Immunobiology

Publications

Ahmari, N; Choi, K; Wu, J; Rizvi, TA; Jackson, M; Kershner, LJ; Kim, M-O; Zhang, X; Dombi, E; Shern, J; Hildeman, DA; Ratner, N. Daytime SHP2 inhibitor dosing, when immune cell numbers are elevated, shrinks neurofibromas. Life Science Alliance. 2025; 8(12).

Alarcon, PC; Ulanowicz, CJ; Damen, MSMA; Eom, J; Sawada, K; Chung, H; Alahakoon, T; Oates, JR; Wayland, JL; Stankiewicz, TE; Moreno-Fernandez, ME; Zacharias, WJ; Salomonis, N; Divanovic, S. Obesity Uncovers the Presence of Inflammatory Lung Macrophage Subsets With an Adipose Tissue Transcriptomic Signature in Influenza Virus Infection. Journal of Infectious Diseases. 2025; 231(2):e317-e327.

Allen, C; Chandrakasan, S; Jordan, MB; Leiding, JW; Marrone, M; Oladapo, A; Pednekar, P; Walkovich, K; Yee, J. Transplant Related Outcomes in Patients with Hemophagocytic Lymphohistiocytosis Treated with Emapalumab As a Bridge to Hematopoietic Stem Cell Transplantation (HSCT): The Real-HLH Study. Transplantation and Cellular Therapy. 2025; 31(2):s163-s164.

Brown-Burke, F; Saadey, R; Mao, H-YC; Marra, P; Brooks, E; Wandtke, A; Hout, I; Leon, S; Sharma, A; Yasin, A; Chen, C-J; Jordan, MB; Baiocchi, RA; Shindiapina, P. PRMT5 inhibition reduces hyperinflammation in a murine model of secondary hemophagocytic lymphohistiocytosis. Blood advances. 2025; 9(10):2379-2392.

Burg, A; Brambley, C; Ferguson, A; Cianciolo, E; Caine, R; Shi, T; Khorki, M; Chukwuma, P; Woodle, E; Maltzman, J; Baker, B; Hildeman, D. Leveraging Heterologous Immunity to Provide Insights into Alloreactivity. American Journal of Transplantation. 2025; 25(8):s94.

Burg, A; Ferguson, A; Rossi, A; Shields, AR; Allman, D; Hildeman, D; Woodle, E. Human Long-Lived Plasma Cells Acquire Resistance to Proteasome Inhibitor-Based Desensitization Treatment by Upregulating Autophagy. American Journal of Transplantation. 2025; 25(8):s315-s316.

Caine, R; Shi, T; Burg, A; Alloway, R; Shields, AR; Roskin, K; Woodle, E; Hildeman, D. Single-Cell RNA/TCR Sequencing: Do Urinary CD8+ T Cell Populations Accurately Reflect Transcriptional Profiling of Allograft Infiltrating CD8+ T Cell Populations? American Journal of Transplantation. 2025; 25(8):s8-s9.

Caldwell, J; Peters, A; Depasquale, E; Burg, A; Caine, R; Begum, G; Woodle, E; Hildeman, D. Integration of scRNAseq Analyses of Kidney and Liver Allograft Rejection Enables Identification of Common and Unique Characteristics. American Journal of Transplantation. 2025; 25(8):s304.

Caldwell, J; Shi, T; Burg, A; Roskin, K; Shields, AR; Woodle, E; Hildeman, D. Co-Stimulatory Blockade Prevents Intragraft Accrual of Class-Switched, Activated B Cells and Th17 T Cells and Promotes Accrual of Tregs. American Journal of Transplantation. 2025; 25(8):s391-s392.

Caminero, A; Tropini, C; Valles-Colomer, M; Shung, DL; Gibbons, SM; Surette, MG; Sokol, H; Tomeo, NJ; Tarr, PI; Verdu, EF. Credible inferences in microbiome research: ensuring rigour, reproducibility and relevance in the era of AI. Nature Reviews Gastroenterology and Hepatology. 2025; 22(11):788-803.

Chandra, S; Greis, KD; Chutipongtanate, S; Luebbering, N; Webster, A; Poisson, K; Fisher, K; Smiley, K; Marsh, RA; Jordan, MB; Davies, SM. Novel CSF Biomarkers for facilitating diagnosis of CNS-HLH from other Neuroinflammatory Disorders. Blood advances. 2025.

Chandrakasan, S; Allen, CE; Bhatla, D; Carter, J; Chien, M; Cooper, R; Draper, L; Eckstein, OS; Hanna, R; Hays, JA; Walkovich, KJ; Yee, JD; Zoref-Lorenz, A; Behrens, EM. Emapalumab treatment in rheumatologic disease-associated hemophagocytic lymphohistiocytosis: a plain language summary. Immunotherapy. 2025; 17(7):461-478.

Chandrakasan, S; Allen, CE; Bhatla, D; Carter, J; Chien, M; Cooper, R; Draper, L; Eckstein, OS; Hanna, R; Hays, JA; Walkovich, KJ; Yee, JD; Zoref-Lorenz, A; Behrens, EM. Emapalumab Treatment in Patients With Rheumatologic Disease-Associated Hemophagocytic Lymphohistiocytosis in the United States: A Retrospective Medical Chart Review Study. Arthritis & Rheumatology. 2025; 77(2):226-238.

Chiang, SCC; Yang, L; Owsley, E; Husami, A; Akeno, N; Cobb, C; Hartog, NL; Elizalde, A; Seroogy, CM; Blanchard-Rohner, G; Marsh, R; Bleesing, J; Jordan, MB; Marwaha, AK. Lipopolysaccharide-responsive and beige-like anchor protein (LRBA) functional deficiency caused by biallelic LRBA missense variants characterized by Evans syndrome or colitis. Journal of Allergy and Clinical Immunology. 2025; 156(2):270-278.

Colom Díaz, PA; Mistry, JJ; Young, KA; Chou, C-H; Boyer, N; Levine, RL; Salomonis, N; Grimes, HL; Trowbridge, JJ. Metallothionein 1 mediates growth and survival of Dnmt3a;Npm1-mutant acute myeloid leukemia. Haematologica. 2026; 111(1):373-378.

Cook, E; Haacker, L; Chandra, S; Jordan, MB; Verkamp, B; Mccarthy, L; Rotz, SJ; Hammoud, MS; Pariury, H; Mckeone, D; Kumar, A. EBV-Associated T/NK-LPD Manifesting As HLH Cured By Nivolumab and Emapalumab, Avoiding the Need for Allogeneic HCT. Transplantation and Cellular Therapy. 2025; 31(2):s43.

Damen, MS; Alarcon, PC; Chan, CC; Stankiewicz, TE; Chung, H; Sawada, K; Ulanowicz, CJ; Eom, J; Oates, JR; Wayland, JL; Helmrath, MA; Sanchez-Gurmaches, J; Moreno-Fernandez, ME; Divanovic, S. A shift in PKM2 oligomeric state instructs adipocyte inflammatory potential. JCI Insight. 2025; 10(22).

Damianos, A; Wang, G; Ustiyan, V; Deng, Z; Wen, B; Kohran, F; Gao, W; Li, E; Lan, Y-W; Do, J; Xia, X; Tilburgs, T; Stanek, J; Kalin, T; Kalinichenko, V. Identification of FOXF1-expresssing Endothelial Cells in the Placentas Tissues. American Journal of Respiratory and Critical Care Medicine. 2025; 211(Abstracts):a2494-a2494.

Fava, A; Wagner, CA; Guthridge, CJ; Macwana, S; Dejager, W; Munroe, ME; Izmirly, P; Belmont, HM; Diamond, B; Davidson, A; Petri, M; Guthridge, JM; Buyon, J; James, JA. Serum Soluble Mediator Signatures of Lupus Nephritis: Histologic Features and Response to Treatment. Arthritis Care and Research. 2025.

Ferchen, K; Zhang, X; Thakkar, K; Li, G; Bernardicius, D; Sen, S; Rawat, P; Olsson, A; Bennett, SN; Potter, C; Morris, S; Singh, H; Salomonis, N; Grimes, HL. A unified multimodal single-cell framework reveals a discrete state model of hematopoiesis in mice. Nature Immunology. 2025; 26(11):2086-2099.

Frøystad, M; Tilburgs, T; Michelsen, TM; Sørbye, IK; Turowski, G; Ueland, T; Lekva, T. Placentas affected by preeclampsia show reduced CD4+ T-cell numbers in decidua basalis and increased EVTs in the chorionic membrane. Placenta. 2025; 171:e272.

Grimes, HL; Zhang, X; Tang, M; Li, G; Bernardicius, D; Van Oudenhove, J; Dezern, A; Ghiaur, G; Halene, S; Salomonis, N. 2003 – MOLECULAR DISSECTION OF AGING CLARIFIES THE IMPACT OF MDS GENETICS AND THERAPY. Experimental Hematology. 2025; 151:104916.

Hari Gopal, S; Alenghat, T; Pammi, M. Early life epigenetics and childhood outcomes: a scoping review. Pediatric Research. 2025; 97(4):1305-1314.

Heekin, S; Lopez-Nunez, O; Smith, J; Denson, N; Denson, L; Miethke, A; Collins, MH; Dillman, J; Miraldi, E; Kofron, JM; Dhaliwal, J; Erdman, L. Implications of Model Loss and Configuration for Sparse Histological Segmentation. In: Machine Learning Methods in Biomedical Field. Springer Nature; 2026:189-217.

Heuer, LS; Sweeney, N; Rojas, M; Zhang, W; Mendelsohn, AR; Huang, M; Yu, B; Ackerman, P; Wei, Q; Herr, AB; Larrick, JW; Ridgway, WM. Higher order receptor clustering due to the IgG3 subclass is necessary for TLR4 signaling and tolerance induction by novel human anti-TLR4 antibodies. mAbs. 2025; 17(1):2515415.

Horisberger, A; Griffith, A; Keegan, J; Arazi, A; Pulford, J; Murzin, E; Howard, K; Hancock, B; Fava, A; Sasaki, T; Diamond, B; Zhang, F; Lederer, JA; Rao, DA. Blood immunophenotyping identifies distinct kidney histopathology and outcomes in patients with lupus nephritis. Journal of Clinical Investigation. 2025; 135(16).

Inamo, J; Keegan, J; Griffith, A; Ghosh, T; Horisberger, A; Howard, K; Pulford, JF; Murzin, E; Hancock, B; Dominguez, ST; Deane, KD; Lederer, J; Rao, DA; Zhang, F. Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis. Journal of Clinical Investigation. 2025; 135(6).

Jess, J; Verkamp, B; Jordan, M. Vitamin D Deficiency Is Prevalent and Resistant to Correction in Patients with Hemophagocytic Lymphohistiocytosis. Journal of Human Immunity. 2025; 1(CIS2025).

Jordan, M; Locatelli, F; Halimi, D; Burillo, E; Jamieson, B; Danquah, A; Monnet, E. Emapalumab induces rapid, durable responses and reliable bridging to curative HSCT in patients with primary HLH: Pooled analysis of prospective trials NI-0501-04, NI-0501-05 and NI-0501-09. Blood. 2025; 146(Supplement 1):4758-4758.

Kawarizadeh, K; Vallez, CN; Aliyazdi, S; Warrick, KA; Carafice, C; Saha, I; Pasare, C. Absence of BCAP in myeloid cells abrogates M2 macrophage differentiation and promotes anti-tumor immunity. iScience. 2025; 28(11):113723.

Khoury, R; Jordan, M; Bleesing, J; Kumar, A; Saldana, BD; Verkamp, B; Davies, S; Marsh, R; Chandra, S. Addition of Thiotepa to Alemtuzumab, Fludarabine, and Melphalan Reduced-Intensity Conditioning Reduces Secondary Graft Failure in Allogeneic HSCT for Inborn Errors of Immunity. Journal of Human Immunity. 2025; 1(CIS2025).

Klepper, CM; Trout, AT; Dong, S; Fei, L; Stankiewicz, TE; Wayland, J; Moreno-Fernandez, ME; Divanovic, S; Xanthakos, SA; Defranco, E; Woo, JG; Mouzaki, M. Maternal metabolic dysfunction-associated steatotic liver disease during pregnancy and its impact on offspring steatosis. Clinical Nutrition ESPEN. 2025; 70:327-335.

Kudira, R; Yang, ZF; Osuji, I; Damen, MSMA; Yang Vom Hofe, A; Singh, M; Karns, R; Bariya, P; Pfuhler, L; Mullen, M; Subramanian, S; Salomonis, N; Miraldi, ER; Miethke, AG. Bile acids engage the SIPR-STAT3 signaling axis to modulate regulatory T cell responses in fibrosing cholangiopathies. Journal of Hepatology. 2025; 83(5):1128-1141.

Lan, JH; Tran, J; Avgay, G; Niemann, M; Bandstra, S; Alloway, RR; First, M; Fitzsimmons, B; Hildeman, D; Gill, JS; Woodle, E. HLA T Cell Epitope Mismatch and the Risk of Acute Rejection Among Participants in the Astellas Double Blind Randomized Early Corticosteroid Cessation Trial. American Journal of Transplantation. 2025; 25(8):s116.

Locatelli, F; Jordan, M; Halimi, D; Burillo, E; Jamieson, B; Monnet, E; Danquah, A. Use of emapalumab is associated with rapid and sustained benefits in primary HLH subgroups, including CNS involvement and previously untreated patients: Pooled analysis of prospective trials NI-0501-04, NI-0501-05 and NI-0501-09. Blood. 2025; 146(Supplement 1):2979-2979.

Marsh, R; Khoury, R; Mizuno, K; Hosawi, A; Cottrell, C; Nguyen, E; Landon, B; Chandra, S; Jordan, M; Kumar, A; Bleesing, J; Davies, S; Moore, C; Mehta, P. Precision Alemtuzumab Dosing Results in Day 0 Target Range Achievement in 80% of IEI Patients and Minimizes Risks of GVHD, Clinically Significant Mixed Chimerism, and Secondary Graft Failure. Journal of Human Immunity. 2025; 1(CIS2025).

Mukhopadhyay, E; Lakes, N; Krishnamurthy, D; Tuazon, JA; Ohayon, DE; Ali, A; Seelamneni, H; Lee, LH; Hildeman, DA; Waggoner, SN. RNA helicase DDX3X promotes NK cell survival by supporting MCL1 expression. Journal of Immunology. 2025; 214(12):3218-3227.

Nasr, W; Pham, V; Xu, J; Jordan, M; Verma, A; Huang, G; Filippi, M-D. Mavs mediates inflammatory memory in hematopoietic stem cells and promotes ineffective hematopoiesis. Blood. 2025; 146(Supplement 1):974.

Ng, LG; Ballesteros, I; Cassatella, MA; Egeblad, M; Fridlender, ZG; Gabrilovich, D; Gao, Q; Granot, Z; Grieshaber-Bouyer, R; Grimes, HL; Udalova, IA; Xue, R; Zhang, N; Kwok, I. From complexity to consensus: A roadmap for neutrophil classification. Immunity. 2025; 58(8):1890-1903.

Peters, M; Teodorescu, P; Pasca, S; Zhang, X; Wang, R; Yegnasubramanian, S; Grimes, LH; Salomonis, N; Gondek, LP; Ghiaur, G. Comprehensive characterization of human bone marrow microenvironment shows age-related changes. Haematologica. 2025; 110(11):2844-2848.

Peters, AL; Depasquale, EAK; Begum, G; Roskin, KM; Kotliar, M; Barski, A; Salomonis, N; Shi, T; Ranganathan, S; Woodle, ES; Hildeman, DA. Single-cell transcriptional landscape of liver transplant rejection reveals tissue persistence of clonally expanded, treatment-resistant T cells. American Journal of Transplantation. 2025; 25(11):2345-2360.

Peters, AL; Depasquale, E; Begum, G; Seraphine, K; Steinkamp, S; Huppert, S; Woodle, E; Hildeman, D. Multiome Sequencing of Chronic Ductopenic Rejection Reveals Roles for Th2 Immunity and Activated Fibroblasts in Cholangiocyte Injury. American Journal of Transplantation. 2025; 25(8):s245.

Prasanphanich, NS; Protti, G; Cappelletti, M; Ma, F; Pithia, N; Dasenbrock, A; Stanek, J; Chougnet, CA; Kallapur, SG; Pellegrini, M; Tilburgs, T; Presicce, P. Granulysin-high decidual NK cells in macaques and humans share signatures of immune defense. Cell reports. 2025; 44(7):115943.

Presicce, P; Beckman, D; Cappelletti, M; Vu, A; Ott, S; Diniz, G; Jobe, A; Chougnet, C; Divanovic, S; Way, SSY; Morrison, J; Kallapur, S. Intrauterine infection causes neuroinflammation and a selective loss of immature neurons in preterm non-human primate (NHP) fetuses 3227. Journal of Immunology. 2025; 214(Supplement_1).

Secchia, S; Beilinson, V; Chen, X; Gucwa, M; Denson, LA; Miraldi, ER; Weirauch, MT; Ikegami, K. Starvation activates ECM-remodeling gene transcription and putative enhancers in fibroblasts despite inducing quiescence. Cell reports. 2025; 44(7):115896.

Sezaki, M; Zhang, X; Yokota, A; Pan, M; Wang, Z; Li, T; Nooruddin, Z; Pietras, EM; Salomonis, N; Grimes, HL; Huang, G. THE TITO BASTIANELLO AND MDSF YOUNG INVESTIGATORS AWARDS. Leukemia Research. 2025; 156:107794.

Shankar, A; Mcalees, JW; Wyder, MA; Hargis, JM; Ediga, HH; Cannata, A; Latayan, J; Greis, KD; Madala, SK; Lewkowich, IP. Phospho-Proteomic Analysis of Interleukin-13 Signaling in Airway Cells Reveals SRC Family Kinase Involvement in Interleukin-13-Induced Inflammatory Responses. International Archives of Allergy and Immunology. 2025; 1-17.

Smith, P; Whillock, AL; Burger, S; Sridhar, A; Lindgren, A; Mahajan, S; Tilburgs, T; Schuldt, NJ. Maternal microbial exposure provides novel insights into the balance between tolerance and host defense during pregnancy 2984. Journal of Immunology. 2025; 214(Supplement_1).

Stevens, J; Culberson, E; Kinder, J; Ramiriqui, A; Gray, J; Bonfield, M; Shao, T-Y; Al Gharaibeh, F; Peterson, L; Steinmeyer, S; Sengupta, S; Alenghat, T; Way, SS; Deshmukh, H. Microbiota-derived inosine programs protective CD8+ T cell responses against influenza in newborns. Cell. 2025; 188(16):4239-4256.e19.

Steyn, S; Brown-Burke, F; Marra, P; Chen, C-J; Saadey, R; Mao, C; Weist, J; Klimaszewski, H; Hout, I; Leon, S; Vaddi, K; Jordan, MB; Baiocchi, R; Shindiapina, P. Exploring PRMT5 Inhibition As a Therapeutic Strategy in Primary and Secondary Hemophagocytic Lymphohistiocytosis. Transplantation and Cellular Therapy. 2025; 31(2):s159.

Treichel, S; Bartram, J; Song, B; Nasr, W; Anderson, C; Xu, J; Sharma, D; Frangiosa, M; Harley, A; D'alessandro, A; Salomonis, N; Grimes, HL; Filippi, M-D. A branched chain amino acid rheostat controls hematopoietic stem cell replicative lifespan. Blood. 2025; 146(Supplement 1):1381.

Tsuda, S; Mahajan, S; Dasenbrock, A; Nakashima, A; Tilburgs, T. AW7 A novel in vitro assay platform to analyze the lymphocytes - HLA-G+ extravillous trophoblasts interaction. Journal of Reproductive Immunology. 2025; 172:104765.

Tursi, AR; Lages, CS; Quayle, K; Koenig, ZT; Loni, R; Eswar, S; Cobeña-Reyes, J; Thornton, S; Tilburgs, T; Andorf, S. Automated descriptive cell type naming in flow and mass cytometry with CytoPheno. Scientific Reports. 2025; 15(1):26750.

Vallez, CN; Ando, S; Araki, K; Pasare, C. Memory CD8+ T cell-induced activation of the innate immune system drives inflammation and anti-viral immunity 3109. Journal of Immunology. 2025; 214(Supplement_1).

Van Gelder, RD; Gokhale, NS; Genoyer, E; Omelia, DS; Anderson, SK; Young, HA; Savan, R. Interleukin-2-mediated NF-κB-dependent mRNA splicing modulates interferon gamma protein production. EMBO Reports. 2025; 26(1):16-35.

Venkatasubramanian, M; Schwartz, L; Ramachandra, N; Bennett, J; Subramanian, KR; Chen, X; Gordon-Mitchell, S; Fromowitz, A; Pradhan, K; Shechter, D; Grimes, HL; Starczynowski, DT; Verma, A; Salomonis, N. Splicing regulatory dynamics for precision analysis and treatment of heterogeneous leukemias. Science Translational Medicine. 2025; 17(797):eadr1471.

Warrick, KA; Molkentin, JD; Pasare, C. Immune checkpoint blockade induces de novo CD8 T cell priming and innate inflammation leading to myocarditis 3714. Journal of Immunology. 2025; 214(Supplement_1).

Warrick, KA; Vallez, CN; Meibers, HE; Pasare, C. Bidirectional Communication Between the Innate and Adaptive Immune Systems. Annual Review of Immunology. 2025; 43(1):489-514.

Whillock, AL; Smith, P; Sridhar, A; Lindgren, A; Berg, J; Mahajan, S; Tilburgs, T; Schuldt, NJ. Maternal natural microbial exposure in mice increases CD8 T cell heterogeneity at the maternal-fetal interface (MFI) phenocopying the human MFI 3993. Journal of Immunology. 2025; 214(Supplement_1).

Whillock, A; Smith, P; Burger, S; Sridhar, A; Lindgren, A; Berg, J; Tsuda, S; Mahajan, S; Tilburgs, T; Schuldt, NJ. Natural microbial exposure populates the maternal fetal interface with diverse T cells. Frontiers in Immunology. 2025; 16:1616491.

Wozny, N; Niebur, H; Jordan, M. T Cell Tropic Epstein Barr Virus in a Patient with Hemophagocytic Lymphohistiocytosis. Journal of Human Immunity. 2025; 1(CIS2025).

Yarawsky, AE; Herr, AB. Assembly landscape of the complete B-repeat superdomain from Staphylococcus epidermidis strain 1457. Biophysical Journal. 2025; 124(2):363-378.

Zhang, X; Tang, M; Li, G; Bernardicius, D; Vanoudenhove, J; Dezern, A; Ghiaur, G; Halene, S; Salomonis, N; Grimes, HL. 5-azacytidine treatment reshapes clonal structure and alters mutation-dependent splicing in MDS patients. Blood. 2025; 146(Supplement 1):2054-2054.

Zoref Lorenz, A; Cahn, E; Mou, E; Wang, Y; Maurer, MJ; Feldman, AL; Negaard, BJ; Mwangi, R; Itchaki, G; Nowakowski, GS; Goyal, G; Witzig, TE; Cerhan, JR; Jordan, M. The optimized HLH inflammatory index: A novel prognostic tool for newly diagnosed patients with diffuse large B-cell lymphoma—Discovery and validation. Journal of Clinical Oncology. 2025; 43(16_suppl):7073-7073.

Zoref-Lorenz, A; Allen, CE; Behrens, EM; Chandrakasan, S; Chien, M; Hermiston, ML; Hinson, A; Intzes, S; Isakoff, MS; Leiding, JW; Walkovich, K; Weinstein, JL; Yee, JD; Jordan, MB. Emapalumab use in malignancy-associated hemophagocytic lymphohistiocytosis in the United States: The REAL-HLH study. Blood advances. 2025.

Zoref-Lorenz, A; Murakami, J; Gurion, R; Iyer, SP; Abadi, U; Cohen, I; Goyal, G; Mohamed, S; Nikiforow, S; Natour, AEH; Itchaki, G; Izraeli, S; Ellis, M; Jordan, MB. The OHI index predicts early mortality from organ dysfunction and survival benefit from etoposide in patients with lymphoma. Blood advances. 2025; 9(17):4515-4525.

Zoref-Lorenz, A; Rocco, J; Schwartz, DM; Jordan, M. Recognizing and Managing Secondary Hemophagocytic Lymphohistiocytosis in Adults: A Practical Clinical Guide. Hematology/Oncology Clinics of North America. 2025; 39(3):577-596.

Zoref-Lorenz, A; Witzig, TE; Cerhan, JR; Jordan, MB. Malignancy-associated HLH: mechanisms, diagnosis, and treatment of a severe hyperinflammatory syndrome. Leukemia and Lymphoma. 2025; 66(4):628-636.

Zoref‐Lorenz, A; Cahn, EJ; Mou, E; Cholack, G; Wang, Y; Maurer, M; Feldman, AL; Negaard, BJ; Mwangi, R; Itchaki, G; Novak, AJ; Witzig, TE; Cerhan, JR; Jordan, M. 122 | IDENTIFYING HARMFUL HYPERINFLAMMATION IN DIFFUSE LARGE B‐CELL LYMPHOMA USING THE OHI (OPTIMIZED HLH INFLAMMATORY) INDEX—DISCOVERY AND VALIDATION IN REAL‐WORLD PATIENTS. Hematological Oncology. 2025; 43(S3).