A photo of David Hildeman.

Director, Immunology Graduate Program

Professor, UC Department of Pediatrics



Biography & Affiliation

Clinical Interests

T cells; autoimmunity; sex differences in immune responses; apoptosis

Research Interests

Molecular factors that control the decision between tolerance and immunity within T lymphocytes; staphylococcal enterotoxins, recombinant vaccinia viruses, lymphocytic choriomeningitis virus and MHC tetrameric reagents; antigen -specific T cell responses; tolerance centers on regulation of mechanisms that control the survival and death of activated T cells in vivo, namely Bcl-2 and its antagonist Bim; manipulation and regulation of antigen-specific T cell responses via novel vaccine strategies to either induce tolerance or enhance immunity; mechanisms underlying sex-based differences in T cell responses and how these differences relate to autoimmune disease.

Academic Affiliation

Professor, UC Department of Pediatrics


Fibrosis, Immunobiology

Science Blog

New Concept for Boosting Flu Vaccine Power Also Might Apply to Future COVID-19 Vaccines

Infectious Diseases and Vaccines

New Concept for Boosting Flu Vaccine Power Also Might Apply to Future COVID-19 Vaccines

David A. Hildeman, PhD7/29/2020


PhD: University of Wisconsin-Madison, Madison, Wisconsin, 1997.


The Variable Genomic NK Cell Receptor Locus Is a Key Determinant of CD4+ T Cell Responses During Viral Infection. Raynor, J; Lin, A; Hummel, SA; Lampe, K; Jordan, M; Hoebe, K; Hildeman, DA. Frontiers in Immunology. 2020; 11.

A prospective, iterative, adaptive trial of carfilzomib-based desensitization. Tremblay, S; Driscoll, JJ; Rike-Shields, A; Hildeman, DA; Alloway, RR; Girnita, AL; Brailey, PA; Woodle, ES. American Journal of Transplantation. 2020; 20:411-421.

Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways. Der, E; Suryawanshi, H; Morozov, P; Kustagi, M; Goilav, B; Ranabathou, S; Izmirly, P; Clancy, R; Belmont, HM; Koenigsberg, M; et al. Nature Immunology. 2019; 20:915-927.

The immune cell landscape in kidneys of patients with lupus nephritis. Arazi, A; Rao, DA; Berthier, CC; Davidson, A; Liu, Y; Hoover, PJ; Chicoine, A; Eisenhaure, TM; Jonsson, AH; Li, S; et al. Nature Immunology. 2019; 20:902-914.

High Dimensional Renal Profiling: Towards a Better Understanding or Renal Transplant Immune Suppression. Castro-Rojas, CM; Alloway, RR; Woodle, ES; Hildeman, DA. Current Transplantation Reports. 2019; 6:60-68.

Olfactomedin 4 marks a subset of neutrophils in mice. Alder, MN; Mallela, J; Opoka, AM; Lahni, P; Hildeman, DA; Wong, HR. Innate Immunity. 2019; 25:22-33.

Gimap5-dependent inactivation of GSK3 beta is required for CD4(+) T cell homeostasis and prevention of immune pathology. Patterson, AR; Endale, M; Lampe, K; Aksoylar, HI; Flagg, A; Woodgett, JR; Hildeman, D; Jordan, MB; Singh, H; Kucuk, Z; et al. Nature Communications. 2018; 9.

Extending Remission and Reversing New-Onset Type 1 Diabetes by Targeted Ablation of Autoreactive T Cells. Carroll, KR; Elfers, EE; Stevens, JJ; McNally, JP; Hildeman, DA; Jordan, MB; Katz, JD. Diabetes. 2018; 67:2319-2328.

A guide to choosing fluorescent protein combinations for flow cytometric analysis based on spectral overlap. Kleeman, B; Olsson, A; Newkold, T; Kofron, M; DeLay, M; Hildeman, D; Grimes, HL. Cytometry Part B: Clinical Cytometry. 2018; 93A:556-562.

mu-1 signaling mediates intrauterine inflammation and chorio-decidua neutrophil recruitment and activation. Presicce, P; Park, C; Senthamaraikannan, P; Bhattacharyya, S; Jackson, C; Kong, F; Rueda, CM; DeFranco, E; Miller, LA; Hildeman, DA; et al. JCI insight. 2018; 3.