Immunobiology

Publications

Alarcon, PC; Damen, MS M A; Ulanowicz, CJ; Sawada, K; Oates, JR; Toth, A; Wayland, JL; Chung, H; Stankiewicz, TE; Moreno-Fernandez, ME; et al. Obesity amplifies influenza virus-driven disease severity in male and female mice. Mucosal Immunology. 2023; 16:843-858.

Atehortua, L; Baig, M; Morris, J; Trentman, S; Davidson, WS; Fichtenbaum, CJ; Chougnet, CA. Impaired response of memory Treg to high density lipoproteins is associated with intermediate/high cardiovascular disease risk in persons with HIV. Frontiers in Immunology. 2023; 14:1146624.

Atehortua, L; Morris, J; Street, SE; Bedel, N; Davidson, WS; Chougnet, CA. Apolipoprotein E-containing HDL decreases caspase-dependent apoptosis of memory regulatory T lymphocytes. Journal of Lipid Research. 2023; 64:100425.

Basu, J; Olsson, A; Ferchen, K; Titerina, EK; Chetal, K; Nicolas, E; Czyzewicz, P; Levchenko, D; Ge, L; Hua, X; et al. ThPOK is a critical multifaceted regulator of myeloid lineage development. Nature Immunology. 2023; 24:1295-1307.

Breckenridge, JE; Dell, G; Steele, H; Cheng, JL; Ghastine, A; Culberson, E; Herro, R. Targeting Fibrosis to Improve Cancer Outcomes. Journal of immunology (Baltimore, Md. : 1950). 2023; 210:245.04.

Cazares, TA; Rizvi, FW; Iyer, B; Chen, X; Kotliar, M; Bejjani, AT; Wayman, JA; Donmez, O; Wronowski, B; Parameswaran, S; et al. maxATAC: Genome-scale transcription-factor binding prediction from ATAC-seq with deep neural networks. Editor, Przytycka TM. PLoS Computational Biology. 2023; 19:e1010863.

Cheng, JL; Steele, H; Breckenridge, J; Dell, G; Ghastine, A; Willicut, A; Herro, R. TL1A control of eczema and psoriasis. Journal of immunology (Baltimore, Md. : 1950). 2023; 210:151.01.

Choi, Y; Lichterman, JN; Coughlin, LA; Poulides, N; Li, W; Del Valle, P; Palmer, SN; Gan, S; Kim, J; Zhan, X; et al. Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal antitumor immunity. Science Immunology. 2023; 8:eabo2003.

Dell, GJ; Steele, H; Cheng, JL; Breckenridge, JE; Willicut, A; Ghastine, A; Culberson, E; Herro, R. 1 Liver + 4 Diseases = n Drugs. Journal of immunology (Baltimore, Md. : 1950). 2023; 210:176.11.

Doll, JR; Moreno-Fernandez, ME; Stankiewicz, TE; Wayland, JL; Wilburn, A; Weinhaus, B; Chougnet, CA; Giordano, D; Cappelletti, M; Presicce, P; et al. BAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth. Cell Reports. 2023; 42:112352.

Eshleman, EM; Alenghat, T. Cleaving an epithelial path to food tolerance. Cell Research. 2023; 33:896-897.

Eshleman, EM; Rice, T; Potter, C; Woo, V; Field, S; Hashimoto-Hill, S; Waddell, A; Engelman, L; Finkelman, FD; Alenghat, T. Microbiota dampen type 2 immunity by epigenetically restricting tuft cell differentiation. Journal of immunology (Baltimore, Md. : 1950). 2023; 210:150.08.

Eshleman, EM; Shao, TY; Woo, V; Rice, T; Engleman, L; Didriksen, BJ; Whitt, J; Haslam, DB; Way, SS; Alenghat, T. Intestinal epithelial HDAC3 and MHC class II coordinate microbiota-specific immunity. The Journal of Clinical Investigation. 2023; 133:e162190.

Ferchen, K; Salomonis, N; Grimes, HL. pyInfinityFlow: optimized imputation and analysis of high-dimensional flow cytometry data for millions of cells. Editor, Kelso J. Bioinformatics. 2023; 39:btad287.

Ferchen, K; Song, B; Potter, C; Zhang, X; Chou, C; Khodoun, M; Finkelman, FD; Salomonis, N; Grimes, HL. Th2 immune responses induced by helminth infection reprogram multilineage progenitors to produce successive waves of neutrophils, basophils, and eosinophils. Journal of immunology (Baltimore, Md. : 1950). 2023; 210:65.01.

Ghosh, D; McAlees, J; Bernstein, J; Lewkowich, I. Maternal Exposure To Phthalate Drives Skin Changes Associated With Increased Susceptibility To House Dust Mite Induced Atopic Dermatitis In Offspring. Journal of Allergy and Clinical Immunology. 2023; 151:ab150.

Hamilton, I; Ikumi, NM; Kshirsagar, S; Goodman, WA; Tilburgs, T. Utilizing primary HLA-G+ extravillous trophoblasts and HLA-G+ EVT-like cell lines to study maternal-fetal interactions. STAR Protocols. 2023; 4:102276.

Ikumi, NM; Koenig, Z; Mahajan, S; Gray, CM; Tilburgs, T. Purification of primary human placental leukocytes to study maternal-fetal interactions. STAR Protocols. 2023; 4:102277.

Kappes, EC; Kattamuri, C; Czepnik, M; Yarawsky, AE; Brûlé, E; Wang, Y; Ongaro, L; Herr, AB; Walton, KL; Bernard, DJ; et al. Follistatin Forms a Stable Complex With Inhibin A That Does Not Interfere With Activin A Antagonism. Endocrinology. 2023; 164:bqad017.

Kesarwani, M; Kincaid, Z; Azhar, M; Menke, J; Schwieterman, J; Ansari, S; Reaves, A; Deininger, ME; Levine, R; Grimes, HL; et al. MAPK-negative feedback regulation confers dependence to JAK2V617F signaling. Leukemia. 2023; 37:1686-1697.

Kharofa, J; Apewokin, S; Alenghat, T; Ollberding, NJ. Metagenomic analysis of the fecal microbiome in colorectal cancer patients compared to healthy controls as a function of age. Cancer Medicine. 2023; 12:2945-2957.

Khorki, ME; Shi, T; Cianciolo, EE; Burg, AR; Chukwuma, PC; Picarsic, JL; Morrice, MK; Woodle, ES; Maltzman, JS; Ferguson, A; et al. Prior viral infection primes cross-reactive CD8+ T cells that respond to mouse heart allografts. Frontiers in Immunology. 2023; 14:1287546.

Kleven, RT; Huang, S; Ford, SM; Sakthivel, K; Thomas, SR; Zuccarello, M; Herr, AB; Holland, CK. Effect of Recombinant Tissue Plasminogen Activator and 120-kHz Ultrasound on Porcine Intracranial Thrombus Density. Ultrasound in Medicine and Biology. 2023; 49:539-548.

Li, G; Song, B; Singh, H; Surya Prasath, VB; Leighton Grimes, H; Salomonis, N. Decision level integration of unimodal and multimodal single cell data with scTriangulate. Nature Communications. 2023; 14:406.

Mahajan, S; Alexander, A; Koenig, Z; Saba, N; Prasanphanich, N; Hildeman, DA; Chougnet, CA; DeFranco, E; Andorf, S; Tilburgs, T. Antigen-specific decidual CD8+ T cells include distinct effector memory and tissue-resident memory cells. JCI insight. 2023; 8:e171806.

Meibers, HE; Warrick, KA; VonHandorf, A; Vallez, CN; Kawarizadeh, K; Saha, I; Donmez, O; Jain, VG; Kottyan, LC; Weirauch, MT; et al. Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells. Cell Reports. 2023; 42:113180.

Miki, H; Kiosses, WB; Manresa, MC; Gupta, RK; Sethi, GS; Herro, R; Da Silva Antunes, R; Dutta, P; Miller, M; Fung, K; et al. Lymphotoxin beta receptor signaling directly controls airway smooth muscle deregulation and asthmatic lung dysfunction. Journal of Allergy and Clinical Immunology. 2023; 151:976-990.e5.

Oates, JR; Sawada, K; Giles, DA; Alarcon, PC; Damen, MS M A; Szabo, S; Stankiewicz, TE; Moreno-Fernandez, ME; Divanovic, S. Thermoneutral housing shapes hepatic inflammation and damage in mouse models of non-alcoholic fatty liver disease. Frontiers in Immunology. 2023; 14:1095132.

Overcast, GR; Meibers, HE; Eshleman, EM; Saha, I; Waggoner, L; Patel, KN; Jain, VG; Haslam, DB; Alenghat, T; Vandussen, KL; et al. IEC-intrinsic IL-1R signaling holds dual roles in regulating intestinal homeostasis and inflammation. The Journal of Experimental Medicine. 2023; 220:e20212523.

Park, S; Helsley, RN; Fadhul, T; Willoughby, JL S; Noetzli, L; Tu, H; Solheim, MH; Fujisaka, S; Pan, H; Dreyfuss, JM; et al. Fructose Induced KHK-C Increases ER Stress and Modulates Hepatic Transcriptome to Drive Liver Disease in Diet-Induced and Genetic Models of NAFLD. 2023; 4:2023.01.27.525605.

Park, SH; Helsley, RN; Fadhul, T; Willoughby, JL S; Noetzli, L; Tu, HC; Solheim, MH; Fujisaka, S; Pan, H; Dreyfuss, JM; et al. Fructose induced KHK-C can increase ER stress independent of its effect on lipogenesis to drive liver disease in diet-induced and genetic models of NAFLD. Metabolism: clinical and experimental. 2023; 145:155591.

Peters, AL; Rogers, M; Begum, G; Sun, Q; Fei, L; Leino, D; Hildeman, D; Woodle, ES. T-cell infiltrate intensity is associated with delayed response to treatment in late acute cellular rejection in pediatric liver transplant recipients. Pediatric Transplantation. 2023; 27:e14475.

Presicce, P; Cappelletti, M; Morselli, M; Ma, F; Senthamaraikannan, P; Protti, G; Nadel, BB; Aryan, L; Eghbali, M; Salwinski, L; et al. Amnion responses to intrauterine inflammation and effects of inhibition of TNF signaling in preterm Rhesus macaque. iScience. 2023; 26:108118.

Ragab, M; Raschdorf, A; Margis, D; Schlichting, H; Hicken, M; Mester, P; Hirose, M; Kubetzko, L; Ibrahim, S; Tews, H; et al. Azathioprine promotes intestinal Paneth cell differentiation in Crohn’s disease. Zeitschrift für Gastroenterologie. 2023; 61:e410.

Rossi, AP; Tremblay, S; Castro-Rojas, CM; Burg, AA; Roskin, KM; Gehman, JM; Rike-Shields, A; Alloway, RR; Brailey, P; Allman, D; et al. Effects of invivo CXCR4 blockade and proteasome inhibition on bone marrow plasma cells in HLA-sensitized kidney transplant candidates. American Journal of Transplantation. 2023; 23:759-775.

Sawada, K; Chung, H; Softic, S; Moreno-Fernandez, ME; Divanovic, S. The bidirectional immune crosstalk in metabolic dysfunction-associated steatotic liver disease. Cell Metabolism. 2023; 35:1852-1871.

Schumacher, MA; Liu, CY; Katada, K; Thai, MH; Hsieh, JJ; Hansten, BJ; Waddell, A; Rosen, MJ; Frey, MR. Deep Crypt Secretory Cell Differentiation in the Colonic Epithelium Is Regulated by Sprouty2 and Interleukin 13. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2023; 15:971-984.

Sezaki, M; Hashimoto, M; Yokota, A; Salomonis, N; Grimes, HL; Huang, G. Downregulation of Mitochondrial Complex II (MC II) in Myelodysplastic Syndromes. Blood. 2023; 142:4583.

Shao, TY; Jiang, TT; Stevens, J; Russi, AE; Troutman, TD; Bernieh, A; Pham, G; Erickson, JJ; Eshleman, EM; Alenghat, T; et al. Kruppel-like factor 2+ CD4 T cells avert microbiota-induced intestinal inflammation. Cell Reports. 2023; 42:113323.

Shi, T; Burg, AR; Caldwell, JT; Roskin, KM; Castro-Rojas, CM; Chukwuma, PC; Gray, GI; Foote, SG; Alonso, JA; Cuda, CM; et al. Single-cell transcriptomic analysis of renal allograft rejection reveals insights into intragraft TCR clonality. The Journal of Clinical Investigation. 2023; 133:e170191.

Smith, CA; Sonneson, GJ; Hoey, RJ; Hinerman, JM; Sheehy, K; Walter, R; Herr, AB; Horn, JR. Molecular recognition requires dimerization of a VHH antibody. mAbs. 2023; 15:2215363.

Song, B; Zhang, X; Bennett, S; Ma, S; Ferchen, K; Salomonis, N; Grimes, HL. High-throughput workflow leveraging spectral flow cytometry and CITE-seq to characterize human bone marrow across race and gender. Journal of immunology (Baltimore, Md. : 1950). 2023; 210:250.13.

Song, B; Zhang, X; Steele, H; Chou, C; Ferchen, K; Salomonis, N; Herro, R; Grimes, HL. Live bacterial ligands universally regulate mTOR activity but are not essential for homeostatic innate immunity. Journal of immunology (Baltimore, Md. : 1950). 2023; 210:65.05.

Steele, H; Cheng, J; Willicut, A; Dell, G; Breckenridge, J; Culberson, E; Ghastine, A; Tardif, V; Herro, R. TNF superfamily control of tissue remodeling and fibrosis. Frontiers in Immunology. 2023; 14:1219907.

Steele, H; Cheng, JL; Willicut, A; Dell, G; Breckenridge, J; Ghastine, A; Herro, R. Shedding LIGHT and TL1A on Pulmonary Fibrosis. Journal of immunology (Baltimore, Md. : 1950). 2023; 210:176.07.

Stiff, A; Nicolet, D; Fornerod, M; Kelly, B; Miller, K; Mrózek, K; Boateng, I; Kain, BN; Garfinkle, E; Hu, EY; et al. Genomic Profiles and Associated Survival Prognosticators in Black Patients with Acute Myeloid Leukemia. Blood. 2023; 142:837.

Thomas, AL; Godarova, A; Wayman, JA; Miraldi, ER; Hildeman, DA; Chougnet, CA. Accumulation of immune-suppressive CD4 + T cells in aging - tempering inflammaging at the expense of immunity. Seminars in Immunology. 2023; 70:101836.

Thomas, AL; Wayman, JA; Almanan, M; Bejjani, AT; Miraldi, ER; Chougnet, CA; Hildeman, DA. Elevated CD153 Expression on Aged T Follicular Helper Cells is Vital for B cell Responses. 2023; 4:2023.03.17.533214.

Thompson, EN; Carlino, MJ; Scanlon, VM; Grimes, HL; Krause, DS. Assay optimization for the objective quantification of human multilineage colony-forming units. Experimental Hematology. 2023; 124:36-44.e3.

Toth, A; Kannan, P; Snowball, J; Kofron, M; Wayman, JA; Bridges, JP; Miraldi, ER; Swarr, D; Zacharias, WJ. Alveolar epithelial progenitor cells require Nkx2-1 to maintain progenitor-specific epigenomic state during lung homeostasis and regeneration. Nature Communications. 2023; 14:8452.

Velez Lopez, A; Waddell, A; Antonacci, S; Castillo, D; Santucci, N; Ollberding, NJ; Eshleman, EM; Denson, LA; Alenghat, T. Microbiota-derived butyrate dampens linaclotide stimulation of the guanylate cyclase C pathway in patient-derived colonoids. Neurogastroenterology and Motility. 2023; 35:e14681.

Vitale, I; Pietrocola, F; Guilbaud, E; Aaronson, SA; Abrams, JM; Adam, D; Agostini, M; Agostinis, P; Alnemri, ES; Altucci, L; et al. Apoptotic cell death in disease-Current understanding of the NCCD 2023. Cell Death and Differentiation. 2023; 30:1097-1154.

Walulik, S; Dean, S; Vick, EJ; Zhu, X; Wunderlich, M; Chou, C; Choi, K; Grimes, HL; Starczynowski, DT; Miles, LA; et al. The Mechanism of Therapy Resistance By Lineage Plasticity in AML and How to Overcome It. Blood. 2023; 142:1410.

Ware, J; Mcelhinney, K; Latham, T; Lane, A; Dienger-Stambaugh, K; Hildeman, D; Spearman, P; Ware, RE. Sustained and Boosted Antibody Responses in Breast Milk After Maternal SARS-CoV-2 Vaccination. Breastfeeding Medicine. 2023; 18:612-620.

Wayland, JL; Doll, JR; Lawson, MJ; Stankiewicz, TE; Oates, JR; Sawada, K; Damen, MS M A; Alarcon, PC; Haslam, DB; Trout, AT; et al. Thermoneutral Housing Enables Studies of Vertical Transmission of Obesogenic Diet-Driven Metabolic Diseases. Nutrients. 2023; 15:4958.

Wayland, JL; Stemen, EL; Doll, JR; Divanovic, S. Protocol for cytokine and uterine immune cell characterization in a mouse model of LPS-induced preterm birth. STAR Protocols. 2023; 4:102643.

Wayman, JA; Thomas, A; Bejjani, A; Katko, A; Almanan, M; Godarova, A; Korinfskaya, S; Cazares, TA; Yukawa, M; Kottyan, LC; et al. An atlas of gene regulatory networks for memory CD4 + T cells in youth and old age. 2023; 4:2023.03.07.531590.

Whaley, KG; Xiong, Y; Karns, R; Hyams, JS; Kugathasan, S; Boyle, BM; Walters, TD; Kelsen, J; LeLeiko, N; Shapiro, J; et al. Multicenter Cohort Study of Infliximab Pharmacokinetics and Therapy Response in Pediatric Acute Severe Ulcerative Colitis. Clinical Gastroenterology and Hepatology. 2023; 21:1338-1347.

Wilburn, AN; McAlees, JW; Haslam, DB; Graspeuntner, S; Schmudde, I; Laumonnier, Y; Rupp, J; Chougnet, CA; Deshmukh, H; Zacharias, WJ; et al. Delayed Microbial Maturation Durably Exacerbates Th17-driven Asthma in Mice. American Journal of Respiratory Cell and Molecular Biology. 2023; 68:498-510.

Yadav, R; Shaikh, T; Tikole, S; Herr, AB; Fitzkee, NC. 1H, 15N, and 13C chemical shift backbone resonance NMR assignment of the accumulation-associated protein (Aap) lectin domain from Staphylococcus epidermidis. Biomolecular NMR Assignments. 2023; 17:95-99.

Yarawsky, AE; Dinu, V; Harding, SE; Herr, AB. Strong non-ideality effects at low protein concentrations: considerations for elongated proteins. European Biophysics Journal. 2023; 52:427-438.

Yarawsky, AE; Ori, AL; English, LR; Whitten, ST; Herr, AB. Convergent behavior of extended stalk regions from staphylococcal surface proteins with widely divergent sequence patterns. Protein Science. 2023; 32:e4707.

Zhang, X; Leighton Grimes, H. Improved detection of measurable residual disease in acute myeloid leukemia. Science Advances. 2023; 9:eadk2533.