Immunobiology

Publications

Alarcon, PC; Damen, MS M A; Madan, R; Deepe, GS; Spearman, P; Way, SS; Divanovic, S. Adipocyte inflammation and pathogenesis of viral pneumonias: an overlooked contribution. Mucosal Immunology. 2021; 14:1224-1234.

Avelino, R; Mulet-Lazaro, R; Havermans, M; Hoogenboezem, R; Smeenk, L; Salomonis, N; Schneider, RK; Rombouts, EJ C; Bindels, E; Grimes, HL; et al. Induced cell-autonomous neutropenia systemically perturbs hematopoiesis in Cebpa enhancer-null mice. Blood Advances. 2021.

Bartram, J; Song, BA; Xu, J; Salomonis, N; Grimes, HL; Filippi, M. Divisional Memory Drives Hematopoietic Stem Cell Functional Diversity. Blood. 2021; 138:20-20.

Basu, J; Reis, BS; Peri, S; Zha, J; Hua, X; Ge, L; Ferchen, K; Nicolas, E; Czyzewicz, P; Cai, KQ; et al. Essential role of a ThPOK autoregulatory loop in the maintenance of mature CD4+ T cell identity and function. Nature Immunology. 2021; 22:969-982.

Bono, C; Guerrero, P; Jordán-Pla, A; Erades, A; Salomonis, N; Grimes, HL; Gil, ML; Yáñez, A. GM-CSF Programs Hematopoietic Stem and Progenitor Cells During Candida albicans Vaccination for Protection Against Reinfection. Frontiers in Immunology. 2021; 12.

Cappelletti, M; Presicce, P; Feiyang, M; Senthamaraikannan, P; Miller, LA; Pellegrini, M; Sim, MS; Jobe, AH; Divanovic, S; Way, SS; et al. The induction of preterm labor in rhesus macaques is determined by the  strength of immune response to intrauterine infection. PLoS Biology. 2021; 19.

Chan, CC; Harley, IT W; Pfluger, PT; Trompette, A; Stankiewicz, TE; Allen, JL; Moreno-Fernandez, ME; Damen, MS M A; Oates, JR; Alarcon, PC; et al. A BAFF/APRIL axis regulates obesogenic diet-driven weight gain. Nature Communications. 2021; 12.

Chandra, S; Chandrakasan, S; Dávila Saldaña, BJ; Bleesing, JJ; Jordan, MB; Kumar, AR; Grimley, MS; Krupski, C; Davies, SM; Khandelwal, P; et al. Experience with a Reduced Toxicity Allogeneic Transplant Regimen for Non-CGD Primary Immune Deficiencies Requiring Myeloablation. Journal of Clinical Immunology. 2021; 41:89-98.

Damen, MS M A; Stankiewicz, TE; Park, SH; Helsley, RN; Chan, CC; Moreno-Fernandez, ME; Doll, JR; Szabo, S; Herbert, DB R; Softic, S; et al. Non-hematopoietic IL-4Rα expression contributes to fructose-driven obesity and metabolic sequelae. International Journal of Obesity. 2021; 45:2377-2387.

Davis, G; York, AJ; Bacon, WC; Lin, SC; McNeal, MM; Yarawsky, AE; Maciag, JJ; Miller, JL C; Locker, KC S; Bailey, M; et al. Seroprevalence of SARS-CoV-2 infection in Cincinnati Ohio USA from August to December 2020. PLoS ONE. 2021; 16.

Eshleman, EM; Alenghat, T. Epithelial sensing of microbiota-derived signals. Genes and Immunity. 2021; 22:237-246.

Ferrell, J; Sharp, S; Kumar, A; Jordan, M; Picarsic, J; Nelson, A. Discrepancies between F-18-FDG PET/CT findings and conventional imaging in Langerhans cell histiocytosis. Pediatric Blood and Cancer. 2021; 68.

Gonzalez, T; Stevens, ML; Kyzy, AB; Alarcon, R; He, H; Kroner, JW; Spagna, D; Grashel, B; Sidler, E; Martin, LJ; et al. Biofilm propensity of Staphylococcus aureus skin isolates is associated with increased atopic dermatitis severity and barrier dysfunction in the MPAACH pediatric cohort. Allergy: European Journal of Allergy and Clinical Immunology. 2021; 76:302-313.

Hashimoto-Hill, S; Alenghat, T. Inflammation-Associated Microbiota Composition Across Domestic Animals. Frontiers in Genetics. 2021; 12.

Hashimoto-Hill, S; Kelly, DR; Alenghat, T. Chapter 12 Epigenomics of intestinal disease. Medical Epigenetics. 2021.

Ho, JS Y; Mok, BW Y; Campisi, L; Jordan, T; Yildiz, S; Parameswaran, S; Wayman, JA; Gaudreault, NN; Meekins, DA; Indran, SV; et al. TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation. Cell. 2021; 184:2618-2632.e17.

Ibrahimova, A; Davies, SM; Lane, A; Jordan, MB; Lake, K; Litts, B; Chaturvedi, V; Owsley, E; Myers, KC; Nelson, AS; et al. α4β7 Integrin expression and blockade in pediatric and young adult gastrointestinal graft-versus-host disease. Pediatric Blood and Cancer. 2021; 68.

Ikumi, NM; Pillay, K; Tilburgs, T; Malaba, TR; Dzanibe, S; Enninga, EA L; Chakraborty, R; Lamorde, M; Myer, L; Khoo, S; et al. T-Cell Homeostatic Imbalance in Placentas From Women With Human Immunodeficiency Virus in the Absence of Vertical Transmission. Journal of Infectious Diseases. 2021; 224:S670-S682.

Jose, S; Mukherjee, A; Horrigan, O; Setchell, KD R; Zhang, W; Moreno-Fernandez, ME; Andersen, H; Sharma, D; Haslam, DB; Divanovic, S; et al. Obeticholic acid ameliorates severity of Clostridioides difficile infection in high fat diet-induced obese mice. Mucosal Immunology. 2021; 14:500-510.

Khandelwal, P; Teusink-Cross, A; Kumar, AR; Bleesing, JJ; Mehta, PA; Jordan, MB; Chandra, S; Davies, SM; Marsh, RA. Daratumumab for the management of autoimmune cytopenias in children and young adults: a case series. British Journal of Haematology. 2021; 194:e84-e89.

Khodoun, MV; Morris, SC; Shao, WH; Potter, C; Angerman, E; Kiselev, A; Yarawsky, AE; Herr, AB; Klausz, K; Otte, A; et al. Suppression of IgE-mediated anaphylaxis and food allergy with monovalent anti-FcεRIα mAbs. Journal of Allergy and Clinical Immunology. 2021; 147:1838-1854.e4.

Kirk, AD; Adams, AB; Durrbach, A; Ford, ML; Hildeman, DA; Larsen, CP; Vincenti, F; Wojciechowski, D; Woodle, ES. Optimization of de novo belatacept-based immunosuppression administered to renal transplant recipients. American Journal of Transplantation. 2021; 21:1691-1698.

Lekva, T; Roland, MC P; Estensen, ME; Norwitz, ER; Tilburgs, T; Henriksen, T; Bollerslev, J; Normann, KR; Magnus, P; Olstad, OK; et al. Dysregulated non-coding telomerase RNA component and associated exonuclease XRN1 in leucocytes from women developing preeclampsia-possible link to enhanced senescence. Scientific Reports. 2021; 11.

Li, Q; Meissner, TB; Wang, F; Du, Z; Ma, S; Kshirsagar, S; Tilburgs, T; Buenrostro, JD; Uesugi, M; Strominger, JL. ELF3 activated by a superenhancer and an autoregulatory feedback loop is required for high-level HLA-C expression on extravillous trophoblasts. Proceedings of the National Academy of Sciences of the United States of America. 2021; 118.

Locker, KC S; Herr, AB. Binding Proteins | Antibodies: Structure and Immune Effector Functions. Encyclopedia of Biological Chemistry III. 2021.

Lu, X; Chen, X; Forney, C; Donmez, O; Miller, D; Parameswaran, S; Hong, T; Huang, Y; Pujato, M; Cazares, T; et al. Global discovery of lupus genetic risk variant allelic enhancer activity. Nature Communications. 2021; 12.

Marsh, RA; Zoref-Lorenz, A; Owsley, E; Chaturvedi, V; Nguyen, TC; Goldman, JR; Henry, MM; Greenberg, JN; Ladisch, S; Hermiston, ML; et al. T-cell activation profiles distinguish hemophagocytic lymphohistiocytosis and early sepsis. Blood. 2021; 137:2337-2346.

McClain, KL; Bigenwald, C; Collin, M; Haroche, J; Marsh, RA; Merad, M; Picarsic, J; Ribeiro, KB; Allen, CE. Histiocytic disorders. . 2021.

McDaniel, MM; Meibers, HE; Pasare, C. Innate control of adaptive immunity and adaptive instruction of innate immunity: bi-directional flow of information. Current Opinion in Immunology. 2021; 73:25-33.

McNelis, K; Yodoshi, T; Divanovic, S; Gandhi, C; Kim, JH; Anton, CG; Trout, AT; Mouzaki, M. Hepatic Steatosis in Infancy: The Beginning of Pediatric Nonalcoholic Fatty Liver Disease?. 2021; 2.

Miraldi, ER; Chen, X; Weirauch, MT. Deciphering cis-regulatory grammar with deep learning. Nature Genetics. 2021; 53:266-268.

Moreno-Fernandez, ME; Damen, MS M A; Divanovic, S. A protocol for isolation of primary human immune cells from the liver and mesenteric white adipose tissue biopsies. STAR Protocols. 2021; 2.

Moreno-Fernandez, ME; Giles, DA; Oates, JR; Chan, CC; Damen, MS M A; Doll, JR; Stankiewicz, TE; Chen, X; Chetal, K; Karns, R; et al. PKM2-dependent metabolic skewing of hepatic Th17 cells regulates pathogenesis of non-alcoholic fatty liver disease. Cell Metabolism. 2021; 33:1187-1204.e9.

Moreno-Fernandez, ME; Sharma, V; Stankiewicz, TE; Oates, JR; Doll, JR; Damen, MS M A; Almanan, MA T A; Chougnet, CA; Hildeman, DA; Divanovic, S. Aging mitigates the severity of obesity-associated metabolic sequelae in a gender independent manner. Nutrition and Diabetes. 2021; 11.

Noah, TK; Lee, JB; Brown, CA; Yamani, A; Tomar, S; Ganesan, V; Newberry, RD; Huffnagle, GB; Divanovic, S; Hogan, SP. Thermoneutrality Alters Gastrointestinal Antigen Passage Patterning and Predisposes to Oral Antigen Sensitization in Mice. Frontiers in Immunology. 2021; 12.

Rossi, AP; Alloway, RR; Hildeman, D; Woodle, ES. Plasma cell biology: Foundations for targeted therapeutic development in transplantation. Immunological Reviews. 2021; 303:168-186.

Schumacher, MA; Hsieh, JJ; Liu, CY; Appel, KL; Waddell, A; Almohazey, D; Katada, K; Bernard, JK; Bucar, EB; Gadeock, S; et al. Sprouty2 limits intestinal tuft and goblet cell numbers through GSK3β-mediated restriction of epithelial IL-33. Nature Communications. 2021; 12.

Serrano-Lopez, J; Hegde, S; Kumar, S; Serrano, J; Fang, J; Wellendorf, AM; Roche, PA; Rangel, Y; Carrington, LJ; Geiger, H; et al. Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics. eLife. 2021; 10.

Shi, T; Roskin, K; Baker, BM; Woodle, ES; Hildeman, D. Advanced Genomics-Based Approaches for Defining Allograft Rejection With Single Cell Resolution. Frontiers in Immunology. 2021; 12.

Slater, A; Di, Y; Clark, JC; Jooss, NJ; Martin, EM; Alenazy, F; Thomas, MR; Ariëns, RA S; Herr, AB; Poulter, NS; et al. Structural characterization of a novel GPVI-nanobody complex reveals a biologically active domain-swapped GPVI dimer. Blood. 2021; 137:3443-3453.

Song, R; Gao, Y; Dozmorov, I; Malladi, V; Saha, I; McDaniel, MM; Parameswaran, S; Liang, C; Arana, C; Zhang, B; et al. IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility. Cell Reports. 2021; 34.

Steele, H; Sachen, K; McKnight, AJ; Soloff, R; Herro, R. Targeting TL1A/DR3 Signaling Offers a Therapeutic Advantage to Neutralizing IL13/IL4Rα in Muco-Secretory Fibrotic Disorders. Frontiers in Immunology. 2021; 12.

Steele, H; Song, B; Willicut, A; Grimes, HL; Herro, R. Isolation of primary immune cells from fibrotic skin, esophageal, and gut tissue. Journal of Immunological Methods. 2021; 497.

Thomas, AL; Alarcon, PC; Divanovic, S; Chougnet, CA; Hildeman, DA; Moreno-Fernandez, ME. Implications of Inflammatory States on Dysfunctional Immune Responses in Aging and Obesity. 2021; 2.

Tilburgs, T. Chapter 2 Presentation and recognition of placental, fetal, and pathogen-derived antigens in human pregnancy. Reproductive Immunology. 2021.

Uddin, J; Tomar, S; Sharma, A; Waggoner, L; Ganesan, V; Marella, S; Yang, Y; Noah, T; Vanoni, S; Patterson, A; et al. PIR-B Regulates CD4+ IL17a+ T-Cell Survival and Restricts T-Cell-Dependent Intestinal Inflammatory Responses. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2021; 12:1479-1502.

van der Heijden, YF; Zhang, B; Chougnet, CA; Huaman, MA. Cytomegalovirus infection is associated with increased prevalence of latent tuberculosis infection. Open Forum Infectious Diseases. 2021.

Waddell, A; Vallance, JE; Fox, S; Rosen, MJ. IL-33 is produced by colon fibroblasts and differentially regulated in acute and chronic murine colitis. Scientific Reports. 2021; 11.

Woo, V; Eshleman, EM; Hashimoto-Hill, S; Whitt, J; Wu, SE; Engleman, L; Rice, T; Karns, R; Qualls, JE; Haslam, DB; et al. Commensal segmented filamentous bacteria-derived retinoic acid primes host defense to intestinal infection. Cell Host and Microbe. 2021; 29:1744-1756.e5.

Ye, H; Minhajuddin, M; Krug, A; Pei, S; Chou, C; Culp-Hill, R; Ponder, J; De Bloois, E; Schniedewind, B; Amaya, ML; et al. The Hepatic Microenvironment Uniquely Protects Leukemia Cells through Induction of Growth and Survival Pathways Mediated by LIPG. Cancer Discovery. 2021; 11:500-519.

Zamakhaeva, S; Chaton, CT; Rush, JS; Ajay Castro, S; Kenner, CW; Yarawsky, AE; Herr, AB; van Sorge, NM; Dorfmueller, HC; Frolenkov, GI; et al. Modification of cell wall polysaccharide guides cell division in Streptococcus mutans. Nature Chemical Biology. 2021; 17:878-887.

Zhang, J; Wu, Q; Johnson, CB; Pham, G; Kinder, JM; Olsson, A; Slaughter, A; May, M; Weinhaus, B; D’Alessandro, A; et al. In situ mapping identifies distinct vascular niches for myelopoiesis. Nature: New biology. 2021; 590:457-462.

Zhang, X; Grimes, HL. Why Single-Cell Sequencing Has Promise in MDS. Frontiers in Oncology. 2021; 11.

Zoref-Lorenz, A; Jordan, MB. Challenges in improving global outcomes for hemophagocytic lymphohistiocytosis. Pediatric Hematology and Oncology. 2021; 38:191-193.