Divanovic Lab

Publications

Klepper, CM; Trout, AT; Dong, S; Fei, L; Stankiewicz, TE; Wayland, J; Moreno-Fernandez, ME; Divanovic, S; Xanthakos, SA; Defranco, E; Woo, JG; Mouzaki, M. Maternal metabolic dysfunction-associated steatotic liver disease during pregnancy and its impact on offspring steatosis. Clinical Nutrition ESPEN. 2025; 70:327-335.

Damen, MS; Alarcon, PC; Chan, CC; Stankiewicz, TE; Chung, H; Sawada, K; Ulanowicz, CJ; Eom, J; Oates, JR; Wayland, JL; Helmrath, MA; Sanchez-Gurmaches, J; Moreno-Fernandez, ME; Divanovic, S. A shift in PKM2 oligomeric state instructs adipocyte inflammatory potential. JCI Insight. 2025; 10(22).

Presicce, P; Beckman, D; Cappelletti, M; Vu, A; Ott, S; Diniz, G; Jobe, A; Chougnet, C; Divanovic, S; Way, SSY; Morrison, J; Kallapur, S. Intrauterine infection causes neuroinflammation and a selective loss of immature neurons in preterm non-human primate (NHP) fetuses 3227. Journal of Immunology. 2025; 214(Supplement_1).

Alarcon, PC; Ulanowicz, CJ; Damen, MSMA; Eom, J; Sawada, K; Chung, H; Alahakoon, T; Oates, JR; Wayland, JL; Stankiewicz, TE; Moreno-Fernandez, ME; Zacharias, WJ; Salomonis, N; Divanovic, S. Obesity Uncovers the Presence of Inflammatory Lung Macrophage Subsets With an Adipose Tissue Transcriptomic Signature in Influenza Virus Infection. Journal of Infectious Diseases. 2025; 231(2):e317-e327.

Park, S-H; Fadhul, T; Conroy, LR; Clarke, HA; Sun, RC; Wallenius, K; Boucher, J; O'mahony, G; Boianelli, A; Persson, M; Bates, EA; Hinds, TD; Divanovic, S; Softic, S. Knockdown of ketohexokinase versus inhibition of its kinase activity exert divergent effects on fructose metabolism. JCI Insight. 2024; 9(23).

Uddin, J; Sharma, A; Wu, D; Tomar, S; Ganesan, V; Reichel, PE; Thota, LNR; Cabrera-Silva, RI; Marella, S; Idelman, G; Divanovic, S; Nusrat, A; Weaver, TE; Hogan, SP. STARD7 maintains intestinal epithelial mitochondria architecture, barrier integrity, and protection from colitis. JCI Insight. 2024; 9(22).

Ragab, M; Schlichting, H; Hicken, M; Mester, P; Hirose, M; Almeida, LN; Christiansen, L; Ibrahim, S; Tews, HC; Divanovic, S; Sina, C; Derer, S. Azathioprine promotes intestinal epithelial cell differentiation into Paneth cells and alleviates ileal Crohn's disease severity. Scientific Reports. 2024; 14(1):12879.

Swertfeger, D; Kim, A; Sexmith, H; Moreno-Fernandez, ME; Davidson, WS; Helmrath, M; Jenkins, T; Okura, T; Geh, E; Xanthakos, SA; Szabo, S; Nakamura, T; Divanovic, S; Shah, AS. Presurgery health influences outcomes following vertical sleeve gastrectomy in adolescents. Obesity. 2024; 32(6):1187-1197.

Mouzaki, M; Woo, JG; Divanovic, S. Gestational and Developmental Contributors of Pediatric MASLD. Seminars in Liver Disease. 2024; 44(1):43-53.

Lempicki, MD; Gray, JA; Abuna, G; Murata, RM; Divanovic, S; Mcnamara, CA; Meher, AK. BAFF neutralization impairs the autoantibody-mediated clearance of dead adipocytes and aggravates obesity-induced insulin resistance. Frontiers in Immunology. 2024; 15:1436900.

Wayland, JL; Stemen, EL; Doll, JR; Divanovic, S. Protocol for cytokine and uterine immune cell characterization in a mouse model of LPS-induced preterm birth. STAR Protocols. 2023; 4(4):102643.

Alarcon, PC; Damen, MSMA; Ulanowicz, CJ; Sawada, K; Oates, JR; Toth, A; Wayland, JL; Chung, H; Stankiewicz, TE; Moreno-Fernandez, ME; Szabo, S; Zacharias, WJ; Divanovic, S. Obesity amplifies influenza virus-driven disease severity in male and female mice. Mucosal Immunology. 2023; 16(6):843-858.

Wayland, JL; Doll, JR; Lawson, MJ; Stankiewicz, TE; Oates, JR; Sawada, K; Damen, MSMA; Alarcon, PC; Haslam, DB; Trout, AT; Woo, JG; Moreno-Fernandez, ME; Mouzaki, M; Divanovic, S. Thermoneutral Housing Enables Studies of Vertical Transmission of Obesogenic Diet-Driven Metabolic Diseases. Nutrients. 2023; 15(23).

Sawada, K; Chung, H; Softic, S; Moreno-Fernandez, ME; Divanovic, S. The bidirectional immune crosstalk in metabolic dysfunction-associated steatotic liver disease. Cell Metabolism. 2023; 35(11):1852-1871.

Park, S-H; Helsley, RN; Fadhul, T; Willoughby, JLS; Noetzli, L; Tu, H-C; Solheim, MH; Fujisaka, S; Pan, H; Dreyfuss, JM; Kern, PA; Divanovic, S; Kahn, CR; Softic, S. Fructose induced KHK-C can increase ER stress independent of its effect on lipogenesis to drive liver disease in diet-induced and genetic models of NAFLD. Metabolism: Clinical and Experimental. 2023; 145:155591.

Ragab, M; Raschdorf, A; Margis, D; Schlichting, H; Hicken, M; Mester, P; Hirose, M; Kubetzko, L; Ibrahim, S; Tews, H; Divanovic, S; Sina, C; Derer, S. Azathioprine promotes intestinal Paneth cell differentiation in Crohn’s disease. Zeitschrift fur Gastroenterologie. 2023; 61(08):e410-e410.

Doll, JR; Moreno-Fernandez, ME; Stankiewicz, TE; Wayland, JL; Wilburn, A; Weinhaus, B; Chougnet, CA; Giordano, D; Cappelletti, M; Presicce, P; Kallapur, SG; Salomonis, N; Tilburgs, T; Divanovic, S. BAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth. Cell reports. 2023; 42(4):112352.

Oates, JR; Sawada, K; Giles, DA; Alarcon, PC; Damen, MSMA; Szabo, S; Stankiewicz, TE; Moreno-Fernandez, ME; Divanovic, S. Thermoneutral housing shapes hepatic inflammation and damage in mouse models of non-alcoholic fatty liver disease. Frontiers in Immunology. 2023; 14:1095132.

Wen, B; Wang, G; Li, E; Kolesnichenko, OA; Tu, Z; Divanovic, S; Kalin, TV; Kalinichenko, VV. In vivo generation of bone marrow from embryonic stem cells in interspecies chimeras. eLife. 2022; 11.

Damen, MSMA; Alarcon, PC; Shah, AS; Divanovic, S. Greasing the inflammatory pathogenesis of viral pneumonias in diabetes. Obesity Reviews. 2022; 23(5):e13415.

Föh, B; Buhre, JS; Lunding, HB; Moreno-Fernandez, ME; König, P; Sina, C; Divanovic, S; Ehlers, M. Microbial metabolite butyrate promotes induction of IL-10+IgM+ plasma cells. PLoS ONE. 2022; 17(3):e0266071.

Moreno-Fernandez, ME; Damen, MSMA; Divanovic, S. A protocol for isolation of primary human immune cells from the liver and mesenteric white adipose tissue biopsies. STAR Protocols. 2021; 2(4):100937.

Alarcon, PC; Damen, MSMA; Madan, R; Deepe, GS; Spearman, P; Way, SS; Divanovic, S. Adipocyte inflammation and pathogenesis of viral pneumonias: an overlooked contribution. Mucosal Immunology. 2021; 14(6):1224-1234.

Damen, MSMA; Stankiewicz, TE; Park, S-H; Helsley, RN; Chan, CC; Moreno-Fernandez, ME; Doll, JR; Szabo, S; Herbert, DR; Softic, S; Divanovic, S. Non-hematopoietic IL-4Rα expression contributes to fructose-driven obesity and metabolic sequelae. International Journal of Obesity. 2021; 45(11):2377-2387.

Cappelletti, M; Presicce, P; Feiyang, M; Senthamaraikannan, P; Miller, LA; Pellegrini, M; Sim, MS; Jobe, AH; Divanovic, S; Way, SS; Chougnet, CA; Kallapur, SG. The induction of preterm labor in rhesus macaques is determined by the  strength of immune response to intrauterine infection. PLoS Biology. 2021; 19(9):e3001385.

Mcnelis, K; Yodoshi, T; Divanovic, S; Gandhi, C; Kim, JH; Anton, CG; Trout, AT; Mouzaki, M. Hepatic Steatosis in Infancy: The Beginning of Pediatric Nonalcoholic Fatty Liver Disease? JPGN Rep. 2021; 2(3):e113.

Moreno-Fernandez, ME; Sharma, V; Stankiewicz, TE; Oates, JR; Doll, JR; Damen, MSMA; Almanan, MATA; Chougnet, CA; Hildeman, DA; Divanovic, S. Aging mitigates the severity of obesity-associated metabolic sequelae in a gender independent manner. Nutrition & Diabetes. 2021; 11(1):15.

Moreno-Fernandez, ME; Giles, DA; Oates, JR; Chan, CC; Damen, MSMA; Doll, JR; Stankiewicz, TE; Chen, X; Chetal, K; Karns, R; Inge, TH; Deshmukh, H; Salomonis, N; Divanovic, S. PKM2-dependent metabolic skewing of hepatic Th17 cells regulates pathogenesis of non-alcoholic fatty liver disease. Cell Metabolism. 2021; 33(6):1187-1204.e9.

Chan, CC; Harley, ITW; Pfluger, PT; Trompette, A; Stankiewicz, TE; Allen, JL; Moreno-Fernandez, ME; Damen, MSMA; Oates, JR; Alarcon, PC; Seeley, RJ; Tschöp, MH; Karp, CL; Divanovic, S. A BAFF/APRIL axis regulates obesogenic diet-driven weight gain. Nature Communications. 2021; 12(1):2911.

Jose, S; Mukherjee, A; Horrigan, O; Setchell, KDR; Zhang, W; Moreno-Fernandez, ME; Andersen, H; Sharma, D; Haslam, DB; Divanovic, S; Madan, R. Obeticholic acid ameliorates severity of Clostridioides difficile infection in high fat diet-induced obese mice. Mucosal Immunology. 2021; 14(2):500-510.

Noah, TK; Lee, J-B; Brown, CA; Yamani, A; Tomar, S; Ganesan, V; Newberry, RD; Huffnagle, GB; Divanovic, S; Hogan, SP. Thermoneutrality Alters Gastrointestinal Antigen Passage Patterning and Predisposes to Oral Antigen Sensitization in Mice. Frontiers in Immunology. 2021; 12:636198.

Uddin, J; Tomar, S; Sharma, A; Waggoner, L; Ganesan, V; Marella, S; Yang, Y; Noah, T; Vanoni, S; Patterson, A; Hoebe, K; Divanovic, S; Munitz, A; Hogan, SP. PIR-B Regulates CD4+ IL17a+ T-Cell Survival and Restricts T-Cell-Dependent Intestinal Inflammatory Responses. Cellular and Molecular Gastroenterology and Hepatology (CMGH). 2021; 12(4):1479-1502.

Thomas, AL; Alarcon, PC; Divanovic, S; Chougnet, CA; Hildeman, DA; Moreno-Fernandez, ME. Implications of Inflammatory States on Dysfunctional Immune Responses in Aging and Obesity. Frontiers in Aging. 2021; 2:732414.