I received my Bachelor of Science degree in Microbiology from the University of Puerto Rico, Mayagüez Campus. I joined the Immunology graduate program at University of Texas Southwestern Medical Center in 2015. My graduate thesis research focuses on uncovering how macrophage behavior is regulated by an adaptor protein called BCAP (B-cell adapter for PI3K). We have defined a role for BCAP in controlling and shaping macrophage activation downstream of Toll-like Receptor signaling, and I’m further investigating the role of this adaptor protein in vivo in the context of tissue repair and tumor immunology. Additionally, in a separate project, I am interested in better understanding the molecular players that engage IRAK1 during rapid inflammasome activation and how this rapid activation can shape the adaptive immune response to an invading pathogen.
I received my Bachelor of Science degree from Westminster College, PA and joined the Molecular Genetics, Biochemistry, and Microbiology PhD program at the University of Cincinnati in 2020. I became a member of the Pasare lab in the Immunology program at Cincinnati Children’s in 2021. My graduate work focuses on the role of Tumor Necrosis Factor alpha (TNFa) in regulating the synthesis of Pro-IL1b in Bone Marrow Derived Dendritic Cells in a time-dependent manner. In a separate project, I am interested in the adaptor protein called BCAP and its role in macrophage activation and differentiation.
I received my Bachelor of Science degree from the University of Tennessee, Knoxville and joined the graduate program at UT Southwestern in 2015. My graduate work focuses on the role of inflammasome activation in adaptive immune responses. While it is known that inflammasome associated cytokines are important for T cell responses, it has not been directly investigated how inflammasome activation in antigen presenting cells can affect adaptive immune response. In a separate project, I am also interested the role of endosomal/phagosomal maturation in innate and adaptive immune responses.
I received my Bachelor of Science degree from the University of Cincinnati, Ohio and joined the Immunology graduate program at Cincinnati Children’s in 2018. My graduate work focuses on how IL-1b mediates the cross-talk between the innate and adaptive immune system during autoimmune inflammation. In a separate project, I am interested in identifying the molecular mechanisms by which VPS33b (vacuolar protein sorting-associated protein 33b) regulates pattern recognition receptor signaling and mediates downstream production of type 1 IFNs.
I obtained my Bachelor of Science in Biochemistry from New Mexico State University and joined the graduate program at University of Texas Southwestern Medical center in 2016. My graduate thesis research focuses on understanding host-pathogen interactions at the mucosal surface. Specifically, my project aims to define the role of IL-1R (Interleukin-1 Receptor), an innate cytokine receptor, on intestinal epithelial cells to regulate intestinal barrier function, intestinal homeostasis, and gut immunity. Additionally, in a separate project, I am interested in better understanding how route of immunization influences the generation of long-term immunological CD8 T cell memory.
Senior Research Assistant / Lab Manager Pasare Lab
I have been working here at Cincinnati Children's for almost six years but I am new addition to the Pasare lab. I received my BS from St. Joseph’s University in Philadelphia in 2002 and then went on to receive my MA from the University of Virginia in 2003. I have been a lab manager for the past 13 years both at UMASS Medical School in Worcester, MA and here at Cincinnati Children's Hospital Medical Center in Allergy & Immunology. I have a background in innate and adaptive immunity and look forward to working with the Pasare Lab. My husband is an assistant professor in the Center of AutoImmune and Genomic Etiology. We have four children that keep us extremely busy outside of work.