Senad Divanovic, PhD

Member, Division of Immunobiology
Associate Professor, UC Department of Pediatrics

senad.divanovic@cchmc.org

My Lab

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About

Biography

My research aims to identify critical knowledge gaps that link immune responses with inflammatory, infectious and metabolic diseases. I gained expertise through the pursuit of studies arising from the reductive analysis of both innate and adaptive immune responses (e.g., TLR, BAFF, Type I IFN and IL-17 signaling) in animal models. These experiences have positioned me well to lead projects aimed at defining the mechanisms underlying immunopathogenesis of various diseases.

Research areas that interest me include immunology, immunometabolism, obesity, non-alcoholic fatty liver disease (NAFLD) and preterm birth. I began my independent research career work at Cincinnati Children's in 2010. My research has been supported by the National Institutes of Health (NIH) since 2013.

The overall goal of my research program is to define the fundamental processes, mechanisms and immune pathways underlying disease pathogenesis. My ultimate objective is translational exploitation of such insights for reducing or eliminating the burden of inflammation-associated diseases.

Specifically, the focus of my laboratory is to exploit:

The immune pathways underlying obesity development and adipocyte-immune like behavior
The immune pathways underling increased infectious susceptibility in obesity
Immunopathogenesis of NAFLD
Obesity-dependent vertical transmission of adverse offspring health outcomes
Immunopathogenesis of preterm birth
The role of thermoneutral housing on immune responses and disease pathogenesis

Further, our experimental models are supported by established and ever-developing platforms of primary human samples from individuals clinically stratified into respective disease categories.

Some of my most notable discoveries include identifying RP105 as a negative regulator of TLR4 signaling, demonstrating how IL-17 axis functions in the regulation of NAFLD progression and employing thermoneutrality as an improved, more “human-like” approach, to study inflammatory and metabolic diseases.

It is my honor to have received several awards, including:

2012 Trustee Award, Cincinnati Children’s
2018 Milstein Award, International Cytokine & Interferon Society (ICIS)
2018 Top 7 Breakthrough Discoveries, Cincinnati Children’s
2020 Cincinnati Children’s Research Foundation (CCRF) Endowed Scholar
2018 Innovative Basic Science Award, American Diabetes Association (ADA)
2015 Preterm Birth Initiative Award, Burroughs Wellcome Fund

Interests

Innate immune responses; obesity; NAFLD; preterm birth; echocardiography; fetal cardiology; Cardiology Consult Service; General Cardiology Outpatient Clinic

Research Areas

Immunobiology, Inflammation and Tolerance

Publications

Greasing the inflammatory pathogenesis of viral pneumonias in diabetes. Damen, MS M A; Alarcon, PC; Shah, AS; Divanovic, S. Obesity Reviews. 2022; 23.

Microbial metabolite butyrate promotes induction of IL-10+IgM+ plasma cells. Föh, B; Buhre, JS; Lunding, HB; Moreno-Fernandez, ME; König, P; Sina, C; Divanovic, S; Ehlers, M. PLoS ONE. 2022; 17.

A protocol for isolation of primary human immune cells from the liver and mesenteric white adipose tissue biopsies. Moreno-Fernandez, ME; Damen, MS M A; Divanovic, S. STAR Protocols. 2021; 2.

A BAFF/APRIL axis regulates obesogenic diet-driven weight gain. Chan, CC; Harley, IT W; Pfluger, PT; Trompette, A; Stankiewicz, TE; Allen, JL; Moreno-Fernandez, ME; Damen, MS M A; Oates, JR; Alarcon, PC; et al. Nature Communications. 2021; 12.

Adipocyte inflammation and pathogenesis of viral pneumonias: an overlooked contribution. Alarcon, PC; Damen, MS M A; Madan, R; Deepe, GS; Spearman, P; Way, SS; Divanovic, S. Mucosal Immunology. 2021; 14:1224-1234.

Non-hematopoietic IL-4Rα expression contributes to fructose-driven obesity and metabolic sequelae. Damen, MS M A; Stankiewicz, TE; Park, SH; Helsley, RN; Chan, CC; Moreno-Fernandez, ME; Doll, JR; Szabo, S; Herbert, DB R; Softic, S; et al. International Journal of Obesity. 2021; 45:2377-2387.

Implications of Inflammatory States on Dysfunctional Immune Responses in Aging and Obesity. Thomas, AL; Alarcon, PC; Divanovic, S; Chougnet, CA; Hildeman, DA; Moreno-Fernandez, ME. 2021; 2.

The induction of preterm labor in rhesus macaques is determined by the strength of immune response to intrauterine infection. Cappelletti, M; Presicce, P; Feiyang, M; Senthamaraikannan, P; Miller, LA; Pellegrini, M; Sim, MS; Jobe, AH; Divanovic, S; Way, SS; et al. PLoS Biology. 2021; 19.

Hepatic Steatosis in Infancy: The Beginning of Pediatric Nonalcoholic Fatty Liver Disease?. McNelis, K; Yodoshi, T; Divanovic, S; Gandhi, C; Kim, JH; Anton, CG; Trout, AT; Mouzaki, M. 2021; 2.

PIR-B Regulates CD4+ IL17a+ T-Cell Survival and Restricts T-Cell-Dependent Intestinal Inflammatory Responses. Uddin, J; Tomar, S; Sharma, A; Waggoner, L; Ganesan, V; Marella, S; Yang, Y; Noah, T; Vanoni, S; Patterson, A; et al. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2021; 12:1479-1502.