Immunobiology

Publications

Arnold, DE; Nofal, R; Wakefield, C; Lehmberg, K; Wustrau, K; Albert, MH; Morris, EC; Heimall, JR; Bunin, NJ; Kumar, A; et al. Reduced-Intensity/Reduced-Toxicity Conditioning Approaches Are Tolerated in XIAP Deficiency but Patients Fare Poorly with Acute GVHD. Journal of Clinical Immunology. 2022; 42:36-45.

Atehortua, LM; Street, S; Davidson, WS; D'Alessandro, A; Chougnet, C. Apolipoprotein E enhance survival of effector memory regulatory T lymphocytes by regulating caspase-dependent apoptosis and lipid metabolism. Journal of immunology (Baltimore, Md. : 1950). 2022; 208:56.01.

Avellino, R; Mulet-Lazaro, R; Havermans, M; Hoogenboezem, R; Smeenk, L; Salomonis, N; Schneider, RK; Rombouts, E; Bindels, E; Grimes, L; et al. Induced cell-autonomous neutropenia systemically perturbs hematopoiesis in Cebpa enhancer-null mice. Blood Advances. 2022; 6:1406-1419.

Chiang, SC C; Owsley, E; Panchal, N; Chaturvedi, V; Terrell, CE; Jordan, MB; Mehta, PA; Davies, SM; Akeno, N; Booth, C; et al. Quercetin ameliorates XIAP deficiency-associated hyperinflammation. Blood. 2022; 140:706-715.

Colom Diaz, PA; Chou, C; Mistry, JJ; Salomonis, N; Daud Khan, M; Grimes, HL; Trowbridge, JJ. Metallothionein 1 (MT1) Is Selectively Required for DNMT3A;NPM1 -Mutant Acute Myeloid Leukemia Proliferation. Blood. 2022; 140:9103-9104.

Crespo, ÂC; Alexander, A; Tilburgs, T. Purification of Primary Decidual Natural Killer Cells for Functional Analysis. Methods in molecular biology (Clifton, N.J.). 2022; 2463:11-29.

Damen, MS M A; Alarcon, PC; Shah, AS; Divanovic, S. Greasing the inflammatory pathogenesis of viral pneumonias in diabetes. Obesity Reviews. 2022; 23:e13415.

Davila Saldana, BJ; John, T; Bonifant, C; Buchbinder, D; Chandra, S; Chandrakasan, S; Chang, W; Chen, L; Elfassy, HL; Geerlinks, AV; et al. High risk of relapsed disease in patients with NK/T-cell chronic active Epstein-Barr virus disease outside of Asia. Blood Advances. 2022; 6:452-459.

Díaz, PC; Chou, C; Mistry, J; Khan, MD; Salomonis, N; Grimes, HL; Trowbridge, J. 3055 – METALLOTHIONEIN 1 (MT1) AS A TARGETABLE DEPENDENCY IN ACUTE MYELOID LEUKEMIA. Experimental Hematology. 2022; 111:s72.

Erickson, JJ; Archer-Hartmann, S; Yarawsky, AE; Miller, JL C; Seveau, S; Shao, TY; Severance, AL; Miller-Handley, H; Wu, Y; Pham, G; et al. Pregnancy enables antibody protection against intracellular infection. Nature. 2022; 606:769-775.

Eshleman, E; Shao, T; Woo, V; Rice, T; Whitt, J; Engleman, L; Way, SS; Alenghat, T. Intestinal epithelial MHC class II regulation by HDAC3 instructs microbiota-specific CD4+ T cells. 2022; 2022.01.01.473735.

Eshleman, EM; Shao, T; Woo, V; Rice, T; Whitt, J; Engleman, L; Way, SS; Alenghat, T. Epithelial MHC class II directs microbiota-specific intestinal immune homeostasis. Journal of immunology (Baltimore, Md. : 1950). 2022; 208:115.03.

Fawad, JA; Luzader, DH; Hanson, GF; Moutinho, TJ; McKinney, CA; Mitchell, PG; Brown-Steinke, K; Kumar, A; Park, M; Lee, S; et al. Histone Deacetylase Inhibition by Gut Microbe-Generated Short-Chain Fatty Acids Entrains Intestinal Epithelial Circadian Rhythms. Gastroenterology. 2022; 163:1377-1390.e11.

Ferchen, K; Song, BA; Chou, C; Zhang, X; Salomonis, N; Grimes, HL. Identification and Isolation of Hematopoietic Stem Cells and Progenitors with Discrete Developmental Gene Expression Programs. Blood. 2022; 140:2856.

Feria, MG; Chang, C; Ticona, E; Moussa, A; Zhang, B; Ballena, I; Azañero, R; Ticona, C; De Cecco, CN; Fichtenbaum, CJ; et al. Pro-Inflammatory Alterations of Circulating Monocytes in Latent Tuberculosis Infection. Open Forum Infectious Diseases. 2022; 9:ofac629.

Föh, B; Buhre, JS; Lunding, HB; Moreno-Fernandez, ME; König, P; Sina, C; Divanovic, S; Ehlers, M. Microbial metabolite butyrate promotes induction of IL-10+IgM+ plasma cells. Editor, Rom S. PloS one. 2022; 17:e0266071.

Grasset, EK; Alenghat, T. Good intentions gone wrong: The B cell block to epithelial repair. Immunity. 2022; 55:2222-2224.

Hashimoto-Hill, S; Colapietro, L; Woo, V; Antonacci, S; Whitt, J; Engleman, L; Alenghat, T. Dietary phytate primes epithelial antibacterial immunity in the intestine. Frontiers in Immunology. 2022; 13:952994.

Hines, MR; Von Bahr Greenwood, T; Beutel, G; Beutel, K; Hays, JA; Horne, A; Janka, G; Jordan, MB; Van Laar, JA M; Lachmann, G; et al. Consensus-Based Guidelines for the Recognition, Diagnosis, and Management of Hemophagocytic Lymphohistiocytosis in Critically Ill Children and Adults. Critical Care Medicine. 2022; 50:860-872.

Jackson, CM; Demmert, M; Mukherjee, S; Isaacs, T; Thompson, R; Chastain, C; Gray, J; Senthamaraikannan, P; Presicce, P; Chetal, K; et al. A potent myeloid response is rapidly activated in the lungs of premature Rhesus macaques exposed to intra-uterine inflammation. Mucosal Immunology. 2022; 15:730-744.

Jacqmin, P; Laveille, C; Snoeck, E; Jordan, MB; Locatelli, F; Ballabio, M; de Min, C. Emapalumab in primary haemophagocytic lymphohistiocytosis and the pathogenic role of interferon gamma: A pharmacometric model-based approach. British Journal of Clinical Pharmacology. 2022; 88:2128-2139.

Jordan, MB. HLH: birds of a feather flock together. Blood. 2022; 140:167-168.

Kawarizadeh, K; Warrick, K; Pasare, C. BCAP plays a central role in regulating canonical M2 macrophage polarization upon various cell extrinsic signals. Journal of immunology (Baltimore, Md. : 1950). 2022; 208:111.04.

Khandelwal, P; Chaturvedi, V; Owsley, E; Efebera, YA; Choe, H; Bostic, M; Kumchala, P; Rajgolikar, G; Ranganathan, P; Garzon, R; et al. Prospective two center study of CD38 bright CD8+ effector memory T-cells as a predictor of acute GVHD. Transplantation Reports. 2022; 7:100100.

Korinfskaya, S; Kotliar, M; Katko, A; Hildeman, D; Miraldi, ER; Barski, A. Role of transcription factor RUNX1 in the maintenance of T helper cell epigenome and rapid recall response. Journal of immunology (Baltimore, Md. : 1950). 2022; 208:56.13.

Leighton Grimes, H; Ferchen, K; Salomonis, N; Song, B; Zhang, X. 2007 – IDENTIFICATION AND ISOLATION OF HEMATOPOIETIC STEM CELLS AND PROGENITORS WITH DISCRETE DEVELOPMENTAL GENE EXPRESSION PROGRAMS. Experimental Hematology. 2022; 111:s35.

Lingel, I; Wilburn, AN; Hargis, J; McAlees, JW; Laumonnier, Y; Chougnet, CA; Deshmukh, H; König, P; Lewkowich, IP; Schmudde, I. Prenatal antibiotics exposure does not influence experimental allergic asthma in mice. Frontiers in Immunology. 2022; 13:937577.

Locker, KC S; Kachapati, K; Wu, Y; Bednar, KJ; Adams, D; Patel, C; Tsukamoto, H; Heuer, LS; Aronow, BJ; Herr, AB; et al. Endosomal Sequestration of TLR4 Antibody Induces Myeloid-Derived Suppressor Cells and Reverses Acute Type 1 Diabetes. Diabetes. 2022; 71:470-482.

Manresa, MC; Miki, H; Miller, J; Okamoto, K; Dobaczewska, K; Herro, R; Gupta, RK; Kurten, R; Aceves, SS; Croft, M. A Deficiency in the Cytokine TNFSF14/LIGHT Limits Inflammation and Remodeling in Murine Eosinophilic Esophagitis. Journal of immunology (Baltimore, Md. : 1950). 2022; 209:ji2200326.

McAlees, JW; Baker, T; Houshel, L; McKnight, C; Lindsley, A; Strait, RT; Zhang, X; Cannata, A; Biagini, JM; Butsch Kovacic, M; et al. Increased nasal epithelial cell responsiveness to IL-17A in paediatric asthmatics with low blood neutrophil count, low traffic-related air pollution exposure and good asthma control. Clinical and Experimental Allergy. 2022; 52:569-573.

McDaniel, MM; Chawla, AS; Jain, A; Meibers, HE; Saha, I; Gao, Y; Jain, V; Roskin, K; Way, SS; Pasare, C. Effector memory CD4+ T cells induce damaging innate inflammation and autoimmune pathology by engaging CD40 and TNFR on myeloid cells. Science Immunology. 2022; 7:eabk0182.

Meibers, H; McDaniel, MM; Jain, A; Chawla, AS; Pasare, C. Effector memory CD4 T cells engage myeloid cells through TNFR and CD40 to induce innate inflammation and autoimmune pathology independent of pattern recognition receptors. Journal of immunology (Baltimore, Md. : 1950). 2022; 208:164.19.

Negi, S; Hashimoto-Hill, S; Alenghat, T. Neonatal microbiota-epithelial interactions that impact infection. Frontiers in Microbiology. 2022; 13:955051.

Ozga, MP; Nicolet, D; Mrózek, K; Yilmaz, S; Kohlschmidt, J; Larkin, KT; Blachly, JS; Oakes, CC; Buss, J; Walker, CJ; et al. Sex-Associated Differences in Frequencies and Outcome Prognostication of Recurrent Molecular Features in Adults with Acute Myeloid Leukemia (AML) (AMLCG, CALGB [Alliance]). Blood. 2022; 140:936-939.

Romano, L; Seu, KG; Papoin, J; Muench, DE; Konstantinidis, D; Olsson, A; Schlum, K; Chetal, K; Chasis, JA; Mohandas, N; et al. Erythroblastic islands foster granulopoiesis in parallel to terminal erythropoiesis. Blood. 2022; 140:1621-1634.

Saha, I; Pasare, C. The B cell adapter for PI3K (BCAP) promotes M2 macrophage phenotype and safeguards tumors from immune surveillance. Journal of immunology (Baltimore, Md. : 1950). 2022; 208:61.08.

Schmidt, AF; Schnell, DJ; Eaton, KP; Chetal, K; Kannan, PS; Miller, LA; Chougnet, CA; Swarr, DT; Jobe, AH; Salomonis, N; et al. Fetal maturation revealed by amniotic fluid cell-free transcriptome in rhesus macaques. JCI insight. 2022; 7:e162101.

Setiadi, A; Zoref-Lorenz, A; Lee, CY; Jordan, MB; Chen, LY C. Malignancy-associated haemophagocytic lymphohistiocytosis. The Lancet Haematology. 2022; 9:e217-e227.

Severance, AL; Kinder, JM; Xin, L; Burg, AR; Shao, TY; Pham, G; Tilburgs, T; Goodman, WA; Mesiano, S; Way, SS. Maternal-fetal conflict averted by progesterone- induced FOXP3+ regulatory T cells. iScience. 2022; 25:104400.

Shankar, A; McAlees, JW; Lewkowich, IP. Modulation of IL-4/IL-13 cytokine signaling in the context of allergic disease. Journal of Allergy and Clinical Immunology. 2022; 150:266-276.

Shanmuganad, S; Hummel, SA; Varghese, V; Hildeman, DA. Bcl-2 Is Necessary to Counteract Bim and Promote Survival of TCRαβ+CD8αα+ Intraepithelial Lymphocyte Precursors in the Thymus. Journal of immunology (Baltimore, Md. : 1950). 2022; 208:651-659.

Shi, T; Malik, A; vom Hofe, AY; Matuschek, L; Mullen, M; Lages, CS; Kudira, R; Singh, R; Zhang, W; Setchell, KD R; et al. Farnesoid X receptor antagonizes macrophage-dependent licensing of effector T lymphocytes and progression of sclerosing cholangitis. Science Translational Medicine. 2022; 14:eabi4354.

Skok Gibbs, C; Jackson, CA; Saldi, GA; Tjärnberg, A; Shah, A; Watters, A; De Veaux, N; Tchourine, K; Yi, R; Hamamsy, T; et al. High-performance single-cell gene regulatory network inference at scale: the Inferelator 3.0. Editor, Mathelier A. Bioinformatics. 2022; 38:2519-2528.

Solomon, M; Song, BA; Govindarajah, V; Good, S; Bartram, J; Cancelas, J; Filippi, M; Salomonis, N; Grimes, HL; Reynaud, D. Hematopoietic Flt3+ Multipotent Progenitors Are Organized in Discrete Functionally and Hierarchically Distinct Populations. Blood. 2022; 140:1981-1982.

Song, B; Ferchen, K; Chou, C; Zhang, X; Steele, H; Herro, R; Salomonis, N; Grimes, HL. 3194 – LIVE BACTERIAL LIGANDS PROGRAM CORE HEMATOPOIETIC GENE EXPRESSION. Experimental Hematology. 2022; 111:s142.

Stevens, J; Steinmeyer, S; Bonfield, M; Peterson, L; Wang, T; Gray, J; Lewkowich, I; Xu, Y; Du, Y; Guo, M; et al. The balance between protective and pathogenic immune responses to pneumonia in the neonatal lung is enforced by gut microbiota. Science Translational Medicine. 2022; 14:eabl3981.

Thomas, AL; Lehn, MA; Janssen, EM; Hildeman, DA; Chougnet, CA. Naturally-aged microglia exhibit phagocytic dysfunction accompanied by gene expression changes reflective of underlying neurologic disease. Scientific Reports. 2022; 12:19471.

Toth, A; Steinmeyer, S; Kannan, P; Gray, J; Jackson, CM; Mukherjee, S; Demmert, M; Sheak, JR; Benson, D; Kitzmiller, J; et al. Inflammatory blockade prevents injury to the developing pulmonary gas exchange surface in preterm primates. Science Translational Medicine. 2022; 14:eabl8574.

Wang, C; Chantraine, C; Viljoen, A; Herr, AB; Fey, PD; Horswill, AR; Mathelié-Guinlet, M; Dufrêne, YF. The staphylococcal biofilm protein Aap mediates cell-cell adhesion through mechanically distinct homophilic and lectin interactions. Editor, Yooseph S. 2022; 1:pgac278.

Wen, B; Wang, G; Li, E; Kolesnichenko, OA; Tu, Z; Divanovic, S; Kalin, TV; Kalinichenko, VV. In vivo generation of bone marrow from embryonic stem cells in interspecies chimeras. eLife. 2022; 11:e74018.

Woo, V; Alenghat, T. Epigenetic regulation by gut microbiota. Gut Microbes. 2022; 14:2022407.

Yarawsky, AE; Hopkins, JB; Chatzimagas, L; Hub, JS; Herr, AB. Solution Structural Studies of Pre-amyloid Oligomer States of the Biofilm Protein Aap. Journal of Molecular Biology. 2022; 434:167708.

Zhang, X; Song, BA; Khan, MD; Ferchen, K; Chou, C; Li, G; DeZern, AE; Ghiaur, G; Halene, S; Salomonis, N; et al. Single-Cell Multiomics Reveal Hypomethylating Agent Partially Restores Hematopoiesis in a LR-MDS Patient at the Cost of Leukemic Transformation. Blood. 2022; 140:9759-9760.

Zoref-Lorenz, A; Murakami, J; Hofstetter, L; Abadi, U; Iyer, S; Mohamed, S; Miller, PG; Natour, AE H; Weinstein, S; Yacobovich, J; et al. P1203: THE OPTIMIZED HLH INFLAMMATORY (OHI) INDEX IDENTIFIES LYMPHOMA PATIENTS WITH UNEXPECTEDLY HIGH MORTALITY NOT RELATED TO DISEASE PROGRESSION. HemaSphere. 2022; 6:1089-1090.

Zoref-Lorenz, A; Murakami, J; Hofstetter, L; Iyer, S; Alotaibi, AS; Mohamed, SF; Miller, PG; Guber, E; Weinstein, S; Yacobovich, J; et al. An improved index for diagnosis and mortality prediction in malignancy-associated hemophagocytic lymphohistiocytosis. Blood. 2022; 139:1098-1110.

Zoref-Lorenz, A; Yuklea, M; Topaz, G; Jordan, MB; Ellis, M. A Case of Chronic Lymphocytic Leukemia Complicated by Hemophagocytic Lymphohistiocytosis: Identifying the Aberrant Immune Response. Journal of General Internal Medicine. 2022; 37:1542-1546.