Pasare Lab

Publications

Kawarizadeh, K; Vallez, CN; Aliyazdi, S; Warrick, KA; Carafice, C; Saha, I; Pasare, C. Absence of BCAP in myeloid cells abrogates M2 macrophage differentiation and promotes anti-tumor immunity. iScience. 2025; 28(11):113723.

Vallez, CN; Ando, S; Araki, K; Pasare, C. Memory CD8+ T cell-induced activation of the innate immune system drives inflammation and anti-viral immunity 3109. Journal of Immunology. 2025; 214(Supplement_1).

Warrick, KA; Molkentin, JD; Pasare, C. Immune checkpoint blockade induces de novo CD8 T cell priming and innate inflammation leading to myocarditis 3714. Journal of Immunology. 2025; 214(Supplement_1).

Warrick, KA; Vallez, CN; Meibers, HE; Pasare, C. Bidirectional Communication Between the Innate and Adaptive Immune Systems. Annual Review of Immunology. 2025; 43(1):489-514.

Lagos, J; Holder, U; Sagadiev, S; Montiel-Armendariz, A; Li, LZ; Pasare, C; Hou, B; Hamerman, JA; Acharya, M. B cell adapter for PI 3-kinase (BCAP) coordinates antigen internalization and trafficking through the B cell receptor. Science Advances. 2024; 10(46):eadp1747.

Saha, I; Chawla, AS; Oliveira, APBN; Elfers, EE; Warrick, K; Meibers, HE; Jain, VG; Hagan, T; Katz, JD; Pasare, C. Alloreactive memory CD4 T cells promote transplant rejection by engaging DCs to induce innate inflammation and CD8 T cell priming. Proceedings of the National Academy of Sciences of the United States of America. 2024; 121(34):e2401658121.

Carroll, SL; Pasare, C; Barton, GM. Control of adaptive immunity by pattern recognition receptors. Immunity. 2024; 57(4):632-648.

Meibers, HE; Warrick, KA; Vonhandorf, A; Vallez, CN; Kawarizadeh, K; Saha, I; Donmez, O; Jain, VG; Kottyan, LC; Weirauch, MT; Pasare, C. Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells. Cell reports. 2023; 42(10):113180.

Nowacka, AA; Pasare, C; Köhl, J. 70 C5a receptor 1 controls antigen and TLR-driven T cell proliferation and differentiation by splenic conventional type 2 dendritic cells. Immunobiology. 2023; 228(5):152521.

Overcast, GR; Meibers, HE; Eshleman, EM; Saha, I; Waggoner, L; Patel, KN; Jain, VG; Haslam, DB; Alenghat, T; Vandussen, KL; Pasare, C. IEC-intrinsic IL-1R signaling holds dual roles in regulating intestinal homeostasis and inflammation. Journal of Experimental Medicine (JEM). 2023; 220(6).

Choi, Y; Lichterman, JN; Coughlin, LA; Poulides, N; Li, W; Del Valle, P; Palmer, SN; Gan, S; Kim, J; Zhan, X; Gao, Y; Evers, BM; Hooper, LV; Pasare, C; Koh, AY. Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal antitumor immunity. Science immunology. 2023; 8(81):eabo2003.

Shi, T; Malik, A; Yang Vom Hofe, A; Matuschek, L; Mullen, M; Lages, CS; Kudira, R; Singh, R; Zhang, W; Setchell, KDR; Hildeman, D; Pasare, C; Wagner, B; Miethke, AG. Farnesoid X receptor antagonizes macrophage-dependent licensing of effector T lymphocytes and progression of sclerosing cholangitis. Science Translational Medicine. 2022; 14(675):eabi4354.

Saha, I; Pasare, C. The B cell adapter for PI3K (BCAP) promotes M2 macrophage phenotype and safeguards tumors from immune surveillance. Journal of Immunology. 2022; 208(Supplement_1):61.08-61.08.

Meibers, H; Mcdaniel, MM; Jain, A; Chawla, AS; Pasare, C. Effector memory CD4 T cells engage myeloid cells through TNFR and CD40 to induce innate inflammation and autoimmune pathology independent of pattern recognition receptors. Journal of Immunology. 2022; 208(Supplement_1):164.19-164.19.

Kawarizadeh, K; Warrick, K; Pasare, C. BCAP plays a central role in regulating canonical M2 macrophage polarization upon various cell extrinsic signals. Journal of Immunology. 2022; 208(Supplement_1):111.04-111.04.

Mcdaniel, MM; Chawla, AS; Jain, A; Meibers, HE; Saha, I; Gao, Y; Jain, V; Roskin, K; Way, SS; Pasare, C. Effector memory CD4+ T cells induce damaging innate inflammation and autoimmune pathology by engaging CD40 and TNFR on myeloid cells. Science immunology. 2022; 7(67):eabk0182.

Mcdaniel, MM; Meibers, HE; Pasare, C. Innate control of adaptive immunity and adaptive instruction of innate immunity: bi-directional flow of information. Current Opinion in Immunology. 2021; 73:25-33.

Brusilovsky, M; Rochman, M; Rochman, Y; Caldwell, JM; Mack, LE; Felton, JM; Habel, JE; Porollo, A; Pasare, C; Rothenberg, ME. Environmental allergens trigger type 2 inflammation through ripoptosome activation. Nature Immunology. 2021; 22(10):1316-1326.

Song, R; Gao, Y; Dozmorov, I; Malladi, V; Saha, I; Mcdaniel, MM; Parameswaran, S; Liang, C; Arana, C; Zhang, B; Weirauch, MT; Kottyan, LC; Wakeland, EK; Pasare, C. IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility. Cell reports. 2021; 34(12):108891.