Sinner Research Lab

The Sinner lab aims to understand the molecular mechanisms underlying the patterning of the mammalian respiratory tract during normal development and its relevance to congenital disease. We focus on the interactions between the developing respiratory tract's two primary components: the epithelium and the mesenchyme. -The epithelium gives rise to the epithelium of the large airways and the respiratory surface of the lung. The mesenchyme gives rise to cartilage, muscle, connective tissue. Cross talk between epithelium and mesenchyme is required for the differentiation of respiratory tract cell lineages. Epithelial-Mesenchymal interactions are mediated by signaling pathways, including the Wnt signaling pathway that promotes the cells' differentiation and behavior during development, homeostasis, and disease. We utilize transgenic mouse models, ex vivo culture systems, and live imaging of embryonic tracheal tissue to study the large airways and peripheral lung formation.

Current projects:

Publications

Grants

Molecular mechanisms underlying trachea formation and the pathology of tracheomalacia and complete tracheal rings

R01 HL144774

04/04/2019-03/31/24

NIH NHLBI

Molecular basis of dorsal-ventral patterning of conducting airways

R03

09/01/2016-08/31/2018

NIH NHLBI

Molecular mechanisms underlying tracheomalacia

1K01HL115447-01

08/01/2012-07/31/2017

NIH NHLBI

Epithelium and mesenchyme.
Click for caption.