He Lab

Publications

Ali, R; Li, H; Zhang, H; Pan, W; Reeder, SB; Harris, D; Masch, W; Aslam, A; Shanbhogue, K; Bernieh, A; Ranganathan, S; Parikh, N; Dillman, JR; He, L. Multi-site, multi-vendor development and validation of a deep learning model for liver stiffness prediction using abdominal biparametric MRI. European Radiology. 2025; 35:4362-4373.

Lu, Z; Li, H; Parikh, NA; Dillman, JR; He, L. RadCLIP: Enhancing Radiologic Image Analysis Through Contrastive Language-Image Pretraining. Journal of Central South University. 2025; PP:1-10.

Jain, S; Ting Fu, T; Barnes-Davis, ME; Sahay, RD; Ehrlich, SR; Liu, C; Habli, M; Parikh, NA. Maternal Hypertension and Adverse Neurodevelopment in a Cohort of Preterm Infants. JAMA Network Open. 2025; 8:e257788.

Jia, W; Li, H; Ali, R; Shanbhogue, KP; Masch, WR; Aslam, A; Harris, DT; Reeder, SB; Dillman, JR; He, L. Investigation of ComBat Harmonization on Radiomic and Deep Features from Multi-Center Abdominal MRI Data. 2025; 38:1016-1027.

Wang, Z; Zhang, T; Wang, X; Zhai, J; He, L; Zuo, Q; Ma, S; Zhang, G; Guo, Y. Role of Complement in the Development of Hypertensive Nephropathy. 2025; 40:308-312.

Ma, S; Zuo, QJ; He, LL; Zhang, GR; Zhang, TT; Wang, ZL; Zhai, JL; Guo, YF. Canagliflozin ameliorates ferritinophagy in HFpEF rats. Journal of geriatric cardiology : JGC. 2025; 22:178-189.

Zhang, H; Li, H; Ali, R; Jia, W; Pan, W; Reeder, SB; Harris, D; Masch, W; Aslam, A; Shanbhogue, K; Parikh, NA; Dillman, JR; He, L. Development and Validation of a Modality-Invariant 3D Swin U-Net Transformer for Liver and Spleen Segmentation on Multi-Site Clinical Bi-parametric MR Images. 2025; 1-12.

Shabanian, M; Taylor, Z; Woods, C; Bernieh, A; Dillman, J; He, L; Ranganathan, S; Picarsic, J; Somasundaram, E. Liver fibrosis classification on trichrome histology slides using weakly supervised learning in children and young adults. Journal of Pathology Informatics. 2025; 16:100416.

He, L; Zuo, Q; Ma, S; Zhang, G; Wang, Z; Zhang, T; Zhai, J; Guo, Y. Canagliflozin attenuates kidney injury, gut-derived toxins, and gut microbiota imbalance in high-salt diet-fed Dahl salt-sensitive rats. Renal Failure. 2024; 46:2300314.

Wang, Z; Zhang, T; Wang, X; Zhai, J; He, L; Ma, S; Zuo, Q; Zhang, G; Guo, Y. Association between circulatory complement activation and hypertensive renal damage: a case-control study. Renal Failure. 2024; 46:2365396.

Mahabee-Gittens, EM; Harun, N; Glover, M; Folger, AT; Parikh, NA; Altaye, M; Arnsperger, A; Beiersdorfer, T; Bridgewater, K; Cahill, T; Wineland, K; Wuertz, S; Wuest, D; Yuan, W. Prenatal tobacco smoke exposure and risk for cognitive delays in infants born very premature. Scientific Reports. 2024; 14:1397.

Wang, J; Li, H; Cecil, KM; Altaye, M; Parikh, NA; He, L. DFC-Igloo: A dynamic functional connectome learning framework for identifying neurodevelopmental biomarkers in very preterm infants. Computer Methods and Programs in Biomedicine. 2024; 257:108479.

Li, Z; Li, H; Ralescu, AL; Dillman, JR; Altaye, M; Cecil, KM; Parikh, NA; He, L. Joint self-supervised and supervised contrastive learning for multimodal MRI data: Towards predicting abnormal neurodevelopment. Artificial Intelligence in Medicine. 2024; 157:102993.

Li, H; Alves, VV; Pednekar, A; Manhard, MK; Greer, J; Trout, AT; He, L; Dillman, JR. Impact of Emerging Deep Learning-Based MR Image Reconstruction Algorithms on Abdominal MRI Radiomic Features. Journal of Computer Assisted Tomography: a radiological journal dedicated to the basic and clinical aspects of reconstructive tomography. 2024; 48:955-962.

Ma, S; Zuo, Q; He, L; Zhang, G; Zhai, J; Zhang, T; Wang, Z; Guo, Y. [Canagliflozin can improve cardiac function in HFpEF rats partly by regulating ferroptosis]. Zhonghua xin xue guan bing za zhi. 2024; 52:1090-1100.

Li, H; Wang, J; Li, Z; Cecil, KM; Altaye, M; Dillman, JR; Parikh, NA; He, L. Supervised contrastive learning enhances graph convolutional networks for predicting neurodevelopmental deficits in very preterm infants using brain structural connectome. Neuroimage. 2024; 291:120579.

Mahabee-Gittens, EM; Priyanka Illapani, VS; Merhar, SL; Kline-Fath, B; Harun, N; He, L; Parikh, NA. Prenatal Opioid Exposure and Risk for Adverse Brain and Motor Outcomes in Infants Born Premature. The Journal of Pediatrics. 2024; 267:113908.

Joshi, A; Li, H; Parikh, NA; He, L. A systematic review of automated methods to perform white matter tract segmentation. Frontiers in Neuroscience. 2024; 18:1376570.

Barnes-Davis, ME; Williamson, BJ; Kline, JE; Kline-Fath, BM; Tkach, J; He, L; Yuan, W; Parikh, NA. Structural connectivity at term equivalent age and language in preterm children at 2 years corrected. Brain Communications. 2024; 6:fcae126.

Kojima, K; Kline, JE; Altaye, M; Kline-Fath, BM; Parikh, NA; Allahverdy, A; Arnsperger, A; Beiersdorfer, T; Bridgewater, K; Cahill, T; Wineland, K; Wuertz, S; Wuest, D; Yuan, W. Corpus Callosum Abnormalities at Term-Equivalent Age Are Associated with Language Development at 2 Years' Corrected Age in Infants Born Very Preterm. The Journal of Pediatrics: X. 2024; 11:200101.

Zuo, Q; He, L; Ma, S; Zhang, G; Zhai, J; Wang, Z; Zhang, T; Wang, Y; Guo, Y. Canagliflozin Alleviates Atherosclerosis Progression through Inflammation, Oxidative Stress, and Autophagy in Western Diet-fed ApoE−/− Mice. Cardiovascular Innovations and Applications. 2024; 9:e981.

Liu, RX; Li, H; Towbin, AJ; Ata, NA; Smith, EA; Tkach, JA; Denson, LA; He, L; Dillman, JR. Machine Learning Diagnosis of Small-Bowel Crohn Disease Using T2-Weighted MRI Radiomic and Clinical Data. American Journal of Roentgenology. 2024; 222:e2329812.

Li, Z; Li, H; Ralescu, AL; Dillman, JR; Altaye, M; Cecil, KM; Parikh, NA; He, L. Joint self-supervised and supervised contrastive learning for multimodal MRI data: Towards predicting abnormal neurodevelopment. 2024; 157:102993.

He, L; Li, H; Parikh, NA. MRI and Artificial Intelligence for Early Prediction of Neurodevelopmental Deficits in Very Preterm Infants. Handbook of the Biology and Pathology of Mental Disorders. : Springer Nature; Springer Nature; 2024.

Zhai, J; Wang, Z; Zhang, T; He, L; Ma, S; Zuo, Q; Zhang, G; Wang, X; Guo, Y. Canagliflozin and irbesartan ameliorate renal fibrosis via the TGF-β1/Smad signaling pathway in Dahl salt-sensitive rats. The Journal of international medical research. 2023; 51:3000605231206289.

Wang, X; Zhang, T; Zhai, J; Wang, Z; Wang, Y; He, L; Ma, S; Xing, H; Guo, Y. MiR-21 attenuates FAS-mediated cardiomyocyte apoptosis by regulating HIPK3 expression. Bioscience Reports: molecular and cellular biology of the cell surface. 2023; 43:bsr20230014.

Zhang, T; Wang, X; Wang, Z; Zhai, J; He, L; Wang, Y; Zuo, Q; Ma, S; Zhang, G; Guo, Y. Canagliflozin Ameliorates Ventricular Remodeling through Apelin/Angiotensin-Converting Enzyme 2 Signaling in Heart Failure with Preserved Ejection Fraction Rats. Pharmacology. 2023; 108:478-491.

Li, Z; Li, H; Ralescu, AL; Dillman, JR; Parikh, NA; He, L. A novel collaborative self-supervised learning method for radiomic data. Neuroimage. 2023; 277:120229.

Wang, J; Li, H; Qu, G; Cecil, KM; Dillman, JR; Parikh, NA; He, L. Dynamic weighted hypergraph convolutional network for brain functional connectome analysis. Medical Image Analysis. 2023; 87:102828.

Qian, J; Li, H; Wang, J; He, L. Recent Advances in Explainable Artificial Intelligence for Magnetic Resonance Imaging. Diagnostics. 2023; 13:1571.

Wang, Z; Zhai, J; Zhang, T; He, L; Ma, S; Zuo, Q; Zhang, G; Wang, Y; Guo, Y. Canagliflozin ameliorates epithelial-mesenchymal transition in high-salt diet-induced hypertensive renal injury through restoration of sirtuin 3 expression and the reduction of oxidative stress. Biochemical and Biophysical Research Communications. 2023; 653:53-61.

Li, H; Li, Z; Du, K; Zhu, Y; Parikh, NA; He, L. A Semi-Supervised Graph Convolutional Network for Early Prediction of Motor Abnormalities in Very Preterm Infants. Diagnostics. 2023; 13:1508.

Prasad, A; Dillman, J; Lubert, A; Trout, A; He, L; Li, H. PREDICTION OF FONTAN OUTCOMES USING T2-WEIGHTED MRI RADIOMIC FEATURES AND MACHINE LEARNING. Journal of the American College of Cardiology. 2023; 81:1618.

Mahabee-Gittens, EM; Kline-Fath, BM; Harun, N; Folger, AT; He, L; Parikh, NA. Prenatal tobacco smoke exposure and risk of brain abnormalities on magnetic resonance imaging at term in infants born very preterm. American Journal of Obstetrics and Gynecology MFM. 2023; 5:100856.

Ma, S; He, L; Zuo, Q; Zhang, G; Guo, Y. Canagliflozin Regulates Ferroptosis, Potentially via Activating AMPK/PGC-1α/Nrf2 Signaling in HFpEF Rats. Cardiovascular Innovations and Applications. 2023; 7:e987.

Li, Z; Li, H; Ralescu, AL; Dillman, JR; Parikh, NA; He, L. A Novel Collaborative Self-Supervised Learning Method for Radiomic Data. 2023; abs/2302.09807.

Zuo, Q; Zhang, G; He, L; Ma, S; Ma, H; Zhai, J; Wang, Z; Zhang, T; Wang, Y; Guo, Y. Canagliflozin Attenuates Hepatic Steatosis and Atherosclerosis Progression in Western Diet-Fed ApoE-Knockout Mice. Drug Design, Development and Therapy. 2022; 16:4161-4177.

Kline, JE; Dudley, J; Illapani, VS P; Li, H; Kline-Fath, B; Tkach, J; He, L; Yuan, W; Parikh, NA. Diffuse excessive high signal intensity in the preterm brain on advanced MRI represents widespread neuropathology. Neuroimage. 2022; 264:119727.

Wang, Y; Fu, GP; Wang, QY; Zhang, TT; He, LL; Zuo, QJ; Zhang, CL; Guo, YF. The relationship between serum miR-21 levels and left atrium dilation in elderly patients with essential hypertension. Journal of geriatric cardiology : JGC. 2022; 19:833-842.

Li, Z; Li, H; Braimah, A; Dillman, JR; Parikh, NA; He, L. A novel Ontology-guided Attribute Partitioning ensemble learning model for early prediction of cognitive deficits using quantitative Structural MRI in very preterm infants. Neuroimage. 2022; 260:119484.

Dillman, JR; Somasundaram, E; Brady, SL; He, L. Current and emerging artificial intelligence applications for pediatric abdominal imaging. Pediatric Radiology: roentgenology, nuclear medicine, ultrasonics, CT, MRI. 2022; 52:2139-2148.

Ali, R; Li, H; Dillman, JR; Altaye, M; Wang, H; Parikh, NA; He, L. A self-training deep neural network for early prediction of cognitive deficits in very preterm infants using brain functional connectome data. Pediatric Radiology: roentgenology, nuclear medicine, ultrasonics, CT, MRI. 2022; 52:2227-2240.

Jain, VG; Kline, JE; He, L; Kline-Fath, BM; Altaye, M; Muglia, LJ; DeFranco, EA; Ambalavanan, N; Parikh, NA. Acute histologic chorioamnionitis independently and directly increases the risk for brain abnormalities seen on magnetic resonance imaging in very preterm infants. American Journal of Obstetrics and Gynecology. 2022; 227:623.e1-623.e13.

Zhao, X; Peng, X; Niu, K; Li, H; He, L; Yang, F; Wu, T; Chen, D; Zhang, Q; Ouyang, M; Guo, J; Pan, Y. A multi-head self-attention deep learning approach for detection and recommendation of neuromagnetic high frequency oscillations in epilepsy. Frontiers in Neuroinformatics. 2022; 16:771965.

Ma, S; He, LL; Zhang, GR; Zuo, QJ; Wang, ZL; Zhai, JL; Zhang, TT; Wang, Y; Ma, HJ; Guo, YF. Canagliflozin mitigates ferroptosis and ameliorates heart failure in rats with preserved ejection fraction. Naunyn-Schmiedeberg's Archives of Pharmacology. 2022; 395:945-962.

Jiang, W; Merhar, SL; Zeng, Z; Zhu, Z; Yin, W; Zhou, Z; Wang, L; He, L; Vannest, J; Lin, W. Neural alterations in opioid-exposed infants revealed by edge-centric brain functional networks. Brain Communications. 2022; 4:fcac112.

Chen, M; Li, H; Fan, H; Dillman, JR; Wang, H; Altaye, M; Zhang, B; Parikh, NA; He, L. ConCeptCNN: A novel multi-filter convolutional neural network for the prediction of neurodevelopmental disorders using brain connectome. Medical Physics. 2022; 49:3171-3184.

Zhang, H; Li, H; Dillman, JR; Parikh, NA; He, L. Multi-Contrast MRI Image Synthesis Using Switchable Cycle-Consistent Generative Adversarial Networks. Diagnostics. 2022; 12:816.

He, L; Ma, S; Zuo, Q; Zhang, G; Wang, Z; Zhang, T; Zhai, J; Guo, Y. An Effective Sodium-Dependent Glucose Transporter 2 Inhibition, Canagliflozin, Prevents Development of Hypertensive Heart Failure in Dahl Salt-Sensitive Rats. Frontiers in Pharmacology. 2022; 13:856386.

Guo, J; Xiao, N; Li, H; He, L; Li, Q; Wu, T; He, X; Chen, P; Chen, D; Xiang, J; Peng, X. Transformer-Based High-Frequency Oscillation Signal Detection on Magnetoencephalography From Epileptic Patients. Frontiers in Molecular Biosciences. 2022; 9:822810.

Li, Z; Li, H; Braimah, A; Dillman, JR; Parikh, NA; He, L. A novel Ontology-guided Attribute Partitioning ensemble learning model for early prediction of cognitive deficits using quantitative Structural MRI in very preterm infants. Neuroimage. 2022; 260:119484.

Li, Z; Li, H; Braimah, A; Dillman, JR; Parikh, NA; He, L. A Novel Ontology-guided Attribute Partitioning Ensemble Learning Model for Early Prediction of Cognitive Deficits using Quantitative Structural MRI in Very Preterm Infants. 2022; abs/2202.04134.

He, L; Li, H; Chen, M; Wang, J; Altaye, M; Dillman, JR; Parikh, NA. Deep Multimodal Learning From MRI and Clinical Data for Early Prediction of Neurodevelopmental Deficits in Very Preterm Infants. Frontiers in Neuroscience. 2021; 15:753033.

Chandwani, R; Kline, JE; Harpster, K; Tkach, J; Parikh, NA; Altaye, M; Arnsperger, A; Beiersdorfer, T; Bridgewater, K; Cahill, T; Wineland, K; Wuertz, S; Wuest, D; Yuan, W. Early micro- and macrostructure of sensorimotor tracts and development of cerebral palsy in high risk infants. Human Brain Mapping. 2021; 42:4708-4721.

Merhar, SL; Jiang, W; Parikh, NA; Yin, W; Zhou, Z; Tkach, JA; Wang, L; Kline-Fath, BM; He, L; Braimah, A; Vannest, J; Lin, W. Effects of prenatal opioid exposure on functional networks in infancy. Developmental Cognitive Neuroscience. 2021; 51:100996.

Merhar, SL; Kline, JE; Braimah, A; Kline-Fath, BM; Tkach, JA; Altaye, M; He, L; Parikh, NA. Prenatal opioid exposure is associated with smaller brain volumes in multiple regions. Pediatric Research. 2021; 90:397-402.

Parikh, MN; Chen, M; Braimah, A; Kline, J; McNally, K; Logan, JW; Tamm, L; Yeates, KO; Yuan, W; He, L; Parikh, NA. Diffusion MRI Microstructural Abnormalities at Term-Equivalent Age Are Associated with Neurodevelopmental Outcomes at 3 Years of Age in Very Preterm Infants. American Journal of Neuroradiology. 2021; 42:1535-1542.

Parikh, NA; Sharma, P; He, L; Li, H; Altaye, M; Priyanka Illapani, VS; Arnsperger, A; Beiersdorfer, T; Bridgewater, K; Cahill, T; Wineland, K; Wuertz, S; Wuest, D; Yuan, W. Perinatal Risk and Protective Factors in the Development of Diffuse White Matter Abnormality on Term-Equivalent Age Magnetic Resonance Imaging in Infants Born Very Preterm. The Journal of Pediatrics. 2021; 233:58-65.e3.

Li, H; Chen, M; Wang, J; Illapani, VS P; Parikh, NA; He, L. Automatic Segmentation of Diffuse White Matter Abnormality on T2-weighted Brain MR Images Using Deep Learning in Very Preterm Infants. Radiology: Artificial Intelligence. 2021; 3:e200166.

Li, H; He, L; Dudley, JA; Maloney, TC; Somasundaram, E; Brady, SL; Parikh, NA; Dillman, JR. DeepLiverNet: a deep transfer learning model for classifying liver stiffness using clinical and T2-weighted magnetic resonance imaging data in children and young adults. Pediatric Radiology: roentgenology, nuclear medicine, ultrasonics, CT, MRI. 2021; 51:392-402.

Logan, JW; Tan, J; Skalak, M; Fathi, O; He, L; Klein, J; Klebanoff, M; Parikh, NA. Adverse effects of perinatal illness severity on neurodevelopment are partially mediated by early brain abnormalities in infants born very preterm. Journal of Perinatology. 2021; 41:519-527.

Kline, JE; Illapani, VS P; Li, H; He, L; Yuan, W; Parikh, NA. Diffuse white matter abnormality in very preterm infants at term reflects reduced brain network efficiency. NeuroImage-Clinical. 2021; 31:102739.