The Pasare Lab focuses on understanding the fundamental mechanisms of activation of the innate immune system and its impact on inflammation and adaptive immunity.

The innate immune system relies on specific receptors called pattern recognition receptors to recognize pathogens. Pathogen recognition by the innate immune system leads to inflammation and also activation of adaptive immunity.

The main goal of the lab is to understand the intricate interplay and cross-talk between the innate and adaptive immune systems. In particular, we strive to understand how the innate immune system induces inflammation and its impact on both protective immunity as well as inflammatory disorders.

We have identified several novel proteins and pathways in cells of both innate and adaptive immune systems and use them as handles to address questions relevant to protective immunity, inflammatory disorders and cancer. We use cutting-edge in vitro and in vivo approaches in our studies that are likely to lead to new targets to treat auto-immunity, inflammatory diseases and cancer.