Molecular Cardiovascular Biology

Publications

Akinborewa, O; Quattrocelli, M. Glucocorticoid receptor epigenetic activity in the heart. Epigenetics. 2025; 20(1):2468113.

Akinborewa, O; Pragasam, ADP; Durumutla, HB; Latimer, H; Mcfarland, K; Quattrocelli, M. Abstract Wed122: LRRC14B is Essential for Cardiac Function via Sarcomeric Protein Quality Control. Circulation Research. 2025; 137(Suppl_1).

Bovo, E; Nikolaienko, R; Yuen, SL; Makarewich, CA; Brinkmann, M; Thomas, DD; Rebbeck, RT; Zima, AV. A piperidinyl amide compound enhances Ca2+ signaling in cardiomyocytes by increasing activity of Ca2+ pump. Biophysical Reports. 2026; 100250.

Brito-Estrada, O; Kuwabara, Y; Gibson, AM; Hassel, KR; Kamradt, ML; Verry, JP; Blair, NS; Bround, MJ; Huo, J; Molkentin, JD; Makarewich, CA. DWORF Gene Therapy Improves Cardiac Calcium Handling and Mitochondrial Function. Circulation Research. 2025; 137(8):1072-1088.

Calvo, C; Smith, C; Song, T; Montecino-Morales, F; Sadayappan, S; Millay, DP; Kim, M. Loss of Ufsp1 does not cause major changes at the neuromuscular junction. PLoS ONE. 2025; 20(8):e0328690.

Calvo, C; Swoboda, CO; Montecino-Morales, F; Nagar, S; Petrany, MJ; Sun, C; Bindu Durumutla, H; Quattrocelli, M; Millay, DP. The multimodal transcriptional response of denervated skeletal muscle involves regulation of Gramd1 genes impacting muscle size. Proceedings of the National Academy of Sciences of the United States of America. 2025; 122(39):e2424246122.

Chaikin, CA; Thakkar, AV; Steffeck, AWT; Pfrender, EM; Hung, K; Zhu, P; Waldeck, NJ; Nozawa, R; Song, W; Futtner, CR; Quattrocelli, M; Bass, J; Ben-Sahra, I; Peek, CB. Control of circadian muscle glucose metabolism through the BMAL1-HIF axis in obesity. Proceedings of the National Academy of Sciences of the United States of America. 2025; 122(13):e2424046122.

Cleary, SR; Teng, ACT; Kongmeneck, AD; Fang, X; Phillips, TA; Cho, EE; Smith, RA; Karkut, P; Makarewich, CA; Kekenes-Huskey, PM; Gramolini, AO; Robia, SL. Dilated cardiomyopathy variant R14del increases phospholamban pentamer stability, blunting dynamic regulation of calcium. Journal of Biological Chemistry. 2025; 301(2):108118.

Coughlin, TM; Makarewich, CA. Emerging roles for microproteins as critical regulators of endoplasmic reticulum function and cellular homeostasis. Seminars in Cell and Developmental Biology. 2025; 170:103608.

Damen, MS; Alarcon, PC; Chan, CC; Stankiewicz, TE; Chung, H; Sawada, K; Ulanowicz, CJ; Eom, J; Oates, JR; Wayland, JL; Helmrath, MA; Sanchez-Gurmaches, J; Moreno-Fernandez, ME; Divanovic, S. A shift in PKM2 oligomeric state instructs adipocyte inflammatory potential. JCI Insight. 2025; 10(22).

Duong, TB; Fernandes, AT; Ravisankar, P; Talbot, JC; Waxman, JS. Tbx1-dependent and independent pathways promote six gene expression downstream of retinoic acid signaling to determine cardiomyocyte number in zebrafish. Developmental Biology. 2025; 524:17-28.

Durumutla, HB; Haller, A; Noble, G; Prabakaran, AD; Mcfarland, K; Latimer, H; Rajput, A; Akinborewa, O; Namjou-Khales, B; Hui, DY; Quattrocelli, M. The human glucocorticoid receptor variant rs6190 increases blood cholesterol and promotes atherosclerosis. Journal of Clinical Investigation. 2025; 135(17).

Gibson, AM; Pan, X; Brito-Estrada, O; Teixeira, JA; Carl, LK; Yue, Y; Kamradt, ML; Burke, MJ; Wadding-Lee, CA; Yao, G; Herzog, RW; Duan, D; Makarewich, CA. DWORF expression is reduced in a large animal model of Duchenne muscular dystrophy. Disease Models & Mechanisms. 2025; 18(6).

Halurkar, MS; Inoue, O; Singh, A; Mukherjee, R; Ginugu, M; Ahn, C; Bonatto Paese, CL; Duszynski, M; Brugmann, SA; Lim, H-W; Sanchez-Gurmaches, J. The widely used Ucp1-Cre transgene elicits complex developmental and metabolic phenotypes. Nature Communications. 2025; 16(1):770.

Hong, J; Shah, V; Krishnan, R; Gomez-Stallons, MV; Poudel, S; Yutzey, KE; Dahia, CL. Klotho mutation does not accelerate intervertebral disc aging in mice. The FASEB Journal. 2025; 39(1):e70279.

Johansen, AKZ; Kasam, RK; Vagnozzi, RJ; Lin, S-CJ; Gomez-Arroyo, J; Shittu, A; Bowers, SLK; Kuwabara, Y; Grimes, KM; Warrick, K; Sargent, MA; Baldwin, TA; Quaggin, SE; Barski, A; Molkentin, JD. Transcription Factor 21 Regulates Cardiac Myofibroblast Formation and Fibrosis. Circulation Research. 2025; 136(1):44-58.

Joss-Moore, LA; Yutzey, KE. Baby breaths: Honoring Kurt Albertine and his contributions to respiratory research in young mammals and to The Anatomical Record. Anatomical Record. 2025; 308(4):1018-1025.

Li, R; Li, X; Morikawa, Y; Grisanti, F; Meng, F; Tsai, C-R; Zhao, Y; Liu, L; Kim, J; Xie, B; Klysik, E; Liu, S; Samee, AH; Martin, J. YAP Induces a Neonatal Like Pro-Renewal Niche in the Adult Heart. Journal of Molecular and Cellular Cardiology Plus. 2025; 12:100304.

Liu, S; Deshmukh, V; Meng, F; Wang, Y; Morikawa, Y; Steimle, JD; Li, RG; Wang, J; Martin, JF. Microtubules Sequester Acetylated YAP in the Cytoplasm and Inhibit Heart Regeneration. Circulation. 2025; 151(1):59-75.

Meng, F; Steimle, JD; Straight, E; Li, RG; Morikawa, Y; Iqbal, Z; Xie, B; Wang, J; Paltzer, WG; Zhao, Y; Karch, JM; Pautler, RG; Li, X; Martin, JF. Gene therapy CM-YAPon protects the mouse heart from myocardial infarction. Nature Cardiovascular Research. 2025; 4(12):1616-1626.

Meng, F; Kim, JH; Tsai, C-R; Steimle, JD; Wang, J; Shi, Y; Li, RG; Xie, B; Deshmukh, V; Liu, S; Li, X; Martin, JF. SARS-CoV-2 NSP13 interacts with TEAD to suppress Hippo-YAP signaling. eLife. 2025; 13.

Meng, F; Kim, JH; Tsai, C-R; Steimle, JD; Wang, J; Shi, Y; Li, RG; Xie, B; Deshmukh, V; Liu, S; Li, X; Martin, JF. SARS-CoV-2 NSP13 interacts with TEAD to suppress Hippo-YAP signaling. eLife. 2025; 13.

Mia, S; Siokatas, G; Sidiropoulou, R; Hoffman, M; Fragkiadakis, K; Markopoulou, E; Elesawy, MI; Roy, R; Blair, S; Kuwabara, Y; Schilling, JD; Molkentin, JD; Marketou, M; Drosatos, K. Hepato-cardiac interorgan communication controls cardiac hypertrophy via combined endocrine-autocrine FGF21 signaling. Cell Reports Medicine. 2025; 6(6):102125.

Millay, D; Hindi, S; Wong, A. 11INVLeveraging the muscle fusogens for gene delivery. Neuromuscular Disorders. 2025; 53:105832.

Minerath, R; Kasam, R; Grimes, K; Prasad, V; Sargent, M; Khalil, H; York, A; Kuwabara, Y; Saviola, A; Alfieri, C; Hansen, K; Yutzey, K; Molkentin, J. Transforming growth factor β-dependent regulation of cardiomyocyte maturation. Journal of Molecular and Cellular Cardiology Plus. 2025; 12:100400.

Morikawa, Y; Kim, JH; Li, RG; Liu, L; Liu, S; Deshmukh, V; Hill, MC; Martin, JF. YAP Overcomes Mechanical Barriers to Induce Mitotic Rounding and Adult Cardiomyocyte Division. Circulation. 2025; 151(1):76-93.

Prabakaran, AD; Quattrocelli, M. The human glucocorticoid receptor variant rs6190 protects the heart from metabolic stress. Journal of Molecular and Cellular Cardiology Plus. 2025; 12:100306.

Prabakaran, AD; Montecino-Morales, F; Mcfarland, K; Govindarajan, T; Durumutla, HB; Latimer, H; Akinborewa, O; Villa, C; Millay, DP; Quattrocelli, M. The human genetic variant rs6190 unveils Foxc1 and Arid5a as novel prometabolic targets of the glucocorticoid receptor in muscle. Science Advances. 2025; 11(28):eadw2593.

Quattrocelli, M. OR29-07 The Rs6190 Polymorphism Unveils Unprecedented Mechanisms Of Cardiovascular Health Elicited By The Glucocorticoid Receptor In Humans And Mice. Journal of the Endocrine Society. 2025; 9(Supplement_1):bvaf149.1857.

Quattrocelli, M. Abstract Thu090: Glucocorticoids activate cardiac ketolysis across heart failure contexts through the clock factor RORα. Circulation Research. 2025; 137(Suppl_1).

Rojas, A; Dahlen, S; Zhang, F; Liu, S. The Cytoskeletal Structure in Cardiomyocyte Maturation and Proliferation. Cells. 2025; 14(19).

Secchia, S; Beilinson, V; Chen, X; Gucwa, M; Denson, LA; Miraldi, ER; Weirauch, MT; Ikegami, K. Starvation activates ECM-remodeling gene transcription and putative enhancers in fibroblasts despite inducing quiescence. Cell reports. 2025; 44(7):115896.

Silver, E; Duran, JM; Gunes, BB; Fenwick, AJ; Maisel, S; Wang, T-M; Manso, AM; Cruz, MS; Gu, Y; Fong, J; Cammarato, A; Mcculloch, AD; Bushway, P; Adler, ED. Human Variant in the Cardiac Troponin I Switch Domain Causes Diastolic Dysfunction in a Novel Mouse Model. Journal of the American Heart Association. 2025; 14(22):e040852.

Tripathi, GM; Dourson, AJ; Montecino-Morales, F; Wayland, JL; Khanna, S; Hofmann, MC; Durumutla, HB; Govindarajan, T; Queme, LF; Millay, DP; Jankowski, MP. Synaptic-like coupling of macrophages to myofibers regulates muscle repair. Current Biology. 2025; 35(24):6010-6023.e5.

Tsai, C-R; Liu, L; Zhao, Y; Kim, JH; Czarnewski, P; Li, RG; Meng, F; Zheng, M; Steimle, J; Zhao, X; Wang, J; Samee, MAH; Li, X; Martin, JF. YAP-Induced Glycolysis Drives Fibroinflammation and Disrupts Fibroblast Fidelity. Circulation Research. 2025; 137(12):1443-1458.

Uscategui Calderon, M; Spaeth, ML; Granitto, M; Gonzalez, BA; Weirauch, MT; Kottyan, LC; Yutzey, KE. GDF10 promotes rodent cardiomyocyte maturation during the postnatal period. Journal of Molecular and Cellular Cardiology. 2025; 201:16-31.

Van Der Maarel, LE; Mungroo, MR; Mulleners, OJ; Rivaud, MR; Verkerk, AO; Van Duijvenboden, K; Tiel Groenestege, FHT; Steimle, JD; Fokkert, L; De Gier-De Vries, C; Jensen, B; Boink, GJJ; Devalla, HD; Christoffels, VM. PITX2 dosage-dependent changes in pacemaker cell state underlie sinus node dysfunction and atrial arrhythmias. Nature Communications. 2025; 16(1):11197.

Wadding-Lee, CA; Makarewich, CA. Microproteins in Metabolism. Cells. 2025; 14(12).

Warrick, KA; Molkentin, JD; Pasare, C. Immune checkpoint blockade induces de novo CD8 T cell priming and innate inflammation leading to myocarditis 3714. Journal of Immunology. 2025; 214(Supplement_1).

Wherley, TJ; Zhao, X; Hindi, SM; Lopes, LJS; Leikina, E; Rowan, FC; Setchell, KDR; Sodt, AJ; Chernomordik, LV; Millay, DP. Myomaker and ether lipids cooperate to promote fusion-competent membrane states. Cell reports. 2026; 45(2):116900.

Yamaguchi, H; Tran, LT; Bi, J; Urayama, A; Yutzey, KE; Mishina, Y; Komatsu, Y. Enhanced BMP signaling in cranial neural crest cells induces aberrant chondrogenesis by upregulating Tbx20 expression during craniofacial development. Biochemical and Biophysical Research Communications. 2025; 765:151834.