Molecular Cardiovascular Biology

Publications

Baldwin, TA; Teuber, JP; Kuwabara, Y; Subramani, A; Lin, SC J; Kanisicak, O; Vagnozzi, RJ; Zhang, W; Brody, MJ; Molkentin, JD. Palmitoylation-dependent regulation of cardiomyocyte Rac1 signaling activity and minor effects on cardiac hypertrophy. The Journal of biological chemistry. 2023; 299:105426.

Bowers, SL K; Meng, Q; Kuwabara, Y; Huo, J; Minerath, R; York, AJ; Sargent, MA; Prasad, V; Saviola, AJ; Galindo, DC; et al. Col1a2-Deleted Mice Have Defective Type I Collagen and Secondary Reactive Cardiac Fibrosis with Altered Hypertrophic Dynamics. Cells. 2023; 12:2174.

Bround, MJ; Havens, JR; York, AJ; Sargent, MA; Karch, J; Molkentin, JD. ANT-dependent MPTP underlies necrotic myofiber death in muscular dystrophy. Science Advances. 2023; 9:eadi2767.

Cossu, G; Tonlorenzi, R; Brunelli, S; Sampaolesi, M; Messina, G; Azzoni, E; Benedetti, S; Biressi, S; Bonfanti, C; Bragg, L; et al. Mesoangioblasts at 20: From the embryonic aorta to the patient bed. Frontiers in Genetics. 2023; 13:1056114.

Durumutla, HB; Villa, C; Panta, M; Wintzinger, M; Pragasam, AD P; Miz, K; Quattrocelli, M. Comprehensive Analyses of Muscle Function, Lean and Muscle Mass, and Myofiber Typing in Mice. Bio-protocol. 2023; 13:e4617.

Farini, A; Tripodi, L; Villa, C; Strati, F; Facoetti, A; Baselli, G; Troisi, J; Landolfi, A; Lonati, C; Molinaro, D; et al. Microbiota dysbiosis influences immune system and muscle pathophysiology of dystrophin-deficient mice. EMBO Molecular Medicine. 2023; 15:e16244.

Fischer, JA; Monroe, TO; Pesce, LL; Sawicki, KT; Quattrocelli, M; Bauer, R; Kearns, SD; Wolf, MJ; Puckelwartz, MJ; Mcnally, EM. Opposing effects of genetic variation in MTCH2 for obesity versus heart failure. Human Molecular Genetics. 2023; 32:15-29.

Florens, N; Kasam, RK; Rudman-Melnick, V; Lin, SC; Prasad, V; Molkentin, JD. Interleukin-33 Mediates Cardiomyopathy After Acute Kidney Injury by Signaling to Cardiomyocytes. Circulation. 2023; 147:746-758.

Franklin, DA; Liu, S; Jin, A; Cui, P; Guo, Z; Arend, KC; Moorman, NJ; He, S; Wang, GG; Wan, YY; et al. Ribosomal protein RPL11 haploinsufficiency causes anemia in mice via activation of the RP-MDM2-p53 pathway. The Journal of biological chemistry. 2023; 299:102739.

Gafranek, JT; D’Aniello, E; Ravisankar, P; Thakkar, K; Vagnozzi, RJ; Lim, HW; Salomonis, N; Waxman, JS. Sinus venosus adaptation models prolonged cardiovascular disease and reveals insights into evolutionary transitions of the vertebrate heart. Nature Communications. 2023; 14:5509.

Grimes, KM; Prasad, V; Huo, J; Kuwabara, Y; Vanhoutte, D; Baldwin, TA; Bowers, SL K; Johansen, AK Z; Sargent, MA; Lin, SC J; et al. Rpl3l gene deletion in mice reduces heart weight over time. Frontiers in Physiology. 2023; 14:1054169.

Hassel, KR; Brito-Estrada, O; Makarewich, CA. Microproteins: Overlooked regulators of physiology and disease. iScience. 2023; 26:106781.

Hindi, SM; Petrany, MJ; Greenfeld, E; Focke, LC; Cramer, AA W; Whitt, MA; Khairallah, RJ; Ward, CW; Chamberlain, JS; Podbilewicz, B; et al. Enveloped viruses pseudotyped with mammalian myogenic cell fusogens target skeletal muscle for gene delivery. Cell. 2023; 186:2062-2077.e17.

Ho, YC; Geng, X; O'Donnell, A; Ibarrola, J; Fernandez-Celis, A; Varshney, R; Subramani, K; Azartash-Namin, ZJ; Kim, J; Silasi, R; et al. PROX1 Inhibits PDGF-B Expression to Prevent Myxomatous Degeneration of Heart Valves. Circulation Research. 2023; 133:463-480.

Huo, J; Prasad, V; Grimes, KM; Vanhoutte, D; Blair, NS; Lin, SC; Bround, MJ; Bers, DM; Molkentin, JD. MCUb is an inducible regulator of calcium-dependent mitochondrial metabolism and substrate utilization in muscle. Cell Reports. 2023; 42:113465.

Kamradt, ML; Makarewich, CA. Mitochondrial microproteins: critical regulators of protein import, energy production, stress response pathways, and programmed cell death. American Journal of Physiology: Cell Physiology. 2023; 325:C807-C816.

Krishna, S; Echevarria, KG; Reed, CH; Eo, H; Wintzinger, M; Quattrocelli, M; Valentine, RJ; Selsby, JT. A fat- and sucrose-enriched diet causes metabolic alterations in mdx mice. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 2023; 325:R692-R711.

Kuwabara, Y; York, AJ; Lin, SC; Sargent, MA; Grimes, KM; Pirruccello, JP; Molkentin, JD. A human FLII gene variant alters sarcomeric actin thin filament length and predisposes to cardiomyopathy. Proceedings of the National Academy of Sciences of USA. 2023; 120:e2213696120.

Morales, ED; Yue, Y; Watkins, TB; Han, J; Pan, X; Gibson, AM; Hu, B; Brito-Estrada, O; Yao, G; Makarewich, CA; et al. Dwarf Open Reading Frame (DWORF) Gene Therapy Ameliorated Duchenne Muscular Dystrophy Cardiomyopathy in Aged mdx Mice. Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease. 2023; 12:e027480.

O'Donnell, A; Gonzalez, BA; Mukherjee, S; Wilson, R; Alfieri, CM; Swoboda, CO; Millay, DP; Zorn, AM; Yutzey, KE. Localized Prox1 Regulates Aortic Valve Endothelial Cell Diversity and Extracellular Matrix Stratification in Mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 2023; 43:1478-1493.

O'Donnell, A; Yutzey, KE. Quality Over Quantity: BMP-9 Regulation of Scar Formation After Myocardial Infarction. JACC: Basic to Translational Science. 2023; 8:1331-1333.

Prabakaran, A; Wintzinger, M; Piczer, K; Miz, K; Walton, A; Bindu Durumutla, H; Quattrocelli, M. OR33-04 Mechanistic Dissection Of Circadian-Specific Glucocorticoid Effects On Exercise Tolerance And Muscle Glucose Utilization. Journal of the Endocrine Society. 2023; 7:bvad114.1772.

Stege, NM; Eijgenraam, TR; Oliveira Nunes Teixeira, V; Feringa, AM; Schouten, EM; Kuster, DW D; Van Der Velden, J; Wolters, AH G; Giepmans, BN G; Makarewich, CA; et al. DWORF Extends Life Span in a PLN-R14del Cardiomyopathy Mouse Model by Reducing Abnormal Sarcoplasmic Reticulum Clusters. Circulation Research. 2023; 133:1006-1021.

Steimle, JD; Kim, C; Rowton, M; Nadadur, RD; Wang, Z; Stocker, M; Hoffmann, AD; Hanson, E; Kweon, J; Sinha, T; et al. ETV2 primes hematoendothelial gene enhancers prior to hematoendothelial fate commitment. Cell Reports. 2023; 42:112665.

Uscategui Calderon, M; Gonzalez, BA; Yutzey, KE. Cardiomyocyte-fibroblast crosstalk in the postnatal heart. Frontiers in Cell and Developmental Biology. 2023; 11:1163331.

Velayutham, N; Calderon, MU; Alfieri, CM; Padula, SL; van Leeuwen, FN; Scheijen, B; Yutzey, KE. Btg1 and Btg2 regulate neonatal cardiomyocyte cell cycle arrest. Journal of Molecular and Cellular Cardiology. 2023; 179:30-41.

Wintzinger, M; Miz, K; York, A; Demonbreun, AR; Molkentin, JD; McNally, EM; Quattrocelli, M. Effects of Glucocorticoids in Murine Models of Duchenne and Limb-Girdle Muscular Dystrophy. Methods in molecular biology (Clifton, N.J.). 2023; 2587:467-478.

Witcher, PC; Sun, C; Millay, DP. Expression of Myomaker and Myomerger in myofibers causes muscle pathology. Skeletal Muscle. 2023; 13:8.

Xu, N; Alfieri, CM; Yu, Y; Yutzey, KE. Abstract 15521: Wnt Signaling Inhibition Prevents Postnatal Inflammation and Disease Progression in Congenital Myxomatous Valve Disease. Circulation. 2023; 148.

Yan, R; Cigliola, V; Oonk, KA; Petrover, Z; DeLuca, S; Wolfson, DW; Vekstein, A; Mendiola, MA; Devlin, G; Bishawi, M; et al. An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair. Cell Stem Cell. 2023; 30:96-111.e6.