Zhang Pregnancy Genomics Lab

Rokas, A; Mesiano, S; Tamam, O; Labella, A; Zhang, G; Muglia, L. Developing a theoretical evolutionary framework to solve the mystery of parturition initiation. eLife. 2020; 9:1-22.

Sakabe, NJ; Aneas, I; Knoblauch, N; Sobreira, DR; Clark, N; Paz, C; Horth, C; Ziffra, R; Kaur, H; Liu, X; et al. Transcriptome and regulatory maps of decidua-derived stromal cells inform gene discovery in preterm birth. Science Advances. 2020; 6:eabc8696-eabc8696.

LaBella, AL; Abraham, A; Pichkar, Y; Fong, SL; Zhang, G; Muglia, LJ; Abbot, P; Rokas, A; Capra, JA. Accounting for diverse evolutionary forces reveals mosaic patterns of selection on human preterm birth loci. Nature Communications. 2020; 11.

Modzelewska, D; Sole-Navais, P; Sandstrom, A; Zhang, G; Muglia, LJ; Flatley, C; Nilsson, S; Jacobsson, B. Changes in data management contribute to temporal variation in gestational duration distribution in the Swedish Medical Birth Registry. PLoS ONE. 2020; 15:e0241911-e0241911.

Chen, J; Bacelis, J; Sole-Navais, P; Srivastava, A; Juodakis, J; Rouse, A; Hallman, M; Teramo, K; Melbye, M; Feenstra, B; et al. Dissecting maternal and fetal genetic effects underlying the associations between maternal phenotypes, birth outcomes, and adult phenotypes: A mendelian-randomization and haplotype-based genetic score analysis in 10,734 mother–infant pairs. PLoS Medicine. 2020; 17:e1003305-e1003305.

Modzelewska, D; Sole-Navais, P; Zhang, G; Muglia, LJ; Nilsson, S; Jacobsson, B. Importance of the environment for gestational duration variability and correlation between relatives - results from the Medical Swedish Birth Registry, 1973-2012. PLoS ONE. 2020; 15:e0236494-e0236494.

Barman, M; Brantsaerer, AL; Nilsson, S; Haugen, M; Lundh, T; Jr, CG F; Zhang, G; Muglia, LJ; Meltzer, HM; Jacobsson, B; et al. Maternal dietary selenium intake is associated with increased gestational length and decreased risk of preterm delivery. The British Journal of Nutrition: an international journal of nutritional science. 2020; 123:209-219.

Robinson, JR; Carroll, RJ; Bastarache, L; Chen, Q; Mou, Z; Wei, W; Connolly, JJ; Mentch, F; Sleiman, P; Crane, PK; et al. Association of Genetic Risk of Obesity with Postoperative Complications Using Mendelian Randomization. World Journal of Surgery. 2020; 44:84-94.

Liu, X; Helenius, D; Skotte, L; Beaumont, RN; Wielscher, M; Geller, F; Juodakis, J; Mahajan, A; Bradfield, JP; Lin, FT; et al. Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration. Nature Communications. 2019; 10.

Monangi, N; Zhang, G; Hallman, M; Teramo, K; Jacobson, B; Muglia, L. Maternal genome and pregnancy outcomes. In: Hod M; Berghella V; Dalton M; Gratacos E; Fanos V, Ed. New Technologies and Perinatal Medicine Prediction and Prevention of Pregnancy Complications. Boca Raton, FL: CRC Press; 2019.

Chen, A; Jandarov, R; Zhou, L; Calafat, AM; Zhang, G; Urbina, EM; Sarac, J; Augustin, DH; Caric, T; Bockor, L; et al. Association of perfluoroalkyl substances exposure with cardiometabolic traits in an island population of the eastern Adriatic coast of Croatia. Science of the Total Environment. 2019; 683:29-36.

Warrington, NM; Beaumont, RN; Horikoshi, M; Day, FR; Helgeland, O; Laurin, C; Bacelis, J; Peng, S; Hao, K; Feenstra, B; et al. Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors. Nature Genetics. 2019; 51:804-814.

Hallman, M; Haapalainen, A; Huusko, JM; Karjalainen, MK; Zhang, G; Muglia, LJ; Ramet, M. Spontaneous premature birth as a target of genomic research. Pediatric Research. 2019; 85:422-431.

Chen, J; Xu, H; Jegga, A; Zhang, K; White, PS; Zhang, G. Novel phenotype-disease matching tool for rare genetic diseases. Genetics in Medicine. 2019; 88:341-348.

Nebert, DW; Zhang, G. Pharmacogenomics. Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics: Foundations. : Elsevier; Elsevier; 2019.

Rappoport, N; Toung, J; Hadley, D; Wong, RJ; Fujioka, K; Reuter, J; Abbott, CW; Oh, S; Hu, D; Eng, C; et al. A genome-wide association study identifies only two ancestry specific variants associated with spontaneous preterm birth. Scientific Reports. 2018; 8.

Sirota, M; Thomas, CG; Liu, R; Zuhl, M; Banerjee, P; Wong, RJ; Quaintance, CC; Leite, R; Chubiz, J; Anderson, R; et al. Data descriptor: Enabling precision medicine in neonatology, an integrated repository for preterm birth research. Scientific Data. 2018; 5.

Bacelis, J; Juodakis, J; Waldorf, KM A; Sengpiel, V; Muglia, LJ; Zhang, G; Jacobsson, B. Uterine distention as a factor in birth timing: retrospective nationwide cohort study in Sweden. BMJ Open. 2018; 8:e022929-e022929.

Zhang, G; Srivastava, A; Bacelis, J; Juodakis, J; Jacobsson, B; Muglia, LJ. Genetic studies of gestational duration and preterm birth. Best Practice and Research: Clinical Obstetrics and Gynaecology. 2018; 52:33-47.

Huusko, JM; Karjalainen, MK; Graham, BE; Zhang, G; Farrow, EG; Miller, NA; Jacobsson, B; Eidem, HR; Murray, JC; Bedell, B; et al. Whole exome sequencing reveals HSPA1L as a genetic risk factor for spontaneous preterm birth. PLoS Genetics. 2018; 14:e1007394-e1007394.

Beaumont, RN; Warrington, NM; Cavadino, A; Tyrrell, J; Nodzenski, M; Horikoshi, M; Geller, F; Myhre, R; Richmond, RC; Paternoster, L; et al. Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics. Human Molecular Genetics. 2018; 27:742-756.

Zhang, G; Feenstra, B; Bacelis, J; Liu, X; Muglia, LM; Juodakis, J; Miller, DE; Litterman, N; Jiang, P; Russell, L; et al. Genetic Associations With Gestational Duration and Spontaneous Preterm Birth. Obstetrical and Gynecological Survey. 2018; 73:83-85.

Mohanty, V; Zhang, G; Komurov, K. Pan-Cancer Analysis of Heritable Genetic Variations Reveals Cancer-Specific Activation of Dormant Oncogenic Pathways. 2018.

Zhang, G; Feenstra, B; Bacelis, J; Liu, X; Muglia, LM; Juodakis, J; Miller, DE; Litterman, N; Jiang, P; Russell, L; et al. Genetic Associations with Gestational Duration and Spontaneous Preterm Birth. The New England journal of medicine. 2017; 377:1156-1167.

Zhang, G; Nebert, DW. Personalized medicine: Genetic risk prediction of drug response. Pharmacology and Therapeutics. 2017; 175:75-90.

Juodakis, J; Bacelis, J; Zhang, G; Muglia, LJ; Jacobsson, B. Time-Variant Genetic Effects as a Cause for Preterm Birth: Insights from a Population of Maternal Cousins in Sweden. G3-Genes Genomes Genetics. 2017; 7:1349-1356.

Huang, M; Graham, BE; Zhang, G; Harder, R; Kodaman, N; Moore, JH; Muglia, L; Williams, SM. Evolutionary triangulation: informing genetic association studies with evolutionary evidence. BioData Mining. 2016; 9.

Brubaker, D; Liu, Y; Wang, J; Tan, H; Zhang, G; Jacobsson, B; Muglia, L; Mesiano, S; Chance, MR. Finding lost genes in GWAS via integrative-omics analysis reveals novel sub-networks associated with preterm birth. Human Molecular Genetics. 2016; 25:ddw325-ddw325.

Jorge-Nebert, LF; Zhang, G; Wilson, KM; Jiang, Z; Butler, R; Gluckman, JL; Pinney, SM; Nebert, DW. Head-and-neck squamous cell carcinoma risk in smokers: no association detected between phenotype and AHR, CYP1A1, CYP1A2, or CYP1B1 genotype. Human Genomics. 2016; 10:39-17.

Bacelis, J; Juodakis, J; Sengpiel, V; Zhang, G; Myhre, R; Muglia, LJ; Nilsson, S; Jacobsson, B. Literature-Informed Analysis of a Genome-Wide Association Study of Gestational Age in Norwegian Women and Children Suggests Involvement of Inflammatory Pathways. PLoS ONE. 2016; 11:e0160335-e0160335.