Oncology

August, KJ; Farooki, S; Fulbright, JM; August, A; Portnoy, JM; Pommert, L; Burke, MJ; Guest, EM. Desensitization to pegaspargase in children with acute lymphoblastic leukemia and lymphoblastic lymphoma. Pediatric Blood and Cancer. 2020; 67.

Baird, K; Glod, J; Steinberg, SM; Reinke, D; Pressey, JG; Mascarenhas, L; Federman, N; Marina, N; Chawla, S; Lagmay, JP; et al. Results of a Randomized, Double-Blinded, Placebo-Controlled, Phase 2.5 Study of Saracatinib (AZD0530), in Patients with Recurrent Osteosarcoma Localized to the Lung. Sarcoma. 2020; 2020:1-6.

Burke, GA A; Beishuizen, A; Bhojwani, D; Burkhardt, B; Minard-Colin, V; Norris, RE; Kabickova, E; Pinarli, FG; Tacyildiz, N; Howes, A; et al. Ibrutinib plus CIT for R/R mature B-NHL in children (SPARKLE trial): initial safety, pharmacokinetics, and efficacy. Leukemia. 2020; 34:2271-2275.

Clarkson, KA; Frenck, RW; Dickey, M; Suvarnapunya, AE; Chandrasekaran, L; Weerts, HP; Heaney, CD; McNeal, M; Detizio, K; Parker, S; et al. Immune response characterization after controlled infection with lyophilized shigella sonnei 53G. mSphere. 2020; 5.

Cooper, TM; Absalon, MJ; Alonzo, TA; Gerbing, RB; Leger, KJ; Hirsch, BA; Pollard, J; Razzouk, BI; Aplenc, R; Kolb, EA. Phase I/II study of CPX-351 followed by fludarabine, cytarabine, and granulocyte-colony stimulating factor for children with relapsed acute myeloid leukemia: A report from the children’s oncology group. Journal of Clinical Oncology. 2020; 38:2170-2177.

Cramer, S; Marcus, MA; Ramkissoon, S; Szabo, S; Pressey, JG. Pediatric BRAF (V600E)-mutated pancreatic acinar cell carcinoma with complete and durable response to dabrafenib and trametinib. JCO Precision Oncology. 2020; 4:801-805.

Daw, NC; Chi, Y; Kalapurakal, JA; Kim, Y; Hoffer, FA; Geller, JI; Perlman, EJ; Ehrlich, PF; Mullen, EA; Warwick, AB; et al. Activity of Vincristine and Irinotecan in Diffuse Anaplastic Wilms Tumor and Therapy Outcomes of Stage II to IV Disease: Results of the Children's Oncology Group AREN0321 Study. Journal of Clinical Oncology. 2020; 38:1558-1568.

de Blank, P; Berman, JI; Prelack, M; Sollee, JR; Lane, A; Waldman, AT; Fisher, MJ. Effect of age and neurofibromatosis type 1 status on white matter integrity in the optic radiations. 2020; 2:i150-i158.

de Blank, P; Fouladi, M; Huse, JT. Molecular markers and targeted therapy in pediatric low-grade glioma. Journal of Neuro-Oncology. 2020; 150:5-15.

de Blank, P; Li, N; Fisher, MJ; Ullrich, NJ; Bhatia, S; Yasui, Y; Sklar, CA; Leisenring, W; Howell, R; Oeffinger, K; et al. Late morbidity and mortality in adult survivors of childhood glioma with neurofibromatosis type 1: report from the Childhood Cancer Survivor Study. Genetics in Medicine. 2020; 22:1794-1802.

DeWire, M; Fuller, C; Hummel, TR; Chow, LM L; Salloum, R; de Blank, P; Pater, L; Lawson, S; Zhu, X; Dexheimer, P; et al. A phase I/II study of ribociclib following radiation therapy in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG). Journal of Neuro-Oncology. 2020; 149:511-522.

D'Souza, AM; Towbin, AJ; Gupta, A; Alonso, M; Nathan, JD; Bondoc, A; Tiao, G; Geller, JI. Clinical heterogeneity of pediatric hepatocellular carcinoma. Pediatric Blood and Cancer. 2020; 67.

Ehrlich, PF; Chi, Y; Chintagumpala, MM; Hoffer, FA; Perlman, EJ; Kalapurakal, JA; Tornwall, B; Warwick, A; Shamberger, RC; Khanna, G; et al. Results of treatment for patients with multicentric or bilaterally predisposed unilateral Wilms tumor (AREN0534): A report from the Children's Oncology Group. Cancer. 2020; 126:3516-3525.

Emberesh, M; Rubinstein, JD; Young, J; Benoit, SW; Dandoy, CE; Weiss, BD. Tolerance of dinutuximab therapy for treatment of high-risk neuroblastoma in two patients with end-stage renal disease on dialysis. Pediatric Blood and Cancer. 2020.

Fangusaro, J; Witt, O; Driever, PH; Bag, AK; de Blank, P; Kadom, N; Kilburn, L; Lober, RM; Robison, NJ; Fisher, MJ; et al. Response assessment in paediatric low-grade glioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group. The Lancet Oncology. 2020; 21:e305-e316.

Frenck, RW; Dickey, M; Suvarnapunya, AE; Chandrasekaran, L; Kaminski, RW; Clarkson, KA; McNeal, M; Lynen, A; Parker, S; Hoeper, A; et al. Establishment of a controlled human infection model with a lyophilized strain of shigella sonnei 53G. mSphere. 2020; 5.

Gasilina, A; Premnauth, G; Gurjar, P; Biesiada, J; Hegde, S; Milewski, D; Ma, G; Kalin, TV; Merino, E; Meller, J; et al. IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models. PLoS ONE. 2020; 15:e0229801-e0229801.

Geller, JI; Cost, NG; Chi, Y; Tornwall, B; Cajaiba, M; Perlman, EJ; Kim, Y; Mullen, EA; Glick, RD; Khanna, G; et al. A prospective study of pediatric and adolescent renal cell carcinoma: A report from the Children's Oncology Group AREN0321 study. Cancer. 2020; 126:5156-5164.

Geller, JI; Pressey, JG; Smith, MA; Kudgus, RA; Cajaiba, M; Reid, JM; Hall, D; Barkauskas, DA; Voss, SD; Cho, SY; et al. ADVL1522: A phase 2 study of lorvotuzumab mertansine (IMGN901) in children with relapsed or refractory wilms tumor, rhabdomyosarcoma, neuroblastoma, pleuropulmonary blastoma, malignant peripheral nerve sheath tumor, or synovial sarcoma—A Children's Oncology Group study. Cancer. 2020; 126:5303-5310.

Gilligan, LA; DeWire-Schottmiller, MD; Fouladi, M; DeBlank, P; Leach, JL. Tumor response assessment in diffuse intrinsic pontine glioma: Comparison of semiautomated volumetric, semiautomated linear, and manual linear tumor measurement strategies. American Journal of Neuroradiology. 2020; 41:866-873.

Golan, K; Singh, AK; Kollet, O; Bertagna, M; Althoff, MJ; Khatib-Massalha, E; Petrovich-Kopitman, E; Wellendorf, AM; Massalha, H; Levin-Zaidman, S; et al. Bone marrow regeneration requires mitochondrial transfer from donor Cx43-expressing hematopoietic progenitors to stroma. Blood. 2020; 136:2607-2619.

Gounder, M; Schöffski, P; Jones, RL; Agulnik, M; Cote, GM; Villalobos, VM; Attia, S; Chugh, R; Chen, TW W; Jahan, T; et al. Tazemetostat in advanced epithelioid sarcoma with loss of INI1/SMARCB1: an international, open-label, phase 2 basket study. The Lancet Oncology. 2020; 21:1423-1432.

Greene, AN; Parks, LG; Solomon, MB; Privette Vinnedge, LM. Loss of DEK Expression Induces Alzheimer’s Disease Phenotypes in Differentiated SH-SY5Y Cells. Frontiers in Molecular Neuroscience. 2020; 13.

Gross, AM; Wolters, PL; Dombi, E; Baldwin, A; Whitcomb, P; Fisher, MJ; Weiss, B; Kim, A; Bornhorst, M; Shah, AC; et al. Selumetinib in children with inoperable plexiform neurofibromas. The New England journal of medicine. 2020; 382:1430-1442.

Gupta, S; Maude, SL; O'Brien, MM; Rau, RE; McNeer, JL. How the COG is Approaching the High-Risk Patient with ALL: Incorporation of Immunotherapy into Frontline Treatment. Clinical Lymphoma, Myeloma and Leukemia. 2020; 20 Suppl 1:S8-S11.

Harker-Murray, PD; Pommert, L; Barth, MJ. Novel therapies potentially available for pediatric b-cell non-hodgkin lymphoma. Journal of the National Comprehensive Cancer Network : JNCCN. 2020; 18:1125-1134.

He, X; Dou, A; Feng, S; Roman-Rivera, A; Hawkins, C; Lawley, L; Zhang, J; Wunderlich, M; Mizukawa, B; Halene, S; et al. Cyclosporine enhances the sensitivity to lenalidomide in MDS/AML in vitro. Experimental Hematology. 2020; 86:21-27.e2.

Itskovich, SS; Gurunathan, A; Clark, J; Burwinkel, M; Wunderlich, M; Berger, MR; Kulkarni, A; Chetal, K; Venkatasubramanian, M; Salomonis, N; et al. MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia. Nature Communications. 2020; 11.

Jones, LM; Melgar, K; Bolanos, L; Hueneman, K; Walker, MM; Jiang, J; Wilson, KM; Zhang, X; Shen, J; Jiang, F; et al. Targeting AML-associated FLT3 mutations with a type I kinase inhibitor. Journal of Clinical Investigation. 2020; 130:2017-2023.

Lafay-Cousin, L; Bouffet, E; Strother, D; Rudneva, V; Hawkins, C; Eberhart, C; Horbinski, C; Heier, L; Souweidane, M; Williams-Hughes, C; et al. Phase II Study of Nonmetastatic Desmoplastic Medulloblastoma in Children Younger Than 4 Years of Age: A Report of the Children's Oncology Group (ACNS1221). Journal of Clinical Oncology. 2020; 38:223-231.

Lawell, MP; Indelicato, DJ; Paulino, AC; Hartsell, W; Laack, NN; Ermoian, RP; Perentesis, JP; Vatner, R; Perkins, S; Mangona, VS; et al. An open invitation to join the Pediatric Proton/Photon Consortium Registry to standardize data collection in pediatric radiation oncology. British Journal of Radiology. 2020; 93:20190673-20190673.

Lazow, MA; Hoffman, L; Schafer, A; Osorio, DS; Boué, DR; Rush, S; Wright, E; Lane, A; DeWire-Schottmiller, MD; Smolarek, T; et al. Characterizing temporal genomic heterogeneity in pediatric low-grade gliomas. Acta Neuropathologica Communications. 2020; 8.

Lazow, MA; Johnson, SL; Johnson, ND; Breneman, JC; Dexheimer, PJ; Szabo, S; Pressey, JG. Genome-driven therapy for chemotherapy-resistant metastatic CDK6-amplified osteosarcoma. JCO Precision Oncology. 2020; 4:498-504.

Lazow, MA; Lawson, SA; Salloum, R; Hummel, TR; Pillay Smiley, N; DeWire-Schottmiller, MD; Fouladi, M; de Blank, P. Trametinib-associated Hyponatremia in a Child With Low-grade Glioma is Not Seen Following Treatment With Alternative MEK Inhibitor. Journal of Pediatric Hematology/Oncology. 2020; Publish Ahead of Print.

Leach, JL; Roebker, J; Schafer, A; Baugh, J; Chaney, B; Fuller, C; Fouladi, M; Lane, A; Doughman, R; Drissi, R; et al. MR imaging features of diffuse intrinsic pontine glioma and relationship to overall survival: report from the International DIPG Registry. Neuro-Oncology. 2020; 22:1647-1657.

Lee, LH; Krupski, C; Clark, J; Wunderlich, M; Lorsbach, RB; Grimley, MS; Burwinkel, M; Nelson, A; Kumar, AR. High-risk LCH in infants is serially transplantable in a xenograft model but responds durably to targeted therapy. Blood Advances. 2020; 4:717-727.

Li, BK; Vasiljevic, A; Dufour, C; Yao, F; Ho, BL B; Lu, M; Hwang, EI; Gururangan, S; Hansford, JR; Fouladi, M; et al. Pineoblastoma segregates into molecular sub-groups with distinct clinico-pathologic features: a Rare Brain Tumor Consortium registry study. Acta Neuropathologica. 2020; 139:223-241.

Liu, X; Feng, B; Vats, A; Tang, H; Seibel, W; Swaroop, M; Tawa, G; Zheng, W; Byrne, L; Schurdak, M; et al. Pharmacological clearance of misfolded rhodopsin for the treatment ofRHO-associated retinitis pigmentosa. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020; 34:10146-10167.

Louis, DN; Wesseling, P; Aldape, K; Brat, DJ; Capper, D; Cree, IA; Eberhart, C; Figarella-Branger, D; Fouladi, M; Fuller, GN; et al. cIMPACT-NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT-Utrecht meeting on future CNS tumor classification and grading. Brain Pathology. 2020; 30:844-856.

Marion, W; Boettcher, S; Ruiz-Torres, S; da Rocha, EL; Lundin, V; Morris, V; Chou, S; Zhao, AM; Kubaczka, C; Aumais, O; et al. An induced pluripotent stem cell model of Fanconi anemia reveals mechanisms of p53-driven progenitor cell differentiation. Blood Advances. 2020; 4:4679-4692.

Meacham, LR; Burns, K; Orwig, KE; Levine, J. Standardizing Risk Assessment for Treatment-Related Gonadal Insufficiency and Infertility in Childhood Adolescent and Young Adult Cancer: The Pediatric Initiative Network Risk Stratification System. Journal of Adolescent and Young Adult Oncology. 2020; 9:662-666.

Muraleedharan, R; Gawali, MV; Tiwari, D; Sukumaran, A; Oatman, N; Anderson, J; Nardini, D; Bhuiyan, MA N; Tkac, I; Ward, AL; et al. AMPK-Regulated Astrocytic Lactate Shuttle Plays a Non-Cell-Autonomous Role in Neuronal Survival. Cell Reports. 2020; 32:108092-108092.

Murphy, M; Chamberlain, A; Tang, P; Turpin, B; Danziger-Isakov, L. Paediatric ganciclovir dosing in extracorporeal membrane oxygenation: Is standard dosing good enough?. Journal of Clinical Pharmacy and Therapeutics. 2020; 45:218-220.

Nowrouzi, A; Sertorio, MG; Akbarpour, M; Knoll, M; Krunic, D; Kuhar, M; Schwager, C; Brons, S; Debus, J; Wells, SI; et al. Personalized assessment of normal tissue radiosensitivity via transcriptome response to photon, proton and carbon irradiation in patient-derived human intestinal organoids. Cancers. 2020; 12:469-469.

Parsons, LN; Mullen, EA; Geller, JI; Chi, Y; Khanna, G; Glick, RD; Aldrink, JH; Valiance, KL; Kim, Y; Fernandez, CV; et al. Outcome analysis of stage I epithelial-predominant favorable-histology Wilms tumors: A report from Children's Oncology Group study AREN03B2. Cancer. 2020; 126:2866-2871.

Pease, NA; Shephard, MS; Sertorio, M; Waltz, SE; Vinnedge, LM P. Dek expression in breast cancer cells leads to the alternative activation of tumor associated macrophages. Cancers. 2020; 12:1936-21.

Phillips, CL; Lane, A; Gerbing, RB; Alonzo, TA; Wilkey, A; Radloff, G; Lange, B; Gamazon, ER; Dolan, ME; Davies, SM. Genomic variants of cytarabine sensitivity associated with treatment-related mortality in pediatric AML: A report from the children's oncology group. Clinical Cancer Research. 2020; 26:2891-2897.

Pommert, L; Liberio, N; Ng, JS; Egelund, TA; Siver, MJ; Katzenstein, HM; Burke, MJ. Concurrent Imatinib Dosing with High-dose Methotrexate Leads to Acute Kidney Injury and Delayed Methotrexate Clearance in Pediatric Patients with Philadelphia Chromosome-positive B-Cell Acute Lymphoblastic Leukemia. Journal of Pediatric Hematology/Oncology. 2020; Publish Ahead of Print.

Pressey, JG; Dandoy, CE; Pater, LE; Rios, JS; Sisson, R; Dasgupta, R; Szabo, S. Small cell carcinoma of the ovary hypercalcemic type (SCCOHT): Comprehensive management of a newly diagnosed young adult. Gynecologic Oncology. 2020; 158:538-546.

Reddy, AT; Strother, DR; Judkins, AR; Burger, PC; Pollack, IF; Krailo, MD; Buxton, AB; Williams-Hughes, C; Fouladi, M; Mahajan, A; et al. Efficacy of High-Dose Chemotherapy and Three-Dimensional Conformal Radiation for Atypical Teratoid/Rhabdoid Tumor: A Report From the Children's Oncology Group Trial ACNS0333. Journal of Clinical Oncology. 2020; 38:1175-1185.

Rossoff, J; Huynh, V; Rau, RE; Macy, ME; Sulis, ML; Schultz, KR; Burke, MJ; Athale, U; O'Brien, MM; Jr, GJ J; et al. Experience with ponatinib in paediatric patients with leukaemia. British Journal of Haematology. 2020; 189:363-368.

Rubinstein, JD; Burns, K; Absalon, M; Lutzko, C; Leemhuis, T; Chandra, S; Hanley, PJ; Keller, MD; Davies, SM; Nelson, A; et al. EBV-directed viral-specific T-lymphocyte therapy for the treatment of EBV-driven lymphoma in two patients with primary immunodeficiency and DNA repair defects. Pediatric Blood and Cancer. 2020; 67.

Rubinstein, JD; Gupta, A; Szabo, S; Pressey, JG. A case of submandibular desmoplastic small round cell tumor: Diagnostic and management approaches to an atypical presentation of a rare tumor. Pediatric Blood and Cancer. 2020; 67.

Rubinstein, JD; Krupski, C; Nelson, AS; O'Brien, MM; Davies, SM; Phillips, CL. Chimeric Antigen Receptor T Cell Therapy in Patients with Multiply Relapsed or Refractory Extramedullary Leukemia. Biology of Blood and Marrow Transplantation. 2020; 26:e280-e285.

Rubinstein, JD; Nelson, AS; Krupski, C; O'Brien, W; Taylor, JM; Badgett, TC; Huang, M; Davies, SM; Phillips, CL. Chimeric antigen receptor T-cell therapy in patients with neurologic comorbidities. Pediatric Blood and Cancer. 2020; 67.

Sandberg, JK; Chi, Y; Smith, EA; Servaes, S; Hoffer, FA; Mullen, EA; Perlman, EJ; Tornwall, B; Ehrlich, PF; Geller, JI; et al. Imaging characteristics of nephrogenic rests versus small wilms tumors: A report from the Children’s Oncology Group Study AREN03B2. American Journal of Roentgenology. 2020; 214:987-994.

Scorletti, F; Cooke-Barber, J; Pressey, JG; Nagarajan, R; Turpin, B; Jenkins, T; Dasgupta, R. Can a children's hospital still cut it? Comparing outcomes of pediatric, adolescent and young adult patients undergoing thoracic surgery for lung metastases. Pediatric Blood and Cancer. 2020; 67.

Senthil Kumar, S; Sengupta, S; Zhu, X; Mishra, DK; Phoenix, T; Dyer, L; Fuller, C; Stevenson, CB; DeWire, M; Fouladi, M; et al. Diffuse Intrinsic Pontine Glioma Cells Are Vulnerable to Mitotic Abnormalities Associated with BMI-1 Modulation. Molecular cancer research : MCR. 2020; 18:1711-1723.

Sheng, Y; Yu, C; Liu, Y; Hu, C; Ma, R; Lu, X; Ji, P; Chen, J; Mizukawa, B; Huang, Y; et al. FOXM1 regulates leukemia stem cell quiescence and survival in MLL-rearranged AML. Nature Communications. 2020; 11.

Sukumaran, A; Choi, K; Dasgupta, B. Insight on Transcriptional Regulation of the Energy Sensing AMPK and Biosynthetic mTOR Pathway Genes. Frontiers in Cell and Developmental Biology. 2020; 8.

Todd, K; Kim, HK; Szabo, S; Johnson, S; Pressey, J; Nagarajan, R; Sorger, J; Dasgupta, R; Turpin, B. Solitary myofibroma preceding the development of multicentric myofibromatosis: A report of two cases with surveillance recommendations. Pediatric Blood and Cancer. 2020; 67.

Turpin, B; Todd, KE; Pressey, JG. Reply to comment on: Solitary myofibroma preceding the development of multicentric myofibromatosis: A report of two cases with surveillance recommendations. Pediatric Blood and Cancer. 2020; 67.

Ullrich, NJ; Prabhu, SP; Reddy, AT; Fisher, MJ; Packer, R; Goldman, S; Robison, NJ; Gutmann, DH; Viskochil, DH; Allen, JC; et al. A phase II study of continuous oral mTOR inhibitor everolimus for recurrent, radiographic-progressive neurofibromatosis type 1-associated pediatric low-grade glioma: A Neurofibromatosis Clinical Trials Consortium study. Neuro-Oncology. 2020; 22:1527-1535.

van der Beek, JN; Geller, JI; de Krijger, RR; Graf, N; Pritchard-Jones, K; Drost, J; Verschuur, AC; Murphy, D; Ray, S; Spreafico, F; et al. Characteristics and Outcome of Children with Renal Cell Carcinoma: A Narrative Review. Cancers. 2020; 12:1776-1776.

Wade, SL; Narad, ME; Moscato, EL; LeBlond, EI; King, JA; Raj, SP; Platt, A; Thompson, AN; Baum, KT; Salloum, R. A Survivor's Journey: Preliminary efficacy of an online problem-solving therapy for survivors of pediatric brain tumor. Pediatric Blood and Cancer. 2020; 67.

Williams, MT; Sugimoto, C; Regan, SL; Pitzer, EM; Fritz, AL; Mascia, AE; Sertorio, M; Vatner, RE; Perentesis, JP; Vorhees, CV. Whole brain proton irradiation in adult Sprague Dawley rats produces dose dependent and non-dependent cognitive, behavioral, and dopaminergic effects. Scientific Reports. 2020; 10.

Young, J; Dahale, D; Demmel, K; O'Brien, M; Geller, J; Courter, J; Haslam, DB; Danziger-Isakov, L; Goldstein, SL. Reducing acute kidney injury in pediatric oncology patients: An improvement project targeting nephrotoxic medications. Pediatric Blood and Cancer. 2020; 67.

Zhong, B; Campagne, O; Salloum, R; Purzner, T; Stewart, CF. LC-MS/MS method for quantitation of the CK2 inhibitor silmitasertib (CX-4945) in human plasma, CSF, and brain tissue, and application to a clinical pharmacokinetic study in children with brain tumors. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 2020; 1152:122254-122254.