The Barske Lab studies the formation and patterning of the skeleton. Our work focuses on three major transitions during early skeletal development:
- How precursor cells first transition into bona fide skeletal progenitors
- How those then initiate maturation into chondrocytes and osteoblasts at specific spatial coordinates
- How mineralization is initiated
By investigating how these critical transitions are controlled, we hope to better understand the disturbed developmental processes underlying skeletal disorders in our pediatric patients, ultimately improving intervention strategies and outcomes.
Our laboratory is located within the Research Building at Cincinnati Children's. Lindsey Barske, PhD, is an assistant professor in the divisions of Human Genetics and Developmental Biology as well as a faculty mentor in the Molecular and Developmental Biology Graduate Program (MDB).