Lang Lab

Jiang, X; Pardue, MT; Mori, K; Ikeda, SI; Torii, H; D'Souza, S; Lang, RA; Kurihara, T; Tsubota, K. Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice. Proceedings of the National Academy of Sciences of the United States of America. 2021; 118.

Zhang, KX; D'Souza, S; Upton, BA; Kernodle, S; Vemaraju, S; Nayak, G; Gaitonde, KD; Holt, AL; Linne, CD; Smith, AN; et al. Violet-light suppression of thermogenesis by opsin 5 hypothalamic neurons. Nature: New biology. 2020; 585:420-425.

Nayak, G; Zhang, KX; Vemaraju, S; Odaka, Y; Buhr, ED; Holt-Jones, A; Kernodle, S; Smith, AN; Upton, BA; D'Souza, S; et al. Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent Adipocyte Light Sensing. Cell Reports. 2020; 30:672-686.e8.

Buhr, ED; Vemaraju, S; Diaz, N; Lang, RA; Van Gelder, RN. Neuropsin (OPN5) Mediates Local Light-Dependent Induction of Circadian Clock Genes and Circadian Photoentrainment in Exposed Murine Skin. Current Biology. 2019; 29:3478-3487.e4.

Nguyen, MT; Vemaraju, S; Nayak, G; Odaka, Y; Buhr, ED; Alonzo, N; Tran, U; Batie, M; Upton, BA; Darvas, M; et al. An opsin 5-dopamine pathway mediates light-dependent vascular development in the eye. Nature Cell Biology. 2019; 21:420-429.

Rao, S; Chun, C; Fan, J; Kofron, JM; Yang, MB; Hegde, RS; Ferrara, N; Copenhagen, DR; Lang, RA. A direct and melanopsin-dependent fetal light response regulates mouse eye development. Nature: New biology. 2013; 494:243-246.

Chauhan, BK; Lou, M; Zheng, Y; Lang, RA. Balanced Rac1 and RhoA activities regulate cell shape and drive invagination morphogenesis in epithelia. Proceedings of the National Academy of Sciences of the United States of America. 2011; 108:18289-18294.

III, SJ A; Lewkowich, I; Rao, S; Mariggi, G; Carpenter, AC; Burr, AR; Fan, J; Ajima, R; Molkentin, JD; Williams, BO; et al. Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells. Nature: New biology. 2011; 474:511-515.

Lin, S; Li, B; Rao, S; Yeo, E; Hudson, TE; Nowlin, BT; Pei, H; Chen, L; Zheng, JJ; Carroll, TJ; et al. Macrophage Wnt7b is critical for kidney repair and regeneration. Proceedings of the National Academy of Sciences of the United States of America. 2010; 107:4194-4199.

Lobov, IB; Rao, S; Carroll, TJ; Vallance, JE; Ito, M; Ondr, JK; Kurup, S; Glass, DA; Patel, MS; Shu, WG; et al. WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature: New biology. 2005; 437:417-421.

LANG, RA; BISHOP, JM. Macrophages are required for cell death and tissue remodeling in the developing mouse eye. Cell. 1993; 74:453-462.

LANG, RA; METCALF, D; CUTHBERTSON, RA; LYONS, I; STANLEY, E; KELSO, A; KANNOURAKIS, G; WILLIAMSON, DJ; KLINTWORTH, GK; GONDA, TJ; et al. Transgenic mice expressing a hemopoietic growth factor gene (GM-CSF) develop accumulations of macrophages, blindness, and a fatal syndrome of tissue damage. Cell. 1988; 51:675-686.

LANG, RA; METCALF, D; GOUGH, NM; DUNN, AR; GONDA, TJ. Expression of a hemopoietic growth factor cDNA in a factor-dependent cell line results in autonomous growth and tumorigenicity. Cell. 1985; 43:531-542.

D'Souza, SP; Swygart, DI; Wienbar, SR; Upton, BA; Zhang, KX; Mackin, RD; Casasent, AK; Samuel, MA; Schwartz, GW; Lang, RA. Retinal patterns and the cellular repertoire of neuropsin (Opn5) retinal ganglion cells. Journal of Comparative Neurology. 2021.

Nakamura, Y; Ueno, M; Niehaus, JK; Lang, RA; Zheng, Y; Yoshida, Y. Modulation of Both Intrinsic and Extrinsic Factors Additively Promotes Rewiring of Corticospinal Circuits after Spinal Cord Injury. Journal of Neuroscience. 2021; 41:10247-10260.

Davies, WI L; Sghari, S; Upton, BA; Nord, C; Hahn, M; Ahlgren, U; Lang, RA; Gunhaga, L. Distinct Opsin 3 (Opn3) Expression in the Developing Nervous System during Mammalian Embryogenesis. eNeuro. 2021; 8.

Jiang, X; Pardue, MT; Mori, K; Ikeda, SI; Torii, H; D'Souza, S; Lang, RA; Kurihara, T; Tsubota, K. Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice. Proceedings of the National Academy of Sciences of the United States of America. 2021; 118.

Upton, BA; D’Souza, SP; Lang, RA. QPLOT Neurons-Converging on a Thermoregulatory Preoptic Neuronal Population. Frontiers in Neuroscience. 2021; 15.

Upton, BA; Díaz, NM; Gordon, SA; Van Gelder, RN; Buhr, ED; Lang, RA. Evolutionary Constraint on Visual and Nonvisual Mammalian Opsins. Journal of Biological Rhythms. 2021; 36:109-126.

Wu, AD; Dan, W; Zhang, Y; Vemaraju, S; Upton, BA; Lang, RA; Buhr, ED; Berkowitz, DE; Gallos, G; Emala, CW; et al. Opsin 3-Gαs Promotes Airway Smooth Muscle Relaxation Modulated by G Protein Receptor Kinase 2. American Journal of Respiratory Cell and Molecular Biology. 2021; 64:59-68.

D'Souza, S; Lang, RA. Retinal ganglion cell interactions shape the developing mammalian visual system. Development (Cambridge). 2020; 147.

Zhang, KX; D'Souza, S; Upton, BA; Kernodle, S; Vemaraju, S; Nayak, G; Gaitonde, KD; Holt, AL; Linne, CD; Smith, AN; et al. Violet-light suppression of thermogenesis by opsin 5 hypothalamic neurons. Nature: New biology. 2020; 585:420-425.

Nadar-Ponniah, PT; Taiber, S; Caspi, M; Koffler-Brill, T; Dror, AA; Siman-Tov, R; Rubinstein, M; Padmanabhan, K; Luxenburg, C; Lang, RA; et al. Striatin Is Required for Hearing and Affects Inner Hair Cells and Ribbon Synapses. Frontiers in Cell and Developmental Biology. 2020; 8.

Diaz, NM; Lang, RA; Van Gelder, RN; Buhr, ED. Wounding Induces Facultative Opn5-Dependent Circadian Photoreception in the Murine Cornea. Investigative Ophthalmology and Visual Science. 2020; 61.

Nayak, G; Zhang, KX; Vemaraju, S; Odaka, Y; Buhr, ED; Holt-Jones, A; Kernodle, S; Smith, AN; Upton, BA; D'Souza, S; et al. Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent Adipocyte Light Sensing. Cell Reports. 2020; 30:672-686.e8.

Buhr, ED; Vemaraju, S; Diaz, N; Lang, RA; Van Gelder, RN. Neuropsin (OPN5) Mediates Local Light-Dependent Induction of Circadian Clock Genes and Circadian Photoentrainment in Exposed Murine Skin. Current Biology. 2019; 29:3478-3487.e4.

Nguyen, MT; Vemaraju, S; Nayak, G; Odaka, Y; Buhr, ED; Alonzo, N; Tran, U; Batie, M; Upton, BA; Darvas, M; et al. An opsin 5-dopamine pathway mediates light-dependent vascular development in the eye. Nature Cell Biology. 2019; 21:420-429.

Nayak, G; Odaka, Y; Prasad, V; Solano, AF; Yeo, E; Vemaraju, S; Molkentin, JD; Trumpp, A; Williams, B; Rao, S; et al. Developmental vascular regression is regulated by a Wnt/β-catenin, MYC and CDKN1A pathway that controls cell proliferation and cell death. Development (Cambridge). 2018; 145.

Sakabe, M; Fan, J; Odaka, Y; Liu, N; Hassan, A; Duan, X; Stump, P; Byerly, L; Donaldson, M; Hao, J; et al. YAP/TAZ-CDC42 signaling regulates vascular tip cell migration. Proceedings of the National Academy of Sciences of the United States of America. 2017; 114:10918-10923.

Muley, A; Odaka, Y; Lewkowich, IP; Vemaraju, S; Yamaguchi, TP; Shawber, C; Dickie, BH; Lang, RA. Myeloid Wnt ligands are required for normal development of dermal lymphatic vasculature. PLoS ONE. 2017; 12.