Immunobiology

Almanan, M; Raynor, J; Ogunsulire, I; Malyshkina, A; Mukherjee, S; Hummel, SA; Ingram, JT; Saini, A; Xie, MM; Alenghat, T; et al. IL-10–producing Tfh cells accumulate with age and link inflammation with age-related immune suppression. Science Advances. 2020; 6:eabb0806-eabb0806.

Antoniou, K; Ender, F; Vollbrandt, T; Laumonnier, Y; Rathmann, F; Pasare, C; Singh, H; Koehl, J. Allergen-Induced C5a/C5aR1 Axis Activation in Pulmonary CD11b⁺ cDCs Promotes Pulmonary Tolerance through Downregulation of CD40. Cells. 2020; 9:300-300.

Boucher, AA; Rosenfeldt, L; Mureb, D; Shafer, J; Sharma, BK; Lane, A; Crowther, RR; McKell, MC; Whitt, J; Alenghat, T; et al. Cell type-specific mechanisms coupling protease-activated receptor-1 to infectious colitis pathogenesis. Journal of Thrombosis and Haemostasis. 2020; 18:91-103.

Cappelletti, M; Doll, JR; Stankiewicz, TE; Lawson, MJ; Sauer, V; Wen, B; Kalinichenko, VV; Sun, X; Tilburgs, T; Divanovic, S. Maternal regulation of inflammatory cues is required for induction of preterm birth. JCI insight. 2020; 5.

Castro-Rojas, CM; Godarova, A; Shi, T; Hummel, SA; Shields, A; Tremblay, S; Alloway, RR; Jordan, MB; Woodle, ES; Hildeman, DA. mTOR Inhibitor Therapy Diminishes Circulating CD8⁺ CD28^- Effector Memory T Cells and Improves Allograft Inflammation in Belatacept-refractory Renal Allograft Rejection. Transplantation. 2020; 104:1058-1069.

Chan, AY; Leiding, JW; Liu, X; Logan, BR; Burroughs, LM; Allenspach, EJ; Skoda-Smith, S; Uzel, G; Notarangelo, LD; Slatter, M; et al. Hematopoietic Cell Transplantation in Patients With Primary Immune Regulatory Disorders (PIRD): A Primary Immune Deficiency Treatment Consortium (PIDTC) Survey. Frontiers in Immunology. 2020; 11.

Chan, CC; Damen, MS M A; Moreno-Fernandez, ME; Stankiewicz, TE; Cappelletti, M; Alarcon, PC; Oates, JR; Doll, JR; Mukherjee, R; Chen, X; et al. Type I interferon sensing unlocks dormant adipocyte inflammatory potential. Nature Communications. 2020; 11.

Chan, CC; Damen, MS M A; Moreno-Fernandez, ME; Stankiewicz, TE; Cappelletti, M; Alarcon, PC; Oates, JR; Doll, JR; Mukherjee, R; Chen, X; et al. Type I interferon sensing unlocks dormant adipocyte inflammatory potential. Nature Communications. 2020; 11.

Chan, CC; Damen, MS M A; Moreno-Fernandez, ME; Stankiewicz, TE; Cappelletti, M; Alarcon, PC; Oates, JR; Doll, JR; Mukherjee, R; Chen, X; et al. Type I interferon sensing unlocks dormant adipocyte inflammatory potential. Nature Communications. 2020; 11.

Crespo, AC; Mulik, S; Dotiwala, F; Ansara, JA; Sen Santara, S; Ingersoll, K; Ovies, C; Junqueira, C; Tilburgs, T; Strominger, JL; et al. Decidual NK Cells Transfer Granulysin to Selectively Kill Bacteria in Trophoblasts. Cell. 2020; 182:1125-1139.e18.

DeVore, SB; Gonzalez, T; Sherenian, MG; Herr, AB; Khurana Hershey, GK. On the surface: Skin microbial exposure contributes to allergic disease. Annals of Allergy, Asthma, and Immunology. 2020; 125:628-638.

Doll, JR; Hoebe, K; Thompson, RL; Sawtell, NM. Resolution of herpes simplex virus reactivation in vivo results in neuronal destruction. PLoS Pathogens. 2020; 16:e1008296-e1008296.

Dwivedi, P; Chutipongtanate, S; Muench, DE; Azam, M; Grimes, HL; Greis, KD. SWATH-Proteomics of Ibrutinib's Action in Myeloid Leukemia Initiating Mutated G-CSFR Signaling. Proteomics: Clinical Applications. 2020; 14:e1900144-1900144.

Fisher, AL; Sangkhae, V; Presicce, P; Chougnet, CA; Jobe, AH; Kallapur, SG; Tabbah, S; Buhimschi, CS; Buhimschi, IA; Ganz, T; et al. Fetal and amniotic fluid iron homeostasis in healthy and complicated murine, macaque, and human pregnancy. JCI insight. 2020; 5.

Gao, Y; Deason, K; Jain, A; Irizarry-Caro, RA; Dozmorov, I; Coughlin, LA; Rauch, I; Evers, BM; Koh, AY; Wakeland, EK; et al. Transcriptional profiling identifies caspase-1 as a T cell–intrinsic regulator of Th17 differentiation. The Journal of Experimental Medicine. 2020; 217.

Herr, AB. Secret(ory) revealed: the long-awaited structures of secretory IgA. Cell Research. 2020; 30:558-559.

Herro, R; Miki, H; Sethi, GS; Mills, D; Mehta, AK; Nguyen, X; Feghali-Bostwick, C; Miller, M; Broide, DH; Soloff, R; et al. TL1A Promotes Lung Tissue Fibrosis and Airway Remodeling. Journal of immunology (Baltimore, Md. : 1950). 2020; 205:2414-2422.

Hinge, A; He, J; Bartram, J; Javier, J; Xu, J; Fjellman, E; Sesaki, H; Li, T; Yu, J; Wunderlich, M; et al. Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition. Cell Stem Cell. 2020; 26:420-430.e6.

Ho, JS Y; Angel, M; Ma, Y; Sloan, E; Wang, G; Martinez-Romero, C; Alenquer, M; Roudko, V; Chung, L; Zheng, S; et al. Hybrid Gene Origination Creates Human-Virus Chimeric Proteins during Infection. Cell. 2020; 181:1502-1517.e23.

Irizarry-Caro, RA; McDaniel, MM; Overcast, GR; Jain, VG; Troutman, TD; Pasare, C. TLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylation. Proceedings of the National Academy of Sciences of USA. 2020; 117:30628-30638.

Jackson, CM; Mukherjee, S; Wilburn, AN; Cates, C; Lewkowich, IP; Deshmukh, H; Zacharias, WJ; Chougnet, CA. Pulmonary Consequences of Prenatal Inflammatory Exposures: Clinical Perspective and Review of Basic Immunological Mechanisms. Frontiers in Immunology. 2020; 11.

Jain, A; Irizarry-Caro, RA; McDaniel, MM; Chawla, AS; Carroll, KR; Overcast, GR; Philip, NH; Oberst, A; Chervonsky, AV; Katz, JD; et al. T cells instruct myeloid cells to produce inflammasome-independent IL-1β and cause autoimmunity. Nature Immunology. 2020; 21:69-74.

Jain, VG; Kong, F; Kallapur, SG; Presicce, P; Senthamaraikannnan, P; Cappelletti, M; Chougnet, CA; Bhattacharyya, S; Pasare, C; Muglia, LJ. IRAK1 is a critical mediator of inflammation-induced preterm birth. Journal of immunology (Baltimore, Md. : 1950). 2020; 204:2651-2660.

Jordan, MB; Locatelli, F. Emapalumab in Primary Hemophagocytic Lymphohistiocytosis. Reply. The New England journal of medicine. 2020; 383:598-599.

Khandelwal, P; Chaturvedi, V; Owsley, E; Lane, A; Heyenbruch, D; Lutzko, CM; Leemhuis, T; Grimley, MS; Nelson, AS; Davies, SM; et al. CD38^brightCD8⁺ T Cells Associated with the Development of Acute GVHD Are Activated, Proliferating, and Cytotoxic Trafficking Cells. Biology of Blood and Marrow Transplantation. 2020; 26:1-6.

Khandelwal, P; Fukuda, T; Teusink-Cross, A; Kashuba, AD M; Lane, A; Mehta, PA; Marsh, RA; Jordan, MB; Grimley, MS; Myers, KC; et al. CCR5 inhibitor as novel acute graft versus host disease prophylaxis in children and young adults undergoing allogeneic stem cell transplant: results of the phase II study. Bone Marrow Transplantation. 2020; 55:1552-1559.

Khodoun, MV; Morris, SC; Angerman, E; Potter, C; Schuman, R; Wunderlich, M; Maciag, JJ; Locker, KC S; Mulloy, JC; Herr, AB; et al. Rapid desensitization of humanized mice with anti-human FcεRIα monoclonal antibodies. Journal of Allergy and Clinical Immunology. 2020; 145:907-921.e3.

Kwok, I; Becht, E; Xia, Y; Ng, M; Teh, YC; Tan, L; Evrard, M; Li, JL Y; Tran, HT N; Tan, Y; et al. Combinatorial Single-Cell Analyses of Granulocyte-Monocyte Progenitor Heterogeneity Reveals an Early Uni-potent Neutrophil Progenitor. Journal of Cleaner Production. 2020; 53:303-318.e5.

Lee, PY; Kellner, ES; Huang, Y; Furutani, E; Huang, Z; Bainter, W; Alosaimi, MF; Stafstrom, K; Platt, CD; Stauber, T; et al. Genotype and functional correlates of disease phenotype in deficiency of adenosine deaminase 2 (DADA2). Journal of Allergy and Clinical Immunology. 2020; 145:1664-1672.e10.

Li, K; Ladle, BH; Kurtulus, S; Sholl, A; Shanmuganad, S; Hildeman, DA. T-cell receptor signal strength and epigenetic control of Bim predict memory CD8⁺ T-cell fate. Cell Death and Differentiation. 2020; 27:1214-1224.

Liu, S; Refaei, M; Liu, S; Decker, A; Hinerman, JM; Herr, AB; Howell, M; Musier-Forsyth, K; Tsang, P. Hairpin RNA-induced conformational change of a eukaryotic-specific lysyl-tRNA synthetase extension and role of adjacent anticodon-binding domain. The Journal of biological chemistry. 2020; 295:12071-12085.

Locatelli, F; Jordan, MB; Allen, C; Cesaro, S; Rizzari, C; Rao, A; Degar, B; Garrington, TP; Sevilla, J; Putti, M; et al. Emapalumab in children with primary hemophagocytic lymphohistiocytosis. The New England journal of medicine. 2020; 382:1811-1822.

Lucas, D; Salomonis, N; Grimes, HL. Unraveling bone marrow architecture. Nature Cell Biology. 2020; 22:5-6.

Manresa, MC; Chiang, AW T; Kurten, RC; Dohil, R; Brickner, H; Dohil, L; Herro, R; Akuthota, P; Lewis, NE; Croft, M; et al. Increased Production of LIGHT by T Cells in Eosinophilic Esophagitis Promotes Differentiation of Esophageal Fibroblasts Toward an Inflammatory Phenotype. Gastroenterology. 2020; 159:1778-1792.e13.

McDaniel, MM; Kottyan, LC; Singh, H; Pasare, C. Suppression of Inflammasome Activation by IRF8 and IRF4 in cDCs Is Critical for T Cell Priming. Cell Reports. 2020; 31:107604-107604.

Moreno-Fernandez, ME; Miraldi, ER; Divanovic, S. Not Chopped Liver—A Careful, Fate-Mapping Study of Macrophages in NASH. Cell Metabolism. 2020; 32:328-330.

Muench, DE; Olsson, A; Ferchen, K; Pham, G; Serafin, RA; Chutipongtanate, S; Dwivedi, P; Song, B; Hay, S; Chetal, K; et al. Mouse models of neutropenia reveal progenitor-stage-specific defects. Nature. 2020; 582:109-114.

Myers, JM B; Sherenian, MG; Kyzy, AB; Alarcon, R; An, A; Flege, Z; Morgan, D; Gonzalez, T; Stevens, ML; He, H; et al. Events in Normal Skin Promote Early-Life Atopic Dermatitis—The MPAACH Cohort. Journal of Allergy and Clinical Immunology-In Practice. 2020; 8:2285-2293.e6.

Newton, HS; Gawali, VS; Chimote, AA; Lehn, MA; Palackdharry, SM; Hinrichs, BH; Jandarov, R; Hildeman, D; Janssen, EM; Wise-Draper, TM; et al. PD1 blockade enhances K + channel activity, Ca 2+ signaling, and migratory ability in cytotoxic T lymphocytes of patients with head and neck cancer. Journal for ImmunoTherapy of Cancer. 2020; 8:e000844-e000844.

Ng, S; Norwitz, GA; Pavlicev, M; Tilburgs, T; Simon, C; Norwitz, ER. Endometrial decidualization: The primary driver of pregnancy health. International Journal of Molecular Sciences. 2020; 21:4092-4092.

Oherle, K; Acker, E; Bonfield, M; Wang, T; Gray, J; Lang, I; Bridges, J; Lewkowich, I; Xu, Y; Ahlfeld, S; et al. Insulin-like Growth Factor 1 Supports a Pulmonary Niche that Promotes Type 3 Innate Lymphoid Cell Development in Newborn Lungs. Immunity. 2020; 52:275-294.e9.

Papuchova, H; Kshirsagar, S; Xu, L; Gomes, HA B; Li, Q; Iyer, V; Norwitz, ER; Strominger, JL; Tilburgs, T. Three types of HLA-G+ extravillous trophoblasts that have distinct immune regulatory properties. Proceedings of the National Academy of Sciences of USA. 2020; 117:15772-15777.

Presicce, P; Cappelletti, M; Senthamaraikannan, P; Ma, F; Morselli, M; Jackson, CM; Mukherjee, S; Miller, LA; Pellegrini, M; Jobe, AH; et al. TNF-Signaling Modulates Neutrophil-Mediated Immunity at the Feto-Maternal Interface During LPS-Induced Intrauterine Inflammation. Frontiers in Immunology. 2020; 11.

Raj, P; Song, R; Zhu, H; Riediger, L; Jun, DJ; Liang, C; Arana, C; Zhang, B; Gao, Y; Wakeland, BE; et al. Deep sequencing reveals a DAP1 regulatory haplotype that potentiates autoimmunity in systemic lupus erythematosus. Genome Biology: biology for the post-genomic era. 2020; 21.

Raynor, J; Lin, A; Hummel, SA; Lampe, K; Jordan, M; Hoebe, K; Hildeman, DA. The Variable Genomic NK Cell Receptor Locus Is a Key Determinant of CD4+ T Cell Responses During Viral Infection. Frontiers in Immunology. 2020; 11.

Softic, S; Stanhope, KL; Boucher, J; Divanovic, S; Lanaspa, MA; Johnson, RJ; Kahn, CR. Fructose and hepatic insulin resistance. Critical Reviews in Clinical Laboratory Sciences (Informa). 2020; 57:308-322.

Stevens, ML; Gonzalez, T; Schauberger, E; Baatyrbek kyzy, A; Andersen, H; Spagna, D; Kalra, MK; Martin, LJ; Haslam, D; Herr, AB; et al. Simultaneous skin biome and keratinocyte genomic capture reveals microbiome differences by depth of sampling. Journal of Allergy and Clinical Immunology. 2020; 146:1442-1445.

Tang, MS; Miraldi, ER; Girgis, NM; Bonneau, RA; Loke, P. Alternative activation of macrophages is accompanied by chromatin remodeling associated with lineage-dependent DNA shape features flanking PU.1 motifs. Journal of immunology (Baltimore, Md. : 1950). 2020; 205:1070-1083.

Thiel, AL; Ragab, M; Wagner, AE; Divanovic, S; Derer, S; Sina, C. Purification and Functional Characterization of the Chloroform/Methanol-Soluble Protein 3 (CM3) From Triticum aestivum in Drosophila melanogaster. Frontiers in Nutrition. 2020; 7.

Toothaker, JM; Presicce, P; Cappelletti, M; Stras, SF; McCourt, CC; Chougnet, CA; Kallapur, SG; Konnikova, L. Immune Cells in the Placental Villi Contribute to Intra-amniotic Inflammation. Frontiers in Immunology. 2020; 11.

Tremblay, S; Driscoll, JJ; Rike-Shields, A; Hildeman, DA; Alloway, RR; Girnita, AL; Brailey, PA; Woodle, ES. A prospective, iterative, adaptive trial of carfilzomib-based desensitization. American Journal of Transplantation. 2020; 20:411-421.

Vieira, RD M; Meagher, A; Crespo, AC; Kshirsagar, SK; Iyer, V; Norwitz, ER; Strominger, JL; Tilburgs, T. Human term pregnancy decidual NK cells generate distinct cytotoxic responses. Journal of immunology (Baltimore, Md. : 1950). 2020; 204:3149-3159.

Woodle, ES; Tremblay, S; Rossi, A; Rojas, CC; Alloway, R; Roskin, K; Allman, D; Hildeman, D. Plasma cell targeting to prevent antibody-mediated rejection. American Journal of Transplantation. 2020; 20 Suppl 4:33-41.

Wu, S; Hashimoto-Hill, S; Woo, V; Eshleman, EM; Whitt, J; Engleman, L; Karns, R; Denson, LA; Haslam, DB; Alenghat, T. Microbiota-derived metabolite promotes HDAC3 activity in the gut. Nature. 2020; 586:108-112.

Yarawsky, AE; Herr, AB. The staphylococcal biofilm protein Aap forms a tetrameric species as a necessary intermediate before amyloidogenesis. The Journal of biological chemistry. 2020; 295:12840-12850.

Yarawsky, AE; Johns, SL; Schuck, P; Herr, AB. The biofilm adhesion protein Aap from Staphylococcus epidermidis forms zinc-dependent amyloid fibers. The Journal of biological chemistry. 2020; 295:4411-4427.

Yue, L; Sharma, V; Horvat, NP; Akuffo, AA; Beatty, MS; Murdun, C; Colin, C; Billington, JM R; Goodheart, WE; Sahakian, E; et al. HDAC11 deficiency disrupts oncogene-induced hematopoiesis in myeloproliferative neoplasms. Blood. 2020; 135:191-207.

Zhang, J; Tracy, C; Pasare, C; Zeng, J; Kraemer, H. Hypersensitivity of Vps33B mutant flies to non-pathogenic infections is dictated by aberrant activation of p38b MAP kinase. Traffic. 2020; 21:578-589.