Hildeman Lab

Publications

Ahmari, N; Choi, K; Wu, J; Rizvi, TA; Jackson, M; Kershner, LJ; Kim, M-O; Zhang, X; Dombi, E; Shern, J; Hildeman, DA; Ratner, N. Daytime SHP2 inhibitor dosing, when immune cell numbers are elevated, shrinks neurofibromas. Life Science Alliance. 2025; 8(12).

Mukhopadhyay, E; Lakes, N; Krishnamurthy, D; Tuazon, JA; Ohayon, DE; Ali, A; Seelamneni, H; Lee, LH; Hildeman, DA; Waggoner, SN. RNA helicase DDX3X promotes NK cell survival by supporting MCL1 expression. Journal of Immunology. 2025; 214(12):3218-3227.

Kudira, R; Yang, ZF; Osuji, I; Damen, MSMA; Yang Vom Hofe, A; Singh, M; Karns, R; Bariya, P; Pfuhler, L; Mullen, M; Subramanian, S; Salomonis, N; Miraldi, ER; Miethke, AG. Bile acids engage the SIPR-STAT3 signaling axis to modulate regulatory T cell responses in fibrosing cholangiopathies. Journal of Hepatology. 2025; 83(5):1128-1141.

Peters, AL; Depasquale, EAK; Begum, G; Roskin, KM; Kotliar, M; Barski, A; Salomonis, N; Shi, T; Ranganathan, S; Woodle, ES; Hildeman, DA. Single-cell transcriptional landscape of liver transplant rejection reveals tissue persistence of clonally expanded, treatment-resistant T cells. American Journal of Transplantation. 2025; 25(11):2345-2360.

Fava, A; Wagner, CA; Guthridge, CJ; Macwana, S; Dejager, W; Munroe, ME; Izmirly, P; Belmont, HM; Diamond, B; Davidson, A; Petri, M; Guthridge, JM; Buyon, J; James, JA. Serum Soluble Mediator Signatures of Lupus Nephritis: Histologic Features and Response to Treatment. Arthritis Care and Research. 2025.

Horisberger, A; Griffith, A; Keegan, J; Arazi, A; Pulford, J; Murzin, E; Howard, K; Hancock, B; Fava, A; Sasaki, T; Diamond, B; Zhang, F; Lederer, JA; Rao, DA. Blood immunophenotyping identifies distinct kidney histopathology and outcomes in patients with lupus nephritis. Journal of Clinical Investigation. 2025; 135(16).

Caldwell, J; Peters, A; Depasquale, E; Burg, A; Caine, R; Begum, G; Woodle, E; Hildeman, D. Integration of scRNAseq Analyses of Kidney and Liver Allograft Rejection Enables Identification of Common and Unique Characteristics. American Journal of Transplantation. 2025; 25(8):s304.

Peters, AL; Depasquale, E; Begum, G; Seraphine, K; Steinkamp, S; Huppert, S; Woodle, E; Hildeman, D. Multiome Sequencing of Chronic Ductopenic Rejection Reveals Roles for Th2 Immunity and Activated Fibroblasts in Cholangiocyte Injury. American Journal of Transplantation. 2025; 25(8):s245.

Caine, R; Shi, T; Burg, A; Alloway, R; Shields, AR; Roskin, K; Woodle, E; Hildeman, D. Single-Cell RNA/TCR Sequencing: Do Urinary CD8+ T Cell Populations Accurately Reflect Transcriptional Profiling of Allograft Infiltrating CD8+ T Cell Populations? American Journal of Transplantation. 2025; 25(8):s8-s9.

Burg, A; Brambley, C; Ferguson, A; Cianciolo, E; Caine, R; Shi, T; Khorki, M; Chukwuma, P; Woodle, E; Maltzman, J; Baker, B; Hildeman, D. Leveraging Heterologous Immunity to Provide Insights into Alloreactivity. American Journal of Transplantation. 2025; 25(8):s94.

Burg, A; Ferguson, A; Rossi, A; Shields, AR; Allman, D; Hildeman, D; Woodle, E. Human Long-Lived Plasma Cells Acquire Resistance to Proteasome Inhibitor-Based Desensitization Treatment by Upregulating Autophagy. American Journal of Transplantation. 2025; 25(8):s315-s316.

Lan, JH; Tran, J; Avgay, G; Niemann, M; Bandstra, S; Alloway, RR; First, M; Fitzsimmons, B; Hildeman, D; Gill, JS; Woodle, E. HLA T Cell Epitope Mismatch and the Risk of Acute Rejection Among Participants in the Astellas Double Blind Randomized Early Corticosteroid Cessation Trial. American Journal of Transplantation. 2025; 25(8):s116.

Caldwell, J; Shi, T; Burg, A; Roskin, K; Shields, AR; Woodle, E; Hildeman, D. Co-Stimulatory Blockade Prevents Intragraft Accrual of Class-Switched, Activated B Cells and Th17 T Cells and Promotes Accrual of Tregs. American Journal of Transplantation. 2025; 25(8):s391-s392.

Inamo, J; Keegan, J; Griffith, A; Ghosh, T; Horisberger, A; Howard, K; Pulford, JF; Murzin, E; Hancock, B; Dominguez, ST; Deane, KD; Lederer, J; Rao, DA; Zhang, F. Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis. Journal of Clinical Investigation. 2025; 135(6).

Rudman-Melnick, V; Vanhoutte, D; Stowers, K; Sargent, M; Adam, M; Ma, Q; Perl, AKT; Miethke, AG; Burg, A; Shi, T; Hildeman, DA; Woodle, ESS; Kofron, JM; Devarajan, P. Gucy1α1 specifically marks kidney, heart, lung and liver fibroblasts. Scientific Reports. 2024; 14(1):29307.

Fava, A; Wagner, CA; Guthridge, CJ; Kheir, J; Macwana, S; Dejager, W; Gross, T; Izmirly, P; Belmont, HM; Diamond, B; Guthridge, JM; Petri, M; Buyon, J; James, JA. Association of Autoantibody Concentrations and Trajectories With Lupus Nephritis Histologic Features and Treatment Response. Arthritis & Rheumatology. 2024; 76(11):1611-1622.

Pundavela, J; Dinglasan, SA; Touvron, M; Hummel, SA; Hu, L; Rizvi, TA; Choi, K; Hildeman, DA; Ratner, N. Stimulator of interferon gene facilitates recruitment of effector CD8 T cells that drive neurofibromatosis type 1 nerve tumor initiation and maintenance. Science Advances. 2024; 10(42):eado6342.

Thorman, AW; Reigle, J; Chutipongtanate, S; Yang, J; Shamsaei, B; Pilarczyk, M; Fazel-Najafabadi, M; Adamczak, R; Kouril, M; Bhatnagar, S; Hildeman, DA; Medvedovic, M; Herr, AB; Meller, J. Accelerating drug discovery and repurposing by combining transcriptional signature connectivity with docking. Science Advances. 2024; 10(35):eadj3010.

Potter, A; Wikenheiser-Brokamp, K; Hildeman, D; Sharma, N; Gu, M; Patel, K; Qureshi, M; Khan, MM; Wallace, C; Ziady, A; Hayes, D. (601) Decoding T Cell Clonal Dynamics in Acute Lung Rejection. The Journal of Heart and Lung Transplantation. 2024; 43(4):s293.

Ochoa, TA; Rossi, A; Woodle, ES; Hildeman, D; Allman, D. The Proteasome Inhibitor Bortezomib Induces p53-Dependent Apoptosis in Activated B Cells. Journal of Immunology. 2024; 212(1):154-164.

Thomas, AL; Godarova, A; Wayman, JA; Miraldi, ER; Hildeman, DA; Chougnet, CA. Accumulation of immune-suppressive CD4 + T cells in aging - tempering inflammaging at the expense of immunity. Seminars in Immunology. 2023; 70:101836.

Mahajan, S; Alexander, A; Koenig, Z; Saba, N; Prasanphanich, N; Hildeman, DA; Chougnet, CA; Defranco, E; Andorf, S; Tilburgs, T. Antigen-specific decidual CD8+ T cells include distinct effector memory and tissue-resident memory cells. JCI Insight. 2023; 8(17).

Ware, J; Mcelhinney, K; Latham, T; Lane, A; Dienger-Stambaugh, K; Hildeman, D; Spearman, P; Ware, RE. Sustained and Boosted Antibody Responses in Breast Milk After Maternal SARS-CoV-2 Vaccination. Breastfeeding Medicine. 2023; 18(8):612-620.

Shi, T; Burg, AR; Caldwell, JT; Roskin, KM; Castro-Rojas, CM; Chukwuma, PC; Gray, GI; Foote, SG; Alonso, JA; Cuda, CM; Shields, AR; Baker, BM; Woodle, ES; Hildeman, DA. Single-cell transcriptomic analysis of renal allograft rejection reveals insights into intragraft TCR clonality. Journal of Clinical Investigation. 2023; 133(14).

Rossi, AP; Tremblay, S; Castro-Rojas, CM; Burg, AA; Roskin, KM; Gehman, JM; Rike-Shields, A; Alloway, RR; Brailey, P; Allman, D; Hildeman, DA; Woodle, ES. Effects of invivo CXCR4 blockade and proteasome inhibition on bone marrow plasma cells in HLA-sensitized kidney transplant candidates. American Journal of Transplantation. 2023; 23(6):759-775.

Peters, AL; Rogers, M; Begum, G; Sun, Q; Fei, L; Leino, D; Hildeman, D; Woodle, ES. T-cell infiltrate intensity is associated with delayed response to treatment in late acute cellular rejection in pediatric liver transplant recipients. Pediatric Transplantation. 2023; 27(3):e14475.

Vitale, I; Pietrocola, F; Guilbaud, E; Aaronson, SA; Abrams, JM; Adam, D; Agostini, M; Agostinis, P; Alnemri, ES; Altucci, L; Zhou, W; Piacentini, M; Kroemer, G; Galluzzi, L. Apoptotic cell death in disease-Current understanding of the NCCD 2023. Cell Death and Differentiation. 2023; 30(5):1097-1154.

Khorki, ME; Shi, T; Cianciolo, EE; Burg, AR; Chukwuma, PC; Picarsic, JL; Morrice, MK; Woodle, ES; Maltzman, JS; Ferguson, A; Katz, JD; Baker, BM; Hildeman, DA. Prior viral infection primes cross-reactive CD8+ T cells that respond to mouse heart allografts. Frontiers in Immunology. 2023; 14:1287546.

Shi, T; Malik, A; Yang Vom Hofe, A; Matuschek, L; Mullen, M; Lages, CS; Kudira, R; Singh, R; Zhang, W; Setchell, KDR; Hildeman, D; Pasare, C; Wagner, B; Miethke, AG. Farnesoid X receptor antagonizes macrophage-dependent licensing of effector T lymphocytes and progression of sclerosing cholangitis. Science Translational Medicine. 2022; 14(675):eabi4354.

Thomas, AL; Lehn, MA; Janssen, EM; Hildeman, DA; Chougnet, CA. Naturally-aged microglia exhibit phagocytic dysfunction accompanied by gene expression changes reflective of underlying neurologic disease. Scientific Reports. 2022; 12(1):19471.

Carlucci, PM; Li, J; Fava, A; Deonaraine, KK; Wofsy, D; James, JA; Putterman, C; Diamond, B; Davidson, A; Fine, DM; Ishimori, M; Weisman, MH; Buyon, JP; Petri, M. High incidence of proliferative and membranous nephritis in SLE patients with low proteinuria in the Accelerating Medicines Partnership. Rheumatology. 2022; 61(11):4335-4343.

Korinfskaya, S; Kotliar, M; Katko, A; Hildeman, D; Miraldi, ER; Barski, A. Role of transcription factor RUNX1 in the maintenance of T helper cell epigenome and rapid recall response. Journal of Immunology. 2022; 208(Supplement_1):56.13-56.13.

Shanmuganad, S; Hummel, SA; Varghese, V; Hildeman, DA. Bcl-2 Is Necessary to Counteract Bim and Promote Survival of TCRαβ+CD8αα+ Intraepithelial Lymphocyte Precursors in the Thymus. Journal of Immunology. 2022; 208(3):651-659.

Rossi, AP; Alloway, RR; Hildeman, D; Woodle, ES. Plasma cell biology: Foundations for targeted therapeutic development in transplantation. Immunological Reviews. 2021; 303(1):168-186.

Moreno-Fernandez, ME; Sharma, V; Stankiewicz, TE; Oates, JR; Doll, JR; Damen, MSMA; Almanan, MATA; Chougnet, CA; Hildeman, DA; Divanovic, S. Aging mitigates the severity of obesity-associated metabolic sequelae in a gender independent manner. Nutrition & Diabetes. 2021; 11(1):15.

Kirk, AD; Adams, AB; Durrbach, A; Ford, ML; Hildeman, DA; Larsen, CP; Vincenti, F; Wojciechowski, D; Woodle, ES. Optimization of de novo belatacept-based immunosuppression administered to renal transplant recipients. American Journal of Transplantation. 2021; 21(5):1691-1698.

Davis, G; York, AJ; Bacon, WC; Lin, S-C; Mcneal, MM; Yarawsky, AE; Maciag, JJ; Miller, JLC; Locker, KCS; Bailey, M; Jordan, MB; Herr, AB; Hildeman, DA; Molkentin, JD. Seroprevalence of SARS-CoV-2 infection in Cincinnati Ohio USA from August to December 2020. PLoS ONE. 2021; 16(7):e0254667.

Thomas, AL; Alarcon, PC; Divanovic, S; Chougnet, CA; Hildeman, DA; Moreno-Fernandez, ME. Implications of Inflammatory States on Dysfunctional Immune Responses in Aging and Obesity. Frontiers in Aging. 2021; 2:732414.

Shi, T; Roskin, K; Baker, BM; Woodle, ES; Hildeman, D. Advanced Genomics-Based Approaches for Defining Allograft Rejection With Single Cell Resolution. Frontiers in Immunology. 2021; 12:750754.