Zhang Pregnancy Genomics Lab

Publications

Srivastava, AK; Juodakis, J; Sole-Navais, P; Chen, J; Bacelis, J; Teramo, K; Hallman, M; Njølstad, PR; Evans, DM; Jacobsson, B; Muglia, LJ; Zhang, G. Haplotype-based analysis distinguishes maternal-fetal genetic contribution to pregnancy-related outcomes. PLoS Genetics. 2025; 21(3):e1011575.

Robinson, JF; Das, S; Khan, W; Khanam, R; Price, JT; Rahman, A; Ahmed, S; Ali, SM; Deb, S; Deveale, B; Jehan, F; Sazawal, S; Stringer, JSA; Fisher, SJ. High rates of placental inflammation among samples collected by the Multi-Omics for Mothers and Infants consortium. American Journal of Obstetrics and Gynecology. 2025; 232(2):230.e1-230.e19.

Sebastião, YV; Thiruvengadam, R; Khanam, R; Mehmood, U; Pervin, J; Desiraju, BK; Kabole, F; Ahmed, S; Aktar, S; Chowdhury, NH; Jehan, F; Baqui, AH; Stringer, JSA; Bhatnagar, S. Association between gestational weight gain and adverse pregnancy outcomes: cohort analysis from South Asia and Sub-Saharan Africa. BMJ Public Health. 2025; 3(1):e000900.

Solé-Navais, P; Juodakis, J; Ytterberg, K; Wu, X; Bradfield, JP; Vaudel, M; Labella, AL; Helgeland, Ø; Flatley, C; Geller, F; Muglia, LJ; Johansson, S; Zhang, G; Jacobsson, B. Genome-wide analyses of neonatal jaundice reveal a marked departure from adult bilirubin metabolism. Nature Communications. 2024; 15(1):7550.

Xu, H; Zhang, G; Chen, J. A novel method for cell deconvolution using DNA methylation in PCA space. BMC Genomics. 2024; 25(1):798.

Srivastava, AK; Monangi, N; Ravichandran, V; Solé-Navais, P; Jacobsson, B; Muglia, LJ; Zhang, G. Recent Advances in Genomic Studies of Gestational Duration and Preterm Birth. Clinics in Perinatology. 2024; 51(2):313-329.

Pavličev, M; Mcdonough-Goldstein, CE; Zupan, AM; Muglia, L; Hu, Y-C; Kong, F; Monangi, N; Dagdas, G; Zupančič, N; Maziarz, J; Sinner, D; Zhang, G; Wagner, G; Muglia, L. A common allele increases endometrial Wnt4 expression, with antagonistic implications for pregnancy, reproductive cancers, and endometriosis. Nature Communications. 2024; 15(1):1152.

Monangi, NK; Xu, H; Fan, Y-M; Khanam, R; Khan, W; Deb, S; Pervin, J; Price, JT; Kaur, L; Al Mahmud, A; Stringer, JSA; Ashorn, P; Zhang, G; Muglia, LJ. Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis. American Journal of Clinical Nutrition. 2024; 119(1):221-231.

Beaumont, RN; Flatley, C; Vaudel, M; Wu, X; Chen, J; Moen, G-H; Skotte, L; Helgeland, Ø; Solé-Navais, P; Banasik, K; Johansson, S; Freathy, RM; Feenstra, B; Njølstad, PR. Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth. Nature Genetics. 2023; 55(11):1807-1819.

Pasanen, A; Karjalainen, MK; Zhang, G; Tiensuu, H; Haapalainen, AM; Ojaniemi, M; Feenstra, B; Jacobsson, B; Palotie, A; Laivuori, H; Muglia, LJ; Rämet, M; Hallman, M. Meta-analysis of genome-wide association studies of gestational duration and spontaneous preterm birth identifies new maternal risk loci. PLoS Genetics. 2023; 19(10):e1010982.

Wang, L; Rossi, RM; Chen, X; Chen, J; Runyon, J; Chawla, M; Miller, D; Forney, C; Lynch, A; Zhang, X; Kottyan, LC; Weirauch, MT; Zhang, G; Muglia, LJ. A functional mechanism for a non-coding variant near AGTR2 associated with risk for preterm birth. BMC Medicine. 2023; 21(1):258.

Sincerbeaux, G; Schulze, K; Kim, H; Baker, S; Wu, LSF; Rebholz, C; Gogain, J; Cuddeback, L; Monangi, N; Zhang, G; West, K. P07-054-23 A Plasma Cuprome Reveals the Biology and Status of Copper in 1st Trimester Pregnant Women in Rural Bangladesh. Current Developments in Nutrition. 2023; 7:101045.

Ge, X; Schulze, K; Stephenson, K; Wu, LS-F; Baker, S; Ali, H; Shaikh, S; Monangi, N; Zhang, G; Landero, J; West, K; Christian, P. P07-023-23 Human Milk Zinc, Copper, and Selenium Concentrations at 3 Months Postpartum Among Bangladeshi Women: Associations With Maternal Plasma Mineral Concentrations. Current Developments in Nutrition. 2023; 7:101014.

Solé-Navais, P; Flatley, C; Steinthorsdottir, V; Vaudel, M; Juodakis, J; Chen, J; Laisk, T; Labella, AL; Westergaard, D; Bacelis, J; Freathy, RM; Johansson, S; Zhang, G; Jacobsson, B. Genetic effects on the timing of parturition and links to fetal birth weight. Nature Genetics. 2023; 55(4):559-567.

Srivastava, AK; Williams, SM; Zhang, G. Heritability Estimation Approaches Utilizing Genome-Wide Data. Current Protocols. 2023; 3(4):e734.

Robinson, JR; Carroll, RJ; Bastarache, L; Chen, Q; Pirruccello, J; Mou, Z; Wei, W-Q; Connolly, J; Mentch, F; Crane, PK; Weng, C; Roden, D; Khera, AV; Denny, JC. Quantifying the phenome-wide disease burden of obesity using electronic health records and genomics. Obesity. 2022; 30(12):2477-2488.

Muglia, LJ; Monangi, N; Hallman, M; Teramo, K; Jacobsson, B; Zhang, G. Preventing Spontaneous Preterm Birth: Insights from Genomics. Annales Academiae Scientiarum Fennicae. 2022; 1(1):108-123.

Yang, Z; Shikany, A; Ni, Y; Zhang, G; Weaver, KN; Chen, J. Using deep learning and electronic health records to detect Noonan syndrome in pediatric patients. Genetics in Medicine. 2022; 24(11):2329-2337.

Sprague, AC; Niu, L; Jandarov, R; Zhang, X; Zhang, G; Chen, A; Šarac, J; Čoklo, M; Missoni, S; Rudan, P; Langevin, SM; Deka, R. Stable methylation loci are associated with systolic blood pressure in a Croatian island population. Epigenomics. 2022; 14(21):1343-1354.

Jain, VG; Monangi, N; Zhang, G; Muglia, LJ. Genetics, epigenetics, and transcriptomics of preterm birth. American Journal of Reproductive Immunology. 2022; 88(4):e13600.

Chen, J; Navais, PS; Xu, H; Flatley, C; Bacelis, J; Monangi, N; Kacerovsky, M; Hallman, M; Teramo, K; Lawlor, DA; Murray, JC; Jacobsson, B; Muglia, LJ; Zhang, G. Interrogating the causal effects of maternal circulating CRP on gestational duration and birth weight. . 2022; 2022.05.16.22275164.

Sole-Navais, P; Flatley, C; Steinthorsdottir, V; Vaudel, M; Juodakis, J; Chen, J; Laisk, T; Labella, AL; Westergaard, D; Bacelis, J; Freathy, RM; Johanson, S; Zhang, G; Jacobsson, B. Genetic effects on the timing of parturition and links to fetal birth weight. . 2022; 2022.05.04.22274624.

Haskell, MJ; Maleta, K; Arnold, CD; Jorgensen, JM; Fan, Y-M; Ashorn, U; Matchado, A; Monangi, NK; Zhang, G; Xu, H; Muglia, LJ; Hallman, M; Ashorn, P; Dewey, KG. Provision of Small-Quantity Lipid-Based Nutrient Supplements Increases Plasma Selenium Concentration in Pregnant Women in Malawi: A Secondary Outcome of a Randomized Controlled Trial. Current Developments in Nutrition. 2022; 6(3):nzac013.

Care, AG; Gupta, JK; Goodfellow, L; Zhang, G; Monangi, N; Belling, E; Landero, J; Chappell, J; Sharp, A; Alfirevic, A; Müller-Myhsok, B; Muglia, LJ; Alfirevic, Z. Maternal selenium levels and whole genome screen in recurrent spontaneous preterm birth population: A nested case control study. European Journal of Obstetrics and Gynecology and Reproductive Biology. 2021; 265:203-211.

Eric, V; Yi, V; Murdock, D; Kalla, SE; Wu, T-J; Sabo, A; Li, S; Meng, Q; Tian, X; Murugan, M; Wiesner, GL; Jarvik, GP; Muzny, D; Gibbs, RA. Neptune: an environment for the delivery of genomic medicine. Genetics in Medicine. 2021; 23(10):1838-1846.

Monangi, N; Xu, H; Khanam, R; Khan, W; Deb, S; Pervin, J; Price, JT; Kennedy, SH; Al Mahmud, A; Fan, Y; Sazawal, S; Stringer, J; Zhang, G; Muglia, L. Association of maternal prenatal selenium concentration and preterm birth: a multicountry meta-analysis. BMJ Global Health. 2021; 6(9).

Huusko, JM; Tiensuu, H; Haapalainen, AM; Pasanen, A; Tissarinen, P; Karjalainen, MK; Zhang, G; Christensen, K; Ryckman, KK; Jacobsson, B; Murray, JC; Kingsmore, SF; Hallman, M; Muglia, LJ; Rämet, M. Integrative genetic, genomic and transcriptomic analysis of heat shock protein and nuclear hormone receptor gene associations with spontaneous preterm birth. Scientific Reports. 2021; 11(1):17115.

Sole-Navais, P; Bacelis, J; Helgeland, Ø; Modzelewska, D; Vaudel, M; Flatley, C; Andreassen, O; Njølstad, PR; Muglia, LJ; Johansson, S; Zhang, G; Jacobsson, B. Autozygosity mapping and time-to-spontaneous delivery in Norwegian parent-offspring trios. Human Molecular Genetics. 2021; 29(23):3845-3858.