Hildeman Lab

Newton, HS; Gawali, VS; Chimote, AA; Lehn, MA; Palackdharry, SM; Hinrichs, BH; Jandarov, R; Hildeman, D; Janssen, EM; Wise-Draper, TM; et al. PD1 blockade enhances K + channel activity, Ca 2+ signaling, and migratory ability in cytotoxic T lymphocytes of patients with head and neck cancer. Journal for ImmunoTherapy of Cancer. 2020; 8:e000844-e000844.

Almanan, M; Raynor, J; Ogunsulire, I; Malyshkina, A; Mukherjee, S; Hummel, SA; Ingram, JT; Saini, A; Xie, MM; Alenghat, T; et al. IL-10–producing Tfh cells accumulate with age and link inflammation with age-related immune suppression. Science Advances. 2020; 6:eabb0806-eabb0806.

Woodle, ES; Tremblay, S; Rossi, A; Rojas, CC; Alloway, R; Roskin, K; Allman, D; Hildeman, D. Plasma cell targeting to prevent antibody-mediated rejection. American Journal of Transplantation. 2020; 20 Suppl 4:33-41.

Castro-Rojas, CM; Godarova, A; Shi, T; Hummel, SA; Shields, A; Tremblay, S; Alloway, RR; Jordan, MB; Woodle, ES; Hildeman, DA. mTOR Inhibitor Therapy Diminishes Circulating CD8⁺ CD28^- Effector Memory T Cells and Improves Allograft Inflammation in Belatacept-refractory Renal Allograft Rejection. Transplantation. 2020; 104:1058-1069.

Li, K; Ladle, BH; Kurtulus, S; Sholl, A; Shanmuganad, S; Hildeman, DA. T-cell receptor signal strength and epigenetic control of Bim predict memory CD8⁺ T-cell fate. Cell Death and Differentiation. 2020; 27:1214-1224.

Raynor, J; Lin, A; Hummel, SA; Lampe, K; Jordan, M; Hoebe, K; Hildeman, DA. The Variable Genomic NK Cell Receptor Locus Is a Key Determinant of CD4+ T Cell Responses During Viral Infection. Frontiers in Immunology. 2020; 11.

Tremblay, S; Driscoll, JJ; Rike-Shields, A; Hildeman, DA; Alloway, RR; Girnita, AL; Brailey, PA; Woodle, ES. A prospective, iterative, adaptive trial of carfilzomib-based desensitization. American Journal of Transplantation. 2020; 20:411-421.

Der, E; Suryawanshi, H; Morozov, P; Kustagi, M; Goilav, B; Ranabathou, S; Izmirly, P; Clancy, R; Belmont, HM; Koenigsberg, M; et al. Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways. Nature Immunology. 2019; 20:915-927.

Arazi, A; Rao, DA; Berthier, CC; Davidson, A; Liu, Y; Hoover, PJ; Chicoine, A; Eisenhaure, TM; Jonsson, AH; Li, S; et al. The immune cell landscape in kidneys of patients with lupus nephritis. Nature Immunology. 2019; 20:902-914.

Castro-Rojas, CM; Alloway, RR; Woodle, ES; Hildeman, DA. High-Dimensional Renal Profiling: Towards a Better Understanding of Renal Transplant Immune Suppression. Current Transplantation Reports. 2019; 6:60-68.

Alder, MN; Mallela, J; Opoka, AM; Lahni, P; Hildeman, DA; Wong, HR. Olfactomedin 4 marks a subset of neutrophils in mice. Innate Immunity. 2019; 25:22-33.

Patterson, AR; Endale, M; Lampe, K; Aksoylar, HI; Flagg, A; Woodgett, JR; Hildeman, D; Jordan, MB; Singh, H; Kucuk, Z; et al. Gimap5-dependent inactivation of GSK3 beta is required for CD4(+) T cell homeostasis and prevention of immune pathology. Nature Communications. 2018; 9.

Carroll, KR; Elfers, EE; Stevens, JJ; McNally, JP; Hildeman, DA; Jordan, MB; Katz, JD. Extending Remission and Reversing New-Onset Type 1 Diabetes by Targeted Ablation of Autoreactive T Cells. Diabetes. 2018; 67:2319-2328.

Kleeman, B; Olsson, A; Newkold, T; Kofron, M; DeLay, M; Hildeman, D; Grimes, HL. A guide to choosing fluorescent protein combinations for flow cytometric analysis based on spectral overlap. Cytometry Part B: Clinical Cytometry. 2018; 93A:556-562.

Presicce, P; Park, C; Senthamaraikannan, P; Bhattacharyya, S; Jackson, C; Kong, F; Rueda, CM; DeFranco, E; Miller, LA; Hildeman, DA; et al. mu-1 signaling mediates intrauterine inflammation and chorio-decidua neutrophil recruitment and activation. JCI insight. 2018; 3.

McKnight, CG; Morris, SC; Perkins, C; Zhu, Z; Hildeman, DA; Bendelac, A; Finkelman, FD. NKT cells contribute to basal IL-4 production but are not required to induce experimental asthma. PLoS ONE. 2017; 12:e0188221-e0188221.

Almanan, M; Raynor, J; Sholl, A; Wang, M; Chougnet, C; Cardin, RD; Hildeman, DA. Tissue-specific control of latent CMV reactivation by regulatory T cells. PLoS Pathogens. 2017; 13:e1006507-e1006507.

McNally, JP; Millen, SH; Chaturvedi, V; Lakes, N; Terrell, CE; Elfers, EE; Carroll, KR; Hogan, SP; Andreassen, PR; Kanter, J; et al. Manipulating DNA damage-response signaling for the treatment of immune-mediated diseases. Proceedings of the National Academy of Sciences of USA. 2017; 114:E4782-E4791.

Li, K; Shanmuganad, S; Carroll, K; Katz, JD; Jordan, MB; Hildeman, DA. Dying to protect: cell death and the control of T-cell homeostasis. Immunological Reviews. 2017; 277:21-43.

Alder, MN; Opoka, AM; Lahni, P; Hildeman, DA; Wong, HR. Olfactomedin-4 Is a Candidate Marker for a Pathogenic Neutrophil Subset in Septic Shock. Critical Care Medicine. 2017; 45:e426-e432.

Berberich, I; Hildeman, DA. The Bcl2a1 gene cluster finally knocked out: first clues to understanding the enigmatic role of the Bcl-2 protein A1. Cell Death and Differentiation. 2017; 24:572-574.

Cappelletti, M; Presicce, P; Lawson, MJ; Chaturvedi, V; Stankiewicz, TE; Vanoni, S; Harley, IT W; McAlees, JW; Giles, DA; Moreno-Fernandez, ME; et al. Type I interferons regulate susceptibility to inflammation-induced preterm birth. JCI insight. 2017; 2.

Rice, TC; Armocida, SM; Kuethe, JW; Midura, EF; Jain, A; Hildeman, DA; Healy, DP; Gulbins, E; Caldwell, CC. Burn injury influences the T cell homeostasis in a butyrate-acid sphingomyelinase dependent manner. Cellular Immunology. 2017; 313:25-31.

Li, K; Faehnrich, A; Roy, E; Cuda, CM; Grimes, HL; Perlman, HR; Kalies, K; Hildeman, DA. Temporal Expression of Bim Limits the Development of Agonist-Selected Thymocytes and Skews Their TCR beta Repertoire. Journal of immunology (Baltimore, Md. : 1950). 2017; 198:257-269.

Tripathi, P; Morris, SC; Perkins, C; Sholl, A; Finkelman, FD; Hildeman, DA. IL-4 and IL-15 promotion of virtual memory CD8(+) T cells is determined by genetic background. European Journal of Immunology. 2016; 46:2333-2339.

Ladle, BH; Li, K; Phillips, MJ; Pucsek, AB; Haile, A; Powell, JD; Jaffee, EM; Hildeman, DA; Gamper, CJ. De novo DNA methylation by DNA methyltransferase 3a controls early effector CD8+ T-cell fate decisions following activation. Proceedings of the National Academy of Sciences of USA. 2016; 113:10631-10636.

Chougnet, C; Hildeman, D. Helios-controller of Treg stability and function. Translational cancer research. 2016; 5:S338-S341.

Kuethe, JW; Armocida, SM; Midura, EF; Rice, TC; Hildeman, DA; Healy, DP; Caldwell, CC. FECAL MICROBIOTA TRANSPLANT RESTORES MUCOSAL INTEGRITY IN A MURINE MODEL OF BURN INJURY. Shock. 2016; 45:647-652.