Publications

Adelman, ER; Huang, HT; Roisman, A; Olsson, A; Colaprico, A; Qin, T; Lindsley, RC; Bejar, R; Salomonis, N; Grimes, HL; et al. Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia. Cancer Discovery. 2019; 9:1080-1101.

Alder, MN; Mallela, J; Opoka, AM; Lahni, P; Hildeman, DA; Wong, HR. Olfactomedin 4 marks a subset of neutrophils in mice. Innate Immunity. 2019; 25:22-33.

Arazi, A; Rao, DA; Berthier, CC; Davidson, A; Liu, Y; Hoover, PJ; Chicoine, A; Eisenhaure, TM; Jonsson, AH; Li, S; et al. The immune cell landscape in kidneys of patients with lupus nephritis. Nature Immunology. 2019; 20:902-914.

Brandt, EB; Lewkowich, IP. RAGE-induced asthma: A role for the receptor for advanced glycation end-products in promoting allergic airway disease. Journal of Allergy and Clinical Immunology. 2019; 144:651-653.

Castro, DM; de Veaux, NR; Miraldi, ER; Bonneau, R. Multi-study inference of regulatory networks for more accurate models of gene regulation. PLoS Computational Biology. 2019; 15:e1006591-e1006591.

Castro-Rojas, CM; Alloway, RR; Woodle, ES; Hildeman, DA. High Dimensional Renal Profiling: Towards a Better Understanding or Renal Transplant Immune Suppression. Current Transplantation Reports. 2019; 6:60-68.

Chan, CC; Damen, MS M A; Alarcon, PC; Sanchez-Gurmaches, J; Divanovic, S. Inflammation and Immunity: From an Adipocyte's Perspective. Journal of Interferon and Cytokine Research. 2019; 39:459-471.

Chowdhury, D; Alrefai, H; Figueroa, JA L; Candor, K; Porollo, A; Fecher, R; Divanovic, S; Jr, DG S; Vignesh, KS. Metallothionein 3 Controls the Phenotype and Metabolic Programming of Alternatively Activated Macrophages. Cell Reports. 2019; 27:3873-3886.e7.

DePasquale, EA K; Schnell, D; Dexheimer, P; Ferchen, K; Hay, S; Chetal, K; Valiente-Alandí, Í; Blaxall, BC; Grimes, HL; Salomonis, N. cellHarmony: cell-level matching and holistic comparison of single-cell transcriptomes. Nucleic Acids Research. 2019; 47:e138-e138.

DePasquale, EA K; Schnell, DJ; Van Camp, PJ; Valiente-Alandí, Í; Blaxall, BC; Grimes, HL; Singh, H; Salomonis, N. DoubletDecon: Deconvoluting Doublets from Single-Cell RNA-Sequencing Data. Cell Reports. 2019; 29:1718-1727.e8.

Der, E; Suryawanshi, H; Morozov, P; Kustagi, M; Goilav, B; Ranabathou, S; Izmirly, P; Clancy, R; Belmont, HM; Koenigsberg, M; et al. Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways. Nature Immunology. 2019; 20:915-927.

Doll, JR; Thompson, RL; Sawtell, NM. Infectious Herpes Simplex Virus in the Brain Stem Is Correlated with Reactivation in the Trigeminal Ganglia. Journal of Virology. 2019; 93.

Dorjbal, B; Stinson, JR; Ma, CA; Weinreich, MA; Miraghazadeh, B; Hartberger, JM; Frey-Jakobs, S; Weidinger, S; Moebus, L; Franke, A; et al. Hypomorphic caspase activation and recruitment domain 11 (CARD11) mutations associated with diverse immunologic phenotypes with or without atopic disease. Journal of Allergy and Clinical Immunology. 2019; 143:1482-1495.

Duy, C; Teater, M; Garrett-Bakelman, FE; Lee, TC; Meydan, C; Glass, JL; Li, M; Hellmuth, JC; Mohammad, HP; Smitheman, KN; et al. Rational Targeting of Cooperating Layers of the Epigenome Yields Enhanced Therapeutic Efficacy against AML. Cancer Discovery. 2019; 9:872-889.

Dwivedi, P; Muench, DE; Wagner, M; Azam, M; Grimes, HL; Greis, KD. Time resolved quantitative phospho-tyrosine analysis reveals Bruton's Tyrosine kinase mediated signaling downstream of the mutated granulocyte-colony stimulating factor receptors. Leukemia. 2019; 33:75-87.

Dwivedi, P; Muench, DE; Wagner, M; Azam, M; Grimes, HL; Greis, KD. Phospho serine and threonine analysis of normal and mutated granulocyte colony stimulating factor receptors. Scientific Data. 2019; 6.

Eckstein, OS; Visser, J; Rodriguez-Galindo, C; Allen, CE; Zinn, DJ; Peckham-Gregory, EC; Lin, H; Henry, MM; Morland, B; Levy, CF; et al. Clinical responses and persistent BRAF V600E(+) blood cells in children with LCH treated with MAPK pathway inhibition. Blood. 2019; 133:1691-1694.

Fajgenbaum, DC; Langan, RA; Japp, AS; Partridge, HL; Pierson, SK; Singh, A; Arenas, DJ; Ruth, JR; Nabel, CS; Stone, K; et al. Identifying and targeting pathogenic PI3K/AKT/ mTOR signaling in IL-6 blockade-refractory idiopathic multicentric Castleman disease. Journal of Clinical Investigation. 2019; 130:4451-4463.

Garcia-Perez, JE; Baxter, RM; Kong, DS; Tobin, R; McCarter, M; Routes, JM; Verbsky, J; Jordan, MB; Dutmer, CM; Hsieh, EW Y. CTLA4 Message Reflects Pathway Disruption in Monogenic Disorders and Under Therapeutic Blockade. Frontiers in Immunology. 2019; 10.

Itoh, A; Ortiz, L; Kachapati, K; Wu, Y; Adams, D; Bednar, K; Mukherjee, S; Chougnet, C; Mittler, RS; Chen, YG; et al. Soluble CD137 Ameliorates Acute Type 1 Diabetes by Inducing T Cell Anergy. Frontiers in Immunology. 2019; 10.

Jordan, MB; Allen, CE; Greenberg, J; Henry, M; Hermiston, ML; Kumar, A; Hines, M; Eckstein, O; Ladisch, S; Nichols, KE; et al. Challenges in the diagnosis of hemophagocytic lymphohistiocytosis: Recommendations from the North American Consortium for Histiocytosis (NACHO). Pediatric Blood and Cancer. 2019; 66.

Khan, A; Bakhru, P; Saikolappan, S; Das, K; Soudani, E; Singh, CR; Estrella, JL; Zhang, D; Pasare, C; Ma, Y; et al. An autophagy-inducing and TLR-2 activating BCG vaccine induces a robust protection against tuberculosis in mice. npj Vaccines. 2019; 4.

Kim, D; McAlees, JW; Bischoff, LJ; Kaur, D; Houshel, LK; Gray, J; Hargis, J; Davis, X; Dudas, PL; Deshmukh, H; et al. Combined administration of anti-IL-13 and anti-IL-17A at individually sub-therapeutic doses limits asthma-like symptoms in a mouse model of Th2/Th17 high asthma. Clinical and Experimental Allergy. 2019; 49:317-330.

La Rosee, P; Horne, A; Hines, M; Greenwood, TV B; Machowicz, R; Berliner, N; Birndt, S; Gil-Herrera, J; Girschikofsky, M; Jordan, MB; et al. Recommendations for the management of hemophagocytic lymphohistiocytosis in adults. Blood. 2019; 133:2465-2477.

Lee, C; Rudneva, VA; Erkek, S; Zapatka, M; Chau, LQ; Tacheva-Grigorova, SK; Garancher, A; Rusert, JM; Aksoy, O; Lea, R; et al. Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma. Nature Communications. 2019; 10.

Lounder, DT; Bin, Q; De Min, C; Jordan, MB. Treatment of refractory hemophagocytic lymphohistiocytosis with emapalumab despite severe concurrent infections. Blood Advances. 2019; 3:47-50.

McAlees, JW; Baker, T; Kaur, D; McKnight, C; Lindsley, A; Strait, RT; Zhang, X; Myers, JM B; Kovacic, MB; Lewkowich, IP. Age and early maternal smoking contribute to epithelial cell IL-13 responsiveness in a pediatric asthma population. Allergy: European Journal of Allergy and Clinical Immunology. 2019; 74:2485-2487.

McMurray, KM J; Vollmer, LL; Ahlbrand, R; Thomas, J; Winter, A; Lewkowich, IP; Sah, R. Immunomodulatory T cell death associated gene-8 (TDAG8) receptor in depression-associated behaviors. Physiology and Behavior. 2019; 209:112598-112598.

Miraldi, ER; Pokrovskii, M; Watters, A; Castro, DM; De Veaux, N; Hall, JA; Lee, J; Ciofani, M; Madar, A; Carriero, N; et al. Leveraging chromatin accessibility for transcriptional regulatory network inference in T Helper 17 Cells. Genome Research. 2019; 29:449-463.

Namjou, B; Lingren, T; Huang, Y; Parameswaran, S; Cobb, BL; Stanaway, IB; Connolly, JJ; Mentch, FD; Benoit, B; Niu, X; et al. GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network. BMC Medicine. 2019; 17.

Oates, JR; McKell, MC; Moreno-Fernandez, ME; Damen, MS M A; Deepe, GS; Qualls, JE; Divanovic, S. Macrophage Function in the Pathogenesis of Non-alcoholic Fatty Liver Disease: The Mac Attack. Frontiers in Immunology. 2019; 10.

Papúchová, H; Meissner, TB; Li, Q; Strominger, JL; Tilburgs, T. The Dual Role of HLA-C in Tolerance and Immunity at the Maternal-Fetal Interface. Frontiers in Immunology. 2019; 10.

Park, DS; Akuffo, AA; Muench, DE; Grimes, HL; Epling-Burnette, PK; Maini, PK; Anderson, AR A; Bonsall, MB. Clonal hematopoiesis of indeterminate potential and its impact on patient trajectories after stem cell transplantation. PLoS Computational Biology. 2019; 15:e1006913-e1006913.

Patterson, AR; Bolcas, P; Lampe, K; Cantrell, R; Ruff, B; Lewkowich, I; Hogan, SP; Janssen, EM; Bleesing, J; Hershey, GK K; et al. Loss of GTPase of immunity-associated protein 5 (Gimap5) promotes pathogenic CD4(+) T-cell development and allergic airway disease. Journal of Allergy and Clinical Immunology. 2019; 143:245-257.e6.

Pokrovskii, M; Hall, JA; Ochayon, DE; Yi, R; Chaimowitz, NS; Seelamneni, H; Carriero, N; Watters, A; Waggoner, SN; Littman, DR; et al. Characterization of Transcriptional Regulatory Networks that Promote and Restrict Identities and Functions of Intestinal Innate Lymphoid Cells. Immunity. 2019; 51:185-197.e6.

Resende, M; Cardoso, MS; Fróis-Martins, R; Borges, M; Jordan, MB; Castro, AG; Appelberg, R. TNF-mediated compensatory immunity to mycobacterium avium in the absence of macrophage activation by IFN-γ. Journal of immunology (Baltimore, Md. : 1950). 2019; 203:2451-2458.

Ryan, RM; Feng, R; Bazacliu, C; Ferkol, TW; Ren, CL; Mariani, TJ; Poindexter, BB; Wang, F; Moore, PE; Chougnet, C; et al. Black Race Is Associated with a Lower Risk of Bronchopulmonary Dysplasia. The Journal of Pediatrics. 2019; 207:130-135.e2.

Ryan, RM; Keller, RL; Poindexter, BB; D'Angio, CT; Shaw, PA; Bellamy, SL; Moore, PE; McPherson, C; Greenberg, JM; Chougnet, C; et al. Respiratory Medications in Infants < 29 Weeks during the First Year Postdischarge: The Prematurity and Respiratory Outcomes Program (PROP) Consortium. The Journal of Pediatrics. 2019; 208:148-155.e3.

Salvany-Celades, M; van der Zwan, A; Benner, M; Setrajcic-Dragos, V; Gomes, HA B; Iyer, V; Norwitz, ER; Strominger, JL; Tilburgs, T. Three Types of Functional Regulatory T Cells Control T Cell Responses at the Human Maternal-Fetal Interface. Cell Reports. 2019; 27:2537-2547.e5.

Schroeder, T; Wiese, AV; Ender, F; Quell, KM; Vollbrandt, T; Duhn, J; Suenderhauf, A; Kuenstner, A; Moreno-Fernandez, ME; Derer, S; et al. Short-term high-fat diet feeding protects from the development of experimental allergic asthma in mice. Clinical and Experimental Allergy. 2019; 49:1245-1257.

Sliz, A; Locker, KC S; Lampe, K; Godarova, A; Plas, DR; Janssen, EM; Jones, H; Herr, AB; Hoebe, K. Gab3 is required for IL-2-and IL-15-induced NK cell expansion and limits trophoblast invasion during pregnancy. Science Immunology. 2019; 4:eaav3866-eaav3866.

Vatner, RE; Janssen, EM. STING, DCs and the link between innate and adaptive tumor immunity. Molecular Immunology. 2019; 110:13-23.

Waddell, A; Vallance, JE; Hummel, A; Alenghat, T; Rosen, MJ. IL-33 Induces Murine Intestinal Goblet Cell Differentiation Indirectly via Innate Lymphoid Cell IL-13 Secretion. Journal of immunology (Baltimore, Md. : 1950). 2019; 202:598-607.

Wang, JC; Bergeron, M; Andersen, H; Tikhtman, R; Haslam, D; Hunter, T; Herr, AB; de Alarcon, A. Feasibility of shotgun metagenomics to assess microbial ecology of pediatric tracheostomy tubes. The Laryngoscope. 2019; 129:317-323.

Woo, V; Eshleman, EM; Rice, T; Whitt, J; Vallance, BA; Alenghat, T. Microbiota Inhibit Epithelial Pathogen Adherence by Epigenetically Regulating C-Type Lectin Expression. Frontiers in Immunology. 2019; 10.

Yeung, DA; Shanker, N; Sohail, A; Weiss, BA; Wang, C; Wellmerling, J; Das, S; Ganju, RK; Miller, JL C; Herr, AB; et al. Clustering, Spatial Distribution, and Phosphorylation of Discoidin Domain Receptors 1 and 2 in Response to Soluble Collagen I. Journal of Molecular Biology. 2019; 431:368-390.