Molecular Cardiovascular Biology

Publications

Broman, MT; Nadadur, RD; Perez-Cervantes, C; Burnicka-Turek, O; Lazarevic, S; Gams, A; Laforest, B; Steimle, JD; Iddir, S; Wang, Z; Weber, CR; McNally, EM; Svensson, EC; Moskowitz, IP. A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network. Circulation. 2024; 149:1205-1230.

Bround, MJ; Abay, E; Huo, J; Havens, JR; York, AJ; Bers, DM; Molkentin, JD. MCU-independent Ca2+ uptake mediates mitochondrial Ca2+ overload and necrotic cell death in a mouse model of Duchenne muscular dystrophy. Scientific Reports. 2024; 14:6751.

Coppola, U; Saha, B; Kenney, J; Waxman, JS. A Foxf1-Wnt-Nr2f1 cascade promotes atrial cardiomyocyte differentiation in zebrafish. Editor, Conlon FL. PLoS Genetics. 2024; 20:e1011222.

Durumutla, HB; Prabakaran, AD; Soussi, FE A; Akinborewa, O; Latimer, H; McFarland, K; Piczer, K; Werbrich, C; Jain, MK; Haldar, SM; Quattrocelli, M. Glucocorticoid chronopharmacology promotes glucose metabolism in heart through a cardiomyocyte-autonomous transactivation program. JCI insight. 2024; 9:e182599.

En, A; Bogireddi, H; Thomas, B; Stutzman, AV; Ikegami, S; LaForest, B; Almakki, O; Pytel, P; Moskowitz, IP; Ikegami, K. Pervasive nuclear envelope ruptures precede ECM signaling and disease onset without activating cGAS-STING in Lamin-cardiomyopathy mice. Cell Reports. 2024; 43:114284.

Franco-Romero, A; Morbidoni, V; Milan, G; Sartori, R; Wulff, J; Romanello, V; Armani, A; Salviati, L; Conte, M; Salvioli, S; Millay, DP; Tooze, SA; Trevisson, E; Sandri, M. C16ORF70/MYTHO promotes healthy aging in C.elegans and prevents cellular senescence in mammals. The Journal of Clinical Investigation. 2024; 134:e165814.

Gonzalez, BA; Harmeyer, SW; Song, T; Sadayappan, S; Yutzey, KE. Dynamic changes in mitral valve extracellular matrix, tissue mechanics and function in a mouse model of Marfan syndrome. Matrix Biology. 2024; 126:1-13.

Grimes, KM; Maillet, M; Swoboda, CO; Bowers, SL K; Millay, DP; Molkentin, JD. MEK1-ERK1/2 signaling regulates the cardiomyocyte non-sarcomeric actin cytoskeletal network. American Journal of Physiology: Heart and Circulatory Physiology. 2024; 326:H180-H189.

Hassel, KR; Gibson, AM; Šeflová, J; Cho, EE; Blair, NS; Van Raamsdonk, CD; Anderson, DM; Robia, SL; Makarewich, CA. Another-regulin regulates cardiomyocyte calcium handling via integration of neuroendocrine signaling with SERCA2a activity. Journal of Molecular and Cellular Cardiology. 2024; 197:45-58.

Huo, J; Molkentin, JD. MCU genetically altered mice suggest how mitochondrial Ca2+ regulates metabolism. Trends in Endocrinology and Metabolism. 2024; 35:918-928.

Huo, J; Molkentin, JD. MICU1 and MICU2, two peas in a pod or entirely different fruits?. Cell Calcium. 2024; 124:102959.

Kamradt, ML; Makarewich, CA. CHKB-DT: A Long Noncoding RNA Critical for Cardiovascular Health. Circulation Research. 2024; 134:442-444.

Li, RG; Li, X; Morikawa, Y; Grisanti-Canozo, FJ; Meng, F; Tsai, C; Zhao, Y; Liu, L; Kim, J; Xie, B; Klysik, E; Liu, S; Samee, MA H; Martin, JF. YAP induces a neonatal-like pro-renewal niche in the adult heart. 2024; 3:283-300.

Li, Z; Gu, M; Zaparte, A; Fu, X; Mahen, K; Mrdjen, M; Li, XS; Yang, Z; Ma, J; Thoudam, T; Brown, JM; Lefer, DJ; Welsh, DA; Sharp, TE. Alcohol-induced gut microbial reorganization and associated overproduction of phenylacetylglutamine promotes cardiovascular disease. Nature Communications. 2024; 15:10788.

Liu, S; Deshmukh, V; Wang, F; Liang, J; Cusick, J; Li, X; Martin, JF. Myocardial Infarction Suppresses Protein Synthesis and Causes Decoupling of Transcription and Translation. JACC: Basic to Translational Science. 2024; 9:792-807.

Liu, Z; Liu, Y; Yu, Z; Tan, C; Pek, N; O’Donnell, A; Wu, A; Glass, I; Winlaw, DS; Guo, M; Spence, JR; Chen, YW; Yutzey, KE; Miao, Y; Gu, M. APOE-NOTCH axis governs elastogenesis during human cardiac valve remodeling. 2024; 3:933-950.

Meng, Q; Yang, B; Qiao, Y; Wu, Y; Chen, J; Lin, X; Molkentin, JD. Genetic and Pharmacologic Inhibition of JAK1/2 Antagonizes Cardiac Fibrosis. Circulation. 2024; 150:899-901.

Patel, P; Mendoza, A; Ramirez, D; Robichaux, D; Molkentin, JD; Karch, J. The adenine nucleotide translocase family underlies cardiac ischemia-reperfusion injury through the mitochondrial permeability pore independently of cyclophilin D. Science Advances. 2024; 10:eadp7444.

Peach, T; Quattrocelli, M. The muscle stem cell case of Benjamin Button: rejuvenating muscle regenerative capacity through nutraceuticals. The Journal of Clinical Investigation. 2024; 134:e185054.

Prabakaran, AD; McFarland, K; Miz, K; Durumutla, HB; Piczer, K; El Abdellaoui Soussi, F; Latimer, H; Werbrich, C; Chung, HJ; Blair, NS; Millay, DP; Morris, AJ; Prideaux, B; Finck, BN; Quattrocelli, M. Intermittent glucocorticoid treatment improves muscle metabolism via the PGC1α/Lipin1 axis in an aging-related sarcopenia model. The Journal of Clinical Investigation. 2024; 134:e177427.

Rabolli, CP; Naarmann-De Vries, IS; Makarewich, CA; Baskin, KK; Dieterich, C; Accornero, F. Nanopore Detection of METTL3-Dependent m6A-Modified mRNA Reveals a New Mechanism Regulating Cardiomyocyte Mitochondrial Metabolism. Circulation. 2024; 149:1319-1322.

Ramachandran, K; Futtner, CR; Sommars, MA; Quattrocelli, M; Omura, Y; Fruzyna, E; Wang, JC; Waldeck, NJ; Senagolage, MD; Telles, CG; Arango, D; Bederman, IR; McNally, EM; Barish, GD. Transcriptional programming of translation by BCL6 controls skeletal muscle proteostasis. Nature Metabolism. 2024; 6:304-322.

Rudman-Melnick, V; Adam, M; Stowers, K; Potter, A; Ma, Q; Chokshi, SM; Vanhoutte, D; Valiente-Alandi, I; Lindquist, DM; Nieman, ML; Kofron, JM; Chung, E; Park, JS; Potter, SS; Devarajan, P. Single-cell sequencing dissects the transcriptional identity of activated fibroblasts and identifies novel persistent distal tubular injury patterns in kidney fibrosis. Scientific Reports. 2024; 14:439.

Rudman-Melnick, V; Vanhoutte, D; Stowers, K; Sargent, M; Adam, M; Ma, Q; Perl, AK T; Miethke, AG; Burg, A; Shi, T; Hildeman, DA; Woodle, ES S; Kofron, JM; Devarajan, P. Gucy1α1 specifically marks kidney, heart, lung and liver fibroblasts. Scientific Reports. 2024; 14:29307.

Small, AM; Yutzey, KE; Binstadt, BA; Voigts Key, K; Bouatia-Naji, N; Milan, D; Aikawa, E; Otto, CM; St. Hilaire, C. Unraveling the Mechanisms of Valvular Heart Disease to Identify Medical Therapy Targets: A Scientific Statement From the American Heart Association. Circulation. 2024; 150:e109-e128.

Stege, NM; de Boer, RA; Makarewich, CA; van der Meer, P; Silljé, HH W. Reassessing the Mechanisms of PLN-R14del Cardiomyopathy: From Calcium Dysregulation to S/ER Malformation. JACC: Basic to Translational Science. 2024; 9:1041-1052.

Sun, C; Swoboda, CO; Morales, FM; Calvo, C; Petrany, MJ; Parameswaran, S; VonHandorf, A; Weirauch, MT; Lepper, C; Millay, DP. Lineage tracing of nuclei in skeletal myofibers uncovers distinct transcripts and interplay between myonuclear populations. Nature Communications. 2024; 15:9372.

Tang, X; Wei, W; Sun, Y; Weaver, TE; Nakayasu, ES; Clair, G; Snowball, JM; Na, CL; Apsley, KS; Martin, EP; Molkentin, JD; Gower, WA; Lin, X; Whitsett, JA. EMC3 regulates trafficking and pulmonary toxicity of the SFTPCI73T mutation associated with interstitial lung disease. The Journal of Clinical Investigation. 2024; 134:e173861.

Vanhoutte, D; Schips, TG; Minerath, RA; Huo, J; Kavuri, NS S; Prasad, V; Lin, SC; Bround, MJ; Sargent, MA; Adams, CM; Molkentin, JD. Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner. Cell Reports. 2024; 43:114149.

Wherley, TJ; Thomas, S; Millay, DP; Saunders, T; Roy, S. Molecular regulation of myocyte fusion. Current Topics in Developmental Biology. 2024; 158:53-82.

Xu, N; Alfieri, CM; Yu, Y; Guo, M; Yutzey, KE. Wnt Signaling Inhibition Prevents Postnatal Inflammation and Disease Progression in Mouse Congenital Myxomatous Valve Disease. Arteriosclerosis, Thrombosis, and Vascular Biology. 2024; 44:1540-1554.

Xu, N; Gonzalez, BA; Yutzey, KE. Macrophage lineages in heart development and regeneration. Heart Development and Disease. : Elsevier; Elsevier; 2024.