Lang Lab

Nayak, G; Zhang, KX; Vemaraju, S; Odaka, Y; Buhr, ED; Holt-Jones, A; Kernodle, S; Smith, AN; Upton, BA; D'Souza, S; et al. Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent Adipocyte Light Sensing. Cell Reports. 2020; 30:672-686.e8.

Buhr, ED; Vemaraju, S; Diaz, N; Lang, RA; Van Gelder, RN. Neuropsin (OPN5) Mediates Local Light-Dependent Induction of Circadian Clock Genes and Circadian Photoentrainment in Exposed Murine Skin. Current Biology. 2019; 29:3478-3487.e4.

Nguyen, MT; Vemaraju, S; Nayak, G; Odaka, Y; Buhr, ED; Alonzo, N; Tran, U; Batie, M; Upton, BA; Darvas, M; et al. An opsin 5-dopamine pathway mediates light-dependent vascular development in the eye. Nature Cell Biology. 2019; 21:420-429.

Rao, S; Chun, C; Fan, J; Kofron, JM; Yang, MB; Hegde, RS; Ferrara, N; Copenhagen, DR; Lang, RA. A direct and melanopsin-dependent fetal light response regulates mouse eye development. Nature. 2013; 494:243-246.

Chauhan, BK; Lou, M; Zheng, Y; Lang, RA. Balanced Rac1 and RhoA activities regulate cell shape and drive invagination morphogenesis in epithelia. Proceedings of the National Academy of Sciences of USA. 2011; 108:18289-18294.

III, SJ A; Lewkowich, I; Rao, S; Mariggi, G; Carpenter, AC; Burr, AR; Fan, J; Ajima, R; Molkentin, JD; Williams, BO; et al. Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells. Nature. 2011; 474:511-516.

Lin, S; Li, B; Rao, S; Yeo, E; Hudson, TE; Nowlin, BT; Pei, H; Chen, L; Zheng, JJ; Carroll, TJ; et al. Macrophage Wnt7b is critical for kidney repair and regeneration. Proceedings of the National Academy of Sciences of USA. 2010; 107:4194-4199.

Lobov, IB; Rao, S; Carroll, TJ; Vallance, JE; Ito, M; Ondr, JK; Kurup, S; Glass, DA; Patel, MS; Shu, WG; et al. WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature. 2005; 437:417-421.

LANG, RA; BISHOP, JM. MACROPHAGES ARE REQUIRED FOR CELL-DEATH AND TISSUE REMODELING IN THE DEVELOPING MOUSE EYE. Cell. 1993; 74:453-462.

LANG, RA; METCALF, D; CUTHBERTSON, RA; LYONS, I; STANLEY, E; KELSO, A; KANNOURAKIS, G; WILLIAMSON, DJ; KLINTWORTH, GK; GONDA, TJ; et al. TRANSGENIC MICE EXPRESSING A HEMATOPOIETIC GROWTH-FACTOR GENE (GM-CSF) DEVELOP ACCUMULATIONS OF MACROPHAGES, BLINDNESS, AND A FATAL SYNDROME OF TISSUE-DAMAGE. Cell. 1988; 53:675-686.

LANG, RA; METCALF, D; GOUGH, NM; DUNN, AR; GONDA, TJ. EXPRESSION OF A HEMATOPOIETIC GROWTH-FACTOR CDNA IN A FACTOR-DEPENDENT CELL-LINE RESULTS IN AUTONOMOUS GROWTH AND TUMORIGENICITY. Cell. 1985; 43:531-542.

D'Souza, S; Lang, RA. Retinal ganglion cell interactions shape the developing mammalian visual system. Development (Cambridge). 2020; 147:dev196535-dev196535.

Zhang, KX; D'Souza, S; Upton, BA; Kernodle, S; Vemaraju, S; Nayak, G; Gaitonde, KD; Holt, AL; Linne, CD; Smith, AN; et al. Violet-light suppression of thermogenesis by opsin 5 hypothalamic neurons. Nature. 2020; 585:420-425.

Nadar-Ponniah, PT; Taiber, S; Caspi, M; Koffler-Brill, T; Dror, AA; Siman-Tov, R; Rubinstein, M; Padmanabhan, K; Luxenburg, C; Lang, RA; et al. Striatin Is Required for Hearing and Affects Inner Hair Cells and Ribbon Synapses. Frontiers in Cell and Developmental Biology. 2020; 8.

Diaz, NM; Lang, RA; Van Gelder, RN; Buhr, ED. Wounding induces facultative opn5-dependent circadian photoreception in the murine cornea. Investigative Ophthalmology and Visual Science. 2020; 61:37-37.

Nayak, G; Zhang, KX; Vemaraju, S; Odaka, Y; Buhr, ED; Holt-Jones, A; Kernodle, S; Smith, AN; Upton, BA; D'Souza, S; et al. Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent Adipocyte Light Sensing. Cell Reports. 2020; 30:672-686.e8.

Buhr, ED; Vemaraju, S; Diaz, N; Lang, RA; Van Gelder, RN. Neuropsin (OPN5) Mediates Local Light-Dependent Induction of Circadian Clock Genes and Circadian Photoentrainment in Exposed Murine Skin. Current Biology. 2019; 29:3478-3487.e4.

Nguyen, MT; Vemaraju, S; Nayak, G; Odaka, Y; Buhr, ED; Alonzo, N; Tran, U; Batie, M; Upton, BA; Darvas, M; et al. An opsin 5-dopamine pathway mediates light-dependent vascular development in the eye. Nature Cell Biology. 2019; 21:420-429.

Nayak, G; Odaka, Y; Prasad, V; Solano, AF; Yeo, E; Vemaraju, S; Molkentin, JD; Trumpp, A; Williams, B; Rao, S; et al. Developmental vascular regression is regulated by a Wnt/beta-catenin, MYC and CDKN1A pathway that controls cell proliferation and cell death. Development (Cambridge). 2018; 145:dev154898-dev154898.

Sakabe, M; Fan, J; Odaka, Y; Liu, N; Hassan, A; Duan, X; Stump, P; Byerly, L; Donaldson, M; Hao, J; et al. YAP/TAZ-CDC42 signaling regulates vascular tip cell migration. Proceedings of the National Academy of Sciences of USA. 2017; 114:10918-10923.

Muley, A; Odaka, Y; Lewkowich, IP; Vemaraju, S; Yamaguchi, TP; Shawber, C; Dickie, BH; Lang, RA. Myeloid Wnt ligands are required for normal development of dermal lymphatic vasculature. PLoS ONE. 2017; 12:e0181549-e0181549.

Palevski, D; Levin-Kotler, L; Kain, D; Naftali-Shani, N; Landa, N; Ben-Mordechai, T; Konfino, T; Holbova, R; Molotski, N; Rosin-Arbesfeld, R; et al. Loss of Macrophage Wnt Secretion Improves Remodeling and Function After Myocardial Infarction in Mice. Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease. 2017; 6.

Zhou, L; Yang, K; Carpenter, A; Lang, RA; Andl, T; Zhang, Y. CD133-positive dermal papilla-derived Wnt ligands regulate postnatal hair growth. The Biochemical journal. 2016; 473:3291-3305.

Wang, Y; Tadjuidje, E; Pandey, RN; III, SJ A; Smith, LE H; Lang, RA; Hegde, RS. The Eyes Absent Proteins in Developmental and Pathological Angiogenesis. The American journal of pathology. 2016; 186:568-578.

Franco, CA; Jones, ML; Bernabeu, MO; Vion, A; Barbacena, P; Fan, J; Mathivet, T; Fonseca, CG; Ragab, A; Yamaguchi, TP; et al. Non-canonical Wnt signalling modulates the endothelial shear stress flow sensor in vascular remodelling. eLife. 2016; 5.

Sessa, R; Yuen, D; Wan, S; Rosner, M; Padmanaban, P; Ge, S; Smith, A; Fletcher, R; Baudhuin-Kessel, A; Yamaguchi, TP; et al. Monocyte-derived Wnt5a regulates inflammatory lymphangiogenesis. Cell Research. 2016; 26:262-265.