Proton Therapy Research

Publications

Shukla S, Saha T, Rama N, et al. Ultra-high dose-rate proton FLASH improves tumor control. Radiother Oncol. 2023;186:109741.

Chimote AA, Lehn MA, Bhati J, Mascia AE, Sertorio M, Lamba MA, Ionascu D, Tang AL, Langevin SM, Khodoun MV, et al. Proton Treatment Suppresses Exosome Production in Head and Neck Squamous Cell Carcinoma. Cancers. 2024; 16(5):1008.

Nelson B, Meier T, Zhang Y, et al. Feasibility Trial of Intensity Modulated Proton Therapy to Reduce Toxicity in Anal Cancer Patients [published online ahead of print, 2023 Apr 24]. Am J Clin Oncol. 2023

Mast TD, Johnstone DA, Dumoulin CL, Lamba MA, Patch SK. Reconstruction of thermoacoustic emission sources induced by proton irradiation using numerical time reversal. Phys Med Biol. 2023;68(2)

Jarvis LA, Zhang R, Pogue BW. The First FLASH Clinical Trial-The Journey of a Thousand Miles Begins With 1 Step. JAMA Oncol. 2023;9(1):69-70.

Mascia AE, Daugherty EC, Zhang Y, et al. Proton FLASH Radiotherapy for the Treatment of Symptomatic Bone Metastases: The FAST-01 Nonrandomized Trial [published correction appears in JAMA Oncol. 2023 Mar 2;:]. JAMA Oncol. 2023;9(1):62-69.

Daugherty EC, Mascia A, Zhang Y, et al. FLASH Radiotherapy for the Treatment of Symptomatic Bone Metastases (FAST-01): Protocol for the First Prospective Feasibility Study. JMIR Res Protoc. 2023;12:e41812.

Lee E, Lourenço AM, Speth J, et al. Ultrahigh dose rate pencil beam scanning proton dosimetry using ion chambers and a calorimeter in support of first in-human FLASH clinical trial. Med Phys. 2022;49(9):6171-6182.

Williams MT, Sugimoto C, Regan SL, et al. Cognitive and behavioral effects of whole brain conventional or high dose rate (FLASH) proton irradiation in a neonatal Sprague Dawley rat model. PLoS One. 2022;17(9):e0274007.

Nelson B, Tadesse DG, Sudhoff M, et al. Hematologic Toxicity Comparison of Intensity Modulated Proton Therapy and Intensity Modulated Radiation Therapy in Anal Cancer Patients. Am J Clin Oncol. 2022;45(6):264-267.

Nelson B, Lamba M, Ewart S, Ike N, Lewis L, Pater L. Normal tissue exposure and second malignancy risk in vertebral-body-sparing craniospinal irradiation. Med Dosim. 2022;47(2):142-145.

Lewis L, Kreinbrink P, Richardson M, et al. Intensity Modulated Proton Therapy Better Spares Non-Adjacent Organs and Reduces the Risk of Secondary Malignant Neoplasms in the Treatment of Sinonasal Cancers. Med Dosim. 2022;47(2):117-122.

Vorhees CV, Vatner RE, Williams MT. Review of Conventional and High Dose Rate Brain Radiation (FLASH): Neurobehavioural, Neurocognitive and Assessment Issues in Rodent Models. Clin Oncol (R Coll Radiol). 2021;33(11):e482-e491.

Zhang Y, Ding Z, Perentesis JP, Khuntia D, Pfister SX, Sharma RA. Can Rational Combination of Ultra-high Dose Rate FLASH Radiotherapy with Immunotherapy Provide a Novel Approach to Cancer Treatment? Clin Oncol (R Coll Radiol). 2021;33(11):713-722.

Breneman J, Perentesis JP, Bradley J, Mascia A, Abel E, Sharda A, Khuntia D, Sharma RA, Simone CB 2nd. In Regard to Buchsbaum et al. Int J Radiat Oncol Biol Phys. 2021;110(5):1544-1545.

Hua CH, Mascia AE, Seravalli E, Lomax AJ, Seiersen K, Ulin K. Advances in radiotherapy technology for pediatric cancer patients and roles of medical physicists: COG and SIOP Europe perspectives. Pediatr Blood Cancer. 2021;68(Suppl 2):e28344.

Frankart AJ, Nagarajan R, Pater L. The impact of proton therapy on cardiotoxicity following radiation treatment. J Thromb Thrombolysis. 2021;51(4):877-883.

Sengupta S, Pater LE, Krummel DP, Aronow BJ, Hirota Y, Phoenix TN, Sasaki AT. Integration of Molecular Analysis, Cutting-edge Mouse Genetic Models and Proton Therapy to Improve Outcomes for Glioma Patients. Gliomas [Internet], Brisbane (AU): Exon Publications. 2021:Chapter 5.

Bryant, C. M., Henderson, R. H., Nichols, R. C., Mendenhall, W. M., Hoppe, B. S., Vargas, C. E., Daniels, T. B., Choo, C. R., Parikh, R. R., Giap, H., Slater, J. D., Vapiwala, N., Barrett, W., Nanda, A., Mishra, M. V., Choi, S., Liao, J. J., Mendenhall, N. P., & Genitourinary Subcommittee of the Particle Therapy Co-Operative Group. Consensus Statement on Proton Therapy for Prostate Cancer. Int J Part Ther. 2021;8(2):1-16.

Cunningham S, McCauley S, Vairamani K, Speth J, Girdhani S, Abel E, Sharma RA, Perentesis JP, Wells SI, Mascia A, Sertorio M. FLASH Proton Pencil Beam Scanning Irradiation Minimizes Radiation-Induced Leg Contracture and Skin Toxicity in Mice. Cancers (Basel). 2021;13(5):1012.

Zhang Y, Zhang L, Court LE, Balter P, Dong L, Yang J. Tissue-specific deformable image registration using a spatial-contextual filter. Comput Med Imaging Graph. 2020; 88:101849.

Sertorio M, Nowrouzi A, Akbarpour M, Chetal K, Salomonis N, Brons S, Mascia A, Ionascu D, McCauley S, Kupneski T, Köthe A, Debus J, Perentesis JP, Abdollahi A, Zheng Y, Wells SI. Differential transcriptome response to proton versus X-ray radiation reveals novel candidate targets for combinatorial PT therapy in lymphoma. Radiother Oncol. 2020;155:293-303.

Williams MT, Sugimoto C, Regan SL, Pitzer EM, Fritz AL, Mascia AE, Sertorio M, Vatner RE, Perentesis JP, Vorhees CV. Whole brain proton irradiation in adult Sprague Dawley rats produces dose dependent and non-dependent cognitive, behavioral, and dopaminergic effects. Sci Rep. 2020;10(1):21584.

Kinoshita K, Zabarmawi Y. Ionization clustering on charged particle tracks as a seed for biologically relevant radiation effects. Phys Rev E. 2020;101(6-1):062411.

Lee E, Perry D, Speth J, Zhang Y, Xiao Z, Mascia A. Measurement-based study on characterizing symmetric and asymmetric respiratory motion interplay effect on target dose distribution in the proton pencil beam scanning. J Appl Clin Med Phys. 2020;21(4):59-67.

Lawell MP, Indelicato DJ, Paulino AC, Hartsell W, Laack NN, Ermoian RP, Perentesis JP, Vatner R, Perkins S, Mangona VS, Hill-Kayser CE, Wolden SL, Kwok Y, Chang JH, Wilkinson JB, MacEwan I, Chang AL, Eaton BR, Ladra MM, Gallotto SL, Weyman EA, Bajaj BVM, Baliga S, Yeap BY, Berrington de Gonzalez A, Yock TI. An open invitation to join the Pediatric Proton / Photon Consortium Registry to standardize data collection in pediatric radiation oncology. Br J Radiol. 2020;93(1107):20190673.

Nowrouzi A, Sertorio MG, Akbarpour M, Knoll M, Krunic D, Kuhar M, Schwager C, Brons S, Debus J, Wells SI, Wells JM, Abdollahi A. Personalized assessment of normal tissue radiosensitivity via transcriptome response to photon, proton and carbon irradiation in patient derived human intestinal organoids. Cancers (Basel). 2020;12(2):469.

Medek S, De B, Pater L, Breneman J, Mahajan A, Wolden S, Vatner RE. Practice Patterns Among Radiation Oncologists Treating Pediatric Patients With Proton Craniospinal Irradiation. Pract Radiat Oncol. 2019;9(6):441-447.

Buchberger D, Kreinbrink P, Kharofa J. Proton Therapy in the Treatment of Anal Cancer in Pelvic Kidney Transplant Recipients: A Case Series. Int J Part Ther. 2019;6(1):28-34.

Yang J, Zhang Y, Zhang Z, Zhang L, Balter P, Court L. Technical Note: Density correction to improve CT number mapping in thoracic deformable image registration. Med Phys. 2019;46(5):2330-2336.

Cao H, Xiao Z, Zhang Y, Kwong T, Danish SF, Weiner J, Wang X, Yue N, Dai Z, Kuang Y, Bai Y, Nie K. Dosimetric comparisons of different hypofractionated stereotactic radiotherapy techniques in treating intracranial tumors > 3 cm in longest diameter. J Neurosurg. 2019;132(4):1024-1032.

Delaney AR, Dong L, Mascia A, Zou W, Zhang Y, Yin L, Rosas S, Hrbacek J, Lomax AJ, Slotman BJ, Dahele M, Verbakel WFAR. Automated Knowledge-Based Intensity-Modulated Proton Planning: An International Multicenter Benchmarking Study. Cancers (Basel). 2018;10(11):420.

Vatner RE, Niemierko A, Misra M, Weyman EA, Goebel CP, Ebb DH, Jones RM, Huang MS, Mahajan A, Grosshans DR, Paulino AC, Stanley T, MacDonald SM, Tarbell NJ, Yock TI. Endocrine Deficiency As a Function of Radiation Dose to the Hypothalamus and Pituitary in Pediatric and Young Adult Patients With Brain Tumors. J Clin Oncol. 2018;36(28):2854-2862.

Breneman JC, Donaldson SS, Constine L, Merchant T, Marcus K, Paulino AC, Followill D, Mahajan A, Laack N, Esiashvili N, Haas-Kogan D, Laurie F, Olch A, Ulin K, Hodgson D, Yock TI, Terezakis S, Krasin M, Panoff J, Chuba P, Hua CH, Hess CB, Houghton PJ, Wolden S, Buchsbaum J, Fitzgerald TJ, Kalapurakal JA. The Children's Oncology Group Radiation Oncology Discipline: 15 Years of Contributions to the Treatment of Childhood Cancer. Int J Radiat Oncol Biol Phys. 2018;101(4):860-874.

Weber DC, Habrand JL, Hoppe BS, Hill Kayser C, Laack NN, Langendijk JA, MacDonald SM, McGovern SL, Pater L, Perentesis JP, Thariat J, Timmerman B, Yock TI, Mahajan A. Proton therapy for pediatric malignancies: Fact, figures and costs. A joint consensus statement from the pediatric subcommittee of PTCOG, PROS and EPTN. Radiother Oncol. 2018;128(1):44-55.

Sertorio M, Perentesis JP, Vatner RE, Mascia AE, Zheng Y, Wells SI. Cancer Cell Metabolism: Implications for X-ray and Particle Radiation Therapy. Int J Part Ther. 2018;5(1):40-48.

Hess CB, Indelicato DJ, Paulino AC, Hartsell WF, Hill-Kayser CE, Perkins SM, Mahajan A, Laack NN, Ermoian RP, Chang AL, Wolden SL, Mangona VS, Kwok Y, Breneman JC, Perentesis JP, Gallotto SL, Weyman EA, Bajaj BVM, Lawell MP, Yeap BY, Yock TI. An Update From the Pediatric Proton Consortium Registry. Front Oncol. 2018;8:165.

Huang Q, Jabbour SK, Xiao Z, Yue N, Wang X, Cao H, Kuang Y, Zhang Y, Nie K. Dosimetric feasibility of 4DCT-ventilation imaging guided proton therapy for locally advanced non-small-cell lung cancer. Radiat Oncol. 2018;13(1):78.

Pater L, Turpin B, Mascia A. Pencil Beam Scanning Proton Therapy for Rhabdomyosarcoma of the Biliary Tract. Cureus. 2017;9(10):e1747.

Meier T, Mascia A, Wolf E, Kharofa J. Dosimetric Comparison of Intensity-Modulated Proton Therapy and Volumetric-Modulated Arc Therapy in Anal Cancer Patients and the Ability to Spare Bone Marrow. Int J Part Ther. 2017;4(2):11-17.

Phan J, Sio TT, Nguyen TP, Takiar V, Gunn GB, Garden AS, Rosenthal DI, Fuller CD, Morrison WH, Beadle B, Ma D, Zafereo ME, Hutcheson KA, Kupferman ME, William WN Jr, Frank SJ. Reirradiation of Head and Neck Cancers With Proton Therapy: Outcomes and Analyses. Int J Radiat Oncol Biol Phys. 2016;96(1):30-41.