Immunobiology

Publications

Ahmari, N; Choi, K; Wu, J; Rizvi, TA; Jackson, M; Kershner, LJ; Kim, MO; Zhang, X; Dombi, E; Shern, J; Hildeman, DA; Ratner, N. Daytime SHP2 inhibitor dosing, when immune cell numbers are elevated, shrinks neurofibromas. Life Science Alliance. 2025; 8:e202503359.

Alarcon, PC; Ulanowicz, CJ; Damen, MS M A; Eom, J; Sawada, K; Chung, H; Alahakoon, T; Oates, JR; Wayland, JL; Stankiewicz, TE; Moreno-Fernandez, ME; Zacharias, WJ; Salomonis, N; Divanovic, S. Obesity Uncovers the Presence of Inflammatory Lung Macrophage Subsets With an Adipose Tissue Transcriptomic Signature in Influenza Virus Infection. The Journal of Infectious Diseases. 2025; 231:e317-e327.

Allen, C; Chandrakasan, S; Jordan, MB; Leiding, JW; Marrone, M; Oladapo, A; Pednekar, P; Walkovich, K; Yee, J. Transplant Related Outcomes in Patients with Hemophagocytic Lymphohistiocytosis Treated with Emapalumab As a Bridge to Hematopoietic Stem Cell Transplantation (HSCT): The Real-HLH Study. Transplantation and Cellular Therapy. 2025; 31:s163-s164.

Ansari, MN; Jha, SK; Khan, A; Rajput, K; Pandey, N; Jain, D; Tripathi, R; Medatwal, N; Sharma, P; Datta, S; Prabhu, JS; Mukhopadhyay, A; Bajaj, A; Dasgupta, U. The mTORC2 subunit RICTOR drives breast cancer progression by promoting ganglioside biosynthesis through transcriptional and epigenetic mechanisms. Editor, Christofk H. PLoS Biology. 2025; 23:e3003362.

Brown-Burke, F; Saadey, R; Mao, HY C; Marra, P; Brooks, E; Wandtke, A; Hout, I; Leon, S; Sharma, A; Yasin, A; Chen, CJ; Jordan, MB; Baiocchi, RA; Shindiapina, P. PRMT5 inhibition reduces hyperinflammation in a murine model of secondary hemophagocytic lymphohistiocytosis. Blood Advances. 2025; 9:2379-2392.

Burg, A; Brambley, C; Ferguson, A; Cianciolo, E; Caine, R; Shi, T; Khorki, M; Chukwuma, P; Woodle, E; Maltzman, J; Baker, B; Hildeman, D. Leveraging Heterologous Immunity to Provide Insights into Alloreactivity. American Journal of Transplantation. 2025; 25:s94.

Burg, A; Ferguson, A; Rossi, A; Shields, AR; Allman, D; Hildeman, D; Woodle, E. Human Long-Lived Plasma Cells Acquire Resistance to Proteasome Inhibitor-Based Desensitization Treatment by Upregulating Autophagy. American Journal of Transplantation. 2025; 25:s315-s316.

Caine, R; Shi, T; Burg, A; Alloway, R; Shields, AR; Roskin, K; Woodle, E; Hildeman, D. Single-Cell RNA/TCR Sequencing: Do Urinary CD8+ T Cell Populations Accurately Reflect Transcriptional Profiling of Allograft Infiltrating CD8+ T Cell Populations?. American Journal of Transplantation. 2025; 25:s8-s9.

Caldwell, J; Peters, A; DePasquale, E; Burg, A; Caine, R; Begum, G; Woodle, E; Hildeman, D. Integration of scRNAseq Analyses of Kidney and Liver Allograft Rejection Enables Identification of Common and Unique Characteristics. American Journal of Transplantation. 2025; 25:s304.

Caldwell, J; Shi, T; Burg, A; Roskin, K; Shields, AR; Woodle, E; Hildeman, D. Co-Stimulatory Blockade Prevents Intragraft Accrual of Class-Switched, Activated B Cells and Th17 T Cells and Promotes Accrual of Tregs. American Journal of Transplantation. 2025; 25:s391-s392.

Caminero, A; Tropini, C; Valles-Colomer, M; Shung, DL; Gibbons, SM; Surette, MG; Sokol, H; Tomeo, NJ; Clark, M; Nguyen, LH; Awoniyi, M; Alenghat, T; Tarr, PI; Verdu, EF. Credible inferences in microbiome research: ensuring rigour, reproducibility and relevance in the era of AI. Nature Reviews: Gastroenterology and Hepatology. 2025; 22:788-803.

Chandrakasan, S; Allen, CE; Bhatla, D; Carter, J; Chien, M; Cooper, R; Draper, L; Eckstein, OS; Hanna, R; Hays, JA; Riskalla, M; Hobday, P; Baker, A; Ward, B. Emapalumab Treatment in Patients With Rheumatologic Disease-Associated Hemophagocytic Lymphohistiocytosis in the United States: A Retrospective Medical Chart Review Study. Arthritis and Rheumatology. 2025; 77:226-238.

Chandrakasan, S; Allen, CE; Bhatla, D; Carter, J; Chien, M; Cooper, R; Draper, L; Eckstein, OS; Hanna, R; Hays, JA; Walkovich, KJ; Yee, JD; Zoref-Lorenz, A; Behrens, EM. Emapalumab treatment in rheumatologic disease-associated hemophagocytic lymphohistiocytosis: a plain language summary. Immunotherapy. 2025; 17:461-478.

Chiang, SC C; Yang, L; Owsley, E; Husami, A; Akeno, N; Cobb, C; Hartog, NL; Elizalde, A; Seroogy, CM; Blanchard-Rohner, G; Marsh, R; Bleesing, J; Jordan, MB; Marwaha, AK. Lipopolysaccharide-responsive and beige-like anchor protein (LRBA) functional deficiency caused by biallelic LRBA missense variants characterized by Evans syndrome or colitis. Journal of Allergy and Clinical Immunology. 2025; 156:270-278.

Compton, SE; DeCamp, LM; Oswald, BM; Kitchen-Goosen, SM; Lau, KH; Fillinger, R; Dahabieh, MS; Ark, AV; Krawczyk, CM; Jones, RG. IL-17 links the tumor suppressor LKB1 to gastrointestinal inflammation and polyposis. Science Advances. 2025; 11:eadt5933.

Cook, E; Haacker, L; Chandra, S; Jordan, MB; Verkamp, B; McCarthy, L; Rotz, SJ; Hammoud, MS; Pariury, H; McKeone, D; Kumar, A. EBV-Associated T/NK-LPD Manifesting As HLH Cured By Nivolumab and Emapalumab, Avoiding the Need for Allogeneic HCT. Transplantation and Cellular Therapy. 2025; 31:s43.

Dahabieh, MS; DeCamp, LM; Oswald, BM; Kitchen-Goosen, SM; Fu, Z; Vos, M; Compton, SE; Longo, J; Foy, NM; Williams, KS; Wu, T; Sheldon, RD; Krawczyk, CM; Jones, RG. The prostacyclin receptor PTGIR is a NRF2-dependent regulator of CD8+ T cell exhaustion. Nature Immunology. 2025; 26:1139-1151.

Damen, MS; Alarcon, PC; Chan, CC; Stankiewicz, TE; Chung, H; Sawada, K; Ulanowicz, CJ; Eom, J; Oates, JR; Wayland, JL; Helmrath, MA; Sanchez-Gurmaches, J; Moreno-Fernandez, ME; Divanovic, S. A shift in PKM2 oligomeric state instructs adipocyte inflammatory potential. JCI insight. 2025; 10:e185914.

Damianos, A; Wang, G; Ustiyan, V; Deng, Z; Wen, B; Kohran, F; Gao, W; Li, E; Lan, Y; Do, J; Xia, X; Tilburgs, T; Stanek, J; Kalin, T; Kalinichenko, V. Identification of FOXF1-expresssing Endothelial Cells in the Placentas Tissues. American Journal of Respiratory and Critical Care Medicine. 2025; 211:a2494.

Ferchen, K; Zhang, X; Thakkar, K; Li, G; Bernardicius, D; Sen, S; Rawat, P; Olsson, A; Bennett, SN; Potter, C; Morris, S; Singh, H; Salomonis, N; Grimes, HL. A unified multimodal single-cell framework reveals a discrete state model of hematopoiesis in mice. Nature Immunology. 2025; 26:2086-2099.

Frøystad, M; Tilburgs, T; Michelsen, TM; Sørbye, IK; Turowski, G; Ueland, T; Lekva, T. Placentas affected by preeclampsia show reduced CD4+ T-cell numbers in decidua basalis and increased EVTs in the chorionic membrane. Placenta. 2025; 171:e272.

Hari Gopal, S; Alenghat, T; Pammi, M. Early life epigenetics and childhood outcomes: a scoping review. Pediatric Research. 2025; 97:1305-1314.

Heuer, LS; Sweeney, N; Rojas, M; Zhang, W; Mendelsohn, AR; Huang, M; Yu, B; Ackerman, P; Wei, Q; Herr, AB; Larrick, JW; Ridgway, WM. Higher order receptor clustering due to the IgG3 subclass is necessary for TLR4 signaling and tolerance induction by novel human anti-TLR4 antibodies. mAbs. 2025; 17:2515415.

Horisberger, A; Griffith, A; Keegan, J; Arazi, A; Pulford, J; Murzin, E; Howard, K; Hancock, B; Fava, A; Sasaki, T; Diamond, B; Zhang, F; Lederer, JA; Rao, DA. Blood immunophenotyping identifies distinct kidney histopathology and outcomes in patients with lupus nephritis. The Journal of Clinical Investigation. 2025; 135:e181034.

Inamo, J; Keegan, J; Griffith, A; Ghosh, T; Horisberger, A; Howard, K; Pulford, JF; Murzin, E; Hancock, B; Dominguez, ST; Tuschl, T; Wofsy, D; Woodle, S; Wyse, A. Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis. The Journal of Clinical Investigation. 2025; 135:e185217.

Jess, J; Verkamp, B; Jordan, M. Vitamin D Deficiency Is Prevalent and Resistant to Correction in Patients with Hemophagocytic Lymphohistiocytosis. 2025; 1.

Kawarizadeh, K; Vallez, CN; Aliyazdi, S; Warrick, KA; Carafice, C; Saha, I; Pasare, C. Absence of BCAP in myeloid cells abrogates M2 macrophage differentiation and promotes anti-tumor immunity. iScience. 2025; 28:113723.

Khoury, R; Jordan, M; Bleesing, J; Kumar, A; Saldana, BD; Verkamp, B; Davies, S; Marsh, R; Chandra, S. Addition of Thiotepa to Alemtuzumab, Fludarabine, and Melphalan Reduced-Intensity Conditioning Reduces Secondary Graft Failure in Allogeneic HSCT for Inborn Errors of Immunity. 2025; 1.

Klepper, CM; Trout, AT; Dong, S; Fei, L; Stankiewicz, TE; Wayland, J; Moreno-Fernandez, ME; Divanovic, S; Xanthakos, SA; DeFranco, E; Woo, JG; Mouzaki, M. Maternal metabolic dysfunction-associated steatotic liver disease during pregnancy and its impact on offspring steatosis. Clinical Nutrition ESPEN. 2025; 70:327-335.

Kudira, R; Yang, ZF; Osuji, I; Damen, MS M A; Yang vom Hofe, A; Singh, M; Karns, R; Bariya, P; Pfuhler, L; Mullen, M; Subramanian, S; Salomonis, N; Miraldi, ER; Miethke, AG. Bile acids engage the SIPR-STAT3 signaling axis to modulate regulatory T cell responses in fibrosing cholangiopathies. Journal of Hepatology. 2025; 83:1128-1141.

Lan, JH; Tran, J; AvGay, G; Niemann, M; Bandstra, S; Alloway, RR; First, M; Fitzsimmons, B; Hildeman, D; Gill, JS; Woodle, E. HLA T Cell Epitope Mismatch and the Risk of Acute Rejection Among Participants in the Astellas Double Blind Randomized Early Corticosteroid Cessation Trial. American Journal of Transplantation. 2025; 25:s116.

Longo, J; DeCamp, LM; Oswald, BM; Teis, R; Reyes-Oliveras, A; Dahabieh, MS; Ellis, AE; Vincent, MP; Damico, H; Gallik, KL; Krawczyk, CM; Haab, BB; Sheldon, RD; Jones, RG. Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control. Cell Metabolism. 2025; 37:1890-1906.e11.

Marsh, R; Khoury, R; Mizuno, K; Hosawi, A; Cottrell, C; Nguyen, E; Landon, B; Chandra, S; Jordan, M; Kumar, A; Bleesing, J; Davies, S; Moore, C; Mehta, P. Precision Alemtuzumab Dosing Results in Day 0 Target Range Achievement in 80% of IEI Patients and Minimizes Risks of GVHD, Clinically Significant Mixed Chimerism, and Secondary Graft Failure. 2025; 1.

Ng, LG; Ballesteros, I; Cassatella, MA; Egeblad, M; Fridlender, ZG; Gabrilovich, D; Gao, Q; Granot, Z; Grieshaber-Bouyer, R; Grimes, HL; Udalova, IA; Xue, R; Zhang, N; Kwok, I. From complexity to consensus: A roadmap for neutrophil classification. Immunity. 2025; 58:1890-1903.

Peters, AL; DePasquale, E; Begum, G; Seraphine, K; Steinkamp, S; Huppert, S; Woodle, E; Hildeman, D. Multiome Sequencing of Chronic Ductopenic Rejection Reveals Roles for Th2 Immunity and Activated Fibroblasts in Cholangiocyte Injury. American Journal of Transplantation. 2025; 25:s245.

Peters, AL; DePasquale, EA K; Begum, G; Roskin, KM; Kotliar, M; Barski, A; Salomonis, N; Shi, T; Ranganathan, S; Woodle, ES; Hildeman, DA. Single-cell transcriptional landscape of liver transplant rejection reveals tissue persistence of clonally expanded, treatment-resistant T cells. American Journal of Transplantation. 2025; 25:2345-2360.

Peters, M; Teodorescu, P; Pasca, S; Zhang, X; Wang, R; Yegnasubramanian, S; Grimes, LH; Salomonis, N; Gondek, LP; Ghiaur, G. Comprehensive characterization of human bone marrow microenvironment shows age-related changes. Haematologica: the hematology journal. 2025; 110:2844-2848.

Prasanphanich, NS; Protti, G; Cappelletti, M; Ma, F; Pithia, N; Dasenbrock, A; Stanek, J; Chougnet, CA; Kallapur, SG; Pellegrini, M; Tilburgs, T; Presicce, P. Granulysin-high decidual NK cells in macaques and humans share signatures of immune defense. Cell Reports. 2025; 44:115943.

Rana, K; Yadav, P; Chakraborty, R; Jha, SK; Agrawal, U; Bajaj, A. Engineered Nanomicelles Delivering the Combination of Steroids and Antioxidants Can Mitigate Local and Systemic Inflammation, Including Sepsis. ACS Applied Materials and Interfaces. 2025; 17:11595-11610.

Secchia, S; Beilinson, V; Chen, X; Gucwa, M; Denson, LA; Miraldi, ER; Weirauch, MT; Ikegami, K. Starvation activates ECM-remodeling gene transcription and putative enhancers in fibroblasts despite inducing quiescence. Cell Reports. 2025; 44:115896.

Sezaki, M; Zhang, X; Yokota, A; Pan, M; Wang, Z; Li, T; Nooruddin, Z; Pietras, EM; Salomonis, N; Grimes, HL; Huang, G. THE TITO BASTIANELLO AND MDSF YOUNG INVESTIGATORS AWARDS. Leukemia Research: clinical and laboratory studies. 2025; 156:107794.

Stevens, J; Culberson, E; Kinder, J; Ramiriqui, A; Gray, J; Bonfield, M; Shao, TY; Al Gharaibeh, F; Peterson, L; Steinmeyer, S; Sengupta, S; Alenghat, T; Way, SS; Deshmukh, H. Microbiota-derived inosine programs protective CD8+ T cell responses against influenza in newborns. Cell. 2025; 188:4239-4256.e19.

Steyn, S; Brown-Burke, F; Marra, P; Chen, C; Saadey, R; Mao, C; Weist, J; Klimaszewski, H; Hout, I; Leon, S; Vaddi, K; Jordan, MB; Baiocchi, R; Shindiapina, P. Exploring PRMT5 Inhibition As a Therapeutic Strategy in Primary and Secondary Hemophagocytic Lymphohistiocytosis. Transplantation and Cellular Therapy. 2025; 31:s159.

Tursi, AR; Lages, CS; Quayle, K; Koenig, ZT; Loni, R; Eswar, S; Cobeña-Reyes, J; Thornton, S; Tilburgs, T; Andorf, S. Automated descriptive cell type naming in flow and mass cytometry with CytoPheno. Scientific Reports. 2025; 15:26750.

Van Gelder, RD; Gokhale, NS; Genoyer, E; Omelia, DS; Anderson, SK; Young, HA; Savan, R. Interleukin-2-mediated NF-κB-dependent mRNA splicing modulates interferon gamma protein production. EMBO Reports. 2025; 26:16-35.

Venkatasubramanian, M; Schwartz, L; Ramachandra, N; Bennett, J; Subramanian, KR; Chen, X; Gordon-Mitchell, S; Fromowitz, A; Pradhan, K; Shechter, D; Grimes, HL; Starczynowski, DT; Verma, A; Salomonis, N. Splicing regulatory dynamics for precision analysis and treatment of heterogeneous leukemias. Science Translational Medicine. 2025; 17:eadr1471.

Warrick, KA; Vallez, CN; Meibers, HE; Pasare, C. Bidirectional Communication Between the Innate and Adaptive Immune Systems. Annual Review of Immunology. 2025; 43:489-514.

Whillock, A; Smith, P; Burger, S; Sridhar, A; Lindgren, A; Berg, J; Tsuda, S; Mahajan, S; Tilburgs, T; Schuldt, NJ. Natural microbial exposure populates the maternal fetal interface with diverse T cells. Frontiers in Immunology. 2025; 16:1616491.

Wozny, N; Niebur, H; Jordan, M. T Cell Tropic Epstein Barr Virus in a Patient with Hemophagocytic Lymphohistiocytosis. 2025; 1.

Yarawsky, AE; Herr, AB. Assembly landscape of the complete B-repeat superdomain from Staphylococcus epidermidis strain 1457. Biophysical Journal. 2025; 124:363-378.

Zoref Lorenz, A; Cahn, E; Mou, E; Wang, Y; Maurer, MJ; Feldman, AL; Negaard, BJ; Mwangi, R; Itchaki, G; Nowakowski, GS; Goyal, G; Witzig, TE; Cerhan, JR; Jordan, M. The optimized HLH inflammatory index: A novel prognostic tool for newly diagnosed patients with diffuse large B-cell lymphoma—Discovery and validation. Journal of Clinical Oncology. 2025; 43:7073.

Zoref‐Lorenz, A; Cahn, EJ; Mou, E; Cholack, G; Wang, Y; Maurer, M; Feldman, AL; Negaard, BJ; Mwangi, R; Itchaki, G; Novak, AJ; Witzig, TE; Cerhan, JR; Jordan, M. 122 | IDENTIFYING HARMFUL HYPERINFLAMMATION IN DIFFUSE LARGE B‐CELL LYMPHOMA USING THE OHI (OPTIMIZED HLH INFLAMMATORY) INDEX—DISCOVERY AND VALIDATION IN REAL‐WORLD PATIENTS. Hematological Oncology. 2025; 43.

Zoref-Lorenz, A; Murakami, J; Gurion, R; Iyer, SP; Abadi, U; Cohen, I; Goyal, G; Mohamed, S; Nikiforow, S; Natour, AE H; Itchaki, G; Izraeli, S; Ellis, M; Jordan, MB. The OHI index predicts early mortality from organ dysfunction and survival benefit from etoposide in patients with lymphoma. Blood Advances. 2025; 9:4515-4525.

Zoref-Lorenz, A; Rocco, J; Schwartz, DM; Jordan, M. Recognizing and Managing Secondary Hemophagocytic Lymphohistiocytosis in Adults: A Practical Clinical Guide. Hematology/Oncology Clinics of North America. 2025; 39:577-596.

Zoref-Lorenz, A; Witzig, TE; Cerhan, JR; Jordan, MB. Malignancy-associated HLH: mechanisms, diagnosis, and treatment of a severe hyperinflammatory syndrome. Leukemia and Lymphoma. 2025; 66:628-636.