A photo of David Hildeman.

Director, Immunology Graduate Program

Professor, UC Department of Pediatrics

513-636-3923

513-636-5355

Biography & Affiliation

Clinical Interests

T cells; autoimmunity; sex differences in immune responses; apoptosis

Research Interests

Molecular factors that control the decision between tolerance and immunity within T lymphocytes; staphylococcal enterotoxins, recombinant vaccinia viruses, lymphocytic choriomeningitis virus and MHC tetrameric reagents; antigen -specific T cell responses; tolerance centers on regulation of mechanisms that control the survival and death of activated T cells in vivo, namely Bcl-2 and its antagonist Bim; manipulation and regulation of antigen-specific T cell responses via novel vaccine strategies to either induce tolerance or enhance immunity; mechanisms underlying sex-based differences in T cell responses and how these differences relate to autoimmune disease.

Academic Affiliation

Professor, UC Department of Pediatrics

Divisions

Fibrosis, Immunobiology

Education

PhD: University of Wisconsin-Madison, Madison, Wisconsin, 1997.

Publications

The Variable Genomic NK Cell Receptor Locus Is a Key Determinant of CD4+ T Cell Responses During Viral Infection. Raynor, J; Lin, A; Hummel, SA; Lampe, K; Jordan, M; Hoebe, K; Hildeman, DA. Frontiers in Immunology. 2020; 11.

A prospective, iterative, adaptive trial of carfilzomib-based desensitization. Tremblay, S; Driscoll, JJ; Rike-Shields, A; Hildeman, DA; Alloway, RR; Girnita, AL; Brailey, PA; Woodle, ES. American Journal of Transplantation. 2020; 20:411-421.

Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways. Der, E; Suryawanshi, H; Morozov, P; Kustagi, M; Goilav, B; Ranabathou, S; Izmirly, P; Clancy, R; Belmont, HM; Koenigsberg, M; et al. Nature Immunology. 2019; 20:915-927.

The immune cell landscape in kidneys of patients with lupus nephritis. Arazi, A; Rao, DA; Berthier, CC; Davidson, A; Liu, Y; Hoover, PJ; Chicoine, A; Eisenhaure, TM; Jonsson, AH; Li, S; et al. Nature Immunology. 2019; 20:902-914.

High Dimensional Renal Profiling: Towards a Better Understanding or Renal Transplant Immune Suppression. Castro-Rojas, CM; Alloway, RR; Woodle, ES; Hildeman, DA. Current Transplantation Reports. 2019; 6:60-68.

Olfactomedin 4 marks a subset of neutrophils in mice. Alder, MN; Mallela, J; Opoka, AM; Lahni, P; Hildeman, DA; Wong, HR. Innate Immunity. 2019; 25:22-33.

Gimap5-dependent inactivation of GSK3 beta is required for CD4(+) T cell homeostasis and prevention of immune pathology. Patterson, AR; Endale, M; Lampe, K; Aksoylar, HI; Flagg, A; Woodgett, JR; Hildeman, D; Jordan, MB; Singh, H; Kucuk, Z; et al. Nature Communications. 2018; 9.

Extending Remission and Reversing New-Onset Type 1 Diabetes by Targeted Ablation of Autoreactive T Cells. Carroll, KR; Elfers, EE; Stevens, JJ; McNally, JP; Hildeman, DA; Jordan, MB; Katz, JD. Diabetes. 2018; 67:2319-2328.

A guide to choosing fluorescent protein combinations for flow cytometric analysis based on spectral overlap. Kleeman, B; Olsson, A; Newkold, T; Kofron, M; DeLay, M; Hildeman, D; Grimes, HL. Cytometry Part B: Clinical Cytometry. 2018; 93A:556-562.

mu-1 signaling mediates intrauterine inflammation and chorio-decidua neutrophil recruitment and activation. Presicce, P; Park, C; Senthamaraikannan, P; Bhattacharyya, S; Jackson, C; Kong, F; Rueda, CM; DeFranco, E; Miller, LA; Hildeman, DA; et al. JCI insight. 2018; 3.