Divanovic Lab

Divanovic Research Lab

Our research program focuses on the role of immune response in inflammation and metabolism. Our expertise in pathways that regulate innate immunity — developed through the pursuit of studies ranging from reductive analysis of TLR ligand signaling to the role of IL-17 axis in experimental models of obesity and infection — have spearheaded the projects aimed at defining the role of the immune mediators in the development and progression of obesity, obesity-associated sequelae and infection / inflammation driven preterm birth.

Recently we have illustrated, to our knowledge, the first evidence for a critical role for IL-17 axis in driving nonalcoholic fatty liver disease (NAFLD) progression, as well as the first report of a role for microbe-driven IL-17 production in exacerbating hepatocellular damage in NAFLD. Current studies are focused on defining the cellular and molecular mechanisms underlying the regulation of NAFLD pathogenesis by the IL-17 axis. Further, we have recently shown that housing animals at thermoneutrality significantly alters animal physiology, immune response and more human-like disease development in mice — something that may allow for better interrogation of cellular and molecular mechanisms underlying disease pathogenesis.

Join the Lab

The Divanovic Lab is currently recruiting for new members. Follow the links below to apply for available opportunities:

Research Assistant II

Contact Us

A photo of Senad Divanovic.

Senad Divanovic, PhD

Associate Professor

Division of Immunobiology, Cincinnati Children's Hospital Medical Center

TCHRF - Location S, Room #S5.405
3333 Burnet Avenue
Cincinnati, Ohio 45229-3039

Phone: 513-636-0286