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A photo of Senad Divanovic.

Member, Division of Immunobiology

Assistant Professor, UC Department of Pediatrics

513-636-0286

Biography & Affiliation

Biography

Dr. Divanovic received his PhD in Molecular and Development Biology from the University of Cincinnati in 2005 with a focus on the regulation of innate immune signaling. He then did a post-doctoral fellowship in the lab of Dr. Christopher Karp where he studied the role of innate immune signaling and inflammation in mouse models of infectious diseases. Among other findings, Dr. Divanovic has identified a biologically important endogenous negative regulator of TLR signaling (Nature Immunol, 6:571) and has shown that tryptophan catabolizing enzymes have opposing biological functions during intracellular infection (J Infectious Dis, 205:152). During post-doctoral fellowship training, Dr. Divanovic began investigating the basic immunology and immune pathogenesis of obesity and obesity-associated sequelae.

Dr. Divanovic’s research has been supported by the National Institutes of Health since 2013. Dr. Divanovic’s research has been described in many publications in numerous prestigious scientific journals including Nature Medicine, Hepatology, and JCI. The past and ongoing work has also been recognized by numerous prestigious awards including the American Diabetes Association Innovative Basic Science Award, the Burroughs Wellcome Fund Award Preterm Birth Initiative, and the Top 7 Breakthrough Discoveries at Cincinnati Children's Hospital Medical Center in 2018.

Clinical Interests

Innate immune responses; obesity; NAFLD; preterm birth; echocardiography; fetal cardiology; Cardiology Consult Service; General Cardiology Outpatient Clinic

Academic Affiliation

Assistant Professor, UC Department of Pediatrics

Departments

Immunobiology, Inflammation and Tolerance

Education

BA: DePauw University, Greencastle, IN, 1998.

MS: Oklahoma State University, Stillwater, OK, 2000.

PhD: University of Cincinnati, Cincinnati, OH, 2005.

Post Doc: Cincinnati Children’s Hospital Medical Center, 2010

Publications

Macrophage Function in the Pathogenesis of Non-alcoholic Fatty Liver Disease: The Mac Attack. Oates, JR; McKell, MC; Moreno-Fernandez, ME; Damen, MS M A; Deepe, GS; Qualls, JE; Divanovic, S. Frontiers in Immunology. 2019; 10.

GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network. Namjou, B; Lingren, T; Huang, Y; Parameswaran, S; Cobb, BL; Stanaway, IB; Connolly, JJ; Mentch, FD; Benoit, B; Niu, X; et al. BMC Medicine. 2019; 17.

Short-term high-fat diet feeding protects from the development of experimental allergic asthma in mice. Schroeder, T; Wiese, AV; Ender, F; Quell, KM; Vollbrandt, T; Duhn, J; Suenderhauf, A; Kuenstner, A; Moreno-Fernandez, ME; Derer, S; et al. Clinical and Experimental Allergy. 2019; 49:1245-1257.

Inflammation and Immunity: From an Adipocyte's Perspective. Chan, CC; Damen, MS M A; Alarcon, PC; Sanchez-Gurmaches, J; Divanovic, S. Journal of Interferon and Cytokine Research. 2019; 39:459-471.

Metallothionein 3 Controls the Phenotype and Metabolic Programming of Alternatively Activated Macrophages. Chowdhury, D; Alrefai, H; Figueroa, JA L; Candor, K; Porollo, A; Fecher, R; Divanovic, S; Jr, DG S; Vignesh, KS. Cell Reports. 2019; 27:3873-3886.e7.

Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology. Zhang, C; Seo, J; Murakami, K; Salem, ES B; Bernhard, E; Borra, VJ; Choi, K; Yuan, CL; Chan, CC; Chen, X; et al. Nature Communications. 2018; 9.

Nicotinamide adenine dinucleotide phosphate (reduced) oxidase 2 modulates inflammatory vigor during nonalcoholic fatty liver disease progression in mice. Mukherjee, R; Moreno-Fernandez, ME; Giles, DA; Cappelletti, M; Stankiewicz, TE; Chan, CC; Divanovic, S. Hepatology Communications. 2018; 2:546-560.

Peroxisomal beta-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease. Moreno-Fernandez, ME; Giles, DA; Stankiewicz, TE; Sheridan, R; Karns, R; Cappelletti, M; Lampe, K; Mukherjee, R; Sina, C; Sallese, A; et al. JCI insight. 2018; 3.

Differential outcomes of TLR2 engagement in inflammation-induced preterm birth. Cappelletti, M; Lawson, MJ; Chan, CC; Wilburn, AN; Divanovic, S. Journal of Leukocyte Biology. 2018; 103:535-543.

Lipopolysaccharide suppresses IgE-mast cell-mediated reactions. Wang, N; McKell, M; Dang, A; Yamani, A; Waggoner, L; Vanoni, S; Noah, T; Wu, D; Kordowski, A; Koehl, J; et al. Clinical and Experimental Allergy. 2017; 47:1574-1585.