in experimental acute colitis. J Pediatr Surg. 2012 Feb;47(2):347-54.

Le LD, Keswani SG, Biesiada J, Lim FY, Kingma PS, Haberman BE, Frischer J, Habli M, Crombleholme TM. The congenital diaphragmatic hernia composite prognostic index correlates with survival in left-sided congenital diaphragmatic hernia. J Pediatr Surg. 2012 Jan;47(1):57-62.

Lawal TA, Falcone RA, von Allmen D, Denson LA, Levitt MA, Warner BW, Frischer JS. The utility of routine pouchogram before ileostomy reversal in children and adolescents following ileal pouch anal anastomosis. J Pediatr Surg. 2011 Jun;46(6):1222-5.

Chernoguz A, Crawford KM, Donovan EC, Vandersall AE, Berglund C, Cripe TP, Frischer JS. EGFR Inhibition Fails to Suppress Vascular Proliferation and Tumor Growth in a Ewing’s Sarcoma Model. J Surg Res. 2012 Mar;173(1):1-9.

Lawal TA, Frischer JS, Falcone RA, Chatoorgoon K, Denson LA, Levitt MA. The transanal approach with laparoscopy or laparotomy for the treatment of rectal strictures in Crohn’s disease. J Laparoendosc Adv Surg Tech A. 2010 Nov;20(9):791-5.

Bischoff A, Gupta A, D’Mello S, Mezoff A, Podberesky D, Barnett S, Keswani S, Frischer JS. Crohn’s disease limited to the appendix: a case report in a pediatric patient. Pediatr Surg Int. 2010 Nov;26(11):1125-8.

Vuletin JF, Lim FY, Cnota J, Kline-Fath B, Salisbury S, Haberman B, Kingma P, Frischer JS, Crombleholme T. Prenatal pulmonary hypertension index: novel prenatal predictor of severe postnatal pulmonary artery hypertension in antenatally diagnosed congenital diaphragmatic hernia. J Pediatr Surg. 2010 Apr;45(4):703-8.

Frischer JS, Lee A, Serur A, Huang J, Bae JO, Kornfield ZN, Eljuga L, Shawber CJ, Feirt N, Mansukhani M, Stempak D, Baruchel S, Bender JG, Kandel JJ, Yamashiro DJ. Inhibition of cyclooxygenase-2 disrupts tumor vascular mural cell recruitment and survival signaling. Cancer Res. 2006 Apr;66(8):4378-84.

Frischer JS, Huang J, Serur A, Kadenhe-Chiweshe A, McCrudden KW, O’Toole K, Holash J, Yancopoulos GD, Yamashiro DJ, Kandel JJ. Effects of potent VEGF blockade on experimental Wilms tumor and its persisting vasculature. Int J Onc. 2004 Sep;25(3):549-53.

Huang J, Frischer JS, Serur A, Kadenhe A, Yokoi A, McCrudden KW, New T, O’Toole K, Zabski S, Rudge JS, Holash J, Yancopoulos GD, Yamashiro DJ, Kandel JJ. Regression of established tumors and metastases by potent vascular endothelial growth factor blockade. Proc Natl Acad Sci USA. 2003 June 24;100(13):7785-90.

Victor F. Garcia, MD, FACS, FAAP Founding Director, Trauma Services

513-636-4371 victor.garcia@cchmc.org

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Victor F. Garcia, MD, FACS, FAAP

Founding Director, Trauma Services

Academic Affiliations

Professor, UC Department of Surgery

Phone 513-636-4371

Fax 513-636-7657

Email victor.garcia@cchmc.org

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Pediatric injury research and control; chest-wall deformities; minimally invasive surgery (use of the laparoscope and thoracoscope to diagnose and treat surgical diseases); surgical weight loss; minority health care

Biography

Victor Garcia, MD, graduated from West Point, the University of Pennsylvania School of Medicine, studied pediatric surgery under C. Everett Koop, and was Walter Reed’s chief of General/Pediatric Surgery.

Vic founded Children’s Trauma Center and led the effort to establish the country’s first Pediatric Weight Loss Surgery Center.

For his ongoing work to eliminate childhood health and social disparities, he has received numerous awards and commendations to include the Martin Luther King Humanitarian Award and the National Jefferson Award.

Vic has an uncompromising belief in the power of systems thinking and stakeholder engagement to solve society’s most intractable problems.

BS: Engineering, United States Military Academy, 1964-1968.

MD: University of Pennsylvania, School of Medicine, Philadelphia, PA, 1974.

Residency: Walter Reed Army Medical Center, Washington, DC, 1978.

Fellowship: Children's Hospital of Philadelphia, Philadelphia, PA.

Certification: Surgery, 1979; Pediatric Surgery, 1982; Surgical Critical Care, 1991.

Chatoorgoon K, Brown RL, Garcia VF, Falcone, RA. Role of Computed Tomography and Clinical Findings in Pediatric Blunt Intestinal Injury. Pediatric Emergency Care. 2012;28 (12): 1338-1342.

Beaudin M, Daugherty M, Geis G, Moody S, Brown RL, Garcia VF, Falcone RA. Assessment of Factors Associated with the Delayed Transfer of Pediatric Trauma Patients. Pediatric Emergency Care. 2012;28 (8): 758-63.

Goldberg J, McClaine RJ, Cook B, Garcia VF, Brown RL, Crone K, Falcone RA. Use of a mild traumatic brain injury guideline to reduce inpatient hospital imaging and charges. Journal of Pediatric Surgery. 2011;46: 1777-1783.

McClaine RJ, Garcia VF. Unnatural Causes: Social Determinants of Child Health and Well-being. The Pediatric Forum, American Medical Association. 2011;165 (5): 476.

Chatoorgoon K, Huezo K, Rangel E, Francios N, Schweer L, Daugherty M, Koehn M, Richetts C, Brown RL, Garcia VF, Falcone RA. Unnecessary Imaging, Not Hospital Distance, or Transportation Mode Impacts Delays in the Transfer of Injured Children. Pediatric Emergency Care. 2010;26 (7): 481-486.

Martin CA, Care M, Rangel EL, Brown RL, Garcia VF, Falcone RA. Severity of head computed tomography scan findings fail to explain racial differences in mortality following child abuse. American Journal of Surgery. 2010;199 (2): 210-215.

Ippisch HM, Inge TH, Daniels SR, Wang B, Khoury PR, Witt SA, Glascock BJ, Garcia VF, Kimball TR. Reversibility of Cardiac Abnormalities in Morbidly Obese Adolescents. Journal of the American College of Cardiology. 2008;51(14): 1342-1348.

Falcone RA , Martin C, Brown RL, Garcia VF. Despite overall low pediatric head injury mortality, disparities exist between races. Journal of Pediatric Surgery. 2008;43(10), 1858-1864.

Falcone RA, Daugherty M, Schweer L, Patterson M, Brown RL, Garcia VF. Multidisciplinary pediatric trauma team training using high-fidelity trauma simulation. Journal of Pediatric Surgery. 2008;43(6), 1065-1071.

Rangel SJ, Martin CA, Brown RL, Garcia VF, Falcone RA. Alarming trends in the improper use of motor vehicle restraints in children: implications for public policy and the development of race-based strategies for improving compliance. Journal of Pediatric Surgery. 2008;43(1), 200-207.

Mounira A. Habli, MD Maternal-Fetal Medicine Specialist, Cincinnati Fetal Center

513-636-2735 mounira.habli@cchmc.org

Michael A. Helmrath, MD, MS Surgical Director, Intestinal Rehabilitation Program

Visit the Helmrath Lab.

513-636-3240 michael.helmrath@cchmc.org

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Michael A. Helmrath, MD, MS

Surgical Director, Intestinal Rehabilitation Program

Director of Surgical Research

Pediatric Surgeon, Colorectal Center

Academic Affiliations

Professor, UC Department of Surgery

Phone 513-636-3240

Email michael.helmrath@cchmc.org

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Visit the Helmrath Lab.

Biography

As a pediatric surgeon, Dr. Helmrath has dedicated his career to the care of patients with intestinal failure. The main focus of his laboratory is directed towards characterizing intestinal stem cells during intestinal adaptation and developing intestinal regenerative strategies. By combining his clinical experience as the surgical director of intestinal research and rehabilitation at Cincinnati Children’s, his long-term goal is to establish translational therapies for the management of patients with short bowel syndrome.

BA: Miami University, Oxford, OH, 1987.

MD: University of Cincinnati College of Medicine, Cincinnati, OH, 1993.

MS: University of Cincinnati College of Medicine, Cincinnati, OH, 1989.

Certification: Board-certified General Surgery; board-certified, Pediatric Surgery.

Michalsky MP, Inge TH, Teich S, Eneli I, Miller R, Brandt ML, Helmrath M, Harmon CM, Zeller MH, Jenkins TM, Courcoulas A, Buncher RC; Teen-LABS Consortium. Adolescent bariatric surgery program characteristics: The Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study experience. Semin Pediatr Surg. 2014 Feb;23(1):5-10.

Inge TH, Zeller MH, Jenkins TM, Helmrath M, Brandt ML, Michalsky MP, Harmon CM, Courcoulas A, Horlick M, Xanthakos SA, Dolan L, Mitsnefes M, Barnett SJ, Buncher R; Teen-LABS Consortium. Perioperative outcomes of adolescents undergoing bariatric surgery: the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study. JAMA Pediatr. 2014 Jan;168(1):47-53.

Ubesie AC, Kocoshis SA, Mezoff AG, Henderson CJ, Helmrath MA, Cole CR. Multiple micronutrient deficiencies among patients with intestinal failure during and after transition to enteral nutrition. J Pediatr. 2013 Dec;163(6):1692-6.

Eradi B, Hamrick M, Bischoff A, Frischer JS, Helmrath M, Hall J, Pena A, Levitt MA. The role of a colon resection in combination with a Malone appendicostomy as part of a bowel management program for the treatment of fecal incontinence. J Pediatr Surg. 2013 Nov; 48(11):2296-300.

Fuller MK, Faulk DM, Sundaram N, Mahe MM, Stout KM, von Furstenberg RJ, Smith BJ, McNaughton KK, Shroyer NF, Helmrath MA, Henning SJ. Intestinal stem cells remain viable after prolonged tissue storage. Cell Tissue Res. 2013 Nov;354(2):441-50.

Devine AA, Gonzalez A, Speck KE, Knight R, Helmrath M, Lund PK, Azcarate-Peril MA. Impact of ileocecal resection and concomitant antibiotics on the microbiome of the murine jejunum and colon. PLoS One. 2013; 8(8):e73140.

Fuller MK, Faulk DM, Sundaram N, Shroyer NF, Henning SJ, Helmrath MA. Intestinal crypts reproducibly expand in culture. J Surg Res. 2012 Nov;178(1):48-54.

Stelzner M, Helmrath M, Dunn JC, Henning SJ, Houchen CW, Kuo C, Lynch J, Li L, Magness ST, Martin MG, Wong MH, Yu J; NIH Intestinal Stem Cell Consortium. A nomenclature for intestinal in vitro cultures. Am J Physiol Gastrointest Liver Physiol. 2012 Jun 15;302(12):G1359-63.

Van Landeghem L, Blue RE, Dehmer JJ, Henning SJ, Helmrath MA, Lund PK. Localized intestinal radiation and liquid diet enhance survival and permit evaluation of long-term intestinal responses to high dose radiation in mice. PLoS One. 2012;7(12):e51310.

Grants

Adolescent Bariatrics: Assessing Health Benefits & Risk. Co-investigator. National Institute of Diabetes and Digestive and Kidney Diseases. Nov 2011–Oct 2016. U01 DK072493.

Human Endocrine Cell Development. Co-investigator. National Institute of Diabetes and Digestive and Kidney Diseases. Apr 2012–Mar 2017. R01 DK092456.

Thomas H. Inge, MD, PhD, FACS, FAAP Surgical Director, Surgical Weight Loss Program for Teens

Visit the Inge Lab.

513-636-4371 thomas.inge@cchmc.org

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Thomas H. Inge, MD, PhD, FACS, FAAP

Surgical Director, Surgical Weight Loss Program for Teens

Director, Center for Bariatric Research and Innovation

Attending Surgeon, Cincinnati Children’s Hospital Medical Center

Academic Affiliations

Professor, UC Department of Surgery

Phone 513-636-4371

Fax 513-636-7657

Email thomas.inge@cchmc.org

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Obesity surgery and research; hypothalamic obesity; neonatal surgery; gastroesophageal reflux disease; minimally invasive surgery; thoracic surgery.

Visit the Inge Lab.

Biography

Thomas H. Inge, MD, PhD, is a Virginia native who grew up in a rural, farming community in Dinwiddie County. He received his BS in biology at the College of William and Mary in Williamsburg, VA, in 1987. Dr. Inge entered the Medical College of Virginia in Richmond, VA, in the Medical Scientist Training Program, and pursued degrees in microbiology/immunology and medicine. He graduated with MD and PhD degrees in 1993.

Dr. Inge received his surgical training at Stanford University Hospital in Palo Alto, CA, where he developed an interest in pediatric surgery. At the completion of his chief resident year in 1998, he moved to Birmingham, AL, for specialty training in pediatric surgery at the Children's Hospital of Alabama, with an emphasis on pediatric minimally invasive surgery. Dr. Inge became a full-time member of the surgical staff at Cincinnati Children's Hospital Medical Center and faculty member of the University of Cincinnati College of Medicine, Department of Surgery, Division of Pediatric Surgery, in July 2000.

In addition to general pediatric surgical practice, Dr. Inge's clinical research focus is related to bariatric surgery in adolescents. He is the surgical director of the Surgical Weight Loss Program for Teens, offering surgery for overweight adolescents with complications from their excess weight. He has served as a consultant to the Food and Drug Administration for projects related to device treatment of pediatric obesity. His laboratory has been continuously funded by the National Institutes of Health (NIH) to conduct clinical outcomes research since 2005. He serves as study chairman of Teen-LABS, a multicenter research consortium examining wide ranging outcomes of adolescent bariatric surgery.

Dr. Inge has given over 125 invited lectures nationally and internationally, has mentored more than dozens of fellows, residents, and students, and has coauthored over 150 original manuscripts, reviews, and book chapters.

BS: College of William and Mary, Williamsburg, VA, 1987.

MD: Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, 1993.

PhD: Virginia Commonwealth University, Richmond, VA, 1993.

Residency: Stanford University Hospital, Stanford, CA, 1998.

Fellowship: Children's Hospital of Alabama, Birmingham, AL, 2000.

Board Certification: Diplomate of the American Board of Surgery, December 1999; Certification in Pediatric Surgery, American Board of Surgery, March 2002.

Inge TH, Courcoulas AP, Jenkins TM, Michalsky MP, Helmrath MA, Brandt ML, Harmon CM, Zeller MH, Chen MK, Xanthakos SA, Horlick M, Buncher CR; Teen- LABS Consortium. Weight Loss and Health Status 3 Years after Bariatric Surgery in Adolescents. N Engl J Med. 2015 Nov 6.

Inge TH, Prigeon R, Elder DA, Jenkins TM, Xanthakos SA, Benoit S, Dolan LM, D’Alessio DA. Gastric bypass improves insulin sensitivity and β-cell function in severely obese adolescents. J Pediatr. 2015 Nov;167(5):1042-1048.

Xanthakos S, Boyce TW, Kleiner DE, Jenkins TM, Brandt ML, Harmon CM, Helmrath MA, Michalsky MP, Courcoulas AP, Zeller MH, Inge TH; Teen-LABS Consortium. High Prevalence of Nonalcoholic Fatty Liver Disease in Adolescents Undergoing Bariatric Surgery. Gastroenterology. 2015 Sep;149(3):623-34.

Kelly A, et.al., Inge TH. Changes in Inflammation, Oxidative Stress, and Adipokines Following Bariatric Surgery among Adolescents with Severe Obesity. Int J Obes (Lond). 2015 Aug 28.

Xiao N, Devarajan P, Inge TH, Jenkins TM, Bennett M, Mitsnefes MM. Subclinical kidney injury before and 1 year after bariatric surgery among adolescents with severe obesity. Obesity (Silver Spring). 2015 Jun;23(6):1234-8.

Michalsky MP, Inge TH, Simmons M, Jenkins TM, Buncher R, Helmrath M, Brandt ML, Harmon CM, Courcoulas A, Chen M, Horlick M, Daniels SR, Urbina EM; Teen-LABS Consortium. Cardiovascular Risk Factors in Severely Obese Adolescents: The Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS) Study. JAMA Pediatr. 2015 May;169(5):438-44.

Inge TH, Zeller MH, Jenkins TM, Helmrath M, Brandt ML, Michalsky MP, Harmon CM, Courcoulas A, Horlick M, Xanthakos SA, Dolan L, Mitsnefes M, Barnett SJ, Buncher R, for the Teen-LABS Consortium. Perioperative Outcomes of Adolescents Undergoing Bariatric Surgery: The Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) Study. JAMA Pediatr. 2014 Jan;168(1):47-53.

Inge TH, King WC, Jenkins TM, Courcoulas AP, Mitsnefes M, Flum DR, Wolfe BM, Pomp A, Dakin GF, Khandelwal S, Zeller MH, Horlick M, Pender JR, Chen JY, Daniels SR. The Effect of Obesity in Adolescence on Adult Health Status. Pediatrics. 2013 Dec;132(6):1098-104.

Inge TH, Jenkins TM, Zeller M, Dolan L, Daniels SR, Garcia VF, Brandt ML, Bean J, Gamm K, Xanthakos SA. Baseline BMI is a strong predictor of nadir BMI after adolescent gastric bypass. J Pediatr. 2010;156(1):103.

Inge TH, Miyano G, Bean J, Helmrath M, Courcoulas A, Harmon CM, Chen MK, Wilson K, Daniels SR, Garcia VF, Brandt ML, Dolan LM. Reversal of type 2 diabetes mellitus and improvements in cardiovascular risk factors after surgical weight loss in adolescents. Pediatrics. 2009 Jan;123(1):214-22.

Helen N. Jones, PhD

is a placental physiologist who has research interests in placental function in pathological pregnancies and the development of non-viral mediated gene therapies in fetal growth restriction. Her lab studies the underlying mechanisms of placental insufficiency and potential therapies leading to increased placental function and fetal growth.

Visit the Jones Lab.

513-636-7861 helen.jones@cchmc.org

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Helen N. Jones, PhD

Academic Affiliations

Assistant Professor, UC Department of Surgery

Phone 513-636-7861

Fax 513-636-3774

Email helen.jones@cchmc.org

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Regulation of placental growth and function; regulation of mechanisms of placental nutrient transfer and consequences for fetal growth

Visit the Jones Lab.

BS: University of St. Andrews, Scotland, 2000.

PhD: Rowett Research Institute, University of Aberdeen, Scotland, 2005.

Wang K, Dong HQ, Zhao ZL, Li YY, Li C, Jones HN, Shi DL,Zhang XZ. Novel Vesicles Self-Assembled from Amphiphilic Star-Armed PEG-Polypeptide Hybrid Copolymers for Drug Delivery. Macromolecular Bioscience 2011;11:65-71.

Jones HN, Powell TL, Jansson T. Differential regulation of placental amino acid transport mechanisms by Adiponectin. Diabetes. 2010;59(5):1161-70.

Jones HN, Powell TL, Jansson T. IL-6 stimulates System A amino acid transporter activity in trophoblast cells through STAT3 and increased expression of SNAT2. Am J Physiol Cell Physiol. 2009;297(5):C1228-35.

Jones HN,Woollett LA, Barbour N, Prasad PD, Powell TL, Jansson T. High-fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57/BL6 mice. FASEB J. 2009;23(1):271-8.

McArdle HJ, Andersen HS, Jones H, Gambling L. Copper and iron transport across the placenta: regulation and interactions. J Neuroendocrinol. 2008;20(4):427-31.

Jones HN, Powell TL, Jansson T. Regulation of Placental Nutrient Transport – A Review. Placenta. 2007;28l; 763- 774.

Ferguson-Smith AC, Moore T, Detmar J, Lewis A, Hemberger M, Jammes H, Kelsey G, Roberts CT, Jones H, Constancia M. Epigenetics and imprinting of the trophoblast -- a workshop report. Placenta. 2006;Suppl A:S122-6.

McArdle HJ, Andersen HS, Jones H, Gambling L. Fetal Programming: Causes and Consequences as Revealed by Studies of Dietary Manipulation in Rats – A Review. Placenta. 2006;27:56-60.

Jones HN, Ashworth CJ, Page KR, McArdle HJ. Cortisol stimulates System A amino acid transport and SNAT2 expression in a human placental cell line (BeWo). Am. J. Physiol Endocrinology and Metabolism. 2006;291(3):E596-603.

Jones HN, Ashworth CJ, Page KR, McArdle HJ. Expression and adaptive regulation of amino acid transport system A in a placental cell line under amino acid restriction. Reproduction. 131:951-60, 2006.

Foong-Yen Lim, MD Surgical Director, Cincinnati Fetal Center

Visit the Lim Lab.

513-636-4371 foong.yen.lim@cchmc.org

Jaimie D. Nathan, MD Surgical Director, Pancreas Care Center

is a pediatric general, thoracic and transplant surgeon, who has a basic science research program in the role of the gut microbiome in the modulation of liver injury and cholangiopathies. His lab studies the gut-liver axis as it relates to the pathogenesis of a number of liver diseases which can progress to end-stage liver disease requiring transplantation.

513-636-4371 jaimie.nathan@cchmc.org

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Jaimie D. Nathan, MD

Surgical Director, Pancreas Care Center

Surgical Director, Kidney and Intestinal Transplant Programs

Associate Surgical Director, Liver Transplant Program

Academic Affiliations

Assistant Professor, UC Department of Surgery

UC Department of Pediatrics

Phone 513-636-4371

Fax 513-636-7657

Email jaimie.nathan@cchmc.org

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Clinical Interests

Hepatobiliary and pancreatic disease; liver, kidney, and intestinal transplantation; pediatric surgical oncology; neonatal surgery; minimally invasive surgery

BS: Yale University, New Haven, CT, 1993.

MD: Yale University, New Haven, CT, 1998.

Residency: General Surgery, Duke University Medical Center, Durham, NC, 1998-2000 and 2002-2005.

Surgical Research Fellowship: Duke University Medical Center, Durham, NC, 2000-2002.

Pediatric Surgery Fellowship: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2005-2007.

Transplant Surgery Fellowship: University of Cincinnati, Cincinnati, OH, 2007-2009.

Certification: American Board of Surgery, General Surgery, 2007; American Board of Surgery, Pediatric Surgery, 2008; American Society of Transplant Surgeons Certification, 2009.

Prada CE, Kaul A, Hopkin RJ, Page KI, Nathan JD, Bartholomew DW, Cohen MB, Heubi JE, Leslie ND, Burrow TA. Recurrent pancreatitis in ornithine transcarbamylase deficiency. Mol Genet Metab. 2012 Aug;106(4):482-484.

Bondoc AJ, Taylor JA, Alonso MH, Nathan JD, Wang Y, Balistreri WF, Bezerra JA, Ryckman FC, Tiao GM. The beneficial impact of revision of Kasai portoenterostomy for biliary atresia: an institutional study. Ann Surg. 2012 Mar;255(3):570-576.

Vigna SR, Shahid RA, Nathan JD, McVey DC, Liddle RA. Leukotriene B4 mediates inflammation via TRPV1 in duct obstruction-induced pancreatitis in rats. Pancreas. 2011 Jul;40(5):708-714.

Nathan JD, Romac J, Peng RY, Peyton M, Rockey DC, Liddle RA. Protection against chronic pancreatitis and pancreatic fibrosis in mice overexpressing pancreatic secretory trypsin inhibitor. Pancreas. 2010 Jan;39(1):e24-30.

Ryckman FC, Bucuvalas JC, Nathan J, Alonso M, Tiao G, Balistreri WF. Outcomes following liver transplantation. Semin Pediatr Surg. 2008 May;17(2):123-30.

Follmar KE, Condron SA, Turner II, Nathan JD, Ludwig KA. Treatment of metronidazole-refractory Clostridium difficile enteritis with vancomycin. Surg Infect. 2008 9:195-200.

Nathan JD, Rudolph JA, Kocoshis SA, Alonso MH, Ryckman FC, Tiao GM. Isolated liver and multivisceral transplantation for total parenteral nutrition-related end-stage liver disease. J Pediatr Surg. 2007 Jan;42(1):143-7.

Patel MB, Nathan JD, Frush DP, Rice HE. Nonoperative management of asymptomatic traumatic pulmonary hernia in a young child. J Trauma. 2007 62:234-235.

Nathan JD, Romac J, Peng RY, Peyton M, MacDonald RJ, Liddle RA. Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice. Gastroenterology. 2005 128:717-727.

Jose L. Peiro, MD Endoscopic Fetal Surgery Director, Cincinnati Fetal Center

is in the cutting-edge of fetal myelomeningocele intrauterine repair innovation, allowing a fetoscopic approach for the treatment of this devastating condition, as well as looking for innovative strategies for treatment of CDH by means fetal tracheal occlusion.

Visit the Peiro Lab.

513-636-6259 jose.peiro@cchmc.org

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Jose L. Peiro, MD

Endoscopic Fetal Surgery Director, Cincinnati Fetal Center

Pediatric Surgeon, Division of General and Thoracic Surgery

Academic Affiliations

Associate Professor, UC Department of Surgery

Phone 513-636-6259

Email jose.peiro@cchmc.org

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Clinical

Neonatal surgery; fetal surgery

Research

Myelomeningocele intrauterine repair; fetal tracheal occlusion for CDH

Visit the Peiro Lab.

MD: Medical School at Universidad Autonoma de Barcelona, Barcelona, Spain, 1989.

MBA: Health and Hospital Management, Universitat Oberta de Catalunya (UOC), Barcelona, Spain, 2010-2012.

Residency: Pediatric Surgery, Hospital Vall Hebron (UAB), Barcelona, Spain, 1991-1995.

Observership: Fetal Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA, 2001.

Burgos L, Encinas JL, García-Cabezas MA, Peiró JL, López-Santamaría M, Jaureguízar E. Bladder Changes After Several Coverage Modalities in the Surgically Induced Model of Myelomeningocele in Lambs. Actas Urol Esp. 2014 January - February;38(1):55-61.

Peiro JL, Fontecha CG, Ruano R, Esteves M, Fonseca C, Marotta M, Haeri S, Belfort MA. Single-Access Fetal Endoscopy (SAFE) for myelomeningocele in sheep model I: amniotic carbon dioxide gas approach. Surg Endosc. 2013 Oct;27(10):3835-40.

Ruano R, Peiro JL, da Silva MM, Campos JA, Carreras E, Tannuri U, Zugaib M. Early fetoscopic tracheal occlusion for extremely severe pulmonary hypoplasia in isolated congenital diaphragmatic hernia: preliminary results. Ultrasound Obstet Gynecol. 2013 Jul;42(1):70-6.

Peiró JL, Encinas JL. Fetal surgery of myelomeningocele: from experimental results to clinical evidence. Cir Pediatr. 2012 Jan;25(1):1-3.

Encinas JL, García-Cabezas MÁ, Barkovich J, Fontecha CG, Peiró JL, Soto GM, Borrell V, Reillo I, López-Santamaría M, Tovar JA, Farmer DL. Maldevelopment of the cerebral cortex in the surgically induced model of myelomeningocele: implications for fetal neurosurgery. J Pediatr Surg. 2011 Apr;46(4):713-22.

Fontecha CG, Peiro JL, Sevilla JJ, Aguirre M, Soldado F, Fresno L, Fonseca C, Chacaltana A, Martinez V. Fetoscopic coverage of experimental myelomeningocele in sheep using a patch with surgical sealant. Eur J Obstet Gynecol Reprod Biol. 2011 Jun;156(2):171-6.

Peiró JL, Carreras E, Guillén G, Arévalo S, Sánchez-Durán MA, Higueras T, Castillo F, Marhuenda C, Lloret J, Martínez-Ibáñez V. Therapeutic indications of fetoscopy: a 5-year institutional experience. J Laparoendosc Adv Surg Tech A. 2009 Apr;19(2):229-36.

Castillo F, Peiró JL, Carreras E, Ruiz C, Linde A, Ribes C, Creus A. The exit procedure (ex-utero intrapartum treatment): management of giant fetal cervical teratoma. J Perinat Med. 2007;35(6):553-5.

Frederick C. Ryckman, MD Sr. Vice President, Medical Operations

513-636-4371 frederick.ryckman@cchmc.org

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Frederick C. Ryckman, MD

Sr. Vice President, Medical Operations

Academic Affiliations

Professor, UC Department of Pediatrics

UC Department of Surgery

Phone 513-636-4371

Fax 513-636-7657

Email frederick.ryckman@cchmc.org

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Clinical Interests

Transplantation; liver; kidney transplantation; small intestine; biliary disease; extracorporeal membrane oxygenation (ECMO); minimally invasive surgery; chest wall abnormalities

Biography

Frederick C. Ryckman, MD, is clinical director of the Division of Pediatric General and Thoracic Surgery.

Dr. Ryckman is also vice president of System Capacity and Perioperative Operations.

Dr. Ryckman is also a pediatric surgeon at the Cincinnati Fetal Center.

BS: Lyman Briggs College of Science and Mathematics, Michigan State University, East Lansing, MI, 1969 to 1973.

MD: University of Michigan Medical School, Ann Arbor, MI, 1977.

Residency: University of Florida Medical Center, Gainesville, FL, 1977 to 1982.

Fellowship: Pediatric Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1982 to 1984.

Certification: National Board of Medical Examiners, 1977; American Board of Surgery, 1983; recertification, 1993; Certificate of Special Competence in Pediatric Surgery, 1986; recertification, 1993.

Wagner LM, Gelfand MJ, Laor T, Ryckman FC, Al-Ghawi H, Bove KE. A Welcome Surprise: Nodular Fasciitis Presenting as Soft Tissue Sarcoma. J Pediatr Hematol Oncol. 2010 Oct 21.

Taylor JA, Ryckman FC. Management of small bowel volvulus around feeding Roux-en-Y limbs. Pediatr Surg Int. 2010 Apr;26(4):439-42.

Ryckman FC, Yelton PA, Anneken AM, Kiessling PE, Schoettker PJ, Kotagal UR. Redesigning intensive care unit flow using variability management to improve access and safety. Jt Comm J Qual Patient Saf. 2009 Nov;35(11):535-43.

Rattan AS, Laor T, Ryckman FC, Brody AS. Pectus excavatum imaging: enough but not too much. Pediatr Radiol. 2010 Feb;40(2):168-72.

Propst EJ, Lin EP, Istaphanous GK, Boesch RP, Ryckman FC, Cotton RT, Rutter MJ. Management of traumatic tracheobronchial separation in a teenager using a fabricated extra-long endotracheal tube. Int J Pediatr Otorhinolaryngol. 2009 Aug;73(8):1163-7.

Ryckman FC, Schoettker PJ, Hays KR, Connelly BL, Blacklidge RL, Bedinghaus CA, Sorter ML, Friend LC, Kotagal UR. Reducing surgical site infections at a pediatric academic medical center. Jt Comm J Qual Patient Saf. 2009 Apr;35(4):192-8.

Dickie B, Dasgupta R, Nair R, Alonso MH, Ryckman FC, Tiao GM, Adams DM, Azizkhan RG. Spectrum of hepatic hemangiomas: management and outcome. J Pediatr Surg. 2009 Jan;44(1):125-33.

Ryckman FC, Bucuvalas JC, Nathan J, Alonso M, Tiao G, Balistreri WF. Outcomes following liver transplantation. Semin Pediatr Surg. 2008 May;17(2):123-30.

Sparling KW, Ryckman FC, Schoettker PJ, Byczkowski TL, Helpling A, Mandel K, Panchanathan A, Kotagal UR. Financial impact of failing to prevent surgical site infections. Qual Manag Health Care. 2007 Jul-Sep;16(3):219-25.

Aimen F. Shaaban, MD Director, Center for Fetal Cellular and Molecular Therapy

is a pediatric surgeon who leads a research program studying in utero transplantation. His laboratory seeks to better understand the manner in which immunologic tolerance develops in the fetus following transplantation in order to design less toxic and more effective therapies for the treatment of numerous diseases such as sickle cell disease, thalassemia, immunodeficiency, spinal muscular atrophy and inherited metabolic disorders.

Visit the Shaaban Lab.

513-636-6259 aimen.shaaban@cchmc.org

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Aimen F. Shaaban, MD

Director, Center for Fetal Cellular and Molecular Therapy

Academic Affiliations

Professor, UC Department of Surgery

Phone 513-636-6259

Email aimen.shaaban@cchmc.org

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Surgical treatment of fetal and newborn diseases including: open and minimally invasive fetal surgery; congenital lung and airway disease; congenital esophageal disease; sacrococcygeal teratoma; conjoined twins; neonatal surgery.

Examination of the mechanisms of long-term immunologic tolerance to prenatally transplanted stem cells; developmental hematology, pluripotent stem cell biology; fetal gene therapy

Visit the Shaaban Lab.

Biography

Dr. Shaaban served as an associate professor of surgery with tenure and as director of the Laboratory for Fetal Cellular Therapy at the University of Iowa Carver College of Medicine from 2008-2012. Prior to that he served as director of the Laboratory for Fetal Cellular Therapy at University of Wisconsin College of Medicine from 2002-2008.

MD: University of Illinois College of Medicine, Chicago, IL, 1991.

General Surgery Residency: University of Iowa Hospital and Clinics, Iowa City, Iowa, Jul 1991-Jun 1996.

Pediatric Surgical Residency: The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, Jul 2000-Jun 2001.

Post-doctoral Fellowship in Fetal Surgery Research: Children's Institute for Surgical Science, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, Jul 1996-Jun 1999.

Certification: Diplomate of the National Board of Medical Examiners, 1991; diplomate of the American Board of Surgery, 1997, 2011; diplomate of the American Board of Pediatric Surgery, 2006.

Grants

NK cell response to prenatal allotransplantation. Principal Investigator. National Heart, Lung and Blood Institute. 2011-2016. R01HL103745.

Soona Shin, PhD

conducts research that aims to decipher the molecular basis underlying liver cancer, with a focus on adult hepatic progenitor cells and fetal hepatoblasts. Dr. Shin hypothesizes that dysregulation of signaling pathways involved in cell differentiation leads to malignant transformation of tissue-specific stem cells. To test this hypothesis, Dr. Shin employs mouse models of carcinogenesis as well as xenograft models of human liver cancer.

Visit the Shin Lab.

513-803-8970 soona.shin@cchmc.org

Soona Shin, PhD

Academic Affiliations

Assistant Professor, UC Department of Surgery

Phone 513-803-8970

Email soona.shin@cchmc.org

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Liver cancer; liver stem cells.

Visit the Shin Lab.

BS: Pharmacy, Seoul National University, Seoul, South Korea, 2002.

MS: Pharmacy, Seoul National University, Seoul, South Korea, 2004.

PhD: Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD, 2009.

Postdoctoral training: Genetics, University of Pennsylvania, Philadelphia, PA, 2012.

Shin S, Upadhyay N, Greenbaum LE, Kaestner KH. Ablation of Foxl1-Cre-labeled hepatic progenitor cells and their descendants impairs recovery of mice from liver injury. Gastroenterology. 2015;148(1):192-202.e3.

Shin S, Le Lay J, Everett LJ, Gupta R, Rafiq K, et al. CREB mediates the insulinotropic and anti-apoptotic effects of GLP-1 signaling in adult mouse β-cells. Molecular metabolism. 2014;3(8):803-12.

Shin S, Kaestner KH. The origin, biology, and therapeutic potential of facultative adult hepatic progenitor cells. Current topics in developmental biology. 2014;107:269-92.

Bochkis IM, Shin S, Kaestner KH. Bile acid-induced inflammatory signaling in mice lacking Foxa2 in the liver leads to activation of mTOR and age-onset obesity. Molecular metabolism. 2013;2(4):447-56.

Shin S, Walton G, Aoki R, Brondell K, Schug J, et al. Foxl1-Cre-marked adult hepatic progenitors have clonogenic and bilineage differentiation potential. Genes & development. 2011;25(11):1185-92.

Shin S, Wakabayashi J, Yates MS, Wakabayashi N, Dolan PM, et al. Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide. European journal of pharmacology. 2009;620(1-3):138-44.

Shin S, Wakabayashi N, Misra V, Biswal S, Lee GH, et al. NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis. Molecular and cellular biology. 2007;27(20):7188-97.

Nikolai Timchenko, PhD Head of Liver Tumor Biology, Liver Tumor Program

focuses his research on liver cancer, non-alcoholic fatty liver disease (NAFLD), and age-associated liver dysfunctions.

513-636-0129 nikolai.timchenko@cchmc.org

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Nikolai Timchenko, PhD

Head of Liver Tumor Biology, Liver Tumor Program

Academic Affiliations

Professor, UC Department of Surgery

Phone 513-636-0129

Email nikolai.timchenko@cchmc.org

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Visit the Timchenko Lab.

Biography

Nikolai A. Timchenko, PhD, came to Cincinnati Children’s Hospital Medical Center in June of 2014 from Baylor College of Medicine (BCM), where he was a professor of pathology and was working in the Huffington Center on aging.

Dr. Timchenko obtained his PhD in the Institute of Experimental Medicine in St. Petersburg, Russia in the field of liver biology and molecular genetics. After moving to the US, Dr. Timchenko worked at BCM as an assistant professor, associate professor, and full professor until 2014.

He is currently a professor in the Division of General and Thoracic Surgery at Cincinnati Children's within the UC Department of Surgery. Dr. Timchenko is also the director of the Liver Tumor Program. He investigates mechanisms of liver cancer in children and adults, mechanisms of NAFLD, and mechanisms of age-associated diseases.

Dr. Timchenko is a member of the Digestive Health Center (Cincinnati Children's) and a professor in the Department of Surgery at the University of Cincinnati.

PhD: Institute of Experimental Medicine, St. Petersburg, Russia.

Training: Post-Doc Fellow, Department of Pathology, Baylor College of Medicine, Houston, TX.

Jin J, Hong IH, Lewis K, Iakova P, Breaux M, Jiang Y, Sullivan E, Jawanmardi N, Timchenko L, Timchenko NA. Cooperation of C/EBP family proteins and chromatin remodeling proteins is essential for termination of liver regeneration in mice. Hepatology. 2014.

Hong I, Lewis K, Iakova P, Jin J, Sullivan E, Jawanmardi N, Timchenko L, Timchenko NA. The age-associated change of C/EBP family proteins causes severe liver injury and acceleration of liver proliferation after CCl4-treatments. JBC. 2014;298:1106-1118.

Jin J, Iakova P, Breaux M, Sullivan E, Jawanmardi N, Chen D, Jiang Y, Medrano EE and Timchenko NA. Increased expression of enzymes of triglyceride synthesis plays is essential for the development of hepatic steatosis. Cell Reports. 2013;3:831-843.

Jiang Y, Iakova P, Jin J, Sullivan S, Sharin, V, Hong I-W, Anakk S, Major A, Darlington G, Finegold M, Moore D, Timchenko, NA. FXR inhibits gankyrin in mouse livers and prevents development of liver cancer. Hepatology. 2013;57:1098-1106.

Jones K, Wei C, Iakova P, Bugiardini E, Schneider-Gold Ch, Meola G, Woodgett G, Killian J, Timchenko NA, Timchenko LT. GSK3beta is a key determinant of muscle pathology in DM1. J Clin Invest. 2012;122:4461-4472.

Jones K, Timchenko L, Timchenko NA. The role of CUGBP1 in age-dependent changes of liver functions. Aging Research Reviews 11. 2012;442-449.

Jin J, Iakova P, Jiang J, Medrano EE, Timchenko NA. The reduction of SIRT1 in livers of old mice leads to impaired body homeostasis and to inhibition of liver proliferation. Hepatology. 2011;54:898-998.

Iakova P, Timchenko LT, Timchenko NA. Intracellular signaling and hepatocellular carcinoma. Seminars in Cancer Biology. 2011;21:28-34.

Jin J, Iakova P, Wang G-l, Shi X, Haefliger S, Finegold M, Timchenko NA. Epigenetic changes play critical role in age-associated dysfunction of the liver. Aging Cell. 2010;9:895-910.

Wang G-L, Shi X, Haefliger S, Jin J, Major A, Iakova P, Finegold M, Timchenko NA. Elimination of C/EBP through the ubiquitin-proteasome system promotes the development of liver cancer in mice. J. Clin. Invest. 2010;120:2549-2562.

Daniel von Allmen, MD Surgeon-in-Chief; Lester W. Martin Chair of Pediatric Surgery

513-636-4371 daniel.vonallmen@cchmc.org

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Daniel von Allmen, MD

Surgeon-in-Chief; Lester W. Martin Chair of Pediatric Surgery

Senior Vice President, Surgical Services

Academic Affiliations

Professor, UC Department of Surgery

Phone 513-636-4371

Fax 513-636-7657

Email daniel.vonallmen@cchmc.org

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Clinical

Pediatric surgical oncology; pediatric inflammatory bowel disease; surgical innovation; surgical robotics

Research

Oncology; innovation; surgical workforce

Biography

Daniel von Allmen, MD, came to Cincinnati from Chapel Hill, NC where he was the surgeon-in-chief and division chief at the North Carolina Children’s Hospital.

Dr. von Allmen completed his general surgery training at the University of Cincinnati and Cincinnati Children’s Hospital Medical Center. He is currently the treasurer of the American Pediatric Surgery Association. He also serves as the secretary treasurer of the Association of Pediatric Surgery Program Directors and is an active member of the Children’s Oncology Group.

Dr. von Allmen's special clinical interests include pediatric surgical oncology, pediatric inflammatory bowel disease, surgical innovation, and surgical robotics.

MD: University of Vermont, College of Medicine, Burlington, VT.

Residency: General Surgery, University of Cincinnati, Cincinnati, OH.

Fellowship: Pediatric Surgery, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH.

Certifications: General Surgery, Pediatric Surgery.