Blaxall Research Lab
The Blaxall Lab has a long-standing interest in understanding the development, progression and regression (treatment) of heart failure. We are particularly interested in developing novel heart failure therapeutics and are pursuing several projects with therapeutic potential, including advanced screening, medicinal chemistry, and drug development. A major focus is also to understand the pathologic intercellular communication between myocyte and non-myocyte (e.g. fibroblast) cells in the heart. Based on large-scale gene expression profiling of both mouse and human heart tissue from non-failing, failing, and genetically or surgically "rescued" cardiac phenotypes, we are also pursuing several genes not previously associated in with heart failure.
For these and other collaborative studies, we utilize a translational approach to investigate the functional cardiac and adrenergic-related relevance of specific genes and molecules. Our investigational techniques range from in vitro biochemistry, pharmacology, cell biology and isolated adult cardiomyocyte contractility studies to high-resolution in vivo cardiac phenotyping in genetic and surgical mouse models of heart failure, coupled with validation in human cardiac myocytes and tissue samples.