Immunobiology

Publications

Allen, CE; Chandrakasan, S; Jordan, MB; Leiding, JW; Marrone, M; Oladapo, A; Pednekar, P; Walkovich, KJ; Yee, J. Transplant Related Outcomes in Patients with Hemophagocytic Lymphohistiocytosis Treated with Emapalumab As a Bridge to Hematopoietic Stem Cell Transplantation: The Real-HLH Study. Blood. 2024; 144:3489.

Atehortua, L; Davidson, WS; Chougnet, CA. Interactions Between HDL and CD4+ T Cells: A Novel Understanding of HDL Anti-Inflammatory Properties. Arteriosclerosis, Thrombosis, and Vascular Biology. 2024; 44:1191-1201.

Baassiri, A; Maziarz, J; Blackburn, HN; Maul-Newby, H; VanOudenhove, J; Zhang, X; Matthews, M; Paul, S; Liu, W; Sefik, E; Salomonis, N; Grimes, HL; Flavell, R; Halene, S. MISTRG6kitW41: Enhanced Engraftment in a Cytokine Humanized Patient-Derived Xenotransplantation Mouse Model. Blood. 2024; 144:1815.

Böhm, S; Wustrau, K; Pachlopnik Schmid, J; Prader, S; Ahlmann, M; Yacobovich, J; Beier, R; Speckmann, C; Behnisch, W; Ifversen, M; Lindemans, C; Henter, JI; Lehmberg, K; Ehl, S. Survival in primary hemophagocytic lymphohistiocytosis, 2016 to 2021: etoposide is better than its reputation. Blood. 2024; 143:872-881.

Carroll, SL; Pasare, C; Barton, GM. Control of adaptive immunity by pattern recognition receptors. Immunity. 2024; 57:632-648.

Chandrakasan, S; Jordan, MB; Baker, A; Behrens, EM; Bhatla, D; Chien, M; Eckstein, OS; Henry, MM; Hermiston, ML; Hinson, AP; Walkovich, KJ; Yee, JD; Zoref-Lorenz, A; Allen, CE. Real-world treatment patterns and outcomes in patients with primary hemophagocytic lymphohistiocytosis treated with emapalumab. Blood Advances. 2024; 8:2248-2258.

Chiang, S; Murguia-Favela, L; Wright, N; Steele, M; Seroogy, C; Blanchard-Rohner, G; Shrikhande, A; Wilson, J; Yang, L; Owsley, E; Derfalvi, B; Brager, R; Jordan, M; Marwaha, A. 68 LRBA dysfunction: a new diagnostic entity caused by biallelic LRBA missense variants results in reduced CTLA-4 expression and autoimmunity. Clinical Immunology. 2024; 262:110010.

Cournoyer, E; Ferrell, J; Sharp, S; Ray, A; Jordan, M; Dandoy, C; Grimley, M; Roy, S; Lorsbach, R; Merrow, AC; Nelson, A; Bartlett, A; Picarsic, J; Kumar, A. Dabrafenib and trametinib in Langerhans cell histiocytosis and other histiocytic disorders. Haematologica: the hematology journal. 2024; 109:1137-1148.

DeTomaso, A; Kim, H; Shauh, J; Adulla, A; Zigo, S; Ghoul, M; Presicce, P; Kallapur, SG; Goodman, W; Tilburgs, T; Way, SS; Hackney, D; Moore, J; Mesiano, S. Progesterone inactivation in decidual stromal cells: A mechanism for inflammation-induced parturition. Proceedings of the National Academy of Sciences of USA. 2024; 121:e2400601121.

DeVore, SB; Schuetz, M; Alvey, L; Lujan, H; Ochayon, DE; Williams, L; Chang, WC; Filuta, A; Ruff, B; Kothari, A; Keles, S; Milner, JD; Supp, DM; Khurana Hershey, GK. Regulation of MYC by CARD14 in human epithelium is a determinant of epidermal homeostasis and disease. Cell Reports. 2024; 43:114589.

Didriksen, BJ; Eshleman, EM; Alenghat, T. Epithelial regulation of microbiota-immune cell dynamics. Mucosal Immunology. 2024; 17:303-313.

Eshleman, EM; Rice, T; Potter, C; Waddell, A; Hashimoto-Hill, S; Woo, V; Field, S; Engleman, L; Lim, HW; Schumacher, MA; Frey, MR; Denson, LA; Finkelman, FD; Alenghat, T. Microbiota-derived butyrate restricts tuft cell differentiation via histone deacetylase 3 to modulate intestinal type 2 immunity. Immunity. 2024; 57:319-332.e6.

Fava, A; Wagner, CA; Guthridge, CJ; Kheir, J; Macwana, S; DeJager, W; Gross, T; Izmirly, P; Belmont, HM; Diamond, B; Guthridge, JM; Petri, M; Buyon, J; James, JA. Association of Autoantibody Concentrations and Trajectories With Lupus Nephritis Histologic Features and Treatment Response. Arthritis and Rheumatology. 2024; 76:1611-1622.

Froehlich, F; Landerholm, K; Neeb, J; Meß, AK; Seiler, DL; Tilburgs, T; Karsten, CM. Emerging role of C5aR2: novel insights into the regulation of uterine immune cells during pregnancy. Frontiers in Immunology. 2024; 15:1411315.

Goubran, M; Spaner, C; Stukas, S; Zoref-Lorenz, A; Shojania, K; Beckett, M; Li, A; Peterson, E; Sekhon, M; Grey, R; Mattman, A; Jordan, MB; Chen, LY C; Setiadi, A. The role of C-reactive protein and ferritin in the diagnosis of HLH, adult-onset still's disease, and COVID-19 cytokine storm. Scientific Reports. 2024; 14:31306.

Govindarajah, V; Sakabe, M; Good, S; Solomon, M; Arasu, A; Chen, N; Zhang, X; Grimes, HL; Kendler, A; Xin, M; Reynaud, D. Gestational diabetes in mice induces hematopoietic memory that affects the long-term health of the offspring. The Journal of Clinical Investigation. 2024; 134:e169730.

Grimes, HL; Ferchen, K; Salomonis, N. 1008 – UNIFIED SINGLE-CELL METHODS SORT DIVERGENT FATES THROUGH GENE REGULATION. Experimental Hematology. 2024; 137:104309.

Henter, JI; Sieni, E; Eriksson, J; Bergsten, E; Hed Myrberg, I; Canna, SW; Coniglio, ML; Cron, RQ; Kernan, KF; Kumar, AR; Bottai, M; Bryceson, YT; Horne, AC; Jordan, MB. Diagnostic guidelines for familial hemophagocytic lymphohistiocytosis revisited. Blood. 2024; 144:2308-2318.

Herro, R; Grimes, HL. The diverse roles of neutrophils from protection to pathogenesis. Nature Immunology. 2024; 25:2209-2219.

Jordan, MB. Hemophagocytic lymphohistiocytosis: A disorder of T cell activation, immune regulation, and distinctive immunopathology. Immunological Reviews. 2024; 322:339-350.

Jordan, MB. Here be dragons: A universal profile of recent T-cell (hyper)activation?. Journal of Allergy and Clinical Immunology. 2024; 153:98-99.

Jordan, MB; Locatelli, F. Exposure-safety relationship for patients with primary hemophagocytic lymphohistiocytosis treated with emapalumab. Pediatric Blood and Cancer. 2024; 71:e30778.

Kain, BN; Sen, S; Nicolet, D; Bennett, SN; Bernardicius, D; Hu, Y; Walker, C; Eisfeld, A; Salomonis, N; Grimes, HL. Phip Is a Potent Leukemia Oncogene Identified in Acute Myeloid Leukemia (AML) Patients of African Ancestry. Blood. 2024; 144:327.

Lempicki, MD; Gray, JA; Abuna, G; Murata, RM; Divanovic, S; McNamara, CA; Meher, AK. BAFF neutralization impairs the autoantibody-mediated clearance of dead adipocytes and aggravates obesity-induced insulin resistance. Frontiers in Immunology. 2024; 15:1436900.

Li, G; Mahajan, S; Ma, S; Jeffery, ED; Zhang, X; Bhattacharjee, A; Venkatasubramanian, M; Weirauch, MT; Miraldi, ER; Grimes, HL; Sheynkman, GM; Tilburgs, T; Salomonis, N. Splicing neoantigen discovery with SNAF reveals shared targets for cancer immunotherapy. Science Translational Medicine. 2024; 16:eade2886.

McDonnell, J; Cousins, K; Younger, ME M; Lane, A; Abolhassani, H; Abraham, RS; Al-Tamemi, S; Aldave-Becerra, JC; Al-Faris, EH; Alfaro-Murillo, A; Lim, XR; Lopes, JP; López, AL; Tarquini, L. COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19: a USIDNET Report. Journal of Clinical Immunology. 2024; 44:86.

Mills, KB; Maciag, JJ; Wang, C; Crawford, JA; Enroth, TJ; Keim, KC; Dufrêne, YF; Robinson, DA; Fey, PD; Herr, AB; Horswill, AR. Staphylococcus aureus skin colonization is mediated by SasG lectin variation. Cell Reports. 2024; 43:114022.

Mouzaki, M; Woo, JG; Divanovic, S. Gestational and Developmental Contributors of Pediatric MASLD. Seminars in Liver Disease. 2024; 44:43-53.

Newman, J; Tong, X; Tan, A; Yeasky, T; De Paiva, VN; Presicce, P; Kannan, PS; Williams, K; Damianos, A; Tamase Newsam, M; Chougnet, CA; Jobe, AH; Brambilla, R; Schmidt, AF. Chorioamnionitis accelerates granule cell and oligodendrocyte maturation in the cerebellum of preterm nonhuman primates. Journal of Neuroinflammation. 2024; 21:16.

Ochoa, TA; Rossi, A; Woodle, ES; Hildeman, D; Allman, D. The Proteasome Inhibitor Bortezomib Induces p53-Dependent Apoptosis in Activated B Cells. Journal of immunology (Baltimore, Md. : 1950). 2024; 212:154-164.

Oelschläger, L; Nicolet, D; Mrózek, K; Schnell, D; Alotaibi, N; Walker, CJ; Mims, A; Blachly, JS; Powell, BL; Kolitz, JE; Salomonis, N; Grimes, HL; Fornerod, M; Eisfeld, A. Transcriptomically Defined Acute Myeloid Leukemia, Myelodysplasia-Related (AML-MR) Phenotype Governs Mutation-Based Disease Group Assignment. Blood. 2024; 144:641.

Ozga, M; Nicolet, D; Mrózek, K; Yilmaz, AS; Kohlschmidt, J; Larkin, KT; Blachly, JS; Oakes, CC; Buss, J; Walker, CJ; Salomonis, N; Herold, T; Mims, AS; Eisfeld, AK. Sex-associated differences in frequencies and prognostic impact of recurrent genetic alterations in adult acute myeloid leukemia (Alliance, AMLCG). Leukemia. 2024; 38:45-57.

Park, SH; Fadhul, T; Conroy, LR; Clarke, HA; Sun, RC; Wallenius, K; Boucher, J; O’Mahony, G; Boianelli, A; Persson, M; Bates, EA; Hinds, TD; Divanovic, S; Softic, S. Knockdown of ketohexokinase versus inhibition of its kinase activity exert divergent effects on fructose metabolism. JCI insight. 2024; 9:e184396.

Potter, A; Wikenheiser-Brokamp, K; Hildeman, D; Sharma, N; Gu, M; Patel, K; Qureshi, M; Khan, MM; Wallace, C; Ziady, A; Hayes, D. (601) Decoding T Cell Clonal Dynamics in Acute Lung Rejection. The Journal of Heart and Lung Transplantation. 2024; 43:s293.

Presicce, P; Roland, C; Senthamaraikannan, P; Cappelletti, M; Hammons, M; Miller, LA; Jobe, AH; Chougnet, CA; DeFranco, E; Kallapur, SG. IL-1 and TNF mediates IL-6 signaling at the maternal-fetal interface during intrauterine inflammation. Frontiers in Immunology. 2024; 15:1416162.

Pundavela, J; Dinglasan, SA; Touvron, M; Hummel, SA; Hu, L; Rizvi, TA; Choi, K; Hildeman, DA; Ratner, N. Stimulator of interferon gene facilitates recruitment of effector CD8 T cells that drive neurofibromatosis type 1 nerve tumor initiation and maintenance. Science Advances. 2024; 10:eado6342.

Ragab, M; Schlichting, H; Hicken, M; Mester, P; Hirose, M; Almeida, LN; Christiansen, L; Ibrahim, S; Tews, HC; Divanovic, S; Sina, C; Derer, S. Azathioprine promotes intestinal epithelial cell differentiation into Paneth cells and alleviates ileal Crohn's disease severity. Scientific Reports. 2024; 14:12879.

Rudman-Melnick, V; Vanhoutte, D; Stowers, K; Sargent, M; Adam, M; Ma, Q; Perl, AK T; Miethke, AG; Burg, A; Shi, T; Hildeman, DA; Woodle, ES S; Kofron, JM; Devarajan, P. Gucy1α1 specifically marks kidney, heart, lung and liver fibroblasts. Scientific Reports. 2024; 14:29307.

Saha, I; Chawla, AS; Oliveira, AP B N; Elfers, EE; Warrick, K; Meibers, HE; Jain, VG; Hagan, T; Katz, JD; Pasare, C. Alloreactive memory CD4 T cells promote transplant rejection by engaging DCs to induce innate inflammation and CD8 T cell priming. Proceedings of the National Academy of Sciences of USA. 2024; 121:e2401658121.

Samer, EK; Morris, SA; Hutter, CM; Gilchrist, DA; Calluori, S; Bly, Z; Osorio, D; Zhang, L; He, W; Fu, R; Borsari, B; Assis, PR; Andreeva, K; Gerstein, MB. Deciphering the impact of genomic variation on function. Nature. 2024; 633:47-57.

Sezaki, M; Yokota, A; Zhang, X; Pan, M; Wang, Z; Hashimoto, M; Nooruddin, Z; Pietras, EM; Salomonis, N; Grimes, HL; Huang, G. Luspatercept Promotes Heme Biosynthesis and Erythroblast Island Formation in a Novel Low-Risk MDS Mouse Model. Blood. 2024; 144:877.

Solomon, M; Song, B; Govindarajah, V; Good, S; Arasu, A; Hinton, EB; Thakkar, K; Bartram, J; Filippi, MD; Cancelas, JA; Salomonis, N; Grimes, HL; Reynaud, D. Slow cycling and durable Flt3+ progenitors contribute to hematopoiesis under native conditions. The Journal of Experimental Medicine. 2024; 221:e20231035.

Steyn, S; Chen, C; Saadey, R; Mao, C; Scherle, PA; Bhagwat, N; Vaddi, K; Brooks, E; Baiocchi, R; Jordan, MB; Shindiapina, P. Targeting PRMT5 in Primary Hemophagocytic Lymphohistiocytosis: A Novel Therapeutic Approach Using a Perforin-Deficient Mouse Model. Blood. 2024; 144:809.

Stiff, A; Fornerod, M; Kain, BN; Nicolet, D; Kelly, BJ; Miller, KE; Mrózek, K; Boateng, I; Bollas, A; Garfinkle, EA R; Salomonis, N; Grimes, HL; Mardis, ER; Eisfeld, AK. Multiomic profiling identifies predictors of survival in African American patients with acute myeloid leukemia. Nature Genetics. 2024; 56:2434-2446.

Swertfeger, D; Kim, A; Sexmith, H; Moreno-Fernandez, ME; Davidson, WS; Helmrath, M; Jenkins, T; Okura, T; Geh, E; Xanthakos, SA; Szabo, S; Nakamura, T; Divanovic, S; Shah, AS. Presurgery health influences outcomes following vertical sleeve gastrectomy in adolescents. Obesity. 2024; 32:1187-1197.

Thorman, AW; Reigle, J; Chutipongtanate, S; Yang, J; Shamsaei, B; Pilarczyk, M; Fazel-Najafabadi, M; Adamczak, R; Kouril, M; Bhatnagar, S; Hildeman, DA; Medvedovic, M; Herr, AB; Meller, J. Accelerating drug discovery and repurposing by combining transcriptional signature connectivity with docking. Science Advances. 2024; 10:eadj3010.

Tsuda, S; Shichino, S; Tilburgs, T; Shima, T; Morita, K; Yamaki-Ushijima, A; Roskin, K; Tomura, M; Sameshima, A; Saito, S; Nakashima, A. CD4+ T cell heterogeneity in gestational age and preeclampsia using single-cell RNA sequencing. Frontiers in Immunology. 2024; 15:1401738.

Uddin, J; Sharma, A; Wu, D; Tomar, S; Ganesan, V; Reichel, PE; Thota, LN R; Cabrera-Silva, RI; Marella, S; Idelman, G; Divanovic, S; Nusrat, A; Weaver, TE; Hogan, SP. STARD7 maintains intestinal epithelial mitochondria architecture, barrier integrity, and protection from colitis. JCI insight. 2024; 9:e172978.

Ujoatu, E; Mukhopadhyay, S; Gurnari, C; Visconte, V; Maciejewski, J; Basu, J; Jha, BK; Grimes, HL; Sykes, S; Kappes, D. Oncogenic Nexus of TET2 with Thpok in Myeloid Neoplasia. Blood. 2024; 144:2716.

Verkamp, B; Jodele, S; Marsh, RA; Sabulski, DA; Davies, SM; Jordan, MB. Emapalumab Therapy Prior to Hematopoietic Stem Cell Transplant Is Associated with Improved Long-Term Chimerism and Event-Free Survival in Pediatric Patients with Hemophagocytic Lymphohistiocytosis. Transplantation and Cellular Therapy. 2024; 30:s93.

Verkamp, B; Jodele, S; Sabulski, A; Marsh, R; Kieser, P; Jordan, MB. Emapalumab therapy for hemophagocytic lymphohistiocytosis before reduced-intensity transplantation improves chimerism. Blood. 2024; 144:2625-2636.

Wallach, I; Bernard, D; Nguyen, K; Ho, G; Morrison, A; Stecula, A; Rosnik, A; O’Sullivan, AM; Davtyan, A; Samudio, B; Lam, A; Cuddihy, AR; White, A; Taglialatela, A. AI is a viable alternative to high throughput screening: a 318-target study. Scientific Reports. 2024; 14:7526.

Webb, JA; Farrow, E; Cain, B; Yuan, Z; Yarawsky, AE; Schoch, E; Gagliani, EK; Herr, AB; Gebelein, B; Kovall, RA. Cooperative Gsx2-DNA binding requires DNA bending and a novel Gsx2 homeodomain interface. Nucleic Acids Research (NAR). 2024; 52:7987-8002.

Wu, Q; Zhang, J; Kumar, S; Shen, S; Kincaid, M; Johnson, CB; Zhang, YS; Turcotte, R; Alt, C; Ito, K; Ito, K; Way, SS; Kofron, JM; Lucas, D. Resilient anatomy and local plasticity of naive and stress haematopoiesis. Nature. 2024; 627:839-846.

Xu, RG; Tiede, C; Calabrese, AN; Cheah, LT; Adams, TL; Gauer, JS; Hindle, MS; Webb, BA; Yates, DM; Slater, A; Herr, AB; Tomlinson, DC; Watson, SP; Ariëns, RA S. Affimer reagents as tool molecules to modulate platelet GPVI-ligand interactions and specifically bind GPVI dimer. Blood Advances. 2024; 8:3917-3928.

Zhang, X; Li, G; Oliverio, A; VanOudenhove, J; DeZern, AE; Ghiaur, G; Halene, S; Grimes, HL; Salomonis, N. Clonal Dissection of MDS and Secondary AML Resolves Shared Splicing Neoantigens and Mechanistic Underpinnings of Hypomethylating Agent Therapeutic Response. Blood. 2024; 144:1810.

Zhang, X; Song, B; Carlino, MJ; Li, G; Ferchen, K; Chen, M; Thompson, EN; Kain, BN; Schnell, D; Thakkar, K; Singh, H; Krause, DS; Salomonis, N; Grimes, HL. An immunophenotype-coupled transcriptomic atlas of human hematopoietic progenitors. Nature Immunology. 2024; 25:703-715.

Zoref-Lorenz, A; Cahn, EJ; Mou, E; Wang, Y; Maurer, MJ; Feldman, AL; Negaard, BJ; Mwangi, R; Itchaki, G; Nowakowski, GS; Goyal, G; Witzig, TE; Cerhan, JR; Jordan, MB. Assessment of the Optimized HLH Inflammatory (OHI) Index in a Prospective Cohort of Patients with Newly Diagnosed Diffuse Large B-Cell Lymphoma. Blood. 2024; 144:1624.

Zoref-Lorenz, A; Fajgenbaum, DC; Korn, S; Kaufmann, T; Anderson, B; Oladapo, A; Saltonstall, L; Fournier, D; Behrens, E; Allen, CE; Jordan, MB. Insights into the Natural History and Treatment Outcomes of Hemophagocytic Lymphohistiocytosis (INTO-HLH) Patient Registry: Study Design and Clinical Characteristics. Blood. 2024; 144:5389.

Zoref-Lorenz, A; Lehmberg, K; Jordan, M. Hemophagocytic Lymphohistiocytosis in the Context of Hematological Malignancies and Solid Tumors. Advances in Experimental Medicine and Biology. 2024; 1448:429-440.