Brain and Spinal Tumors Research Studies

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Other Neurofibromatosis Trials

PBTC-050: A Phase I and Surgical Study of Ribociclib and Everolimus (RAD001) in Children With Recurrent or Refractory Malignant Brain Tumors

  • Conditions: Brain Spinal Tumors Medulloblastoma Relapse, Adult - Brain Spinal Tumors Medulloblastoma Relapse, Brain Spinal Tumor Low Grade Glioma Relapse, Adult - Brain Spinal Tumor Low Grade Glioma Relapse, Brain Spinal Tumor DIPG Relapse, Adult - Brain Spinal Tumor DIPG Relapse, Brain and Spinal Tumor Ependymoma Relapse, Adult - Brain and Spinal Tumor Ependymoma Relapse, Adult - Brain Spinal Neurofibromatosis Sarcoma MPNST Relapse, Brain Spinal Neurofibromatosis Sarcoma MPNST Relapse, Brain Spinal Neurofibromatosis OPG, Adult - Brain Spinal Neurofibromatosis OPG, Brain Spinal Neurofibromatosis Other, Adult - Brain Spinal Neurofibromatosis Other, Brain Spinal Other All Other, Adult - Brain Spinal Other All Other, Brain Spinal Other ATRT, Adult - Brain Spinal Other ATRT, Brain Spinal Other Craniopharyngioma, Adult - Brain Spinal Other Craniopharyngioma, Adult - Brain Spinal Other Germ Cell Tumor, Brain Spinal Other Germ Cell Tumor, Brain Spinal Other Choroid Plexus Tumor, Adult - Brain Spinal Other Choroid Plexus Tumor

PURPOSE: This phase I trial studies the side effects and best dose of ribociclib and everolimus and to see how well they work in treating patients with malignant brain tumors that have come back or do not respond to treatment. Ribociclib may stop the growth of tumor cells by blocking some of the enz ...More