Tilburgs Lab
Publications

Publications

Li, G; Mahajan, S; Ma, S; Jeffery, ED; Zhang, X; Bhattacharjee, A; Venkatasubramanian, M; Weirauch, MT; Miraldi, ER; Grimes, HL; Sheynkman, GM; Tilburgs, T; Salomonis, N. Splicing neoantigen discovery with SNAF reveals shared targets for cancer immunotherapy. Science Translational Medicine. 2024; 16(730):eade2886.

Mahajan, S; Alexander, A; Koenig, Z; Saba, N; Prasanphanich, N; Hildeman, DA; Chougnet, CA; Defranco, E; Andorf, S; Tilburgs, T. Antigen-specific decidual CD8+ T cells include distinct effector memory and tissue-resident memory cells. JCI Insight. 2023; 8(17).

Crespo, ÂC; Mulik, S; Dotiwala, F; Ansara, JA; Sen Santara, S; Ingersoll, K; Ovies, C; Junqueira, C; Tilburgs, T; Strominger, JL; Lieberman, J. Decidual NK Cells Transfer Granulysin to Selectively Kill Bacteria in Trophoblasts. Cell. 2020; 182(5):1125-1139.e18.

Papuchova, H; Kshirsagar, S; Xu, L; Bougleux Gomes, HA; Li, Q; Iyer, V; Norwitz, ER; Strominger, JL; Tilburgs, T. Three types of HLA-G+ extravillous trophoblasts that have distinct immune regulatory properties. Proceedings of the National Academy of Sciences of the United States of America. 2020; 117(27):15772-15777.

De Mendonça Vieira, R; Meagher, A; Crespo, ÂC; Kshirsagar, SK; Iyer, V; Norwitz, ER; Strominger, JL; Tilburgs, T. Human Term Pregnancy Decidual NK Cells Generate Distinct Cytotoxic Responses. Journal of Immunology. 2020; 204(12):3149-3159.

Salvany-Celades, M; Van Der Zwan, A; Benner, M; Setrajcic-Dragos, V; Bougleux Gomes, HA; Iyer, V; Norwitz, ER; Strominger, JL; Tilburgs, T. Three Types of Functional Regulatory T Cells Control T Cell Responses at the Human Maternal-Fetal Interface. Cell reports. 2019; 27(9):2537-2547.e5.

Papúchová, H; Meissner, TB; Li, Q; Strominger, JL; Tilburgs, T. The Dual Role of HLA-C in Tolerance and Immunity at the Maternal-Fetal Interface. Frontiers in Immunology. 2019; 10:2730.

Van Der Zwan, A; Bi, K; Norwitz, ER; Crespo, ÂC; Claas, FHJ; Strominger, JL; Tilburgs, T. Mixed signature of activation and dysfunction allows human decidual CD8+ T cells to provide both tolerance and immunity. Proceedings of the National Academy of Sciences of the United States of America. 2018; 115(2):385-390.

Ferreira, LMR; Meissner, TB; Tilburgs, T; Strominger, JL. HLA-G: At the Interface of Maternal-Fetal Tolerance. Trends in Immunology. 2017; 38(4):272-286.

Crespo, ÂC; Strominger, JL; Tilburgs, T. Expression of KIR2DS1 by decidual natural killer cells increases their ability to control placental HCMV infection. Proceedings of the National Academy of Sciences of the United States of America. 2016; 113(52):15072-15077.

Tilburgs, T; Crespo, ÂC; Van Der Zwan, A; Rybalov, B; Raj, T; Stranger, B; Gardner, L; Moffett, A; Strominger, JL. Human HLA-G+ extravillous trophoblasts: Immune-activating cells that interact with decidual leukocytes. Proceedings of the National Academy of Sciences of the United States of America. 2015; 112(23):7219-7224.

Tilburgs, T; Scherjon, SA; Van Der Mast, BJ; Haasnoot, GW; Versteeg-V D Voort-Maarschalk, M; Roelen, DL; Van Rood, JJ; Claas, FHJ. Fetal-maternal HLA-C mismatch is associated with decidual T cell activation and induction of functional T regulatory cells. Journal of Reproductive Immunology. 2009; 82(2):148-157.

Tilburgs, T; Roelen, DL; Van Der Mast, BJ; De Groot-Swings, GM; Kleijburg, C; Scherjon, SA; Claas, FH. Evidence for a selective migration of fetus-specific CD4+CD25bright regulatory T cells from the peripheral blood to the decidua in human pregnancy. Journal of Immunology. 2008; 180(8):5737-5745.

Tsuda, S; Mahajan, S; Dasenbrock, A; Nakashima, A; Tilburgs, T. AW7 A novel in vitro assay platform to analyze the lymphocytes - HLA-G+ extravillous trophoblasts interaction. Journal of Reproductive Immunology. 2025; 172:104765.

Frøystad, M; Tilburgs, T; Michelsen, TM; Sørbye, IK; Turowski, G; Ueland, T; Lekva, T. Placentas affected by preeclampsia show reduced CD4+ T-cell numbers in decidua basalis and increased EVTs in the chorionic membrane. Placenta. 2025; 171:e272.

Whillock, AL; Smith, P; Sridhar, A; Lindgren, A; Berg, J; Mahajan, S; Tilburgs, T; Schuldt, NJ. Maternal natural microbial exposure in mice increases CD8 T cell heterogeneity at the maternal-fetal interface (MFI) phenocopying the human MFI 3993. Journal of Immunology. 2025; 214(Supplement_1).

Smith, P; Whillock, AL; Burger, S; Sridhar, A; Lindgren, A; Mahajan, S; Tilburgs, T; Schuldt, NJ. Maternal microbial exposure provides novel insights into the balance between tolerance and host defense during pregnancy 2984. Journal of Immunology. 2025; 214(Supplement_1).

Tursi, AR; Lages, CS; Quayle, K; Koenig, ZT; Loni, R; Eswar, S; Cobeña-Reyes, J; Thornton, S; Tilburgs, T; Andorf, S. Automated descriptive cell type naming in flow and mass cytometry with CytoPheno. Scientific Reports. 2025; 15(1):26750.

Prasanphanich, NS; Protti, G; Cappelletti, M; Ma, F; Pithia, N; Dasenbrock, A; Stanek, J; Chougnet, CA; Kallapur, SG; Pellegrini, M; Tilburgs, T; Presicce, P. Granulysin-high decidual NK cells in macaques and humans share signatures of immune defense. Cell reports. 2025; 44(7):115943.

Damianos, A; Wang, G; Ustiyan, V; Deng, Z; Wen, B; Kohran, F; Gao, W; Li, E; Lan, Y-W; Do, J; Xia, X; Tilburgs, T; Stanek, J; Kalin, T; Kalinichenko, V. Identification of FOXF1-expresssing Endothelial Cells in the Placentas Tissues. American Journal of Respiratory and Critical Care Medicine. 2025; 211(Abstracts):a2494-a2494.

Whillock, A; Smith, P; Burger, S; Sridhar, A; Lindgren, A; Berg, J; Tsuda, S; Mahajan, S; Tilburgs, T; Schuldt, NJ. Natural microbial exposure populates the maternal fetal interface with diverse T cells. Frontiers in Immunology. 2025; 16:1616491.

Detomaso, A; Kim, H; Shauh, J; Adulla, A; Zigo, S; Ghoul, M; Presicce, P; Kallapur, SG; Goodman, W; Tilburgs, T; Way, S-S; Hackney, D; Moore, J; Mesiano, S. Progesterone inactivation in decidual stromal cells: A mechanism for inflammation-induced parturition. Proceedings of the National Academy of Sciences of the United States of America. 2024; 121(25):e2400601121.

Li, G; Mahajan, S; Ma, S; Jeffery, ED; Zhang, X; Bhattacharjee, A; Venkatasubramanian, M; Weirauch, MT; Miraldi, ER; Grimes, HL; Sheynkman, GM; Tilburgs, T; Salomonis, N. Splicing neoantigen discovery with SNAF reveals shared targets for cancer immunotherapy. Science Translational Medicine. 2024; 16(730):eade2886.

Tsuda, S; Shichino, S; Tilburgs, T; Shima, T; Morita, K; Yamaki-Ushijima, A; Roskin, K; Tomura, M; Sameshima, A; Saito, S; Nakashima, A. CD4+ T cell heterogeneity in gestational age and preeclampsia using single-cell RNA sequencing. Frontiers in Immunology. 2024; 15:1401738.

Froehlich, F; Landerholm, K; Neeb, J; Meß, A-K; Seiler, DL; Tilburgs, T; Karsten, CM. Emerging role of C5aR2: novel insights into the regulation of uterine immune cells during pregnancy. Frontiers in Immunology. 2024; 15:1411315.

Mahajan, S; Alexander, A; Koenig, Z; Saba, N; Prasanphanich, N; Hildeman, DA; Chougnet, CA; Defranco, E; Andorf, S; Tilburgs, T. Antigen-specific decidual CD8+ T cells include distinct effector memory and tissue-resident memory cells. JCI Insight. 2023; 8(17).

Ikumi, NM; Koenig, Z; Mahajan, S; Gray, CM; Tilburgs, T. Purification of primary human placental leukocytes to study maternal-fetal interactions. STAR Protocols. 2023; 4(2):102277.

Hamilton, I; Ikumi, NM; Kshirsagar, S; Goodman, WA; Tilburgs, T. Utilizing primary HLA-G+ extravillous trophoblasts and HLA-G+ EVT-like cell lines to study maternal-fetal interactions. STAR Protocols. 2023; 4(2):102276.

Doll, JR; Moreno-Fernandez, ME; Stankiewicz, TE; Wayland, JL; Wilburn, A; Weinhaus, B; Chougnet, CA; Giordano, D; Cappelletti, M; Presicce, P; Kallapur, SG; Salomonis, N; Tilburgs, T; Divanovic, S. BAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth. Cell reports. 2023; 42(4):112352.

Severance, AL; Kinder, JM; Xin, L; Burg, AR; Shao, T-Y; Pham, G; Tilburgs, T; Goodman, WA; Mesiano, S; Way, SS. Maternal-fetal conflict averted by progesterone- induced FOXP3+ regulatory T cells. iScience. 2022; 25(6):104400.

Crespo, ÂC; Alexander, A; Tilburgs, T. Purification of Primary Decidual Natural Killer Cells for Functional Analysis. Methods in Molecular Biology. 2022; 2463:11-29.

Ikumi, NM; Pillay, K; Tilburgs, T; Malaba, TR; Dzanibe, S; Enninga, EAL; Chakraborty, R; Lamorde, M; Myer, L; Khoo, S; Jaspan, HB; Gray, CM. T-Cell Homeostatic Imbalance in Placentas From Women With Human Immunodeficiency Virus in the Absence of Vertical Transmission. Journal of Infectious Diseases. 2021; 224(12 Suppl 2):S670-S682.

Lekva, T; Roland, MCP; Estensen, ME; Norwitz, ER; Tilburgs, T; Henriksen, T; Bollerslev, J; Normann, KR; Magnus, P; Olstad, OK; Aukrust, P; Ueland, T. Dysregulated non-coding telomerase RNA component and associated exonuclease XRN1 in leucocytes from women developing preeclampsia-possible link to enhanced senescence. Scientific Reports. 2021; 11(1):19735.

Li, Q; Meissner, TB; Wang, F; Du, Z; Ma, S; Kshirsagar, S; Tilburgs, T; Buenrostro, JD; Uesugi, M; Strominger, JL. ELF3 activated by a superenhancer and an autoregulatory feedback loop is required for high-level HLA-C expression on extravillous trophoblasts. Proceedings of the National Academy of Sciences of the United States of America. 2021; 118(9).

Tilburgs, T. Chapter 2 Presentation and recognition of placental, fetal, and pathogen-derived antigens in human pregnancy. In: Reproductive Immunology. Elsevier; 2021:23-37.

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