Sinner Lab

Publications

Bottasso-Arias, N; Leesman, L; Burra, K; Snowball, J; Shah, R; Mohanakrishnan, M; Xu, Y; Sinner, D. BMP4 and Wnt signaling interact to promote mouse tracheal mesenchyme morphogenesis. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2022; 322:L224-L242.

Sinner, DI; Carey, B; Zgherea, D; Kaufman, KM; Leesman, L; Wood, RE; Rutter, MJ; de Alarcon, A; Elluru, RG; Harley, JB; Whitsett, JA; Trapnell, BC. Complete Tracheal Ring Deformity. A Translational Genomics Approach to Pathogenesis. American Journal of Respiratory and Critical Care Medicine. 2019; 200:1267-1281.

Gerhardt, B; Leesman, L; Burra, K; Snowball, J; Rosenzweig, R; Guzman, N; Ambalavanan, M; Sinner, D. Notum attenuates Wnt/β-catenin signaling to promote tracheal cartilage patterning. Developmental Biology. 2018; 436:14-27.

Snowball, J; Ambalavanan, M; Whitsett, J; Sinner, D. Endodermal Wnt signaling is required for tracheal cartilage formation. Developmental Biology. 2015; 405:56-70.

Snowball, J; Ambalavanan, M; Cornett, B; Lang, R; Whitsett, J; Sinner, D. Mesenchymal Wnt signaling promotes formation of sternum and thoracic body wall. Developmental Biology. 2015; 401:264-275.

Cornett, B; Snowball, J; Varisco, BM; Lang, R; Whitsett, J; Sinner, D. Wntless is required for peripheral lung differentiation and pulmonary vascular development. Developmental Biology. 2013; 379:38-52.

Sinner, DI; Kim, GJ; Henderson, GC; Igal, RA. StearoylCoA desaturase-5: a novel regulator of neuronal cell proliferation and differentiation. Editor, Katoh M. PloS one. 2012; 7:e39787.

Sinner, D; Kordich, JJ; Spence, JR; Opoka, R; Rankin, S; Lin, SJ; Jonatan, D; Zorn, AM; Wells, JM. Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells. Molecular and Cellular Biology. 2007; 27:7802-7815.

Sinner, D; Rankin, S; Lee, M; Zorn, AM. Sox17 and beta-catenin cooperate to regulate the transcription of endodermal genes. Development (Cambridge). 2004; 131:3069-3080.

Miao, Y; Pek, NM; Tan, C; Jiang, C; Yu, Z; Iwasawa, K; Shi, M; Kechele, DO; Sundaram, N; Pastrana-Gomez, V; Zorn, AM; Chen, YW; Guo, M; Gu, M. Co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids. Cell. 2025; 188:4295-4313.e27.

Bottasso-Arias, N; Mohanakrishnan, M; Trovillion, S; Burra, K; Russell, NX; Wu, Y; Xu, Y; Sinner, D. Wnt5a and Notum influence the temporal dynamics of cartilaginous mesenchymal condensations in developing trachea. Frontiers in Cell and Developmental Biology. 2025; 13:1523833.

Pavličev, M; McDonough-Goldstein, CE; Zupan, AM; Muglia, L; Hu, YC; Kong, F; Monangi, N; Dagdas, G; Zupančič, N; Maziarz, J; Sinner, D; Zhang, G; Wagner, G; Muglia, L. A common allele increases endometrial Wnt4 expression, with antagonistic implications for pregnancy, reproductive cancers, and endometriosis. Nature Communications. 2024; 15:1152.

Liu, Z; Lu, C; Ma, L; Li, C; Luo, H; Liu, Y; Liu, X; Li, H; Cui, Y; Zeng, J; Li, L; Wang, J; Stainier, DY R; Yin, W. The T-Type Calcium Channel CACNA1H is Required for Smooth Muscle Cytoskeletal Organization During Tracheal Tubulogenesis. Advanced Science. 2024; 11:e2308622.

Russell, NX; Burra, K; Shah, RM; Bottasso-Arias, N; Mohanakrishnan, M; Snowball, J; Ediga, HH; Madala, SK; Sinner, D. Wnt signaling regulates ion channel expression to promote smooth muscle and cartilage formation in developing mouse trachea. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2023; 325:L788-L802.

Bottasso-Arias, N; Burra, K; Sinner, D; Riede, T. Disruption of BMP4 signaling is associated with laryngeal birth defects in a mouse model. Developmental Biology. 2023; 500:10-21.

Katz Kadosh, O; Nebor, I; Smith, MM; Hart, CK; Tabangin, ME; Burra, K; Kasten, JL; Sinner, DI; de Alarcon, A. In Reference to Establishing an Endoscopic Chronic Subglottic Stenosis Rabbit Model. The Laryngoscope. 2023; 133:E32.

Kadosh, OK; Nebor, I; Smith, MM; Hart, CK; Tabangin, ME; Burra, K; Kasten, JL; Sinner, DI; de Alarcon, A. Establishing an Endoscopic Chronic Subglottic Stenosis Rabbit Model. The Laryngoscope. 2022; 132:1909-1915.

Zhou, Y; Yang, Y; Guo, L; Qian, J; Ge, J; Sinner, D; Ding, H; Califano, A; Cardoso, WV. Airway basal cells show regionally distinct potential to undergo metaplastic differentiation. eLife. 2022; 11:e80083.

Khattar, D; Fernandes, S; Snowball, J; Guo, M; Gillen, MC; Jain, SS; Sinner, D; Zacharias, W; Swarr, DT. PI3K signaling specifies proximal-distal fate by driving a developmental gene regulatory network in SOX9+ mouse lung progenitors. eLife. 2022; 11:e67954.

Bottasso-Arias, N; Leesman, L; Burra, K; Snowball, J; Shah, R; Mohanakrishnan, M; Xu, Y; Sinner, D. BMP4 and Wnt signaling interact to promote mouse tracheal mesenchyme morphogenesis. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2022; 322:L224-L242.

Gajjala, PR; Kasam, RK; Soundararajan, D; Sinner, D; Huang, SK; Jegga, AG; Madala, SK. Dysregulated overexpression of Sox9 induces fibroblast activation in pulmonary fibrosis. JCI insight. 2021; 6:e152503.

Nasr, T; Holderbaum, AM; Chaturvedi, P; Agarwal, K; Kinney, JL; Daniels, K; Trisno, SL; Ustiyan, V; Shannon, JM; Wells, JM; Sinner, D; Kalinichenko, VV; Zorn, AM. Disruption of a hedgehog-foxf1-rspo2 signaling axis leads to tracheomalacia and a loss of sox9+ tracheal chondrocytes. DMM Disease Models and Mechanisms. 2021; 14:dmm046573.

Falla-Zuñiga, LF; Sinner, D; Moreno-Martínez, D; Castellanos-Garzón, JA; Salazar-Monsalve, L; Pustovrh, MC. Mus musculus: biomodelo de expresión de Desyodinasa (DIO3) y Transtiretina (TTR) en el desarrollo placentario. Entramado. 2021; 17:218-230.

Igal, RA; Sinner, DI. Stearoyl-CoA desaturase 5 (SCD5), a Δ-9 fatty acyl desaturase in search of a function. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 2021; 1866:158840.