Tilburgs Lab

Publications

Crespo, AC; Mulik, S; Dotiwala, F; Ansara, JA; Sen Santara, S; Ingersoll, K; Ovies, C; Junqueira, C; Tilburgs, T; Strominger, JL; et al. Decidual NK Cells Transfer Granulysin to Selectively Kill Bacteria in Trophoblasts. Cell. 2020; 182:1125-1139.e18.

Papuchova, H; Meissner, TB; Li, Q; Strominger, JL; Tilburgs, T. The Dual Role of HLA-C in Tolerance and Immunity at the Maternal-Fetal Interface. Frontiers in Immunology. 2019; 10:2730.

Salvany-Celades, M; van der Zwan, A; Benner, M; Setrajcic-Dragos, V; Gomes, HA B; Iyer, V; Norwitz, ER; Strominger, JL; Tilburgs, T. Three Types of Functional Regulatory T Cells Control T Cell Responses at the Human Maternal-Fetal Interface. Cell Reports. 2019; 27:2537-2547.e5.

Ferreira, LM R; Meissner, TB; Tilburgs, T; Strominger, JL. HLA-G: At the Interface of Maternal-Fetal Tolerance. Trends in Immunology. 2017; 38:272-286.

Crespo, AC; van der Zwan, A; Ramalho-Santos, J; Strominger, JL; Tilburgs, T. Cytotoxic potential of decidual NK cells and CD8+ T cells awakened by infections. Journal of Reproductive Immunology. 2017; 119:85-90.

Crespo, AC; Strominger, JL; Tilburgs, T. Expression of KIR2DS1 by decidual natural killer cells increases their ability to control placental HCMV infection. Proceedings of the National Academy of Sciences of USA. 2016; 113:15072-15077.

Ferreira, LM R; Meissner, TB; Mikkelsen, TS; Mallard, W; O'Donnell, CW; Tilburgs, T; Gomes, HA B; Camahort, R; Sherwood, RI; Gifford, DK; et al. A distant trophoblast-specific enhancer controls HLA-G expression at the maternal-fetal interface. Proceedings of the National Academy of Sciences of USA. 2016; 113:5364-5369.

Tilburgs, T; Evans, JH; Crespo, AC; Strominger, JL. The HLA-G cycle provides for both NK tolerance and immunity at the maternal-fetal interface. Proceedings of the National Academy of Sciences of USA. 2015; 112:13312-13317.

Tilburgs, T; Strominger, JL. CD8+ effector T cells at the fetal-maternal interface, balancing fetal tolerance and antiviral immunity. American journal of reproductive immunology and microbiology : AJRIM. 2013; 69:395-407.

Houser, BL; Tilburgs, T; Hill, J; Nicotra, ML; Strominger, JL. Two unique human decidual macrophage populations. Journal of immunology (Baltimore, Md. : 1950). 2011; 186:2633-2642.

Tilburgs, T; Schonkeren, D; Eikmans, M; Nagtzaam, NM; Datema, G; Swings, GM; Prins, F; van Lith, JM; van der Mast, BJ; Roelen, DL; et al. Human decidual tissue contains differentiated CD8+ effector-memory T cells with unique properties. Journal of immunology (Baltimore, Md. : 1950). 2010; 185:4470-4477.

Tilburgs, T; Scherjon, SA; van der Mast, BJ; Haasnoot, GW; Versteeg-v.d. Voort-Maarschalk, M; Roelen, DL; van Rood, JJ; Claas, FH J. Fetal-maternal HLA-C mismatch is associated with decidual T cell activation and induction of functional T regulatory cells. Journal of Reproductive Immunology. 2009; 82:148-157.

Tilburgs, T; Roelen, DL; van der Mast, BJ; de Groot-Swings, GM; Kleijburg, C; Scherjon, SA; Claas, FH. Evidence for a selective migration of fetus-specific CD4+CD25bright regulatory T cells from the peripheral blood to the decidua in human pregnancy. Journal of immunology (Baltimore, Md. : 1950). 2008; 180:5737-5745.

Li, G; Mahajan, S; Ma, S; Jeffery, ED; Zhang, X; Bhattacharjee, A; Venkatasubramanian, M; Weirauch, MT; Miraldi, ER; Grimes, HL; et al. Splicing neoantigen discovery with SNAF reveals shared targets for cancer immunotherapy. Science Translational Medicine. 2024; 16:eade2886.

Mahajan, S; Alexander, A; Koenig, Z; Saba, N; Prasanphanich, N; Hildeman, DA; Chougnet, CA; DeFranco, E; Andorf, S; Tilburgs, T. Antigen-specific decidual CD8+ T cells include distinct effector memory and tissue-resident memory cells. JCI insight. 2023; 8:e171806.

Hamilton, I; Ikumi, NM; Kshirsagar, S; Goodman, WA; Tilburgs, T. Utilizing primary HLA-G+ extravillous trophoblasts and HLA-G+ EVT-like cell lines to study maternal-fetal interactions. STAR Protocols. 2023; 4:102276.

Ikumi, NM; Koenig, Z; Mahajan, S; Gray, CM; Tilburgs, T. Purification of primary human placental leukocytes to study maternal-fetal interactions. STAR Protocols. 2023; 4:102277.

Doll, JR; Moreno-Fernandez, ME; Stankiewicz, TE; Wayland, JL; Wilburn, A; Weinhaus, B; Chougnet, CA; Giordano, D; Cappelletti, M; Presicce, P; et al. BAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth. Cell Reports. 2023; 42:112352.

Severance, AL; Kinder, JM; Xin, L; Burg, AR; Shao, TY; Pham, G; Tilburgs, T; Goodman, WA; Mesiano, S; Way, SS. Maternal-fetal conflict averted by progesterone- induced FOXP3+ regulatory T cells. iScience. 2022; 25:104400.

Crespo, ÂC; Alexander, A; Tilburgs, T. Purification of Primary Decidual Natural Killer Cells for Functional Analysis. Methods in molecular biology (Clifton, N.J.). 2022; 2463:11-29.

Ikumi, NM; Pillay, K; Tilburgs, T; Malaba, TR; Dzanibe, S; Enninga, EA L; Chakraborty, R; Lamorde, M; Myer, L; Khoo, S; et al. T-Cell Homeostatic Imbalance in Placentas From Women With Human Immunodeficiency Virus in the Absence of Vertical Transmission. Journal of Infectious Diseases. 2021; 224:S670-S682.

Lekva, T; Roland, MC P; Estensen, ME; Norwitz, ER; Tilburgs, T; Henriksen, T; Bollerslev, J; Normann, KR; Magnus, P; Olstad, OK; et al. Dysregulated non-coding telomerase RNA component and associated exonuclease XRN1 in leucocytes from women developing preeclampsia-possible link to enhanced senescence. Scientific Reports. 2021; 11:19735.

Li, Q; Meissner, TB; Wang, F; Du, Z; Ma, S; Kshirsagar, S; Tilburgs, T; Buenrostro, JD; Uesugi, M; Strominger, JL. ELF3 activated by a superenhancer and an autoregulatory feedback loop is required for high-level HLA-C expression on extravillous trophoblasts. Proceedings of the National Academy of Sciences of USA. 2021; 118:e2025512118.

Tilburgs, T. Chapter 2 Presentation and recognition of placental, fetal, and pathogen-derived antigens in human pregnancy. Reproductive Immunology. : Elsevier; Elsevier; 2021.

Cappelletti, M; Doll, JR; Stankiewicz, TE; Lawson, MJ; Sauer, V; Wen, B; Kalinichenko, VV; Sun, X; Tilburgs, T; Divanovic, S. Maternal regulation of inflammatory cues is required for induction of preterm birth. JCI insight. 2020; 5:e138812.

Crespo, AC; Mulik, S; Dotiwala, F; Ansara, JA; Sen Santara, S; Ingersoll, K; Ovies, C; Junqueira, C; Tilburgs, T; Strominger, JL; et al. Decidual NK Cells Transfer Granulysin to Selectively Kill Bacteria in Trophoblasts. Cell. 2020; 182:1125-1139.e18.

Papuchova, H; Kshirsagar, S; Xu, L; Gomes, HA B; Li, Q; Iyer, V; Norwitz, ER; Strominger, JL; Tilburgs, T. Three types of HLA-G+ extravillous trophoblasts that have distinct immune regulatory properties. Proceedings of the National Academy of Sciences of USA. 2020; 117:15772-15777.

Vieira, RD M; Meagher, A; Crespo, AC; Kshirsagar, SK; Iyer, V; Norwitz, ER; Strominger, JL; Tilburgs, T. Human Term Pregnancy Decidual NK Cells Generate Distinct Cytotoxic Responses. Journal of immunology (Baltimore, Md. : 1950). 2020; 204:3149-3159.

Ng, S; Norwitz, GA; Pavlicev, M; Tilburgs, T; Simon, C; Norwitz, ER. Endometrial Decidualization: The Primary Driver of Pregnancy Health. International Journal of Molecular Sciences. 2020; 21:E4092.