Oncology

Publications

Abu-Arja, MH; Osorio, DS; Lassaletta, A; Graham, RT; Coven, SL; Stanek, JR; Bouffet, E; Finlay, JL; Abdelbaki, MS. Prognostic factors for patients with relapsed central nervous system nongerminomatous germ cell tumors. Pediatric Blood and Cancer. 2022; 69.

Al Atrash, E; Abdullah, MF; Pressey, J; Mohan, S. GIST presenting as refractory iron-deficiency anaemia in paediatric patient. BMJ Case Reports. 2022; 15.

Azhar, M; Kincaid, Z; Kesarwani, M; Menke, J; Sweiterman, J; Ansari, S; Reaves, A; Ahmed, A; Shahzad, R; Khan, A; et al. Rational polypharmacological targeting of FLT3, JAK2, ABL, and ERK1 suppresses the adaptive resistance to FLT3 inhibitors in AML. Blood Advances. 2022.

Bahakel, H; Murphy, C; Frenck, RW; Grimley, MS; Marsh, RA; Paulsen, GC; Haslam, DB; Phillips, CL; Courter, J; Spearman, P; et al. Single Site Experience of the use of Monoclonal Antibodies for the Treatment of COVID-19 in High-risk Pediatric and Young Adult Patients. Pediatric Infectious Disease Journal. 2022; 41:985-988.

Bahakel, H; Murphy, CR; Frenck, RW; Grimley, M; Phillips, C; Schulert, G; Spearman, P; Courter, JD; Paulsen, GC; Danziger-Isakov, LA. 1119. Covid-19 Mab Use in High-Risk Pediatric Patients. Open Forum Infectious Diseases. 2022; 9.

Bareja, R; Ismail, M; Martin, D; Nayate, A; Tamrazi, B; Salloum, R; Margol, A; Judkins, A; Iyer, S; de Blank, P; et al. NIMG-88. A TRANSFER LEARNING APPROACH FOR AUTOMATIC SEGMENTATION OF TUMOR SUB-COMPARTMENTS IN PEDIATRIC MEDULLOBLASTOMA USING MULTIPARAMETRIC MRI: PRELIMINARY FINDINGS. Neuro-Oncology. 2022; 24:vii185-vii186.

Barreyro, L; Sampson, AM; Ishikawa, C; Hueneman, KM; Choi, K; Pujato, MA; Chutipongtanate, S; Wyder, M; Haffey, WD; O'Brien, E; et al. Blocking UBE2N abrogates oncogenic immune signaling in acute myeloid leukemia. Science Translational Medicine. 2022; 14.

Bender, J; Rubinstein, J; Pommert, L. 106 GEMCITABINE, OXALIPLATIN, AND ANTI-CD20 THERAPY IS SAFE AND EFFECTIVE IN CHILDREN AND YOUNG ADULTS WITH NON-HODGKIN LYMPHOMA UNFIT FOR INTENSIVE THERAPY. Leukemia Research. 2022; 121:s63-s64.

Brungardt, JG; Burns, KC; Dasgupta, R. Fertility preservation in children and young adults with cancer. Current Opinion in Pediatrics. 2022; 34:48-52.

Budde, A; Baust, K; Weinhold, L; Bernstein, M; Bielack, S; Dhooge, C; Hjorth, L; Janeway, KA; Jenney, M; Krailo, MD; et al. Linking EORTC QLQ-C-30 and PedsQL/PEDQOL physical functioning scores in patients with osteosarcoma. European Journal of Cancer. 2022; 170:209-235.

Cacciotti, C; Chordas, C; Valentino, K; Allen, R; Lenzen, A; Burns, K; Nagarajan, R; Manley, P; Pillay-Smiley, N. Cardiac dysfunction in medulloblastoma survivors treated with photon irradiation. 2022; 9:338-343.

Chihanga, T; Vicente-Muñoz, S; Ruiz-Torres, S; Pal, B; Sertorio, M; Andreassen, PR; Khoury, R; Mehta, P; Davies, SM; Lane, AN; et al. Head and Neck Cancer Susceptibility and Metabolism in Fanconi Anemia. Cancers. 2022; 14.

D'Alessandro, P. Commentary on McNeil et al. and Wolfe et al. 2022; 6:1-1.

D'Alessandro, PR; Lo, AC; Spencer, MH; Farinha, P; Armstrong, L; Dolman, PJ; Cheng, S. Primary cutaneous follicle center lymphoma of the medial canthus of the eye in an 11-year old. Pediatric Blood and Cancer. 2022; 69.

Daugherty, EC; Mascia, AE; Sertorio, MG B; Zhang, Y; Lee, E; Xiao, Z; Speth, J; Woo, J; McCann, C; Russell, K; et al. FAST-01: Results of the First-in-Human Study of Proton FLASH Radiotherapy. International Journal of Radiation Oncology Biology Physics. 2022; 114.

de Blank, PM K; Gross, AM; Akshintala, S; Blakeley, JO; Bollag, G; Cannon, A; Dombi, E; Fangusaro, J; Gelb, BD; Hargrave, D; et al. MEK inhibitors for neurofibromatosis type 1 manifestations: Clinical evidence and consensus. Neuro-Oncology. 2022; 24:1845-1856.

Desai, JM; Karve, AS; Gudelsky, GA; Gawali, MV; Seibel, W; Sallans, L; DasGupta, B; Desai, PB. Brain pharmacokinetics and metabolism of the AMP-activated protein kinase selective inhibitor SBI-0206965, an investigational agent for the treatment of glioblastoma. Investigational New Drugs. 2022; 40:944-952.

Dewire, M; Lazow, M; Campagne, O; Leach, J; Fuller, C; Senthil Kumar, S; Stanek, J; De Blank, P; Hummel, TR; Pillay-Smiley, N; et al. Phase I study of ribociclib and everolimus in children with newly diagnosed DIPG and high-grade glioma: A CONNECT pediatric neuro-oncology consortium report. Neuro-Oncology Advances. 2022; 4.

Fabrizio, VA; Phillips, CL; Lane, A; Baggott, C; Prabhu, S; Egeler, E; Mavroukakis, S; Pacenta, H; Rossoff, J; Stefanski, HE; et al. Tisagenlecleucel outcomes in relapsed/refractory extramedullary ALL: a Pediatric Real World CAR Consortium Report. Blood Advances. 2022; 6:600-610.

Geller, JI; Vandenheuval, K; Smith, E; Kotagal, M; Pater, L. Pediatric Renal Tumors. Pediatric Nephrology. 2022.

Gracia-Maldonado, G; Clark, J; Burwinkel, M; Greenslade, B; Wunderlich, M; Salomonis, N; Leone, D; Gatti, E; Pierre, P; Kumar, AR; et al. LAMP-5 is an essential inflammatory-signaling regulator and novel immunotherapy target for mixed lineage leukemia-rearranged acute leukemia. Haematologica. 2022; 107:803-815.

Greene, AN; Nguyen, ET; Paranjpe, A; Lane, A; Privette Vinnedge, LM; Solomon, MB. In silico gene expression and pathway analysis of DEK in the human brain across the lifespan. European Journal of Neuroscience. 2022; 56:4720-4743.

Greene, AN; Solomon, MB; Privette Vinnedge, LM. Novel molecular mechanisms in Alzheimer's disease: The potential role of DEK in disease pathogenesis. Frontiers in Aging Neuroscience. 2022; 14.

Gulati, R; Johnston, M; Rivas, M; Cast, A; Kumbaji, M; Hanlon, MA; Lee, S; Zhou, P; Lake, C; Schepers, E; et al. β-catenin cancer-enhancing genomic regions axis is involved in the development of fibrolamellar hepatocellular carcinoma. Hepatology Communications. 2022; 6:2950-2963.

Harris, MK; Graham, RT; Cappellano, AM; Margol, AS; Michaiel, G; Crawford, JR; Ioakeim-Ioannidou, M; Stanek, JR; Liu, KX; MacDonald, SM; et al. Multi-institutional analysis of central nervous system germ cell tumors in patients with Down syndrome. Pediatric Blood and Cancer. 2022; 69.

Hegde, S; Gasilina, A; Wunderlich, M; Lin, Y; Buchholzer, M; Krumbach, OH F; Akbarzadeh, M; Ahmadian, MR; Seibel, W; Zheng, Y; et al. Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia. Leukemia. 2022; 36:637-647.

Iyer, S; Ismail, M; Tamrazi, B; Salloum, R; de Blank, P; Margol, A; Correa, R; Chen, J; Bera, K; Statsevych, V; et al. Novel MRI deformation-heterogeneity radiomic features are associated with molecular subgroups and overall survival in pediatric medulloblastoma: Preliminary findings from a multi-institutional study. Frontiers in Oncology. 2022; 12.

Jones, LQ M; Starczynowski, DT. IKAROS and MENIN in synergy in AML. 2022; 3:528-529.

Karve, AS; Desai, JM; Dave, N; Wise-Draper, TM; Gudelsky, GA; Phoenix, TN; DasGupta, B; Sengupta, S; Plas, DR; Desai, PB. Potentiation of temozolomide activity against glioblastoma cells by aromatase inhibitor letrozole. Cancer Chemotherapy and Pharmacology. 2022; 90:345-356.

Kotch, C; Avery, R; Getz, KD; Bouffet, E; De Blank, P; Listernick, R; Gutmann, DH; Bornhorst, M; Campen, C; Liu, GT; et al. Risk factors for treatment-refractory and relapsed optic pathway glioma in children with neurofibromatosis type 1. Neuro-Oncology. 2022; 24:1377-1386.

Lamble, AJ; Chi, Y; Chang, BH; Verma, A; Faulk, KE; Stevens, AM; Pommert, L; Tucker, S; Brookhart, B; Shah, NN; et al. Phase I Study of Tagraxofusp with or without Chemotherapy in Pediatric Patients with Relapsed or Refractory CD123-Expressing Hematologic Malignancies: A Therapeutic Advances in Childhood Leukemia and Lymphoma (TACL) Consortium Trial. Blood. 2022; 140:6102-6103.

Lazow, MA; Fuller, C; Trout, AT; Stanek, JR; Reuss, J; Turpin, BK; Szabo, S; Salloum, R. Immunohistochemical assessment and clinical, histopathologic, and molecular correlates of membranous somatostatin type-2A receptor expression in high-risk pediatric central nervous system tumors. Frontiers in Oncology. 2022; 12.

Lazow, MA; Nievelstein, MT; Lane, A; Bandopadhayhay, P; DeWire-Schottmiller, M; Fouladi, M; Glod, JW; Greiner, RJ; Hoffman, LM; Hummel, TR; et al. Volumetric endpoints in diffuse intrinsic pontine glioma: comparison to cross-sectional measures and outcome correlations in the International DIPG/DMG Registry. Neuro-Oncology. 2022; 24:1598-1608.

Lazow, MA; Salloum, R; Pressey, JG. Comorbidity Burden in a Cohort of Adolescent and Young Adult Patients Diagnosed with Central Nervous System Tumors and Sarcomas. Journal of Adolescent and Young Adult Oncology. 2022.

Lin, S; Larrue, C; Scheidegger, NK; Seong, BK A; Dharia, NV; Kuljanin, M; Wechsler, CS; Kugener, G; Robichaud, AL; Conway, AS; et al. An In Vivo CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML. Cancer Discovery. 2022; 12:432-449.

Locatelli, F; Luisi, F; Pianovski, M; Salvino, MA; Fagioli, F; Epelman, S; Britto De Abreu Lima, L; Norris, R; Odone Filho, V; Zecca, M; et al. P1088: UPDATED DATA FROM A PHASE 1/2 STUDY OF BRENTUXIMAB VEDOTIN COMBINED WITH CHEMOTHERAPY IN PEDIATRIC PATIENTS WITH ADVANCED STAGE CLASSICAL HODGKIN LYMPHOMA. HemaSphere. 2022; 6:978-979.

Luo, Z; Xia, M; Shi, W; Zhao, C; Wang, J; Xin, D; Dong, X; Xiong, Y; Zhang, F; Berry, K; et al. Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis. Nature. 2022; 612:787-794.

Ly, I; Liu, T; Cai, W; Michaels, O; Kwon, D; Bredella, M; Jordan, J; Borcherding, D; Boswell, D; Burgess, C; et al. NIMG-16. COMPARISON OF A STIR- AND T1-WEIGHTED-BASED RADIOMICS MODEL TO DIFFERENTIATE BETWEEN PLEXIFORM NEUROFIBROMAS AND MALIGNANT PERIPHERAL NERVE SHEATH TUMORS IN NEUROFIBROMATOSIS TYPE 1 (NF1). Neuro-Oncology. 2022; 24:vii164-vii165.

Macy, M; Cash, T; Pinto, N; Pressey, JG; Szalontay, L; Furman, WL; Bukowinski, A; Foster, JH; Friedman, GK; HaDuong, J; et al. 82 (PB072) Phase I dose-escalation study of the pan-PI3 K inhibitor copanlisib in children and adolescents with relapsed/refractory solid tumors. European Journal of Cancer. 2022; 174:s28-s29.

Majzner, RG; Ramakrishna, S; Yeom, KW; Patel, S; Chinnasamy, H; Schultz, LM; Richards, RM; Jiang, L; Barsan, V; Mancusi, R; et al. GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas. Nature. 2022; 603:934-941.

McBee, MP; Woodhouse, C; Trout, AT; Geller, JI; Smith, EA; Zhang, B; Towbin, AJ. Skeletal muscle mass as a marker to predict outcomes in children and young adults with cancer. Abdominal Radiology. 2022; 47:452-459.

McGrady, ME; Perez, MN; Bernstein, J; Strenk, M; Kiger, MA; Norris, RE. Adherence and Barriers to Inpatient Physical Therapy Among Adolescents and Young Adults with Hematologic Malignancies. Journal of Adolescent and Young Adult Oncology. 2022; 11:605-610.

Merjaneh, N; Young, J; Mangoli, A; Olsen, M; Setty, B; Lane, A; Nagarajan, R; Pressey, JG; Turpin, B. Chemotherapy-induced thrombocytopenia in Ewing sarcoma: Implications and potential for romiplostim supportive care. Pediatric Blood and Cancer. 2022; 69.

Miller, TP; DeGroote, NP; Taylor, Z; Pommert, L; Awoniyi, O; Board, S; Ugboh, N; Joshi, V; Weisnicht, A; Ambrosino, N; et al. Severe Adverse Events Associated with Concentrations of High Dose Methotrexate in Pediatric Acute Lymphoblastic Leukemia Patients. Blood. 2022; 140:2185-2186.

Moskop, A; Pommert, L; Baggott, C; Prabhu, S; Pacenta, HL; Phillips, CL; Rossoff, J; Stefanski, HE; Talano, JA; Margossian, SP; et al. Real-world use of tisagenlecleucel in infant acute lymphoblastic leukemia. Blood Advances. 2022; 6:4251-4255.

Muhammad, B; Parks, LG; Komurov, K; Privette Vinnedge, LM. Defective transcription elongation in human cancers imposes targetable proteotoxic vulnerability. Translational Oncology. 2022; 16.

Muraleedharan, R; Dasgupta, B. AMPK in the brain: its roles in glucose and neural metabolism. FEBS Journal. 2022; 289:2247-2262.

Muto, T; Guillamot, M; Yeung, J; Fang, J; Bennett, J; Nadorp, B; Lasry, A; Redondo, LZ; Choi, K; Gong, Y; et al. TRAF6 functions as a tumor suppressor in myeloid malignancies by directly targeting MYC oncogenic activity. Cell Stem Cell. 2022; 29:298-314.e9.

Nayak, RC; Chang, KH; Singh, AK; Kotliar, M; Desai, M; Wellendorf, AM; Wunderlich, M; Bartram, J; Mizukawa, B; Cuadrado, M; et al. Nuclear Vav3 is required for polycomb repression complex-1 activity in B-cell lymphoblastic leukemogenesis. Nature Communications. 2022; 13.

Niederkorn, M; Ishikawa, C; M. Hueneman, K; Bartram, J; Stepanchick, E; R. Bennett, J; E. Culver-Cochran, A; Bolanos, LC; Uible, E; Choi, K; et al. The deubiquitinase USP15 modulates cellular redox and is a therapeutic target in acute myeloid leukemia. Leukemia. 2022; 36:438-451.

O'Brien, MM; Ji, L; Shah, NN; Rheingold, SR; Bhojwani, D; Yuan, CM; Xu, X; Yi, JS; Harris, AC; Brown, PA; et al. (2022) Phase II Trial of Inotuzumab Ozogamicin in Children and Adolescents With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia: Children's Oncology Group Protocol AALL1621. 40:956-967.

Odia, Y; Koschmann, C; Tarapore, R; Allen, J; Hall, M; Daghistani, D; Khatib, Z; Aguilera, D; MacDonald, T; de Blank, P; et al. SYST-07 WINDOW-OF-OPPORTUNITY STUDY OF ONC201 IN PEDIATRIC PATIENTS WITH DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) AND THALAMIC GLIOMA. Neuro-Oncology Advances. 2022; 4:i22-i22.

Perazzo, D; Moore, R; Kasparian, NA; Rodts, M; Horowitz-Kraus, T; Crosby, L; Turpin, B; Beck, AF; Hutton, J. Chronic pediatric diseases and risk for reading difficulties: a narrative review with recommendations. Pediatric Research. 2022; 92:966-978.

Pommert, L; Cooper, TM; Gerbing, RB; Brodersen, L; Loken, M; Gamis, A; Aplenc, R; Alonzo, TA; Kolb, EA. Blood Count Recovery Following Induction Therapy for Acute Myeloid Leukemia in Children Does Not Predict Survival. Cancers. 2022; 14.

Pommert, L; Schafer, ES; Malvar, J; Gossai, N; Florendo, E; Pulakanti, K; Heimbruch, K; Stelloh, C; Chi, YY; Sposto, R; et al. Decitabine and vorinostat with FLAG chemotherapy in pediatric relapsed/refractory AML: Report from the therapeutic advances in childhood leukemia and lymphoma (TACL) consortium. American Journal of Hematology. 2022; 97:613-622.

Pommert, L; Tarlock, K. The evolution of targeted therapy in pediatric AML: gemtuzumab ozogamicin, FLT3/IDH/BCL2 inhibitors, and other therapies. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 2022; 2022:603-610.

Power-Hays, A; Dandoy, CE; Lorts, A; Perentesis, JP; Unaka, N; Ware, RE; McGann, PT. US News & World Report and quality metrics: Inclusion of sickle cell disease is a matter of equity. Pediatric Blood and Cancer. 2022; 69.

Roohollahi, K; de Jong, Y; Pai, G; Zaini, MA; de Lint, K; Sie, D; Rooimans, MA; Rockx, D; Hoskins, EE; Ameziane, N; et al. BIRC2-BIRC3 amplification: a potentially druggable feature of a subset of head and neck cancers in patients with Fanconi anemia. Scientific Reports. 2022; 12.

Rubinstein, JD; Jodele, S; Heyenbruch, D; Wilhelm, J; Thomas, S; Lutzko, C; Zhu, X; Leemhuis, T; Cancelas, JA; Keller, M; et al. Off-the-Shelf Third-Party Virus-Specific T Cell Therapy to Treat JC Polyomavirus Infection in Hematopoietic Stem Cell Transplantation Recipients. Transplantation and cellular therapy. 2022; 28:116.e1-116.e7.

Rubinstein, JD; Lutzko, C; Leemhuis, T; Zhu, X; Pham, G; Ray, L; Thomas, S; Dourson, C; Wilhelm, J; Lane, A; et al. Scheduled administration of virus-specific T cells for viral prophylaxis after pediatric allogeneic stem cell transplant. Blood Advances. 2022; 6:2897-2907.

Sabulski, A; Grier, DD; Myers, KC; Davies, SM; Rubinstein, JD. Acute myeloid leukemia in SRP54-mutated congenital neutropenia. 2022; 3:521-525.

Sanders, BE; Wolsky, R; Doughty, ES; Wells, KL; Ghosh, D; Ku, L; Pressey, JG; Bitler, BB; Brubaker, LW. Small cell carcinoma of the ovary hypercalcemic type (SCCOHT): A review and novel case with dual germline SMARCA4 and BRCA2 mutations. Gynecologic Oncology Reports. 2022; 44.

Schafer, ES; Chao, K; Stevens, AM; Jo, E; Hilsenbeck, SG; Gossai, NP; Doan, A; Colace, SI; Guinipero, T; Otterson, D; et al. Real-world experience in treating pediatric relapsed/refractory or therapy-related myeloid malignancies with decitabine, vorinostat, and FLAG therapy based on a phase 1 study run by the TACL consortium. Pediatric Blood and Cancer. 2022; 69.

Scheuermann, A; Harker-Murray, P; Pommert, L. Posterior Reversible Encephalopathy Syndrome in the Setting of Asparaginase-associated Pancreatitis in 2 Pediatric Patients With Acute Leukemia. Journal of Pediatric Hematology/Oncology. 2022; 44:e709-e712.

Schultz, LM; Baggott, C; Prabhu, S; Pacenta, HL; Phillips, CL; Rossoff, J; Stefanski, HE; Talano, JA; Moskop, A; Margossian, SP; et al. Disease Burden Affects Outcomes in Pediatric and Young Adult B-Cell Lymphoblastic Leukemia After Commercial Tisagenlecleucel: A Pediatric Real-World Chimeric Antigen Receptor Consortium Report. Journal of Clinical Oncology. 2022; 40:945-955.

Silva de Araujo, BE; Velleuer, E; Dietrich, R; Pomjanski, N; de Santana Almeida Araujo, IK; Schlensog, M; Wells, SI; Dorsman, JC; Schramm, M. Detection of cytogenetic changes and chromosomal aneuploidy with fluorescent in situ hybridization in cytological specimens of oral cancers in Fanconi anemia-Proof of concept. Clinical and Experimental Dental Research. 2022; 8:108-116.

Singh, N; Romick-Rosendale, L; Watanabe-Chailland, M; Privette Vinnedge, LM; Komurov, K. Drug resistance mechanisms create targetable proteostatic vulnerabilities in Her2+ breast cancers. PLoS ONE. 2022; 17.

Sumazin, P; Peters, TL; Sarabia, SF; Kim, HR; Urbicain, M; Hollingsworth, EF; Alvarez, KR; Perez, CR; Pozza, A; Najaf Panah, MJ; et al. Hepatoblastomas with carcinoma features represent a biological spectrum of aggressive neoplasms in children and young adults. Journal of Hepatology. 2022; 77:1026-1037.

Thapaliya, S; Sung, AJ; Sharp, SE; Turpin, BK; Zhang, B; Nehus, EJ; Trout, AT. Agreement between serum estimates of glomerular filtration rate (GFR) and a reference standard of radioisotopic GFR in children with cancer. Pediatric Radiology. 2022; 52:903-909.

Vicente-Muñoz, S; Hunt, BG; Lange, TE; Wells, SI; Waltz, SE. NMR-based metabolomic analysis identifies RON-DEK-β-catenin dependent metabolic pathways and a gene signature that stratifies breast cancer patient survival. PLoS ONE. 2022; 17.

Webster, AL H; Sanders, MA; Patel, K; Dietrich, R; Noonan, RJ; Lach, FP; White, RR; Goldfarb, A; Hadi, K; Edwards, MM; et al. Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancer. Nature. 2022; 612:495-502.

Williams, MT; Sugimoto, C; Regan, SL; Pitzer, EM; Fritz, AL; Sertorio, M; Mascia, AE; Vatner, RE; Perentesis, JP; Vorhees, CV. Cognitive and behavioral effects of whole brain conventional or high dose rate (FLASH) proton irradiation in a neonatal Sprague Dawley rat model. PLoS ONE. 2022; 17.

Wunderlich, M; Chen, J; Sexton, C; Manning, N; Byerly, L; O’Brien, E; Perentesis, J; Mulloy, J; Mizukawa, B. PDX models of relapsed pediatric AML preserve global gene expression patterns and reveal therapeutic targets. 2022.